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ClinicalTrials.gov public records Last synced Oct 19, 2026, 2:55 PM EDT

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Showing 121–144 of 290 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: TKA Clear all
Terminated Not applicable Interventional

Medial Peel Release Technique TKA Randomized Clinical Trial

NCT05154058
View directory record Official record
Conditions
Total Knee Arthroplasty, Osteoarthritis, Knee
Interventions
Medial Subperiosteal Release with Sharp Dissection, Medial Subperiosteal Release with Electrocautery
Procedure
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 27, 2023 · Synced Oct 19, 2026, 2:55 PM EDT
Recruiting Not applicable Interventional

Fiber Smoothie Supplement

NCT06896240
View directory record Official record
Conditions
Total Knee Arthroplasty Revision, Inflammatory Markers, Gut Microbiota
Interventions
Assigned Interventions
Dietary Supplement
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
40 Years to 80 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 28, 2026 · Synced Oct 19, 2026, 2:55 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Antibiotic Loaded Cement After TKA

NCT05429671
View directory record Official record
Conditions
Total Knee Arthoplasty
Interventions
total knee arthroplasty, Tobramycin, Gentamicin, Antibiotic cement spacer
Procedure · Drug · Device
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 30, 2024 · Synced Oct 19, 2026, 2:55 PM EDT
Terminated Not applicable Interventional

Standard Total Knee Arthroplasty Using Platelet Rich Plasma (PRP)

NCT01075230
View directory record Official record
Conditions
Osteoarthritis
Interventions
Total knee arthroplasty
Procedure
Lead sponsor
Exactech
Industry
Eligibility
Not listed
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 1, 2022 · Synced Oct 19, 2026, 2:55 PM EDT
Not yet recruiting Phase 4 Interventional

Suzetrigine vs. Standard Care Pain Relief Following Outpatient Knee Replacement Surgery

NCT07796152
View directory record Official record
Conditions
Knee Arthroplasty, Total, Post Operative Pain, Acute, Opioid Consumption, Postoperative
Interventions
Suzetrigine, Opioid standard care pain medicine
Drug
Lead sponsor
Endeavor Health
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Skokie, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Oct 19, 2026, 2:55 PM EDT
Active, not recruiting Phase 4 Interventional Accepts healthy volunteers

Intravenous (IV) Hydrocortisone for TKA (Total Knee Arthroplasty)

NCT04082533
View directory record Official record
Conditions
Pain, Arthrofibrosis, Osteoarthritis, Knee
Interventions
Hydrocortisone, Dextrose 5% in water (D5W)
Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 83 Years
Enrollment
65 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 19, 2026, 2:55 PM EDT
Completed Phase 4 Interventional

Postoperative Pain and Analgesic Requirements After Preoperative Methadone for Primary TKA

NCT06691633
View directory record Official record
Conditions
Osteoarthritis (OA) of the Knee
Interventions
Preoperative Methadone, Preoperative Oxycodone
Drug
Lead sponsor
University of Louisville
Other
Eligibility
21 Years to 89 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Nov 15, 2024 · Synced Oct 19, 2026, 2:55 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Muscle Regrowth During Physical Rehabilitation and Amino Acid Supplementation

NCT00760383
View directory record Official record
Conditions
Osteoarthritis
Interventions
Essential amino acids, Alanine
Dietary Supplement
Lead sponsor
University of Oregon
Other
Eligibility
60 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2013
U.S. locations
2
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Dec 4, 2014 · Synced Oct 19, 2026, 2:55 PM EDT
Withdrawn Not applicable Interventional

Kinematics After Total Knee Arthroplasty

NCT03093077
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
DePuy ATTUNE total knee arthroplasty system
Device
Lead sponsor
Kristin Zhao, PhD
Other
Eligibility
40 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 25, 2018 · Synced Oct 19, 2026, 2:55 PM EDT
Completed Not applicable Interventional Results available

Study to Evaluate the Safety and Effectiveness of REAL INTELLIGENCE™ CORI™ in Knee Arthroplasty Procedures

NCT04786119
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee
Interventions
CORI Robotics
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
4
States / cities
Phoenix, Arizona • Morrisville, North Carolina • New Albany, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 31, 2025 · Synced Oct 19, 2026, 2:55 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effect of Therapeutic Joint Arthrocentesis on Pain and Quadriceps Function in Patients With Knee Osteoarthritis

NCT04146649
View directory record Official record
Conditions
Effusion Joint
Interventions
Arthrocentesis
Procedure
Lead sponsor
Colorado Joint Replacement
Other
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
2
States / cities
Aurora, Colorado • Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 31, 2023 · Synced Oct 19, 2026, 2:55 PM EDT
Recruiting Phase 1Phase 2 Interventional

Mitigation of Arthrofibrosis After Total Knee Arthroplasty Using Losartan

NCT06108063
View directory record Official record
Conditions
Knee Arthroplasty, Total
Interventions
Losartan, Placebo - Losartan
Drug
Lead sponsor
Steadman Philippon Research Institute
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Vail, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 12, 2024 · Synced Oct 19, 2026, 2:55 PM EDT
Completed No phase listed Observational Results available

Diagnostic Utility of a Novel Point-of-Care Test of Calprotectin for Revision Total Knee Arthroplasty

NCT03694925
View directory record Official record
Conditions
Prosthetic Joint Infection
Interventions
Calprotectin test
Diagnostic Test
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
2
States / cities
Weston, Florida • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 17, 2020 · Synced Oct 19, 2026, 2:55 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Investigating Patient Satisfaction With Smart Knee Implants

