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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: The Unified Protocol Clear all
Completed Not applicable Interventional Results available

Community Study of Outcome Monitoring for Emotional Disorders in Teens

NCT02567266
View directory record Official record
Conditions
Depression, Anxiety
Interventions
Unified Protocol for Adolescents (UP-A), Youth Outcomes Questionnaire, Treatment as Usual
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
12 Years to 18 Years
Enrollment
196 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
2
States / cities
West Hartford, Connecticut • Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated Aug 17, 2021 · Synced Sep 25, 2026, 4:57 PM EDT
Not listed Not applicable Interventional

Randomized Clinical Trial of Supplementing Brief Psychotherapy With a Mobile App

NCT06555094
View directory record Official record
Conditions
Suicidal Ideation, Suicide, Suicide Attempt
Interventions
Ecological momentary assessment (EMA), Treatment as usual (TAU), Brief skills sessions plus EMI skills practice prompts
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Piscataway, New Jersey
Source: ClinicalTrials.gov public record
Updated Aug 14, 2024 · Synced Sep 25, 2026, 4:57 PM EDT
Recruiting Phase 3 Interventional

Affirmative Family and Individual Psychotherapy for Sexual and Gender Minority Adults and Their Nonaccepting Parents

NCT05766592
View directory record Official record
Conditions
Mental Health Issue, Parent-Child Relations
Interventions
LGBTQ-affirmative CBT, ABFT-SGM
Behavioral
Lead sponsor
Yale University
Other
Eligibility
20 Years and older
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 12, 2026 · Synced Sep 25, 2026, 4:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Unified Intervention for Young Gay and Bisexual Men's Minority Stress, Mental Health, and HIV Risk

NCT02929069
View directory record Official record
Conditions
HIV, Acquired Immunodeficiency Syndrome
Interventions
ESTEEM, CMHT, VCT
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 35 Years · Male only
Enrollment
254 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
2
States / cities
New Haven, Connecticut • Miami, Florida
Source: ClinicalTrials.gov public record
Updated Oct 17, 2022 · Synced Sep 25, 2026, 4:57 PM EDT
Active, not recruiting Not applicable Interventional

Integrated CBT to Improve Functioning in Veterans With Anxiety and Substance Use

NCT04871100
View directory record Official record
Conditions
Anxiety Disorder, Posttraumatic Stress Disorder, Hazardous Drinking
Interventions
Unified Protocol- Alcohol, Usual care
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Sep 25, 2026, 4:57 PM EDT
Completed Not applicable Interventional Results available

Addressing Psychological Risk Factors Underlying Smoking Persistence in COPD Patients: The Fresh Start Study

NCT04043728
View directory record Official record
Conditions
Copd, Smoking Cessation, Nicotine Dependence, Tobacco Use, Cigarette Smoking
Interventions
Unified Protocol adapted for smoking cessation
Behavioral
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 16, 2021 · Synced Sep 25, 2026, 4:57 PM EDT
Recruiting Not applicable Interventional

Comparative Effectiveness of SPARCS and Unified Protocol for Youth With Chronic Medical Conditions and Trauma-Related Distress

NCT07483333
View directory record Official record
Conditions
Trauma Exposure, Trauma, Trauma and Stressor Related Disorder, Mental Health Functioning, Chronic Medical Conditions, Chronic Medical Condition, Chronic Medical Illness, Posttraumatic Stress Disorder PTSD, Posttraumatic Stress Disorders, Posttraumatic Stress Symptoms, Posttraumatic Stress
Interventions
Structured Psychotherapy for Adolescents Responding to Chronic Stress - Group, Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Children and Adolescents - Group, Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Children and Adolescents - Individual, Structured Psychotherapy for Adolescents Responding to Chronic Stress - Individual
Behavioral
Lead sponsor
Anthony Vesco
Other
Eligibility
8 Years to 18 Years
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Sep 25, 2026, 4:57 PM EDT
Completed Not applicable Interventional

Project COPE (Coping Options for Parent Empowerment)

NCT04715906
View directory record Official record
Conditions
Anxiety Disorders, Depression
Interventions
UP-Caregiver
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Apr 26, 2022 · Synced Sep 25, 2026, 4:57 PM EDT
Completed No phase listed Observational

Novel Stimulation Patterns for the Treatment of Dystonia

NCT02468843
View directory record Official record
Conditions
Dystonia, Cervical Dystonia
Interventions
Biphasic DBS stimulation, Unified Dystonia Rating Scale, Burke-Fahn- Marsden scale
Device · Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 26, 2016 · Synced Sep 25, 2026, 4:57 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Battery-preserving Stimulation Patterns for Deep Brain Stimulation

NCT02569021
View directory record Official record
Conditions
Parkinsons Disease, Essential Tremor
Interventions
Biphasic DBS stimulation, Unified Parkinson's Disease Rating Scale, Tremor Rating Scale, Kinesia accelerometer, Trigno wireless system, GaitRite walking assessment.
Device · Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 23, 2016 · Synced Sep 25, 2026, 4:57 PM EDT
Not listed Not applicable Interventional

The SEMS Project: Staying Employed With MS

NCT03647904
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
SEMS Project
Behavioral
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years to 65 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
East Hanover, New Jersey
Source: ClinicalTrials.gov public record
Updated Aug 26, 2018 · Synced Sep 25, 2026, 4:57 PM EDT
Not listed Not applicable Interventional

