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Conditions: Deep Venous Thromboses, Pulmonary Embolism, Venous Thromboembolism
Interventions: DDimer test; Diagnostic Test
Lead sponsor: Diagnostica Stago; Industry
Eligibility: Up to 79 Years
Enrollment: 5,935 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2024
U.S. locations: 12
States / cities: New Haven, Connecticut • Chicago, Illinois • Indianapolis, Indiana + 9 more

Conditions: Stress Disorders, Post-Traumatic
Interventions: Adjunctive writing to amplify response and engagement (AWARE), Cognitive processing therapy (CPT), Prolonged exposure (PE); Behavioral
Lead sponsor: Boston University; Other
Eligibility: 18 Years and older
Enrollment: 54 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Traumatic Injury, PTSD, Posttraumatic Stress Disorder
Interventions: Treatment as Usual, Brief Prolonged Exposure Therapy; Behavioral
Lead sponsor: Baylor Research Institute; Other
Eligibility: 18 Years to 75 Years
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 3
States / cities: Dallas, Texas • Temple, Texas • Milwaukee, Wisconsin

Conditions: PTSD
Interventions: Extended Training in Prolonged Exposure Therapy for PTSD, Standard Training in Prolonged Exposure Therapy for PTSD; Behavioral
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 65 Years
Enrollment: 128 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2021
U.S. locations: 3
States / cities: Colorado Springs, Colorado • Fort Campbell North, Kentucky • El Paso, Texas

Conditions: Stress Disorders, Post-Traumatic, Substance Use Disorders
Interventions: Prolonged Exposure Therapy, Cognitive Processing Therapy, Present Centered Therapy; Behavioral
Lead sponsor: Center for Veterans Research and Education; Other
Eligibility: 18 Years and older
Enrollment: 426 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 14
States / cities: San Diego, California • Tampa, Florida • Atlanta, Georgia + 11 more

Conditions: Post Traumatic Stress Disorder
Interventions: Quetiapine Fumarate, Standard of care meducations; Drug · Other
Lead sponsor: The University of Texas Health Science Center at San Antonio; Other
Eligibility: 18 Years and older
Enrollment: 28 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: San Antonio, Texas

Conditions: Spinal Cord Injuries, PTSD, Post-Traumatic Stress Disorder
Interventions: Brief Prolonged Exposure Therapy, Treatment as Usual; Behavioral
Lead sponsor: Baylor Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Acute DVT of Lower Extremity
Interventions: Vascular Boot, Standard of Care; Combination Product · Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Post-traumatic Stress Disorder, Suicide, Self-injurious Behavior
Interventions: Dialectical Behavior Therapy, Dialectical Behavior Therapy Prolonged Exposure protocol; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 12 Years and older
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Physical Inactivity
Interventions: ACtive Children Enhance LEaRning and AttenTION (ACCELERATION); Behavioral
Lead sponsor: University of Houston; Other
Eligibility: 8 Years to 11 Years
Enrollment: 257 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Cancer
Interventions: Aspiration Thrombectomy; Procedure
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Limited-Stage Small Cell Lung Cancer
Interventions: HLX10, carboplatin/cisplatin-etoposide, Thoracic radiotherapy, Placebo, Prophylactic Cranial Irradiation (PCI); Drug · Radiation
Lead sponsor: Shanghai Henlius Biotech; Industry
Eligibility: 18 Years and older
Enrollment: 511 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2028
U.S. locations: 31
States / cities: Arcadia, California • Los Alamitos, California • Los Angeles, California + 26 more

Conditions: Self-directed Violence, Post-traumatic Stress Disorder (PTSD)
Interventions: Dialectical Behavior Therapy, Dialectical Behavior Therapy Prolonged Exposure protocol, Prolonged Exposure therapy, Suicide risk management; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 125 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 4
States / cities: Minneapolis, Minnesota • Durham, North Carolina • San Antonio, Texas + 1 more

Conditions: PTSD
Interventions: psilocybin, Supportive Therapy, Prolonged Exposure Therapy; Drug · Behavioral
Lead sponsor: Emory University; Other
Eligibility: 18 Years and older
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Posttraumatic Stress Disorder (PTSD), Substance Use Disorders (SUD), Comorbidity, Trauma and Stressor Related Disorders
Interventions: Massed Prolonged Exposure Therapy (M-PE), Standard outpatient SUD care; Behavioral
Lead sponsor: Rutgers, The State University of New Jersey; Other
Eligibility: 18 Years and older
Enrollment: 168 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Jacksonville, Florida

Conditions: Pulmonary Embolism
Interventions: Anticoagulant Therapy, Catheter-Directed Therapy; Drug · Device
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years and older
Enrollment: 500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 40
States / cities: Birmingham, Alabama • Palo Alto, California • Sacramento, California + 33 more