NCT06968143
View directory record Official record
Conditions
Total Knee Arthroplasty, Knee Replacement, Knee Replacement Arthroplasty, Knee Osteoarthritis
Interventions
Smart Knee Implant
Device
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Oct 19, 2026, 2:55 PM EDT
Terminated No phase listed Observational

Clinical Outcomes of Knee Replacement

NCT01705366
View directory record Official record
Conditions
Knee Arthroplasty
Interventions
Non-MAKO® Robot Assisted Total Knee Arthroplasty, MAKO® Robot Assisted Medial Knee Arthroplasty, MAKO® Robot Assisted Medial and PF Knee Arthroplasty, RESTORIS Multicompartmental Knee System, Depuy Knee Replacement System, Stryker® Knee Replacement System
Procedure · Device
Lead sponsor
Northwest Surgical Specialists, Vancouver
Other
Eligibility
21 Years and older
Enrollment
316 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
1
States / cities
Vancouver, Washington
Source: ClinicalTrials.gov public record
Updated Sep 26, 2018 · Synced Oct 19, 2026, 2:55 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Adductor Canal Block Versus Liposomal Bupivacaine in TKA

NCT04086186
View directory record Official record
Conditions
Total Knee Arthroplasty, Post-operative Pain Control
Interventions
Liposomal Bupivacaine Peri-articular Injection, Adductor canal block
Procedure
Lead sponsor
Good Samaritan Regional Medical Center, Oregon
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Corvallis, Oregon
Source: ClinicalTrials.gov public record
Updated Sep 11, 2019 · Synced Oct 19, 2026, 2:55 PM EDT
Recruiting Phase 4 Interventional

Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplasty

NCT06083480
View directory record Official record
Conditions
Osteoarthritis, Knee, Total Knee Arthroplasty, Chronic Postsurgical Pain
Interventions
GlyNAC (combination of glycine and n-acetylcysteine), Placebo
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
50 Years and older
Enrollment
148 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 11, 2025 · Synced Oct 19, 2026, 2:55 PM EDT
Completed Not applicable Interventional Results available

Liposomal Bupivacaine Versus Standard Analgesia in Total Joint Arthroplasty (TJA)

NCT02197273
View directory record Official record
Conditions
Osteoarthritis, Knee, Osteoarthritis, Hip, Osteoarthritis, Shoulder
Interventions
Liposomal bupivacaine, Standard of care analgesia
Drug
Lead sponsor
OhioHealth
Other
Eligibility
18 Years and older
Enrollment
211 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 21, 2016 · Synced Oct 19, 2026, 2:55 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Unipolar vs. Bipolar Hemostasis in Total Knee Arthroplasty: A Prospective Randomized Trial

NCT01003080
View directory record Official record
Conditions
Knee Arthroplasty
Interventions
Aquamantys Device, Standard of care treatment for hemostasis during a total knee arthroplasty.
Device · Other
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
111 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
2
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Sep 21, 2018 · Synced Oct 19, 2026, 2:55 PM EDT
Completed Phase 3 Interventional Results available

Efficacy And Safety Of Pregabalin For Pain Following Total Knee Replacement

NCT00442546
View directory record Official record
Conditions
Osteoarthritis, Postoperative Pain
Interventions
pregabalin, Placebo
Drug
Lead sponsor
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
307 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
27
States / cities
Northport, Alabama • Tuscaloosa, Alabama • Phoenix, Arizona + 21 more
Source: ClinicalTrials.gov public record
Updated Jan 22, 2021 · Synced Oct 19, 2026, 2:55 PM EDT
Terminated Not applicable Interventional

Visionaire: A Prospective Study

NCT01937572
View directory record Official record
Conditions
Osteoarthritis
Interventions
Visionaire system (Knee MRI), No Knee MRI
Other
Lead sponsor
The Hawkins Foundation
Other
Eligibility
18 Years to 100 Years
Enrollment
149 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 5, 2018 · Synced Oct 19, 2026, 2:55 PM EDT
Completed Not applicable Interventional Results available

Improvement of Patient Satisfaction and Overall Outcomes Using HealthLoop

NCT03481595
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee, Arthroplasty, Replacement, Hip
Interventions
HealthLoop mobile application
Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
294 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 24, 2021 · Synced Oct 19, 2026, 2:55 PM EDT
Completed Phase 2 Interventional

Study to Evaluate Safety/Efficacy of a Single Pre-Op Dose of AYX1 Injection to Treat Pain After Knee Replacement Surgery

NCT01731730
View directory record Official record
Conditions
Postsurgical Pain
Interventions
Placebo Injection, AYX1 Injection 110 mg, AYX1 Injection 330 mg
Drug
Lead sponsor
Adynxx, Inc.
Industry
Eligibility
40 Years to 80 Years
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
7
States / cities
Sheffield, Alabama • Phoenix, Arizona • Boynton Beach, Florida + 4 more
Source: ClinicalTrials.gov public record
Updated Jan 27, 2015 · Synced Oct 19, 2026, 2:55 PM EDT
Active, not recruiting No phase listed Observational

Persona IQ Cohort Study

NCT06089291
View directory record Official record
Conditions
Osteo Arthritis Knee, Knee Arthritis, Monitoring Orthopedic Devices, Total Knee Arthroplasty, Total Knee Replacement
Interventions
Persona IQ
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
4
States / cities
Granger, Indiana • St Louis, Missouri • Charlotte, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Oct 19, 2026, 2:55 PM EDT