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Showing 1–15 of 15 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Standard Root Planing Clear all
Not listed Not applicable Interventional Accepts healthy volunteers

Effects of Scaling and Root Planing With and Without Er:YAG Laser in Chronic Periodontitis Patients

NCT03003689
View directory record Official record
Conditions
Chronic Periodontitis
Interventions
Scaling and Root Planing, Er:YAG Laser
Procedure · Device
Lead sponsor
Tufts University School of Dental Medicine
Other
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 10, 2018 · Synced Sep 2, 2026, 7:27 PM EDT
Not listed Phase 3 Interventional

PeRiodontal Treatment to Eliminate Minority InEquality and Rural Disparities in Stroke

NCT02541032
View directory record Official record
Conditions
Periodontal Disease, Stroke, TIA
Interventions
Intensive dental treatment, Standard dental treatment, Arestin
Procedure · Drug
Lead sponsor
University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
2
States / cities
Chapel Hill, North Carolina • Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 17, 2019 · Synced Sep 2, 2026, 7:27 PM EDT
Completed Not applicable Interventional

Standard Root Planing vs. Periodontal Structure Repair Device for Treatment of Pockets Caused by Periodontal Disease

NCT03671512
View directory record Official record
Conditions
Periodontal Diseases
Interventions
Periodontal Structure Repair (PSR), Standard Root Planing
Device
Lead sponsor
Periovance, Inc
Industry
Eligibility
18 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
4
States / cities
Birmingham, Alabama • Cambridge, Massachusetts • Stony Brook, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 29, 2020 · Synced Sep 2, 2026, 7:27 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Adjunctive Hydrogen Peroxide for Periodontal Therapy

NCT03262701
View directory record Official record
Conditions
Periodontitis, Chronic
Interventions
Hydrogen Peroxide Gel, 13 weeks, Hydrogen Peroxide Gel, 26 weeks, Scaling and Root planing group
Drug · Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 80 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Dec 20, 2022 · Synced Sep 2, 2026, 7:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Role of Infected Blood Dendritic Cells in Heart Disease Risk

NCT01568944
View directory record Official record
Conditions
Chronic Periodontitis
Interventions
Oral Antibiotic and Oral Rinse, Standard Treatment
Drug · Procedure
Lead sponsor
Augusta University
Other
Eligibility
40 Years and older
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated May 11, 2020 · Synced Sep 2, 2026, 7:27 PM EDT
Withdrawn Phase 3 Interventional Accepts healthy volunteers

Scaling and Root Planning With Localized Delivery of Autogenous Growth Factors- Platelet Rich Fibrin (PRF)

NCT04978324
View directory record Official record
Conditions
Periodontitis Chronic Generalized Severe, Periodontitis Chronic Generalized Moderate
Interventions
leukocyte platelet rich fibrin (L-PRF), Scaling and Root Planing
Biological · Procedure
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated May 11, 2022 · Synced Sep 2, 2026, 7:27 PM EDT
Completed Not applicable Interventional

The Effect of Non-Surgical Periodontal Therapy on Glycemic Control and Bacterial Levels in a Mexican-American Population With Type 2 Diabetes

NCT01128374
View directory record Official record
Conditions
Type 2 Diabetes Mellitus, Periodontal Disease
Interventions
Periodontal Scaling and root planing
Procedure
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
134 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 14, 2013 · Synced Sep 2, 2026, 7:27 PM EDT
Completed Phase 2 Interventional Results available

Impact of Periodontal Therapy on Patients With Diabetes

NCT04830969
View directory record Official record
Conditions
Diabetes Mellitus, Type II, Periodontitis
Interventions
Chlorhexidine gluconate oral rinse, Scaling & Root Planing, Soft Picks
Drug · Procedure · Device
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
25 Years and older
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Feb 28, 2023 · Synced Sep 2, 2026, 7:27 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

The Use of a Non-Incised Minimally Invasive Flap Procedure in Conjunction With Emdogain® MI Compared to Traditional SRCP

NCT05964699
View directory record Official record
Conditions
Periodontitis, Attachment Loss, Periodontal
Interventions
Minimally invasive periodontal therapy with use of Emdogain, Minimally invasive periodontal therapy without the use of Emdogain
Procedure
Lead sponsor
Texas A&M University
Other
Eligibility
30 Years to 75 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 20, 2024 · Synced Sep 2, 2026, 7:27 PM EDT
Completed Phase 2 Interventional Results available

Effect of Three Periodontal Therapies in Current Smokers and Non-Smokers

NCT00066066
View directory record Official record
Conditions
Periodontitis, Periodontal Diseases
Interventions
Scaling and root planing, Metronidazole, Amoxicillin, Doxycycline
Procedure · Drug
Lead sponsor
The Forsyth Institute
Other
Eligibility
20 Years and older
Enrollment
146 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2009
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 21, 2013 · Synced Sep 2, 2026, 7:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mechanisms and Treatment Response of Aggressive Periodontitis in Children

NCT01330719
View directory record Official record
Conditions
Aggressive Periodontitis
Interventions
Diseased periodontal treatment, Conventional periodontal treatment
Procedure
Lead sponsor
University of Florida
Other
Eligibility
5 Years to 90 Years
Enrollment
514 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2022
U.S. locations
10
States / cities
Brooker, Florida • Fort Lauderdale, Florida • Gainesville, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Mar 11, 2024 · Synced Sep 2, 2026, 7:27 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Periodontal Inflammation and Epigenetics in Obese Individuals

NCT07610902
View directory record Official record
Conditions
Obesity, Periodontitis
Interventions
Non-surgical periodontal therapy will be administered
Procedure
Lead sponsor
Louisiana State University Health Sciences Center in New Orleans
Other
Eligibility
18 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated May 27, 2026 · Synced Sep 2, 2026, 7:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Treatment of Periodontitis With Er:YAG Laser

NCT03628872
View directory record Official record
Conditions
Generalized Moderate Chronic Periodontitis, Generalized Severe Chronic Periodontitis, Periodontal Diseases
Interventions
Scaling and root planing, Er:YAG Laser, Hand instruments
Procedure · Device
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 8, 2024 · Synced Sep 2, 2026, 7:27 PM EDT
Terminated Not applicable Interventional

Dental Carotid Cognitive Study

NCT03755362
View directory record Official record
Conditions
Carotid Stenosis, Mild Cognitive Impairment, Periodontitis
Interventions
Standard Treatment, Intensive Treatment
Procedure
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
60 Years to 100 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Sep 2, 2026, 7:27 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Novel Dental Gel as an Adjunct to Scaling and Root Planing

NCT05384132
View directory record Official record
Conditions
Periodontal Diseases, Gingival Diseases, Gingival Pocket, Gum Bleed, Plaque, Dental
Interventions
SRP + Livfresh Dental Gel, SRP + standard flouride dentifrice
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 85 Years
Enrollment
76 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2028
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 16, 2025 · Synced Sep 2, 2026, 7:27 PM EDT