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Conditions: Squamous Cell Carcinoma of Skin, Carcinoma, Squamous Cell
Interventions: Pegylated Interferon alpha-2b, Capecitabine, 5-FU; Drug
Lead sponsor: H. Lee Moffitt Cancer Center and Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2018
U.S. locations: 1
States / cities: Tampa, Florida

Conditions: Ventral Hernia, Ventral Incisional Hernia, Post Operative Pain
Interventions: PT Group, Usual Care; Other
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 18 Years to 75 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Pancreatic Cancer, Retroperitoneal Pain Syndrome
Interventions: Simulation-free workflow, Celiac plexus SBRT; Other · Radiation
Lead sponsor: Case Comprehensive Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Trauma, Hemorrhagic Shock
Interventions: Type AB plasma, Crystalloid fluid (standard of care for resuscitation); Biological · Drug
Lead sponsor: Denver Health and Hospital Authority; Other
Eligibility: 18 Years and older
Enrollment: 144 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Denver, Colorado

Conditions: Bone Metastases
Interventions: MR- High intensity focused ultrasound, External beam radiotherapy; Procedure · Radiation
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Nicotine Dependence, Major Depressive Disorder
Interventions: Varenicline, BASC, Standard treatment; Drug · Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years and older
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 2
States / cities: Chicago, Illinois • Philadelphia, Pennsylvania

Conditions: Hospital Discharge Summary Understanding
Interventions: AI-Generated Discharge Instructions, Standard of Care Discharge Instructions; Behavioral
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years and older
Enrollment: 61 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025
U.S. locations: 1
States / cities: New York, New York

Conditions: Recurrent Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8, Stage III Lung Cancer AJCC v8, Unresectable Lung Non-Small Cell Carcinoma
Interventions: Carboplatin, Cisplatin, Etoposide, Paclitaxel, Pemetrexed, Proton Beam Radiation Therapy, Quality-of-Life Assessment, Questionnaire Administration; Drug · Radiation · Other
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2023
U.S. locations: 2
States / cities: Scottsdale, Arizona • Rochester, Minnesota

Conditions: Ischemic Stroke
Interventions: Non-invasive ventilatory treatment with auto-BPAP; Device
Lead sponsor: Technische Universität Dresden; Other
Eligibility: 18 Years to 80 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2013
U.S. locations: 1
States / cities: Memphis, Tennessee

Conditions: Glioblastoma
Interventions: Temozolomide, Bavituximab, Radiation; Drug · Radiation
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 2
States / cities: Boston, Massachusetts

Conditions: Patellofemoral Pain
Interventions: Clinical Practice Guideline-adherent Care, Usual Care; Other
Lead sponsor: Sara Gorczynski, PT, DPT; Federal
Eligibility: 18 Years and older
Enrollment: 440 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: San Diego, California

Conditions: Diabetic Foot, Lower Extremity Wound
Interventions: Matrion, Conventional Care Wound Management; Other
Lead sponsor: LifeNet Health; Industry
Eligibility: 21 Years to 80 Years
Enrollment: 108 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 8
States / cities: Tucson, Arizona • Carmichael, California • Fresno, California + 5 more

Conditions: Sickle Cell Disease (SCD), Sickle Cell Disease Vaso-occlusive Crisis, Sickle Cell Anemia Crisis, Sickle Cell Anemia in Children, Sickle Cell Anemia (HbSS, or HbSβ-thalassemia0), Sickle Cell Hemoglobin C Disease, Pain Crisis
Interventions: Buprenorphine Buccal Film [Belbuca]; Drug
Lead sponsor: Natasha Archer; Other
Eligibility: 12 Years to 22 Years
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2032
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Quality of Life, Tobacco Use Cessation, Physical Activity
Interventions: Will use HIT patient feedback to activate patients., Patients will not receive HIT patient feedback.; Other
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years and older
Enrollment: 666 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Common Variable Immune Deficiency, Specific Antibody Deficiency, X-linked Agammaglobulinemia
Interventions: Zostavax®; Biological
Lead sponsor: University of South Florida; Other
Eligibility: 60 Years and older
Enrollment: 2 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: St. Petersburg, Florida

Conditions: Intracerebral Hemorrhage, ICH - Intracerebral Hemorrhage
Interventions: Minimally Invasive surgery (MIS), Deferoxamine, Standard Medical Care (SMD); Procedure · Drug · Other
Lead sponsor: University of Illinois at Chicago; Other
Eligibility: 18 Years to 80 Years
Enrollment: 240 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Circadian Dysrhythmia, Sleep Disturbance, Critical Illness, Children, Only
Interventions: Daytime light exposure, Daytime restricted feeding; Other
Lead sponsor: State University of New York at Buffalo; Other
Eligibility: 3 Years to 6 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Schizophrenia
Interventions: SEP-363856, Prior antipsychotic (risperidone, olanzapine, quetiapine or aripiprazole); Drug
Lead sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 7
States / cities: Little Rock, Arkansas • Rogers, Arkansas • Long Beach, California + 4 more

