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Showing 1–24 of 195 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Surgical Site Infection Clear all
Active, not recruiting Phase 1 Interventional

Precision Antibiotic Dosing for Appendectomy

NCT06860802
View directory record Official record
Conditions
Appendicitis (Diagnosis)
Interventions
Cefoxitin
Drug
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Sep 20, 2026, 2:42 PM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

The Role of Guideline-adherent Perioperative Antibiotic Administration and the Risk of Surgical Site Infections After Non-cardiac Surgery.

NCT03982810
View directory record Official record
Conditions
Surgical Site Infection, Antibiotic Prophylaxis
Interventions
Antibiotics
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 24, 2022 · Synced Sep 20, 2026, 2:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Decreasing Infection In Arthroscopic Shoulder Surgery

NCT02219776
View directory record Official record
Conditions
Post Operative Infection Arthroscopic Shoulder Surgery, Infection
Interventions
Benzoyl Peroxide solution Plus Chlorhexidine Scrub, Standard of Care - Chlorhexidine Scrub only
Drug · Other
Lead sponsor
McLaren Health Care
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2021
U.S. locations
1
States / cities
Lansing, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 24, 2022 · Synced Sep 20, 2026, 2:42 PM EDT
Terminated Phase 4 Interventional Results available

Preadmission Skin Wipe Use for Surgical Site Infection Prophylaxis in Adult Orthopaedic Surgery Patients

NCT03401749
View directory record Official record
Conditions
Surgical Site Infection
Interventions
Chlorhexidine Gluconate 2% Wipe, Theraworx Bath Wipes
Drug · Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 64 Years
Enrollment
203 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated May 1, 2022 · Synced Sep 20, 2026, 2:42 PM EDT
Completed Phase 3 Interventional Results available

Topical Vancomycin for Neurosurgery Wound Prophylaxis

NCT02284126
View directory record Official record
Conditions
Infection, Surgery, Nervous System Diseases
Interventions
Vancomycin
Drug
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
1,103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 28, 2025 · Synced Sep 20, 2026, 2:42 PM EDT
Terminated Phase 1 Interventional

Dose Escalation Trial of Intrasite Vancomycin Pharmacokinetics

NCT01764750
View directory record Official record
Conditions
Surgical Site Infection
Interventions
Intrasite Vancomycin, IV Vancomycin
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated May 10, 2018 · Synced Sep 20, 2026, 2:42 PM EDT
Completed Not applicable Interventional Results available

Prevena™ vs Dermabond in Groin Wound Infections in Vascular Surgery

NCT02836990
View directory record Official record
Conditions
Wound Infection
Interventions
Prevena Incision Management System, Dermabond
Device
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years and older
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
2
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Dec 27, 2020 · Synced Sep 20, 2026, 2:42 PM EDT
Terminated Phase 2 Interventional Results available

Preoperative Application of Chlorhexidine to Reduce Infection With Cesarean Section After Labor

NCT03423147
View directory record Official record
Conditions
Cesarean Section, Surgical Site Infection, Nosocomial Infection
Interventions
2% chlorhexidine gluconate cloth, 4% Chlorhexidine gluconate vaginal scrub
Drug
Lead sponsor
Angela Bianco
Other
Eligibility
18 Years and older · Female only
Enrollment
319 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 22, 2023 · Synced Sep 20, 2026, 2:42 PM EDT
Completed Not applicable Interventional Results available

Wound Infection Alexis Wound Retractor

NCT00323453
View directory record Official record
Conditions
Appendicitis
Interventions
Open appendectomy using Alexis Wound Retractor followed by standardized wound closure, Open appendectomy with standardized wound closure
Device · Procedure
Lead sponsor
Santa Barbara Cottage Hospital
Other
Eligibility
18 Years and older
Enrollment
109 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Santa Barbara, California
Source: ClinicalTrials.gov public record
Updated Nov 22, 2018 · Synced Sep 20, 2026, 2:42 PM EDT
Completed Phase 3 Interventional Results available

Reducing INfection at the Surgical SitE With Antibiotic Irrigation During Ventral Hernia Repair (RINSE Trial)

NCT03945357
View directory record Official record
Conditions
Ventral Hernia Repair
Interventions
Gemcitabine/ clindamycin, Normal saline
Drug
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 23, 2023 · Synced Sep 20, 2026, 2:42 PM EDT
Recruiting Phase 3 Interventional

Diluted Aqueous Povidone-Iodine Compared to Saline to Decrease Surgical Site Infections

NCT06363877
View directory record Official record
Conditions
Surgical Site Infection
Interventions
Povidone-Iodine, Normal Saline
Drug
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 80 Years
Enrollment
1,100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Nov 18, 2025 · Synced Sep 20, 2026, 2:42 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Floraseal Versus Iodine Impregnated Adhesive Drapes

NCT03466489
View directory record Official record
Conditions
Surgical Site Infection, Surgical Wound Infection
Interventions
Floraseal
Device
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jul 21, 2019 · Synced Sep 20, 2026, 2:42 PM EDT
Not listed Not applicable Interventional

A Comparative Study to Assess the Prevention of Surgical Site Infection (SSI's) in Revision Total Joint Arthroplasty Patients Treated With Single-Use Negative Pressure Wound Therapy (PICO™) or Standard Care Dressings (AQUACEL® Ag SURGICAL Dressing)

