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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Recruiting Phase 2Phase 3 Interventional

Novel Approaches to the Treatment of Hypothyroidism

NCT06731764
View directory record Official record
Conditions
Hypothyroidism
Interventions
Levothyroxine, Levothyroxine/Liothyronine once daily, Levothyroxine/Liothyronine twice daily
Drug
Lead sponsor
UConn Health
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced Sep 6, 2026, 5:59 AM EDT
Completed Phase 2 Interventional Results available

Thyroid and Glucose and Energy Metabolism

NCT00106119
View directory record Official record
Conditions
Thyroid Diseases
Interventions
Liothyronine and Levothyroxine
Drug
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years to 65 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2013
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 22, 2015 · Synced Sep 6, 2026, 5:59 AM EDT
Completed Phase 4 Interventional Results available

Discontinuation of Levothyroxine Therapy for Patients With Subclinical Hypothyroidism

NCT04288115
View directory record Official record
Conditions
Subclinical Hypothyroidism
Interventions
Levothyroxine, Placebo
Drug · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
North Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Nov 17, 2023 · Synced Sep 6, 2026, 5:59 AM EDT
Withdrawn Phase 3 Interventional

Thyroxine Treatment in Premature Infants With Intraventricular Hemorrhage

NCT03390530
View directory record Official record
Conditions
Intraventricular Hemorrhage of Prematurity
Interventions
Thyroxine, Placebo
Drug
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
3 Days to 6 Days
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jul 7, 2022 · Synced Sep 6, 2026, 5:59 AM EDT
Completed Phase 2 Interventional Results available

Energy Metabolism in Thyroidectomized Patients

NCT04782856
View directory record Official record
Conditions
Thyroid Goiter, Hypothyroidism, Thyroid Cancer
Interventions
Levothyroxine, Liothyronine, Placebo
Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 89 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 13, 2024 · Synced Sep 6, 2026, 5:59 AM EDT
Terminated Phase 4 Interventional Results available

Use of Tirosint®-SOL or Tablet Formulations of Levothyroxine in Pediatric Patients With Congenital Hypothyroidism (CH)

NCT05228184
View directory record Official record
Conditions
Congenital Hypothyroidism
Interventions
Tirosint®-SOL, Levothyroxine Sodium
Drug
Lead sponsor
IBSA Institut Biochimique SA
Industry
Eligibility
1 Day to 9 Months
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
10
States / cities
Los Angeles, California • Orange, California • San Francisco, California + 7 more
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Sep 6, 2026, 5:59 AM EDT
Completed Phase 3 Interventional

Precision Medicine Approach for Early Dementia & Mild Cognitive Impairment

NCT05894954
View directory record Official record
Conditions
Mild Cognitive Impairment, Dementia, Mild
Interventions
Precision Medicine Approach, Hormones and Medications tailored to lab tests, combined with devices that support stress management and brain exercises, Standard-of-Care, Lifestyle including diet, exercise, stress management
Dietary Supplement · Combination Product · Behavioral
Lead sponsor
Alzheimer's Prevention and Reversal Project, Inc.
Other
Eligibility
45 Years to 76 Years
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
6
States / cities
Folsom, California • San Rafael, California • Walnut Creek, California + 3 more
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Sep 6, 2026, 5:59 AM EDT
Terminated Phase 1 Interventional

Gene Therapy and Radioactive Iodine in Treating Patients With Locally Recurrent Prostate Cancer That Did Not Respond to Radiation Therapy

NCT00788307
View directory record Official record
Conditions
Prostate Cancer
Interventions
Ad5-CMV-NIS, Liothyronine Sodium, Reverse Transcriptase Polymerase Chain Reaction, laboratory biomarker analysis, Iodine I 131, Iodine I 123
Biological · Drug · Genetic + 2 more
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 120 Years · Male only
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2018
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Sep 6, 2026, 5:59 AM EDT
Not listed Not applicable Interventional

