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ClinicalTrials.gov public records Last synced Nov 15, 2026, 2:47 AM EST

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Showing 25–48 of 228 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Smoking abstinence Clear all

Conditions: Smoking Cessation
Interventions: Usual care, Reduction, 5Rs; Behavioral
Lead sponsor: University of Vermont; Other
Eligibility: 18 Years and older
Enrollment: 560 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: Tobacco Dependence
Interventions: cognitive-behavioral withdrawal regulation strategies, relaxation strategies, early withdrawal exposure; Behavioral
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years and older
Enrollment: 400 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2026
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Schizophrenia, Schizoaffective Disorder, Smokers
Interventions: bupropion + nicotine patch + nicotine gum or lozenges, Placebo pill + placebo patch; Drug
Lead sponsor: North Suffolk Mental Health Association; Other
Eligibility: 18 Years to 70 Years
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2009
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Smoking Cessation, Smoking, Tobacco, Smoking Reduction
Interventions: Contingency Management - Increasing, Fixed payments; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 83 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2024
U.S. locations: 2
States / cities: San Francisco, California

Conditions: Tobacco Use Disorder, Homelessness
Interventions: Nicotine Patches, mobile contingency management (mCM), Smoking cessation counseling, Nicotine rescue method, Bupropion; Drug · Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 70 Years
Enrollment: 133 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2018
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: COPD, Smoking, Tobacco Use
Interventions: THS use, Cigarette, Smoking Abstinence; Other
Lead sponsor: Philip Morris Products S.A.; Industry
Eligibility: 35 Years to 65 Years
Enrollment: 715 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 81
States / cities: Brandon, Florida • Cape Coral, Florida • Clearwater, Florida + 41 more

Conditions: Smoking Cessation, Harm Reduction
Interventions: Nicoderm, Nicorette 4Mg Chewing Gum, Nicorette Lozenge Product, NJOY e-cigarette, on!; Drug · Other
Lead sponsor: Rose Research Center, LLC; Industry
Eligibility: 22 Years to 65 Years
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 2
States / cities: Charlotte, North Carolina • Raleigh, North Carolina

Conditions: Cigarette Smoking
Interventions: Quit Smoking Now (QSN), Prize-based Contingency Management (CM); Other · Behavioral
Lead sponsor: University of Miami; Other
Eligibility: 18 Years and older · Female only
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Schizophrenia, Nicotine Dependence, Smoking, Tobacco
Interventions: Music session; Behavioral
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years and older
Enrollment: 2 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: New York, New York

Conditions: Smoking
Interventions: Cognitive Behavioral Counseling, Mobile Contingency Management, Bupropion, Transdermal nicotine patch, Nicotine polacrilex, Nicotine lozenge; Behavioral · Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Substance Abuse
Interventions: Nicotine Replacement Treatment (NRT), Brief Advice, Contingency Management, Non-Contingent Reinforcement; Drug · Behavioral
Lead sponsor: Brown University; Other
Eligibility: 18 Years and older
Enrollment: 340 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2014
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Cigarette Smoking
Interventions: Contingency Management, Brief smoking cessation counseling; Behavioral
Lead sponsor: UConn Health; Other
Eligibility: 18 Years and older
Enrollment: 51 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Farmington, Connecticut

Conditions: Smoking, Smoking Cessation, Adherence, Nicotine Dependence, Motivation
Interventions: Short Term Combination Nicotine Replacement Therapy (patch + gum), Long Term Combination Nicotine Replacement Therapy (patch + gum), Intensive Maintenance Counseling, Cognitive Medication Adherence Counseling (CAM), Electronic Medication Monitoring Device (the Helping Hand) + Feedback, Automated Adherence Prompting Phone Calls; Drug · Behavioral
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years to 99 Years
Enrollment: 544 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Smoking Cessation, Pregnancy
Interventions: Phone-based postpartum continuing care, Standard care; Behavioral
Lead sponsor: Battelle Memorial Institute; Other
Eligibility: 18 Years and older · Female only
Enrollment: 130 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 2
States / cities: Bloomington, Illinois • Baltimore, Maryland

Conditions: Smoking Cessation
Interventions: Telephone counseling, Voucher, Nicotine patches; Behavioral · Drug
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 3,706 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: San Diego, California

Conditions: Cigarette Smoking
Interventions: Smoking abstinence; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 70 Years
Enrollment: 305 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Nicotine Use Disorder
Interventions: Practice Quit Attempt; Other
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 45 Years
Enrollment: 82 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2023
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Nicotine Dependence
Interventions: Varenicline, Placebo; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 65 Years
Enrollment: 38 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2008
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Tobacco Use Cessation
Interventions: Counseling, Contingency management, Nicotine patches; Other · Behavioral · Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 103 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Smoking, Smoking Behaviors, Smoking Cessation
Interventions: Take a Break plus Nicotine replacement therapy (NRT) Sampling, The Comparison, Community Paramedicine Standard Plus Enhanced Implementation Program, Community Paramedicine Standard Implementation Program; Behavioral · Other
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 800 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Nicotine Dependence, Smoking, Sleep Disorders, Intrinsic
Interventions: Exercise; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years to 45 Years
Enrollment: 88 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2013
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Smoking
Interventions: 6 hour smoking abstinence, Delay to Smoking Task (smoking cues), Delay to Smoking Task (nonsmoking cues); Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 41 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Smoking Cessation
Interventions: Quitline Incentive, Tobacco Cessation Incentive, Way to Health (WTH) Platform, Quitline Delivered Treatment; Behavioral
Lead sponsor: Children's Hospital of Philadelphia; Other
Eligibility: 14 Years to 21 Years
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Smoking, Tobacco Abstinence
Interventions: Smokefree TXT Program, nicotine replacement patches, Nicotine Replacement Gum, Faxed Referral CT Smokers Quitline; Other · Drug · Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014
U.S. locations: 1
States / cities: New Haven, Connecticut

Search by objective public record fields.

Not Quite Ready to Quit

Early Withdrawal Exposure and Negative Affect Withdrawal (NAW) Regulation Training for Smoking Cessation

Smoking Relapse Prevention in Schizophrenia

Contingency Management for Smoking Cessation

Abstinence Reinforcement Therapy (ART) for Homeless Veteran Smokers

Effect of Switching From Cigarette Smoking to THS on Disease Progression in Mild to Moderate COPD Subjects With Chronic Bronchitis Symptoms.

Adaptive Use of Nicotine Substitution to Maintain Smoking Reduction/Abstinence in Nicotine Responders

Contingency Management for Smoking Cessation in Pregnant Minority Women

Music to Reduce Use of Smoking in Patients With Schizophrenia

Smoking Treatment and Exercise Program for Underserved Populations (STEP UP)

Contingency Management for Smoking in Substance Abusers

Contingency Management for Smoking in Substance Abusers

Evaluation of Treatments to Improve Smoking Cessation Medication Adherence

Phone-Based Postpartum Continuing Care for Smoking Cessation

Providing Free Nicotine Patches to Quitline Smokers

Mechanisms of the Nicotine Metabolism Effect on Tobacco Dependence

Neural Basis of Eating Behavior in Abstinent Smokers

Effects of Varenicline on Brain Activity During Nicotine Abstinence

Low-Cost Contingency Management for Smoking Cessation

Take A Break - Rural

The Effect of Exercise on Acute Nicotine Withdrawal

Effects of Smoking Environment on Craving and Smoking

BE Smokefree: Behavioral Economics Incentives to Engage Adolescents in Smoking Cessation

Texting to Promote Tobacco Abstinence in Emergency Department Smokers: A Pilot Study