NCT02664168
View directory record Official record
Conditions
Surgical Wound Infection
Interventions
Aquacel Ag Surgical Dressing, Single-Use Negative Pressure Wound Therapy (PICO)
Device
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2016
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 11, 2018 · Synced Sep 20, 2026, 2:42 PM EDT
Not listed Not applicable Interventional

Abdominal Closure Bundle to Reduce Surgical Site Infection in Patients Undergoing C-sections. Cesarean Section Lead to Reduction in Surgical Site Infection? - A Randomized Controlled Trial

NCT03500055
View directory record Official record
Conditions
Surgical Site Infection, Cesarean Section; Infection
Interventions
Abdominal Closure Bundle
Procedure
Lead sponsor
Abington Memorial Hospital
Other
Eligibility
18 Years and older · Female only
Enrollment
850 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Abington, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 4, 2018 · Synced Sep 20, 2026, 2:42 PM EDT
Completed Not applicable Interventional

Randomized Trial to Assess PO Versus IV Antibiotics

NCT01714596
View directory record Official record
Conditions
Wound Infection
Interventions
PO versus IV antibiotics Route of administration evaluation
Other
Lead sponsor
Major Extremity Trauma Research Consortium
Other
Eligibility
18 Years to 84 Years
Enrollment
233 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2020
U.S. locations
24
States / cities
Birmingham, Alabama • Los Angeles, California • San Francisco, California + 21 more
Source: ClinicalTrials.gov public record
Updated Feb 10, 2021 · Synced Sep 20, 2026, 2:42 PM EDT
Completed Phase 3 Interventional Results available

Comparative Study of Ceftaroline vs. Vancomycin Plus Aztreonam in Adult Subjects With Complicated Skin Infections

NCT00424190
View directory record Official record
Conditions
Bacterial Infections
Interventions
IV Vancomycin plus IV Aztreonam, Ceftaroline
Drug
Lead sponsor
Forest Laboratories
Industry
Eligibility
18 Years and older
Enrollment
698 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007
U.S. locations
15
States / cities
Dothan, Alabama • Long Beach, California • Los Angeles, California + 11 more
Source: ClinicalTrials.gov public record
Updated Mar 13, 2017 · Synced Sep 20, 2026, 2:42 PM EDT
Completed Not applicable Interventional Results available

Negative Pressure Wound Therapy to Reduce Surgical Site Infection

NCT01905397
View directory record Official record
Conditions
Patients Undergoing Hepatopancreatobiliary Surgery
Interventions
Conventional wound therapy, Negative pressure wound therapy
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
164 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2021
U.S. locations
2
States / cities
Indianapolis, Indiana • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 1, 2022 · Synced Sep 20, 2026, 2:42 PM EDT
Completed No phase listed Observational

Rapid Identification of Key Pathogens in Wound Infection by Molecular Means

NCT00287599
View directory record Official record
Conditions
Postoperative Wound Infection, Traumatic Wound Infection, Closed Soft Tissue Abscess
Interventions
Not listed
Lead sponsor
Brentwood Biomedical Research Institute
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
2
States / cities
Los Angeles, California • Sylmar, California
Source: ClinicalTrials.gov public record
Updated Feb 7, 2012 · Synced Sep 20, 2026, 2:42 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Postoperative Antibiotic Requirements Following Immediate Breast Reconstruction

NCT01244698
View directory record Official record
Conditions
Bacterial Infection, Anti-infective Agents, Breast Implantation
Interventions
Cefadroxil discontinued early, Cefadroxil until drain removal
Drug
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years and older · Female only
Enrollment
132 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated May 12, 2014 · Synced Sep 20, 2026, 2:42 PM EDT
Completed Not applicable Interventional

Improving Antimicrobial Prescribing Practices in the Neonatal ICU

NCT03079245
View directory record Official record
Conditions
Infants in Neonatal Intensive Care Units
Interventions
Education Plus (E+), Clinical Decision Support, Prescriber Audit and Feedback
Other
Lead sponsor
Columbia University
Other
Eligibility
Not listed
Enrollment
6,184 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
4
States / cities
Wilmington, Delaware • New York, New York • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 13, 2017 · Synced Sep 20, 2026, 2:42 PM EDT
Completed Not applicable Interventional Results available

Supplemental Oxygen in Colorectal Surgery: A Quality Improvement Project

NCT01777568
View directory record Official record
Conditions
30% Oxygen Concentration During Colorectal Surgery, 80% Oxygen Concentration During Colorectal Surgery
Interventions
30% oxygen, 80% oxygen
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
5,749 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 4, 2019 · Synced Sep 20, 2026, 2:42 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

The Effect of Forced Air Warming During Cesarean Section on Postoperative Infectious Morbidity

NCT00696462
View directory record Official record
Conditions
Cesarean Section
Interventions
forced-air warming
Device
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 12, 2012 · Synced Sep 20, 2026, 2:42 PM EDT
Completed Not applicable Interventional Results available

Comparison of Surgical Skin Preps During Cesarean Deliveries

NCT01870583
View directory record Official record
Conditions
Surgical Site Infection Following Cesarean Delivery
Interventions
Iodine povidone, Chlorhexidine, Combination iodine and chlorhexidine
Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
1,404 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
2
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Oct 1, 2017 · Synced Sep 20, 2026, 2:42 PM EDT
Completed Phase 3 Interventional

Local Warming of Surgical Incisions

NCT01026259
View directory record Official record
Conditions
Surgical Wound Infection
Interventions
Warming of surgical incision, Warming dressing without actual warming
Other
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
146 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Dec 3, 2009 · Synced Sep 20, 2026, 2:42 PM EDT