Desiccated Thyroid Extract and Levothyroxine for Hypothyroidism Treatment

NCT01739972
View directory record Official record
Conditions
Primary Hypothyroidism.
Interventions
Levothyroxine, Desiccated thyroid extract
Drug
Lead sponsor
Walter Reed National Military Medical Center
Federal
Eligibility
18 Years to 65 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
2
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 3, 2012 · Synced Sep 6, 2026, 5:59 AM EDT
Recruiting Phase 2Phase 3 Interventional

A Study to Assess the Safety and Efficacy of Oral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants

NCT06345339
View directory record Official record
Conditions
Hypothyroidism
Interventions
Armour Thyroid, Levothyroxine
Drug
Lead sponsor
AbbVie
Industry
Eligibility
18 Years to 75 Years
Enrollment
2,800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
134
States / cities
Birmingham, Alabama • Bonita, California • Burbank, California + 109 more
Source: ClinicalTrials.gov public record
Updated Jan 4, 2026 · Synced Sep 6, 2026, 5:59 AM EDT
Completed Phase 4 Interventional

Sequenced Treatment Alternatives to Relieve Depression (STAR*D)

NCT00021528
View directory record Official record
Conditions
Depression
Interventions
citalopram, BuproprionSR, buspirone, Lithium, mirtazapine, nortriptyline, sertraline, tranylcypromine, VenlafaxineXR, Cognitive Therapy, T3 (Triiodothyronine)
Drug · Behavioral
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 75 Years
Enrollment
4,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2006
U.S. locations
41
States / cities
Birmingham, Alabama • Tuscaloosa, Alabama • Chula Vista, California + 20 more
Source: ClinicalTrials.gov public record
Updated Sep 24, 2009 · Synced Sep 6, 2026, 5:59 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Study of Levothyroxine and Enlicitide Decanoate (MK-0616) in Healthy Adult Participants (MK-0616-028)

NCT06625814
View directory record Official record
Conditions
Healthy
Interventions
Levothyroxine, Enlicitide Decanoate
Drug
Lead sponsor
Merck Sharp & Dohme LLC
Industry
Eligibility
19 Years to 50 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Oct 2, 2024 · Synced Sep 6, 2026, 5:59 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Fasting Study of Levothyroxine Sodium Tablets 200 mg to Synthroid Tablets 200 mg

NCT00648557
View directory record Official record
Conditions
Healthy
Interventions
Levothyroxine Sodium Tablets 200 mg, Synthroid Tablets 200 mg
Drug
Lead sponsor
Mylan Pharmaceuticals Inc
Industry
Eligibility
18 Years to 50 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003
U.S. locations
1
States / cities
Fargo, North Dakota
Source: ClinicalTrials.gov public record
Updated Apr 23, 2024 · Synced Sep 6, 2026, 5:59 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Fasting Study of Levothyroxine Sodium Tablets 300 μg to Levothroid® Tablets 300 μg

NCT00648700
View directory record Official record
Conditions
Healthy
Interventions
Levothyroxine Sodium Tablets 300 μg, Levothroid® Tablets 300 μg
Drug
Lead sponsor
Mylan Pharmaceuticals Inc
Industry
Eligibility
18 Years to 50 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005
U.S. locations
1
States / cities
Fargo, North Dakota
Source: ClinicalTrials.gov public record
Updated Apr 23, 2024 · Synced Sep 6, 2026, 5:59 AM EDT
Completed Phase 4 Interventional Results available

Neurocognitive and Metabolic Effects of Mild Hypothyroidism

NCT00565864
View directory record Official record
Conditions
Hypothyroidism
Interventions
L-thyroxine (L-T4)
Drug
Lead sponsor
Oregon Health and Science University
Other
Eligibility
20 Years to 75 Years
Enrollment
173 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Aug 21, 2018 · Synced Sep 6, 2026, 5:59 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Postpartum Thyroid Measures and Mood

