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ClinicalTrials.gov public records Last synced Nov 14, 2026, 8:34 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 25–48 of 89 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Smoking Relapse Prevention Clear all

Conditions: Smoking Cessation, Alcohol Use
Interventions: Mindfulness-Based Relapse Prevention for Smoking and Alcohol (MBRP-SA), Quitline Support; Behavioral
Lead sponsor: H. Lee Moffitt Cancer Center and Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 600 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Tampa, Florida

Conditions: Smoking Cessation, Tobacco Use Cessation, Tobacco Smoking
Interventions: Nicorette, Tobacco Quit-line, Brief Behavioral Counseling, Intensive Behavioral Counseling; Drug · Behavioral
Lead sponsor: University of Miami; Other
Eligibility: 18 Years and older
Enrollment: 608 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Nicotine Dependence
Interventions: GSK598809, Placebo; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 84 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2013
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Cigarette Smoker, Current Every Day Smoker, Current Smoker
Interventions: Questionnaire Administration, Repetitive Transcranial Magnetic Stimulation, Sham Intervention; Other · Procedure
Lead sponsor: Roswell Park Cancer Institute; Other
Eligibility: 18 Years and older
Enrollment: 206 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2026
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Smoking
Interventions: Telephone Counseling, Telephone Assessments; Behavioral
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 370 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2021
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Smoking, Smoking Cessation
Interventions: Culturally Specific CBT, Standard CBT; Behavioral
Lead sponsor: University of Miami; Other
Eligibility: 18 Years to 65 Years
Enrollment: 345 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: Coral Gables, Florida

Conditions: Smoking Cessation
Interventions: Quitline Service + 10 automated monitoring calls, Quitline service + 20 automated monitoring calls; Behavioral
Lead sponsor: Indiana University; Other
Eligibility: 18 Years and older
Enrollment: 1,785 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Smoking Cessation
Interventions: Android Wear smartwatch, Adaptive Treatment, Nicotine Patch, interviewing-based counseling; Behavioral · Drug
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Smoking
Interventions: Varenicline, Placebo; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 70 Years
Enrollment: 247 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2013
U.S. locations: 10
States / cities: Birmingham, Alabama • Bloomington, Indiana • Boston, Massachusetts + 6 more

Conditions: Smoking Cessation, Weight Loss
Interventions: BAS+, SC; Behavioral
Lead sponsor: Abramson Cancer Center at Penn Medicine; Other
Eligibility: 18 Years to 65 Years
Enrollment: 288 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2021
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Smoking
Interventions: Web+phone; Behavioral
Lead sponsor: Oregon Research Institute; Other
Eligibility: 18 Years to 60 Years · Female only
Enrollment: 62 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Eugene, Oregon

Conditions: Tobacco Use Disorder, Smoking Cessation
Interventions: Nicotine Polacrilex Gum (2 mg), Cognitive Behavioral Group Therapy (CBGT); Drug · Behavioral
Lead sponsor: University of Hawaii; Other
Eligibility: 18 Years to 80 Years
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Honolulu, Hawaii

Conditions: Smoking Cessation
Interventions: Moms Quit, Text4Baby; Behavioral
Lead sponsor: University of Kansas Medical Center; Other
Eligibility: 18 Years and older · Female only
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Kansas City, Kansas

Conditions: Smoking Cessation, Smoking, Nicotine Dependence
Interventions: CIS - telephone cessation quitline counseling, Lozenge - nicotine mini-lozenges, Emails - Brief smoking prevention messages, Full website - standard smokefree.gov website content, Lite website - lite version of smokefree.gov, Full mailed booklet - NCI's detailed 36-page quit guide, brief mailed booklet - smaller version of NCI's booklet; Other
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older
Enrollment: 1,034 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Smoking Cessation
Interventions: NRT, Web Guide, Tweet2Quit; Drug · Behavioral
Lead sponsor: University of California, Irvine; Other
Eligibility: 21 Years to 59 Years
Enrollment: 980 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2022
U.S. locations: 2
States / cities: Irvine, California • Stanford, California

Conditions: Cigarette Smoking-Related Carcinoma
Interventions: Informational Intervention, Media Intervention, Questionnaire Administration, Smoking Cessation Intervention, Survey Administration, Telephone-Based Intervention, Tobacco Cessation Counseling; Other · Behavioral
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years and older · Female only
Enrollment: 191 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2026
U.S. locations: 1
States / cities: Houston, Texas

