Search | Clinical Trials Finder

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ClinicalTrials.gov public records Last synced Nov 7, 2026, 3:06 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1513–1536 of 1,664 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Sham (Control) Clear all

Conditions: Respiratory Tract Diseases, Cardiovascular Diseases
Interventions: DIY portable air cleaner with a highly effective filter, DIY portable air cleaner with sham filtration; Other
Lead sponsor: Environmental Protection Agency (EPA); Federal
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023
U.S. locations: 1
States / cities: Fresno, California

Conditions: ACL Injury
Interventions: Neuromuscular Training; Other
Lead sponsor: Children's Hospital Medical Center, Cincinnati; Other
Eligibility: 10 Years to 19 Years · Female only
Enrollment: 593 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2013
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Obstructive Sleep Apnea
Interventions: Oral appliance, Oxygen, Oral appliance plus oxygen, No treatment; Device · Drug · Other
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 21 Years to 79 Years
Enrollment: 41 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2023
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Type 2 Diabetes
Interventions: Duodenal Mucosal Resurfacing (DMR), Duodenal Mucosal Resurfacing (Sham); Device
Lead sponsor: Fractyl Health Inc.; Industry
Eligibility: 21 Years to 70 Years
Enrollment: 320 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 51
States / cities: Phoenix, Arizona • Scottsdale, Arizona • Los Angeles, California + 39 more

Conditions: Parkinson's Disease
Interventions: EMST - Active Treatment, sham EMST; Device
Lead sponsor: University of Florida; Other
Eligibility: 35 Years to 85 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2008
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Healthy, Pain
Interventions: Selective Nerve Stimulation (SNS) stimulator device; Device
Lead sponsor: Codman & Shurtleff; Industry
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Raynham, Massachusetts

Conditions: Breast Cancer
Interventions: Acupuncture, Sham acupuncture; Behavioral
Lead sponsor: University of Illinois Chicago; Other
Eligibility: 18 Years and older · Female only
Enrollment: 252 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2031
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Patellofemoral Pain Syndrome, Anterior Knee Pain Syndrome
Interventions: Dry Needling, Sham Dry Needling, Physical Therapy; Device · Other
Lead sponsor: Ohio State University; Other
Eligibility: 18 Years to 40 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2030
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Autosomal Dominant Retinitis Pigmentosa, Eye Diseases, Eye Diseases, Hereditary, Retinal Dystrophies, Retinal Disease, Retinitis, Vision Tunnel, Vision Disorders
Interventions: QR-1123, Sham procedure; Drug · Other
Lead sponsor: ProQR Therapeutics; Industry
Eligibility: 18 Years and older
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 5
States / cities: Aurora, Colorado • Gainesville, Florida • Lexington, Kentucky + 2 more

Conditions: Pupillary Response
Interventions: Transcutaneous Auricular Vagal Nerve Stimulation (taVNS), Sham Stimulation; Procedure
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 65 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: New York, New York

Conditions: Parkinsons Disease, Sleep
Interventions: Osteopathic Manipulative Treatment, Sham (No Treatment); Procedure
Lead sponsor: New York Institute of Technology; Other
Eligibility: Not listed
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Old Westbury, New York

Conditions: Macular Telangiectasia Type 2 (MacTel)
Interventions: NT-501, Sham Procedure; Combination Product · Procedure
Lead sponsor: Neurotech Pharmaceuticals; Industry
Eligibility: 21 Years to 80 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 16
States / cities: La Jolla, California • Los Angeles, California • Palo Alto, California + 13 more

Conditions: Asthma
Interventions: JNJ-18054478, sham comparator; Drug
Lead sponsor: Johnson & Johnson Pharmaceutical Research & Development, L.L.C.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2008
U.S. locations: 29
States / cities: Scottsdale, Arizona • Long Beach, California • Los Angeles, California + 26 more

Conditions: Migraine With or Without Aura, Migraine, Migraine Headache
Interventions: Mi-Helper; Device
Lead sponsor: Mi-Helper, Inc.; Industry
Eligibility: 18 Years to 70 Years
Enrollment: 156 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025
U.S. locations: 1
States / cities: Indian Harbour Beach, Florida

Conditions: Keratoconus
Interventions: Riboflavin and Sodium Iodide solution and Ultraviolet-A treatment, Placebo and sham treatment; Combination Product
Lead sponsor: Epion Therapeutics; Industry
Eligibility: 8 Years to 45 Years
Enrollment: 396 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 13
States / cities: Rowland Heights, California • San Francisco, California • Miami, Florida + 10 more

Conditions: Stroke, Cerebrovascular Accident (CVA), Hemiparesis
Interventions: Transcutaneous Vagus Nerve Stimulation (tVNS), Sham Transcutaneous Vagus Nerve Stimulation (tVNS); Device
Lead sponsor: Northwell Health; Other
Eligibility: 18 Years to 85 Years
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Manhasset, New York

