Search | Clinical Trials Finder

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ClinicalTrials.gov public records Last synced Nov 14, 2026, 8:34 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 98 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Sertraline + Placebo Clear all

Conditions: Post-Traumatic Stress Disorders
Interventions: Sertraline and Risperidone; Drug
Lead sponsor: Emory University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 65 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2004 – 2006
U.S. locations: 3
States / cities: Atlanta, Georgia • Durham, North Carolina • Charleston, South Carolina

Conditions: Stress Disorders, Post-Traumatic, Alcohol Abuse, Substance-Related Disorders
Interventions: Seeking Safety, Sertraline, Pill placebo; Behavioral · Drug
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 18 Years to 65 Years
Enrollment: 69 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2013
U.S. locations: 1
States / cities: New York, New York

Conditions: Depressive Disorder, Major
Interventions: Sertraline and Elzasonan Combination, Sertraline, Placebo; Drug
Lead sponsor: Pfizer; Industry
Eligibility: 18 Years and older
Enrollment: 262 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2007
U.S. locations: 4
States / cities: Beverly Hills, California • Norwich, Connecticut • New York, New York + 1 more

Conditions: Depressive Disorder, Major
Interventions: electronic diary, Sertraline, Placebo, voice acoustics; Procedure · Drug
Lead sponsor: Pfizer; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 165 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2007
U.S. locations: 12
States / cities: Norwich, Connecticut • Aventura, Florida • Jacksonville, Florida + 7 more

Conditions: Depressive Disorder, Major
Interventions: sertraline (Zoloft); Drug
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years to 65 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2003
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Traumatic Brain Injury
Interventions: Placebo, Sertraline; Drug
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 18 Years to 85 Years
Enrollment: 94 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2014
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Major Depressive Disorder
Interventions: Placebo, Cariprazine; Drug
Lead sponsor: Forest Laboratories; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 819 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 39
States / cities: Garden Grove, California • National City, California • Oceanside, California + 34 more

Conditions: Heart Failure, Congestive, Chronic Heart Failure, Depression
Interventions: Sertraline, Placebo; Drug
Lead sponsor: Duke University; Other
Eligibility: 45 Years and older
Enrollment: 469 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2008
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Stress Disorders, Post-Traumatic
Interventions: Brexpiprazole, Sertraline, Brexpiprazole Matching Placebo, Sertraline Matching Placebo; Drug
Lead sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 336 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 54
States / cities: Tuscaloosa, Alabama • Phoenix, Arizona • Little Rock, Arkansas + 48 more

Conditions: Depression
Interventions: Sertraline, Metformin; Drug
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 20 Years to 60 Years
Enrollment: 206 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2013
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Depression
Interventions: Placebo, identified as placebo to participants, Celexa or other antidepressant as clinically indicated, Placebo, identifed to participants as "Active medication"; Other · Drug
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years to 60 Years
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2015
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Alcoholism, Depression
Interventions: naltrexone (Revia), sertraline (Zoloft), Placebo; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 21 Years to 65 Years
Enrollment: 171 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2000 – 2006
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Major Depression
Interventions: Triiodothyronine, Placebo, Sertraline; Drug · Other
Lead sponsor: Emory University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 153 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1996 – 2003
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Post-Traumatic Stress Disorder
Interventions: sertraline and risperidone; Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2006
U.S. locations: 2
States / cities: Atlanta, Georgia • Charleston, South Carolina

Conditions: Obsessive-Compulsive Disorder
Interventions: Cognitive Behavior Therapy, Educational Support, Sertraline; Behavioral · Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 8 Years to 16 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1997 – 2002
U.S. locations: 2
States / cities: Durham, North Carolina • Philadelphia, Pennsylvania

Conditions: Psychotic Depression
Interventions: Sertraline + Olanzapine, Sertraline + Placebo; Drug
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 18 Years to 85 Years
Enrollment: 269 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2017
U.S. locations: 3
States / cities: Worcester, Massachusetts • White Plains, New York • Pittsburgh, Pennsylvania