NCT00565032
View directory record Official record
Conditions
Postpartum Depression
Interventions
Not listed
Lead sponsor
Oklahoma State University Center for Health Sciences
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2000 – 2001
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jan 27, 2010 · Synced Sep 6, 2026, 5:59 AM EDT
Completed Phase 2 Interventional Results available

Study of XP-8121 For the Treatment of Adult Subjects With Hypothyroidism

NCT05823012
View directory record Official record
Conditions
Hypothyroidism
Interventions
levothyroxine sodium
Drug
Lead sponsor
Xeris Pharmaceuticals
Industry
Eligibility
18 Years to 65 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
6
States / cities
Chula Vista, California • Montclair, California • Miami Lakes, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 2, 2025 · Synced Sep 6, 2026, 5:59 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Effects of Liothyronine on Energy Expenditure and Cardiovascular Function

NCT03098433
View directory record Official record
Conditions
Healthy
Interventions
Liothyronine, Levothyroxine, Placebos
Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 45 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 25, 2021 · Synced Sep 6, 2026, 5:59 AM EDT
Completed Not applicable Interventional Results available

Thyroid Hormone Dose Adjustment in Pregnancy

NCT00230802
View directory record Official record
Conditions
Pregnancy, Hypothyroidism
Interventions
Anticipatory dose increase of levothyroxine, levothyroxine
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
Female only
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 22, 2016 · Synced Sep 6, 2026, 5:59 AM EDT
Terminated Phase 4 Interventional Results available

Use of Liquid Stable Levothyroxine in Trisomy 21 Pediatric Patients

NCT04747275
View directory record Official record
Conditions
Hypothyroidism, Trisomy 21
Interventions
Liquid stable levothyroxine (L-T4) Tirosint-SOL, Oral tablet levothyroxine (L-T4)
Drug
Lead sponsor
Children's Mercy Hospital Kansas City
Other
Eligibility
2 Months to 4 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 12, 2023 · Synced Sep 6, 2026, 5:59 AM EDT
Completed Phase 3 Interventional Results available

Intravenous Thyroxine for Heart-Eligible Organ Donors

NCT04415658
View directory record Official record
Conditions
Brain Death, Heart Failure
Interventions
Thyroxine, Saline
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
14 Years to 55 Years
Enrollment
838 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
14
States / cities
Phoenix, Arizona • San Diego, California • Denver, Colorado + 11 more
Source: ClinicalTrials.gov public record
Updated Jan 9, 2024 · Synced Sep 6, 2026, 5:59 AM EDT
Completed Phase 2 Interventional

A Study of T3 Therapy in Patients With Hypothyroidism

NCT01800617
View directory record Official record
Conditions
Hypothyroidism
Interventions
Liothyronine, Sodium
Drug
Lead sponsor
Ipe, LLC
Industry
Eligibility
18 Years to 65 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2013
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jul 1, 2014 · Synced Sep 6, 2026, 5:59 AM EDT
Not listed Not applicable Interventional

A Pilot Feasibility Trial of Thyroid Hormone Replacement in Dialysis Patients

NCT03191188
View directory record Official record
Conditions
Thyroid Disease, Kidney Diseases, Chronic
Interventions
Levothyroxine Sodium, Placebo Oral Tablet
Drug
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years to 75 Years
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Jun 13, 2021 · Synced Sep 6, 2026, 5:59 AM EDT
Completed Phase 2 Interventional

A Study Evaluation the Safety and Efficacy of Hormone Replacement Therapy With North Star Compared to Levothyroxine in Patients With Primary Hypothyroidism

NCT05712421
View directory record Official record
Conditions
Hypothyroidism
Interventions
North Star, Levothyroxine
Drug
Lead sponsor
Neuvosyn Laboratories, LLC
Industry
Eligibility
18 Years to 75 Years
Enrollment
303 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
31
States / cities
Birmingham, Alabama • Canoga Park, California • Greenbrae, California + 23 more
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Sep 6, 2026, 5:59 AM EDT