Conditions: Parkinson's Disease
Interventions: VY-AADC02, Sham (Placebo) Surgery; Biological · Other
Lead sponsor: Neurocrine Biosciences; Industry
Eligibility: 40 Years to 75 Years
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2024
U.S. locations: 11
States / cities: Irvine, California • Sacramento, California • San Francisco, California + 8 more

Conditions: Obesity, Overweight
Interventions: Active Elipse Device, Elipse Sham Device; Device
Lead sponsor: Allurion Technologies; Industry
Eligibility: 22 Years to 65 Years
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 12
States / cities: Scottsdale, Arizona • Aurora, Colorado • Bolingbrook, Illinois + 9 more

Conditions: Healthy
Interventions: Transcranial Direct Current Stimulation; Device
Lead sponsor: University of California, Davis; Other
Eligibility: 18 Years to 50 Years
Enrollment: 75 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: Sacramento, California

Conditions: Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature, Bronchopulmonary Dysplasia, Respiration, Artificial, Respiratory Distress Syndrome, Newborn, Sepsis
Interventions: Vitamin A, Sham Procedure; Drug · Other
Lead sponsor: NICHD Neonatal Research Network; Network
Eligibility: 24 Hours to 96 Hours
Enrollment: 807 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1996 – 1999
U.S. locations: 11
States / cities: Palo Alto, California • New Haven, Connecticut • Washington D.C., District of Columbia + 8 more

Conditions: Multiple Drug Use
Interventions: IBMT, NF; Behavioral
Lead sponsor: Arizona State University; Other
Eligibility: 18 Years and older
Enrollment: 35 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Phoenix, Arizona

Conditions: Diabetic Retinopathy
Interventions: Surabgene Lomparvovec, Sham, Topical Steroid, Artificial Tears; Drug
Lead sponsor: AbbVie; Industry
Eligibility: 18 Years and older
Enrollment: 576 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2036
U.S. locations: 39
States / cities: Mesa, Arizona • Phoenix, Arizona • Scottsdale, Arizona + 36 more

Conditions: Chronic Heart Failure With Reduced Ejection Fraction
Interventions: Vericiguat, Placebo; Drug
Lead sponsor: Merck Sharp & Dohme LLC; Industry
Eligibility: 18 Years and older
Enrollment: 6,106 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 84
States / cities: Alexander City, Alabama • Birmingham, Alabama • Huntsville, Alabama + 74 more

Conditions: Pain, Postoperative
Interventions: Local anesthesia at incision site, Sham QL, Sham Local, QL; Drug
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years and older · Female only
Enrollment: 76 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Houston, Texas

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ASPIRE Health Tulare County

Neuromuscular Intervention Targeted to Mechanisms of ACL Load in Female Athletes

Combined Upper-airway and Breathing Control Therapies for Obstructive Sleep Apnea

Evaluation of the Efficacy and Safety of DMR Using the Revita® in Subjects With Inadequately Controlled Type 2 Diabetes

Expiratory Muscle Training in Patients With Parkinson's Disease

Selective Nerve Stimulation (SNS) Pilot Study

Effects, Metabolic Mechanisms and Predictors of Response to Acupuncture in Treating Psychoneurological Symptoms Among Breast Cancer Survivors

The Effects of Dry Needling on Patients With Knee Pain

A Study to Evaluate the Safety and Tolerability of QR-1123 in Subjects With Autosomal Dominant Retinitis Pigmentosa Due to the P23H Mutation in the RHO Gene

taVNS on Pupillary Response and Perceptual Learning

Effects of Osteopathic Manipulative Treatment Protocol on Sleep Quality in Parkinson's Disease Subjects

A Study to Determine the Safety and Efficacy of NT-501 in Macular Telangiectasia Type 2 - Protocol A

Effectiveness and Safety Study for JNJ-18054478 in Asthma Patients.

Cooling to Alleviate Migraine #3

Epithelium-On Corneal Cross-linking in Subjects 8 to 45 Years of Age With Keratoconus

Transcutaneous Vagus Nerve Stimulation (tVNS) and Robotic Training to Improve Arm Function After Stroke

VY-AADC02 for Parkinson's Disease With Motor Fluctuations (RESTORE-1)

THE ENLIGHTEN STUDY

Effects of PFC tDCS on Cognitive Control, Attention Lapses and Coordinated Neural Activity in the Theta and Alpha Bands

Vitamin A Supplementation for Extremely-Low-Birth-Weight Infants

Brain Mechanisms of Reducing Polysubstance Use

Surabgene Lomparvovec Administered in the Suprachoroidal Space in Adult Participants With Diabetic Retinopathy Without Center-Involved Diabetic Macular Edema

A Study of Vericiguat (MK-1242) in Participants With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-035)

The Role of Quadratus Lumborum Blocks Following Minimally Invasive Hysterectomy