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ClinicalTrials.gov public records Last synced Nov 15, 2026, 7:38 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 29 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Standard Care at Lung Cancer Screening Clear all

Conditions: Non-small Cell Lung Cancer, Colorectal Cancer, Triple Negative Breast Cancer, Pancreas Cancer
Interventions: Immunotherapy, Chemotherapy, CRC surgical resection, Colonoscopy; Drug · Procedure
Lead sponsor: Persephone Biosciences; Industry
Eligibility: 18 Years and older
Enrollment: 5,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2028
U.S. locations: 10
States / cities: Orange, California • San Diego, California • Miami, Florida + 6 more

Conditions: Lung Cancer Metastatic, EGFR Gene Mutation
Interventions: Osimertinib, Alisertib; Drug
Lead sponsor: Collin Blakely; Other
Eligibility: 18 Years and older
Enrollment: 23 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2025
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Lung Carcinoma
Interventions: Screening Questionnaire Administration, X-Ray Imaging; Other · Procedure
Lead sponsor: National Cancer Institute (NCI); NIH
Eligibility: 55 Years to 74 Years
Enrollment: 154,901 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1993 – 2027
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Ovarian Carcinoma, Ovarian Germ Cell Tumor
Interventions: Laboratory Biomarker Analysis, Screening Questionnaire Administration, Ultrasound Imaging; Other · Procedure
Lead sponsor: National Cancer Institute (NCI); NIH
Eligibility: 55 Years to 74 Years · Female only
Enrollment: 78,216 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1993 – 2027
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Smoking Cessation
Interventions: Phone-based Tobacco Treatment, Nicotine Replacement, and Stepped Care Intervention, E-Referral to the Tobacco Quitline; Behavioral
Lead sponsor: Georgetown University; Other
Eligibility: 50 Years to 80 Years
Enrollment: 1,188 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Smoking, Smoking Cessation, Lung Cancer Screening, Smoking, Tobacco, Smoking Behaviors
Interventions: Escape, Standard Care; Other
Lead sponsor: Dana-Farber Cancer Institute; Other
Eligibility: 55 Years to 77 Years
Enrollment: 153 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2026
U.S. locations: 2
States / cities: Boston, Massachusetts

Conditions: Head and Neck Cancer
Interventions: Lung Cancer Screening Education, Semi-Structured Interview, Standard of Care Lung Cancer Screening Program; Behavioral
Lead sponsor: University of Miami; Other
Eligibility: 18 Years to 80 Years
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2029
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Prostate Carcinoma
Interventions: Laboratory Biomarker Analysis, Medical Examination Assessment, Screening Questionnaire Administration; Other · Procedure
Lead sponsor: National Cancer Institute (NCI); NIH
Eligibility: 55 Years to 74 Years · Male only
Enrollment: 76,685 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1993 – 2027
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Smoking, Smoking Cessation, Tobacco Use Cessation
Interventions: Usual Care, RiskProfile-Clin, RiskProfile-Gen; Behavioral
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years and older
Enrollment: 915 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Lung Non-Small Cell Carcinoma, Stage III Lung Cancer AJCC v8
Interventions: Best Practice, Biospecimen Collection, Communication Intervention, Comprehensive Geriatric Assessment, Electronic Health Record Review, Survey Administration; Other · Procedure
Lead sponsor: City of Hope Medical Center; Other
Eligibility: 60 Years and older
Enrollment: 180 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2031
U.S. locations: 3
States / cities: Duarte, California • Rochester, New York • Columbus, Ohio

Conditions: Lung Cancer Screening, Smoking Cessation
Interventions: Smoking Cessation Counseling, Decision Aid, Shared decision making (SDM), CHW Navigation; Behavioral
Lead sponsor: Boston University; Other
Eligibility: 55 Years to 80 Years
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Lung Cancer, Shared Decision Making
Interventions: tobacco dependence/smoking cessation counseling, SDM, Decision Aid, LDCT brochure; Behavioral · Other
Lead sponsor: Boston University; Other
Eligibility: 55 Years to 80 Years
Enrollment: 102 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Smoking Cessation, Smoking Behaviors, Smoking, Tobacco, Smoking, Cigarette, Smoking (Tobacco) Addiction
Interventions: ACT Lung Health Intervention; Behavioral
Lead sponsor: Dana-Farber Cancer Institute; Other
Eligibility: 18 Years to 100 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 2
States / cities: Boston, Massachusetts