Conditions: Posttraumatic Stress Disorder
Interventions: Mirtazapine, Sertraline, Sugar pill; Drug · Other
Lead sponsor: Research Foundation for Mental Hygiene, Inc.; Other
Eligibility: 18 Years to 75 Years
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: New York, New York

Conditions: Major Depressive Disorder (MDD)
Interventions: SSRI (escitalopram or sertraline), Extended-Release Memantine, Placebo; Drug
Lead sponsor: Jeffrey Miller; Other
Eligibility: 18 Years to 50 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Major Depressive Disorder
Interventions: SPD489 (Lisdexamfetamine dimesylate ), Placebo; Drug
Lead sponsor: Shire; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 1,262 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 47
States / cities: Birmingham, Alabama • Carson, California • Irvine, California + 42 more

Conditions: Major Depressive Disorder
Interventions: Antidepressant + SPD489 (Lisdexamfetamine dimesylate ), Antidepressant + Placebo; Drug
Lead sponsor: Shire; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 1,105 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 36
States / cities: Scottsdale, Arizona • Little Rock, Arkansas • Costa Mesa, California + 31 more

Conditions: Depression
Interventions: Omega-3 supplement, Placebo; Drug
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 25 Years and older
Enrollment: 144 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2018
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Major Depressive Disorder
Interventions: Levomilnacipran ER, Paroxetine, Sertraline, Citalopram or Fluoxetine., Placebo; Drug
Lead sponsor: Forest Laboratories; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 262 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 20
States / cities: Birmingham, Alabama • Little Rock, Arkansas • Cerritos, California + 17 more

Conditions: Traumatic Brain Injury
Interventions: sertraline; Drug
Lead sponsor: Walter Reed Army Medical Center; Federal
Eligibility: 18 Years to 65 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2000 – 2007
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Social Anxiety Disorder
Interventions: Ziprasidone, Sertraline; Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 51 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2009
U.S. locations: 2
States / cities: Durham, North Carolina

Search by objective public record fields.

Civilian Post-Traumatic Stress Disorder Risperidone Clinical Trial

Combined Treatment for Alcohol-Dependent Individuals With PTSD

A Research Study to Compare the Treatments of a Combination of Elzasonan With Zoloft, to Zoloft Alone, or Placebo in People With Major Depressive Disorder (MDD)

Study for Evaluating Different Methods of Measuring Depression Treatment Response

Study of Medication and Placebo Response in Major Depression

Treatment Strategy to Prevent Mood Disorders Following Traumatic Brain Injury

Safety and Efficacy of Cariprazine as an Adjunctive to Antidepressant Therapy in Major Depressive Disorder

Antidepressant Medication Treatment for Depression in Individuals With Chronic Heart Failure

A Study of Flexible Dose Brexpiprazole as Monotherapy or Combination Therapy in the Treatment of Adults With Post-traumatic Stress Disorder (PTSD)

Adding an Insulin-Sensitizing Medication to Depression Treatment for People Who Are Depressed and Overweight

Predictors of Antidepressant Response

Sertraline for Alcohol Dependence and Depression

Thyroid Medication and Antidepressants for Treating Major Depression

Risperidone Augmentation for PTSD

Treatment of Obsessive-Compulsive Disorder (OCD) in Children

Sustaining Remission of Psychotic Depression

Combined Mirtazapine and SSRI Treatment of PTSD: A Placebo-Controlled Trial

Pattern Separation in Major Depressive Disorder

Efficacy and Safety Study of SPD489 in Combination With an Antidepressant in the Treatment of Adults With Major Depressive Disorder

Efficacy and Safety Study of SPD489 in Combination With an Antidepressant in the Treatment of Adults With Major Depressive Disorder

Omega-3 for Depression and Other Cardiac Risk Factors - 2

Safety and Efficacy of Levomilnacipran ER (F2695 SR) in Adults With Fatigue Associated With Major Depressive Disorder

Sertraline vs. Placebo for Symptoms Following Traumatic Brain Injury

Geodon for the Treatment of Refractory Social Anxiety Disorder