Conditions: Kidney Transplantation in Highly Sensitized Patients
Interventions: Imlifidase, PLEX, IVIg, Anti-CD20 antibodies, Eculizumab, Remain on wait list; Drug · Procedure · Other
Lead sponsor: Hansa Biopharma AB; Industry
Eligibility: 18 Years to 70 Years
Enrollment: 64 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 25
States / cities: Birmingham, Alabama • Phoenix, Arizona • Los Angeles, California + 16 more

Conditions: Pulmonary Embolism, Pulmonary Embolism Subacute Massive
Interventions: inhaled nitric oxide (iNO); Drug
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Posttraumatic Stress Disorder
Interventions: Family Supported Prolonged Exposure, Standard Prolonged Exposure; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 128 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2022
U.S. locations: 3
States / cities: Decatur, Georgia • Ann Arbor, Michigan • Minneapolis, Minnesota

Conditions: Acute-On-Chronic Liver Failure
Interventions: SMT + PE-A 5%, Standard Medical Treatment; Biological · Other
Lead sponsor: Instituto Grifols, S.A.; Industry
Eligibility: 18 Years to 79 Years
Enrollment: 274 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2025
U.S. locations: 10
States / cities: Coronado, California • Los Angeles, California • Atlanta, Georgia + 7 more

Conditions: Acute Coronary Syndrome, Pulmonary Embolism
Interventions: Webtool; Device
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years to 99 Years
Enrollment: 550 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2013
U.S. locations: 4
States / cities: Boston, Massachusetts • Jackson, Mississippi • Charlotte, North Carolina + 1 more

Conditions: Posttraumatic Stress Disorders, Chronic Insomnia
Interventions: CBTI-PE, Hygiene-PE; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 19 Years and older
Enrollment: 94 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2022
U.S. locations: 1
States / cities: San Diego, California

Conditions: Pulmonary Embolism, Chronic Thromboembolic Pulmonary Hypertension
Interventions: SEARCH algorithm; Other
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 8
States / cities: Fresno, California • Irvine, California • Los Angeles, California + 5 more

Conditions: Posttraumatic Stress Disorder, PTSD
Interventions: Modular Cognitive Processing Therapy, Modular Prolonged Exposure Therapy, Step Down Treatment, Digital Interventions, Cognitive Processing Therapy (CPT), Prolonged Exposure (PE); Behavioral
Lead sponsor: The University of Texas Health Science Center at San Antonio; Other
Eligibility: 18 Years and older
Enrollment: 302 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 4
States / cities: Augusta, Georgia • Ann Arbor, Michigan • Battle Creek, Michigan + 1 more

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ThRombosis ExclUsion STudy

Enhancing PTSD Treatment Outcomes by Improving Patient-Provider Communication

Trauma BPE Prolonged Exposure Therapy for Injured Individuals Admitted to a Level I Trauma Center

Implementation of Prolonged Exposure in the Military

Psychotherapy for PTSD Among Veterans Also Receiving Drug or Alcohol Treatment

Quetiapine Augmentation of PE Therapy for the Treatment of Co-occurring PTSD and Mild Traumatic Brain Injury

Brief Prolonged Exposure Therapy Versus Clinical Standard to Reduce Posttraumatic Stress Post Spinal Cord Injury

Vascular Boot Warming Program After Acute Deep Vein Thrombosis (DVT) ± Pulmonary Embolism (PE)

Effectiveness of PTSD Treatment For Suicidal and Multi-Diagnostic Clients

ACtive Children Enhance LEaRning and AttenTION: A Randomized Controlled Trial (RCT)

A Prospective Single Center, Single Arm, Single-institution Registry That Aims to Assess the Safety and Quality of Life Benefits of Computer-assisted Vacuum Thrombectomy (CAVT) in the Treatment of Cancer Patients With Intermediate Risk Pulmonary Embolism (PE)

A Study to Evaluate the Efficacy and Safety of Serplulimab in Combination With Chemotherapy and Concurrent Radiotherapy in Patients With Limited-Stage Small Cell Lung Cancer

Evaluating Treatments for Suicidal Veterans With PTSD

Psilocybin-Assisted Therapy

Project COMET: Massed Prolonged Exposure for PTSD and SUD

Pulmonary Embolism - Thrombus Removal With Catheter-Directed Therapy

Renal Function in Highly Sensitized Patients 1 Year After Desensitization With Imlifidase Prior to DD Kidney Tx

Effect of iNO in Patients With Submassive and Massive PE

Improving Veteran Adherence to Treatment for PTSD Through Partnering With Families

Short-term Survival of Subjects With Acute-on-chronic Liver Failure After Plasma Exchange With Human Serum Albumin 5%

Assessment of Acute Disease to Reduce Imaging Costs

Integrated CBT-I and PE on Sleep and PTSD Outcomes (Impact Study)

Validation of SEARCH, a Novel Hierarchical Algorithm to Define Long-term Outcomes After Pulmonary Embolism

Adaptive Decision-making And Personalized Treatment for PTSD (ADAPT-PTSD)