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ClinicalTrials.gov public records Last synced Sep 3, 2026, 10:44 AM EDT

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Showing 1–24 of 287 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: TKA Clear all
Completed No phase listed Observational Accepts healthy volunteers

Clinical Outcomes With Omni Apex Ultracongruent Knee System

NCT01367938
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
OMNI Apex Ultracongruent Knee Device
Device
Lead sponsor
Spokane Joint Replacement Center
Other
Eligibility
21 Years to 80 Years
Enrollment
69 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2018
U.S. locations
1
States / cities
Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Dec 4, 2018 · Synced Sep 3, 2026, 10:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Unipolar vs. Bipolar Hemostasis in Total Knee Arthroplasty: A Prospective Randomized Trial

NCT01003080
View directory record Official record
Conditions
Knee Arthroplasty
Interventions
Aquamantys Device, Standard of care treatment for hemostasis during a total knee arthroplasty.
Device · Other
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
111 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
2
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Sep 20, 2018 · Synced Sep 3, 2026, 10:44 AM EDT
Completed Not applicable Interventional Results available

Tourniquet on Total Knee Arthroplasty

NCT04923724
View directory record Official record
Conditions
Arthritis Knee
Interventions
tourniquet, No tourniquet
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
165 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Creve Coeur, Missouri
Source: ClinicalTrials.gov public record
Updated May 14, 2025 · Synced Sep 3, 2026, 10:44 AM EDT
Completed Not applicable Interventional Results available

Improving Physical Activity and Gait Symmetry After Total Knee Arthroplasty

NCT04090125
View directory record Official record
Conditions
Knee Replacement, Total, Knee Arthroplasty, Total
Interventions
PAS Intervention, Attention Control
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 4, 2024 · Synced Sep 3, 2026, 10:44 AM EDT
Completed Not applicable Interventional Results available

Improvement of Patient Satisfaction and Clinical Outcomes Using JointCOACH

NCT03499028
View directory record Official record
Conditions
Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee
Interventions
JointCOACH
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
446 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 19, 2021 · Synced Sep 3, 2026, 10:44 AM EDT
Terminated Not applicable Interventional Results available

Triathlon PSR Outcomes Study

NCT04618770
View directory record Official record
Conditions
Arthroplasty, Knee
Interventions
Triathlon PSR Tibial Insert
Device
Lead sponsor
Stryker Orthopaedics
Industry
Eligibility
18 Years to 75 Years
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 10, 2023 · Synced Sep 3, 2026, 10:44 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Collagen Peptide Supplementation on Connective Tissue Remodeling, Functional Outcomes, and Wound Healing After Total Knee Arthroplasty (TKA)

NCT05823727
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
SOLUGEL, Placebo
Dietary Supplement
Lead sponsor
University of Arkansas
Other
Eligibility
50 Years to 75 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated May 26, 2026 · Synced Sep 3, 2026, 10:44 AM EDT
Completed Not applicable Interventional Results available

Randomized Fixed Bearing vs Mobile Bearing Cruciate Substituting TKA

NCT00289107
View directory record Official record
Conditions
Osteoarthritis, Rheumatoid Arthritis, Other Inflammatory Arthritis, Post-Traumatic Arthritis, Juvenile Rheumatoid Arthritis, Avascular Necrosis
Interventions
Total Knee Arthroplasty, Total knee replacement
Device
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
18 Years to 75 Years
Enrollment
149 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2007
U.S. locations
3
States / cities
Greensboro, North Carolina • Austin, Texas • Lakewood, Washington
Source: ClinicalTrials.gov public record
Updated May 2, 2023 · Synced Sep 3, 2026, 10:44 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Pregabalin for Central Sensitization in TKA

NCT05460871
View directory record Official record
Conditions
Osteo Arthritis Knee, Central Nervous System Sensitization
Interventions
Pregabalin 75mg
Drug
Lead sponsor
University of Iowa
Other
Eligibility
50 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 3, 2025 · Synced Sep 3, 2026, 10:44 AM EDT
Completed Not applicable Interventional

Tka Assay for CDK4/6i

NCT06572800
View directory record Official record
Conditions
Anatomic Stage IV Breast Cancer AJCC v8, Metastatic HER2-Negative Breast Carcinoma
Interventions
DiviTum-TKa
Device
Lead sponsor
Yale University
Other
Eligibility
18 Years and older · Female only
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
18
States / cities
Derby, Connecticut • Fairfield, Connecticut • Glastonbury, Connecticut + 13 more
Source: ClinicalTrials.gov public record
Updated Oct 7, 2025 · Synced Sep 3, 2026, 10:44 AM EDT
Completed Not applicable Interventional Results available

Improvement of Patient Satisfaction and Overall Outcomes Using HealthLoop

NCT03481595
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee, Arthroplasty, Replacement, Hip
Interventions
HealthLoop mobile application
Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
294 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 23, 2021 · Synced Sep 3, 2026, 10:44 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Antibiotic Loaded Cement After TKA

NCT05429671
View directory record Official record
Conditions
Total Knee Arthoplasty
Interventions
total knee arthroplasty, Tobramycin, Gentamicin, Antibiotic cement spacer
Procedure · Drug · Device
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 29, 2024 · Synced Sep 3, 2026, 10:44 AM EDT
Active, not recruiting No phase listed Observational

