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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Spontaneous Breathing Clear all
Recruiting Not applicable Interventional

Careful Ventilation in Acute Respiratory Distress Syndrome (COVID-19 and Non-COVID-19)

NCT03963622
View directory record Official record
Conditions
ARDS
Interventions
Respiratory Mechanics, Standard Ventilation Strategy
Other
Lead sponsor
Unity Health Toronto
Other
Eligibility
18 Years and older
Enrollment
740 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Sep 26, 2026, 2:24 PM EDT
Not listed No phase listed Observational

Predictors of Upper Airway Function and Sleep-disordered Breathing in the Critically Ill

NCT02112604
View directory record Official record
Conditions
Critically Ill, Obstructive Sleep Apnea
Interventions
Ventilator, Alice PDx, Pulmonary function test, Muscle strength tests, Grip strength measurement, Sedatives and muscle relaxants given in the ICU
Device · Other · Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 16, 2016 · Synced Sep 26, 2026, 2:24 PM EDT
Terminated No phase listed Observational Results available

Study of Airway Pressure Release Ventilation and Intracranial Pressure in Patients With Severe Traumatic Brain Injury

NCT02507973
View directory record Official record
Conditions
Injury, Brain, Traumatic, Traumatic Brain Injury
Interventions
Airway Pressure Release Ventilation, Low Tidal Volume Ventilation
Other
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
14 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 27, 2022 · Synced Sep 26, 2026, 2:24 PM EDT
Recruiting Not applicable Interventional

Automatic Tube Compensation vs. Pressure Support Ventilation During Spontaneous Breathing Trials in Adults

NCT07005505
View directory record Official record
Conditions
Spontaneous Breathing Trial in ICU
Interventions
Pressure Support Ventilation (PSV), Automatic tube compensation (ATC)
Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
880 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Sep 26, 2026, 2:24 PM EDT
Completed Not applicable Interventional Results available

A Comparison of Different Ventilation Strategies in Children Using the Proseal™ Laryngeal Mask Airway

NCT00966433
View directory record Official record
Conditions
Intraoperative Ventilation
Interventions
Spontaneous ventilation, Pressure support Ventilation, Pressure control ventilation
Procedure · Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
12 Months to 5 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 4, 2018 · Synced Sep 26, 2026, 2:24 PM EDT
Not listed Not applicable Interventional

The Frequency of Screening and SBT Technique Trial: The FAST Trial

NCT02969226
View directory record Official record
Conditions
Critically Ill
Interventions
Once daily screening, Twice daily screening, PS SBTs, T-piece SBTs
Procedure
Lead sponsor
Unity Health Toronto
Other
Eligibility
16 Years and older
Enrollment
760 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
5
States / cities
Long Beach, California • Los Angeles, California • Boston, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Dec 4, 2018 · Synced Sep 26, 2026, 2:24 PM EDT
Withdrawn Phase 2 Interventional

Airway Pressure Release Ventilation (APRV) Compared to ARDSnet Ventilation

NCT00793013
View directory record Official record
Conditions
Acute Lung Injury, Adult Respiratory Distress Syndrome, Kidney Injury
Interventions
Volume-Cycled Assist-Control (AC) mode, Airway Pressure Release Ventilation (APRV) mode
Device
Lead sponsor
University of Tennessee, Chattanooga
Other
Eligibility
18 Years to 85 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Chattanooga, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 3, 2020 · Synced Sep 26, 2026, 2:24 PM EDT
Active, not recruiting Phase 2 Interventional

Hybrid Functional Electrical Stimulation Exercise to Prevent Cardiopulmonary Declines in High-level Spinal Cord Injury

NCT04458324
View directory record Official record
Conditions
Spinal Cord Injuries
Interventions
Buspirone Hydrochloride, Buspirone placebo, Noninvasive Ventilation (NIV), Sham Non-invasive ventilation (NIV), Functional Electrical Stimulation Row Training (FESRT)
Drug · Device · Other
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 55 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 4, 2026 · Synced Sep 26, 2026, 2:24 PM EDT
Completed Phase 4 Interventional Results available

Continuous Chest Compressions vs AHA Standard CPR of 30:2

NCT01372748
View directory record Official record
Conditions
Out of Hospital Cardiac Arrest
Interventions
Standard CPR, Continuous chest compressions
Other
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
23,711 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
5
States / cities
Birmingham, Alabama • Pittsburgh, Pennsylvania • Dallas, Texas + 2 more
Source: ClinicalTrials.gov public record
Updated Dec 27, 2016 · Synced Sep 26, 2026, 2:24 PM EDT
Completed Not applicable Interventional Results available

Acute Effect of Ventilatory Support During Exercise in Spinal Cord Injury

NCT03267212
View directory record Official record
Conditions
Spinal Cord Injury
Interventions
Non-invasive ventilation(NIV), Sham Non-invasive ventilation(NIV), Functional Electrical Stimulation Row Training (FESRT)
Device · Other
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 8, 2020 · Synced Sep 26, 2026, 2:24 PM EDT
Completed Not applicable Interventional

PAV vs Assist Control After Failed SBT

NCT02773433
View directory record Official record
Conditions
Weaning Mode Comparison
Interventions
Proportional Assist Ventilation
Other
Lead sponsor
University of Louisville
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Dec 6, 2016 · Synced Sep 26, 2026, 2:24 PM EDT
Completed Phase 2 Interventional

Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial (PROSPECT): A Feasibility Clinical Trial