Mindfulness-based Dance/Movement Therapy for Chronic Low Back Pain

NCT03986489
View directory record Official record
Conditions
Chronic Low-back Pain
Interventions
Mindfulness-based dance/movement therapy (M-DMT), Chronic pain social support group
Behavioral
Lead sponsor
Drexel University
Other
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 14, 2021 · Synced Sep 25, 2026, 4:57 PM EDT
Completed Not applicable Interventional

Outcomes of a Self-guided Versus Therapist-guided Online Mental Health Treatment

NCT04810988
View directory record Official record
Conditions
Depression, Anxiety, Mood
Interventions
Unified Protocol, Therapist Support
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 21, 2024 · Synced Sep 25, 2026, 4:57 PM EDT
Recruiting Not applicable Interventional

Recovery Through Inhibitory Learning, Self-Efficacy Building, Problem Solving, and Community Building

NCT07217795
View directory record Official record
Conditions
Alcohol Use Disorder (AUD), PTSD
Interventions
CBT + expressive writing, Wait-List Control
Behavioral
Lead sponsor
University of Rhode Island
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Dec 8, 2025 · Synced Sep 25, 2026, 4:57 PM EDT
Completed Not applicable Interventional

CO-PARENT: COVID-19 - Parent Action in Response to Emotions and Needs for Treatment

NCT04431856
View directory record Official record
Conditions
Anxiety, Depression, Traumatic Stress Disorder
Interventions
Unified Protocol for COVID-19 Parenting Stress (UP-COVID), SHG
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Nov 30, 2020 · Synced Sep 25, 2026, 4:57 PM EDT
Completed Not applicable Interventional

Assisting Obsessive Compulsive Disorder (OCD) Patients With Discontinuing Long-term Serotonin Reuptake Inhibitors (SRIs)

NCT02103621
View directory record Official record
Conditions
Obsessive Compulsive Disorder
Interventions
Unified Protocol (UP), Taper and Monitoring (TAP-M)
Behavioral
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 75 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jun 13, 2018 · Synced Sep 25, 2026, 4:57 PM EDT
Not listed Not applicable Interventional

Meeting an Unmet Need in Multiple Sclerosis

NCT05953519
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
Unified Protocol
Behavioral
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
East Hanover, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 19, 2023 · Synced Sep 25, 2026, 4:57 PM EDT
Recruiting Not applicable Interventional

Comparing Two Different Emotion Therapies for Autistic Youth and Young Adults

NCT06158581
View directory record Official record
Conditions
Autism Spectrum Disorder
Interventions
The Emotion Awareness and Skills Enhancement Program, The Unified Protocol
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
10 Years to 30 Years
Enrollment
470 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
2
States / cities
Tuscaloosa, Alabama • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Sep 25, 2026, 4:57 PM EDT
Completed Not applicable Interventional Results available

Stress, Emotion Regulation, and Alcohol in Women Veterans

NCT04393623
View directory record Official record
Conditions
Alcohol Use Disorder, Post Traumatic Stress Disorder
Interventions
Cognitive Reappraisal, Psychoeducation
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older · Female only
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Leeds, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 26, 2026 · Synced Sep 25, 2026, 4:57 PM EDT
Completed Not applicable Interventional

Exploring Two Treatments for Misophonia

NCT04198597
View directory record Official record
Conditions
Misophonia
Interventions
Unified Protocol for Transdiagnostic Treatment of Emotional Disorders, Process-based Cognitive Behavioral Therapy
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 24, 2022 · Synced Sep 25, 2026, 4:57 PM EDT
Completed Not applicable Interventional

Efficacy Evaluation of a Unified Transdiagnostic Treatment for Anxiety Disorders

NCT01243606
View directory record Official record
Conditions
Anxiety Disorders, Mood Disorders
Interventions
Single Diagnosis Treatment Protocol, Unified Protocol (UP)
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 8, 2017 · Synced Sep 25, 2026, 4:57 PM EDT
Recruiting Not applicable Interventional

Unified Protocol: Community Connections

NCT06038721
View directory record Official record
Conditions
Mental Health Issue, Anxiety Disorder, Depressive Disorder, Parenting
Interventions
The Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders in Children, The Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders in Adolescents
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
7 Years to 17 Years
Enrollment
1,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated Sep 20, 2026 · Synced Sep 25, 2026, 4:57 PM EDT
Active, not recruiting Not applicable Interventional

Unified Protocol for Preventing Emotional and Academic Challenges in Education (U-PEACE)

NCT06056674
View directory record Official record
Conditions
Emotions
Interventions
U-PEACE Intervention, SAU
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
13 Years to 18 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated Aug 16, 2026 · Synced Sep 25, 2026, 4:57 PM EDT
Suspended Not applicable Interventional

Stress, Anxiety, and Mood Group Therapy

NCT03855683
View directory record Official record
Conditions
Depressive Disorders, Anxiety Disorders
Interventions
Unified Protocol for The Treatment of Emotional Disorders
Behavioral
Lead sponsor
Palo Alto University
Other
Eligibility
18 Years to 50 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Los Altos, California
Source: ClinicalTrials.gov public record
Updated Sep 17, 2020 · Synced Sep 25, 2026, 4:57 PM EDT