Post Market Follow-Up Study of the EVOLUTION® Total Knee Arthroplasty System With Cruciate Sacrificing Inserts

NCT02351414
View directory record Official record
Conditions
Joint Disease
Interventions
Total Knee Arthroplasty (EVOLUTION®)
Device
Lead sponsor
MicroPort Orthopedics Inc.
Industry
Eligibility
21 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2028
U.S. locations
1
States / cities
Morton Grove, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 12, 2022 · Synced Sep 3, 2026, 10:44 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

A Study of the Construct Validity of Community Walking Speed Data Collected Remotely With the Canary canturioTM te Tibial Extension

NCT05539326
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Performance Clinical Outcome Test
Other
Lead sponsor
Canary Medical
Industry
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
6
States / cities
Frisco, Colorado • South Bend, Indiana • Jackson, Mississippi + 3 more
Source: ClinicalTrials.gov public record
Updated Sep 20, 2023 · Synced Sep 3, 2026, 10:44 AM EDT
Recruiting Phase 2 Interventional

Pain Reprocessing Therapy in Post-Operative Knee Pain

NCT06800209
View directory record Official record
Conditions
Pain, Chronic, Knee Pain Chronic
Interventions
Pain reprocessing therapy (PRT), Usual care
Behavioral · Other
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
2
States / cities
Aurora, Colorado • New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 4, 2026 · Synced Sep 3, 2026, 10:44 AM EDT
Terminated Not applicable Interventional Results available

Geniculate Artery Embolization for Treatment of Persistent Knee Pain Post Total Knee Arthroplasty

NCT06134817
View directory record Official record
Conditions
Knee Pain
Interventions
Embozene Color-Advanced Microspheres.
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
30 Years to 85 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 6, 2025 · Synced Sep 3, 2026, 10:44 AM EDT
Withdrawn Phase 4 Interventional

Losartan Use to Mitigate Arthrofibrosis Following Total Join Arthroplasty

NCT05157464
View directory record Official record
Conditions
Arthrofibrosis
Interventions
Losartan
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 30, 2023 · Synced Sep 3, 2026, 10:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Preoperative Cognitive Therapy for Improving Health Outcomes After TKA in High-risk Catastrophizing Subjects

NCT01772329
View directory record Official record
Conditions
Catastrophization
Interventions
Cognitive Therapy, Routine Care
Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 85 Years
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 27, 2022 · Synced Sep 3, 2026, 10:44 AM EDT
Not yet recruiting Not applicable Interventional

Knee Replacement Rehabilitation Care Pathways

NCT07598539
View directory record Official record
Conditions
Knee Replacement, Total
Interventions
TKA Journey - patient education, Optimized Rehab Scheduling, Usual Rehab
Behavioral · Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
275 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Sep 3, 2026, 10:44 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Comparison of Mobile-Bearing and Fixed-Bearing All-Polyethylene Tibia Total Knee Designs

NCT00894361
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
TKA surgery with the rotating platform mobile-bearing knee design, TKA surgery with the all-polyethylene tibia knee design
Procedure
Lead sponsor
Minneapolis Veterans Affairs Medical Center
Federal
Eligibility
60 Years to 85 Years
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2007
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 6, 2020 · Synced Sep 3, 2026, 10:44 AM EDT
Completed Not applicable Interventional Results available

Randomized Fixed Bearing vs Mobile Bearing Cruciate Retaining TKA

NCT00289094
View directory record Official record
Conditions
Osteoarthritis, Rheumatoid Arthritis, Post-traumatic Arthritis, Juvenile Rheumatoid Arthritis, Avascular Necrosis of Bone
Interventions
Total knee replacement
Device
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
18 Years to 75 Years
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2007
U.S. locations
2
States / cities
Billings, Montana • Vancouver, Washington
Source: ClinicalTrials.gov public record
Updated Sep 12, 2022 · Synced Sep 3, 2026, 10:44 AM EDT
Terminated Not applicable Interventional Results available

Visionaire™ Versus Standard Instrumentation Safety and Efficacy in Total Knee Arthroplasty (TKA)

NCT01084772
View directory record Official record
Conditions
Degenerative Arthritis of Knee
Interventions
VISIONAIRE Total Knee Arthroplasty, Standard Total Knee Arthroplasty
Other
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
Not listed
Enrollment
134 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
6
States / cities
Park Ridge, Illinois • Springfield, Illinois • St Louis, Missouri + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 2, 2020 · Synced Sep 3, 2026, 10:44 AM EDT
Completed No phase listed Observational

Safety and Performance of Journey II XR Total Knee System

NCT03798847
View directory record Official record
Conditions
Journey II XR Total Knee System
Interventions
Journey II XR TKA
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
683 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
12
States / cities
Phoenix, Arizona • Aurora, Illinois • Port Huron, Michigan + 9 more
Source: ClinicalTrials.gov public record
Updated Jul 13, 2023 · Synced Sep 3, 2026, 10:44 AM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Metal Ion Concentrations After Total Knee Arthroplasty

NCT06447922
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee, Total Knee Replacement, Blood Metal Ion Concentration
Interventions
Metal ion level testing
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 100 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Sep 3, 2026, 10:44 AM EDT