Conditions: HIV/AIDS, Nicotine Dependence
Interventions: Varenicline, Nicotine patch, Standard treatment, Standard treatment + Managed Problem Solving (MAPS) adherence intervention; Drug · Behavioral
Lead sponsor: Abramson Cancer Center at Penn Medicine; Other
Eligibility: 18 Years and older
Enrollment: 340 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2026
U.S. locations: 2
States / cities: Chicago, Illinois • Philadelphia, Pennsylvania

Conditions: Smoking Cessation, Smoking, Smoking Reduction, Smoking, Cigarette, Smoking (Tobacco) Addiction, Smoking Habit
Interventions: Guided Imagery Intervention, Standard Behavioral Control; Other
Lead sponsor: University of Arizona; Other
Eligibility: 18 Years and older
Enrollment: 1,209 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Tucson, Arizona

Conditions: Smoking Cessation
Interventions: Telephone Counseling, Self-Help Materials; Behavioral
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years to 75 Years
Enrollment: 2,277 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2008
U.S. locations: 1
States / cities: San Diego, California

Conditions: Smoking, Lung Cancer
Interventions: Telephone Counseling, Minimal Treatment; Behavioral
Lead sponsor: Georgetown University; Other
Eligibility: 55 Years to 80 Years
Enrollment: 95 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2016
U.S. locations: 3
States / cities: Washington D.C., District of Columbia • Burlington, Massachusetts • Hackensack, New Jersey

Conditions: Tobacco Dependence
Interventions: ProChange ExpertSystem; Behavioral
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 360 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2018
U.S. locations: 3
States / cities: Menlo Park, California • San Francisco, California • San Rafael, California

Conditions: Lung Cancer, Heart Disease, COPD
Interventions: Smoking cessation treatment plus moderate intensity exercise, Smoking cessation treatment plus health education; Behavioral
Lead sponsor: The Miriam Hospital; Other
Eligibility: 18 Years to 65 Years · Female only
Enrollment: 59 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2008
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Cigarette Smoking, Marijuana Abuse
Interventions: bupropion, transdermal nicotine patch, Nicotine polacrilex, nicotine lozenge, counseling for marijuana and smoking cessation, mobile contingency management; Drug · Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Cigarette Smoking
Interventions: Smoking Cessation Guideline Implementation; Behavioral
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 18 Years and older
Enrollment: 898 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2013
U.S. locations: 4
States / cities: Denver, Colorado • Iowa City, Iowa • Minneapolis, Minnesota + 1 more

Search by objective public record fields.

Testing an MBI for Smoking Cessation and Alcohol Use Among Cancer Survivors

Smoking Cessation Program in the Construction Sector

Effectiveness of GSK598809, a Selective D3 Antagonist, Added to CBT and NRT for Smoking Cessation and Relapse Prevention

rTMS in Promoting Smoking Cessation and Preventing Relapse in Current Smokers

Combined Treatment for Tobacco and Alcohol Use in Puerto Rico

Culturally Specific Interventions: African American Smokers

Technology-Enhanced Quitline Services to Prevent Smoking Relapse

Using Machine Learning to Develop Just-in-Time Adaptive Interventions for Smoking Cessation

A Study of Varenicline for Prevention of Relapse to Smoking in Patients With Schizophrenia or Bipolar Disorder

Behavioral Activation for Smoking Cessation and the Prevention of Post-Cessation Weight Gain

Web and Phone Intervention to Maintain Postpartum Tobacco Abstinence

Quit-Smoking Study for Native Hawaiians

Helping Moms Quit Pilot Trial

Evaluation of National Cancer Institute (NCI) Smoking Intervention Resources

Twitter-enabled Mobile Messaging for Smoking Relapse Prevention (Tweet2Quit)

Increasing Access to Smoking Cessation and Smoke Free Home Services for Low-Income Pregnant Women in Northeast Texas

Optimizing Tobacco Use Treatment for PLWHA

Testing the Efficacy of A Scalable, Telephone-Delivered, Guided Imagery Tobacco Cessation Intervention

Smokers' Quitline for Asian Language Speakers

Lombardi Comprehensive Cancer Center/Legacy Pilot Study to Reduce Adverse Smoking Outcomes in the Context of Lung Cancer Screening

Tobacco Treatment for Employable Californians, Total IMPACT Study

Does Moderate Intensity Exercise Help Prevent Smoking Relapse Among Women?

Mobile Contingency Management for Marijuana and Tobacco Cessation

Improving the Delivery of Smoking Cessation Guidelines in Hospitalized Veterans