Conditions: Non Small Cell Lung Cancer
Interventions: Circulating Tumor Deoxyribonucleic acid (ctDNA) Assay, Pembrolizumab, Platinum Doublet Chemotherapy; Diagnostic Test · Drug
Lead sponsor: University of Miami; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Smoking Cessation
Interventions: Removal of Financial Barriers, Financial Incentives, Mobile Health Application; Behavioral
Lead sponsor: Abramson Cancer Center at Penn Medicine; Other
Eligibility: 18 Years and older
Enrollment: 3,228 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 5
States / cities: Oakland, California • Detroit, Michigan • Danville, Pennsylvania + 2 more

Conditions: Lung Cancer
Interventions: Low-dose CT scan; Device
Lead sponsor: Guardant Health, Inc.; Industry
Eligibility: 50 Years to 80 Years
Enrollment: 12,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 125
States / cities: Birmingham, Alabama • Fayetteville, Arkansas • Anaheim, California + 105 more

Conditions: Lung Cancer
Interventions: Centralized Screening Unit Implementation; Other
Lead sponsor: Albert Einstein College of Medicine; Other
Eligibility: 50 Years to 77 Years
Enrollment: 9,460 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Tobacco Use Cessation
Interventions: Nicotine patch, Varenicline, Nicotine metabolism, Genetically-informed lung cancer risk score, NCI "Clearing the Air"; Drug · Genetic · Behavioral
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 67 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Colon Carcinoma, Rectal Carcinoma
Interventions: Screening Questionnaire Administration, Sigmoidoscopy; Other · Procedure
Lead sponsor: National Cancer Institute (NCI); NIH
Eligibility: 55 Years to 74 Years
Enrollment: 154,900 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1993 – 2027
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Lung Cancer, Smoking Cessation, Tobacco Use Cessation
Interventions: Patient Decision Aid, Standard Educational Information, Follow-Up Assessments: Questionnaires; Behavioral
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 55 Years to 77 Years
Enrollment: 516 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: Ridgeland, Mississippi

Conditions: Lung Cancer
Interventions: Best Practice, Cancer Educational Materials, Behavioral, Psychological or Informational Intervention, Counseling; Other · Behavioral
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 55 Years to 80 Years
Enrollment: 2,355 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Smoking, Lung Cancer
Interventions: Best Practice, Nicotine Patch, Quality-of-Life Assessment, Questionnaire Administration, Tobacco Cessation Counseling; Other · Drug
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 55 Years to 77 Years
Enrollment: 358 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2027
U.S. locations: 3
States / cities: Galveston, Texas • Houston, Texas • Tyler, Texas

Conditions: Lung Carcinoma, Metastatic Lung Carcinoma, Stage IV Lung Cancer AJCC v8
Interventions: Best Practice, Questionnaire Administration; Other
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Lung Cancer
Interventions: Referral to Telemedicine LCS Counseling Visit, Usual Care; Behavioral
Lead sponsor: University of Pennsylvania; Other
Eligibility: 55 Years to 77 Years
Enrollment: 137 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

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ARGONAUT: Stool and Blood Sample Bank for Cancer Patients

Alisertib in Combination With Osimertinib in Metastatic EGFR-mutant Lung Cancer

Screening for Lung Cancer in Older Patients (PLCO Screening Trial)

Screening for Ovarian Cancer in Older Patients (PLCO Screening Trial)

Tobacco Education and Lung Health Study (TEAL)

Digitally Enhanced Smoking Cessation for High Risk Smokers

PromotinG Lung Cancer screenIng Awareness and Implementation in Hispanics/Latinx Head and Neck canceR Survivors

Screening for Prostate Cancer in Older Patients (PLCO Screening Trial)

Precision Prevention Strategy to Increase Uptake and Engagement in Lung Cancer Screening and Smoking Cessation Treatment

Evaluation of Geriatric Assessment and Management for Older Adults With Non-small Cell Lung Cancer Receiving Chemotherapy Radiation Therapy

Inpatient Smokers and LDCT Screening Part 2

Inpatient Smokers and LDCT Screening RCT

ACT Lung Health Intervention: Phase Two

ctDNA to Predict Response to Chemo-Immunotherapy and Detect Minimal Residual Disease in Non-Small Cell Lung Cancer

Comparing Smoking Cessation Interventions Among Underserved Patients Referred for Lung Cancer Screening

Screening for High Frequency Malignant Disease

Centralized Screening Unit (CSU) at Montefiore-Einstein

PRecision Interventions for SMoking in the SCCS

Screening for Colorectal Cancer in Older Patients (PLCO Screening Trial)

PCORI-CER-1306-03385 Informed Decisions About Lung Cancer Screening

Proactive Outreach and Shared Decision Making in Improving Lung Cancer Screening Rates in Primary Care Patients

Centralized Lung Cancer EARly Detection Among Smokers (CLEAR Study)

Novel INPUT Screening Tool to Improve Illness Understanding in Patients With Metastatic or Incurable Lung Cancer

Using Connected Health to Increase Lung Cancer Screening