Conditions: Avoidant/Restrictive Food Intake Disorder
Interventions: Family-based Treatment for ARFID, Manualized Non-Specific Usual Care for ARFID; Behavioral
Lead sponsor: Stanford University; Other
Eligibility: 6 Years to 12 Years
Enrollment: 98 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2026
U.S. locations: 1
States / cities: Stanford, California

Conditions: Asthma
Interventions: Educational Video and Question Prompt List; Behavioral
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 11 Years to 17 Years
Enrollment: 359 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Supracondylar Humerus Fracture, Anxiety
Interventions: Supracondylar Pin Removal After Imaging With VR, Supracondylar Pin Removal Before Imaging, Supracondylar Pin Removal Before Imaging With VR; Other
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 3 Years to 10 Years
Enrollment: 140 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Systemic Lupus Erythematosus (SLE), Cutaneous Lupus Erythematosus (CLE)
Interventions: Enpatoran; Drug
Lead sponsor: EMD Serono Research & Development Institute, Inc.; Industry
Eligibility: 18 Years to 76 Years
Enrollment: 404 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2031
U.S. locations: 1
States / cities: Billerica, Massachusetts

Conditions: Brain Injuries, Traumatic
Interventions: ICP + PbtO2 guided management strategy, ICP guided management strategy; Other
Lead sponsor: University of Michigan; Other
Eligibility: 14 Years and older
Enrollment: 1,094 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2027
U.S. locations: 48
States / cities: Los Angeles, California • Palo Alto, California • Sacramento, California + 38 more

Conditions: Hematopoietic Stem Cell Transplantation
Interventions: Interval Exercise Training/Motivational Accelerometry; Behavioral
Lead sponsor: UNC Lineberger Comprehensive Cancer Center; Other
Eligibility: 18 Years to 75 Years
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

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Capecitabine or 5-FU With Pegylated Interferon Alpha-2b in Unresectable/Metastatic Cutaneous Squamous Cell Carcinoma

The IMPACT Study: Personalized Physical Therapy for Better Recovery and a Stronger Core After Hernia Surgery

Simulation-Free Celiac Plexus Pain Ablation Using Stereotactic Body Radiotherapy (SBRT) in Participants With Cancer-Related Celiac Pain

Control of Major Bleeding After Trauma Study

MR Guided Focused Ultrasound vs Radiotherapy for Palliative Pain Tx in Bone Metastases

Behavioral Activation and Varenicline for Smoking Cessation in Depressed Smokers

Using Generative Artificial Intelligence (AI) to Create Patient-Friendly Discharge Summaries

Platinum Doublet Chemotherapy and Proton Beam Radiation Therapy in Treating Patients With Stage II-III Non-small Cell Lung Cancer That Cannot Be Removed by Surgery

Reversal of the Neurological Deficit in Acute Stroke With the Signal of Efficacy Trial of Auto BPAP to Limit Damage From Suspected Sleep Apnea

Bavituximab With Radiation and Temozolomide for Patients With Newly Diagnosed Glioblastoma

Evaluating the Effectiveness of Clinical Practice Guideline Adherence for Patellofemoral Pain

Matrion™ Decellularized Placental Membrane in Subjects With Diabetic Foot Ulcers

Buprenorphine for the Management of Pain in Children With Sickle Cell Disease

Functional Assessment Screening Patient Reported Information

Assessment of Immunogenicity of Zostavax® in Patients With Antibody Deficiency 60 Years of Age and Older

Synergistic Minimally Invasive Surgery and Deferoxamine in ICH

PICU-related Sleep and Circadian Dysregulation Pilot Study

A Clinical Study That Will Assess How Food Moves Through the Stomach and Effects Blood Glucose Levels in Subjects With Schizophrenia Taking SEP-363856 or and Prior Antipsychotic (PA) Standard

Confirming the Efficacy/Mechanism of Family Therapy for Children With Low Weight ARFID

Using Question Prompt Lists During Pediatric Asthma Visits to Increase Adolescent Involvement

Anxiety Surrounding Supracondylar Pin Removal in Children: A Randomized Controlled Trial

A Long-Term Extension (LTE) Study Of Enpatoran In Cutaneous Manifestations Of Lupus With Or Without Systemic Disease [Elowen-LTE]

Brain Oxygen Optimization in Severe TBI, Phase 3

Fitness in Allogeneic Stem Cell Transplantation