NCT01782755
View directory record Official record
Conditions
Ventilator Associated Pneumonia (VAP), Other Infections, Antibiotic-Associated Diarrhea, C-Difficile, Duration of Mechanical Ventilation, Length of ICU Stay, Length of Hospital Stay, ICU and Hospital Mortality
Interventions
L. rhamnosus GG - Probiotic, Placebo - Microcrystalline Cellulose
Drug · Other
Lead sponsor
McMaster University
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
2
States / cities
Rochester, Minnesota • St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 27, 2019 · Synced Sep 26, 2026, 2:24 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Controlling Urgency Through Relaxation Exercises

NCT02202031
View directory record Official record
Conditions
Overactive Bladder, Urgency Urinary Symptoms, Urgency Incontinence
Interventions
Paced Respiration, Music Therapy
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years and older · Female only
Enrollment
161 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 29, 2019 · Synced Sep 26, 2026, 2:24 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Prophylactic DR-CPAP on Late Preterm Infants Born by C-section: an RCT

NCT05204719
View directory record Official record
Conditions
Premature Birth
Interventions
Prophylactic Delivery Room Continuous Positive Airway Pressure
Procedure
Lead sponsor
University of Oklahoma
Other
Eligibility
1 Minute to 5 Minutes
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
3
States / cities
Indianapolis, Indiana • St Louis, Missouri • Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Sep 26, 2026, 2:24 PM EDT
Completed Not applicable Interventional Results available

The Effects of Ketamine on Respiratory Stimulation and Transpulmonary Pressures

NCT01969227
View directory record Official record
Conditions
Mechanical Ventilation, Airway Patency, Respiratory Depression
Interventions
Subanesthetic ketamine
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2022
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Sep 26, 2026, 2:24 PM EDT
Completed No phase listed Observational

Weaning And Variability Evaluation

NCT01237886
View directory record Official record
Conditions
Mechanically Ventilated Patients, Extubation
Interventions
Not listed
Lead sponsor
Ottawa Hospital Research Institute
Other
Eligibility
18 Years and older
Enrollment
660 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
7
States / cities
Ann Arbor, Michigan • Billings, Montana • Lebanon, New Hampshire + 4 more
Source: ClinicalTrials.gov public record
Updated Jul 6, 2017 · Synced Sep 26, 2026, 2:24 PM EDT
Completed Not applicable Interventional Results available

Ventilatory Support to Improve Exercise Training in High Level Spinal Cord Injury

NCT02865343
View directory record Official record
Conditions
Spinal Cord Injury
Interventions
Non-invasive Ventilation(NIV), Sham Non-invasive ventilation(NIV)
Device
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 60 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 8, 2023 · Synced Sep 26, 2026, 2:24 PM EDT
Recruiting No phase listed Observational

Lung Function Monitoring During Hypoxemia Episodes

NCT06535074
View directory record Official record
Conditions
Hypoxemia of Newborn
Interventions
Detecting changes in lung volume with hypoxemia episodes
Other
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
Not listed
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Sep 26, 2026, 2:24 PM EDT
Not yet recruiting Not applicable Interventional

PRECISION-CPR: PRecision-Controlled Ventilation in CPR

NCT07088120
View directory record Official record
Conditions
Cardiac Arrest (CA)
Interventions
Precision-Controlled Ventilation with Real-Time Feedback, Standard Manual Ventilation During CPR
Device · Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
852 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced Sep 26, 2026, 2:24 PM EDT
Completed No phase listed Observational

Oxygenation Instability and Maturation of Control of Breathing in Premature Infants

NCT03445689
View directory record Official record
Conditions
Infant,Premature
Interventions
Assessment of oxygenation instability, Determination of mechanisms of hypoxemia episodes, Assessment of respiratory instability, apneic threshold of CO2, Assessment of peripheral chemoreceptor function, Assessment of central chemo-receptor function
Other
Lead sponsor
University of Miami
Other
Eligibility
Not listed
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Mar 17, 2025 · Synced Sep 26, 2026, 2:24 PM EDT
Completed No phase listed Observational

Ultrasound Assessment of the Inferior Vena Cava in Children

NCT03948282
View directory record Official record
Conditions
Surgery
Interventions
Not listed
Lead sponsor
Alok Moharir
Other
Eligibility
1 Year to 12 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 5, 2019 · Synced Sep 26, 2026, 2:24 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Heart Inflammation and Mental Stress Study

NCT03695146
View directory record Official record
Conditions
Hypertension
Interventions
Paced breathing, Active relaxation
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
21 Years to 65 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Feb 14, 2024 · Synced Sep 26, 2026, 2:24 PM EDT
Completed Not applicable Interventional

A Controlled Breathing Intervention to Reduce Stress and Improve Symptoms in COPD Patients (REST)

NCT06404008
View directory record Official record
Conditions
COPD, Stress, Dyspnea
Interventions
REST, Education
Behavioral · Other
Lead sponsor
University of Texas at Austin
Other
Eligibility
40 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Nov 16, 2025 · Synced Sep 26, 2026, 2:24 PM EDT
Terminated Not applicable Interventional

Transpulmonary Pressure Guided Mechanical Ventilation Weaning in Obesity

NCT05530434
View directory record Official record
Conditions
Respiratory Failure, Obesity
Interventions
transpulmonary pressure guided positive end expiratory pressure, standard positive end expiratory pressure
Other
Lead sponsor
University of Mississippi Medical Center
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Jackson, Mississippi
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Sep 26, 2026, 2:24 PM EDT