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ClinicalTrials.gov public records Last synced Oct 4, 2026, 10:22 AM EDT

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Showing 73–96 of 206 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Therapeutic Melatonin Clear all
Active, not recruiting Phase 1Phase 2 Interventional Accepts healthy volunteers

Treatment of Orthostatic Intolerance

NCT00262470
View directory record Official record
Conditions
Tachycardia, Chronic Orthostatic Intolerance
Interventions
Acetazolamide, Atomoxetine, NO Drug, Clonidine, Entacapone, Entacapone & Propranolol, Atomoxetine & Propranolol, Indomethacin, Mecamylamine, Isosorbide Dinitrate, Melatonin, Midodrine, Modafinil, Octreotide, Placebo, Propranolol, Modafinil & Propranolol, Sertraline, IV Saline, Drinking Water, Breathing Device, memantine, Abdominal binder
Drug · Other · Dietary Supplement + 3 more
Lead sponsor
Satish R. Raj
Other
Eligibility
18 Years to 70 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1997 – 2029
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 8, 2025 · Synced Oct 4, 2026, 10:22 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Exploratory Study of Melatonin Induced Sleep Regularization in Severe Brain Injury

NCT02732288
View directory record Official record
Conditions
Disorders of Consciousness
Interventions
melatonin
Dietary Supplement
Lead sponsor
Rockefeller University
Other
Eligibility
18 Years to 65 Years
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 30, 2023 · Synced Oct 4, 2026, 10:22 AM EDT
Not listed Not applicable Interventional

Sleep Quality and Pain Medication Use Following Arthroscopic Rotator Cuff Repair

NCT04278677
View directory record Official record
Conditions
Sleep Disturbance
Interventions
melatonin
Dietary Supplement
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Egg Harbor, New Jersey
Source: ClinicalTrials.gov public record
Updated Feb 20, 2020 · Synced Oct 4, 2026, 10:22 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Sleep and Circadian Contributions to Nighttime Blood Pressure

NCT05656768
View directory record Official record
Conditions
Sleep, Circadian Rhythm, Blood Pressure, Hypertension
Interventions
Constant Routine Protocol
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
1,427 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Oct 4, 2026, 10:22 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Mechanistic Effect of Walnut Consumption on Sleep Quality

NCT06430086
View directory record Official record
Conditions
Poor Sleep Quality
Interventions
Walnut consumption, HCHS consumption
Other
Lead sponsor
Columbia University
Other
Eligibility
45 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 31, 2026 · Synced Oct 4, 2026, 10:22 AM EDT
Not yet recruiting Not applicable Interventional

Circadian Light Exposure Adjustment for Restfulness

NCT07391852
View directory record Official record
Conditions
Sleep Onset Latency
Interventions
Amber Tinted Glasses, Clear Glasses, Smart Lightbulbs
Device
Lead sponsor
University of Arizona
Other
Eligibility
60 Months to 83 Months
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Feb 6, 2026 · Synced Oct 4, 2026, 10:22 AM EDT
Terminated Not applicable Interventional Results available

Young Blind Child Melatonin Treatment Study

NCT00688935
View directory record Official record
Conditions
Blindness
Interventions
Melatonin
Biological
Lead sponsor
Oregon Health and Science University
Other
Eligibility
1 Year to 20 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2015
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 27, 2019 · Synced Oct 4, 2026, 10:22 AM EDT
Recruiting No phase listed Observational

Sensing Physiological Symptoms of Opioid Withdrawal and Cravings in Patients With Opioid Use Disorder

NCT06487533
View directory record Official record
Conditions
Opioid Withdrawal, Opioid Use Disorder
Interventions
EmbracePlus Smartwatch, Corti Sensor
Device
Lead sponsor
Spark Biomedical, Inc.
Industry
Eligibility
18 Years to 50 Years
Enrollment
20 participants
Timeline
2025 – 2027
U.S. locations
2
States / cities
Center City, Minnesota • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 28, 2026 · Synced Oct 4, 2026, 10:22 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Disease Modifying Potential of 5mg of Melatonin on Cognition and Brain Health in Aging

NCT03954899
View directory record Official record
Conditions
Mild Cognitive Impairment, Cognitive Decline, Healthy Aging
Interventions
melatonin, placebo
Dietary Supplement · Other
Lead sponsor
Natalie Denburg
Other
Eligibility
56 Years to 85 Years
Enrollment
230 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2028
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Sep 28, 2026 · Synced Oct 4, 2026, 10:22 AM EDT
Completed Not applicable Interventional Results available

Study of Melatonin on Sleep, Pain, and Confusion After Joint Replacement Surgery

NCT01505465
View directory record Official record
Conditions
Postoperative Pain, Delirium, Confusion, Sleep
Interventions
Melatonin, Placebo
Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 90 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 11, 2022 · Synced Oct 4, 2026, 10:22 AM EDT
Completed Phase 1Phase 2 Interventional

Melatonin and Sleep in Preventing Delirium in the Hospital

NCT02597231
View directory record Official record
Conditions
Delirium
Interventions
Melatonin, Placebo
Dietary Supplement · Other
Lead sponsor
Scripps Health
Other
Eligibility
65 Years to 100 Years
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Oct 4, 2017 · Synced Oct 4, 2026, 10:22 AM EDT
Recruiting Not applicable Interventional

Studying Melatonin and Recovery in Teens

NCT06093477
View directory record Official record
Conditions
Juvenile; Scoliosis, Scoliosis Idiopathic, Scoliosis; Adolescence, Scoliosis;Congenital, Kyphosis, Spondylolisthesis, Pectus Surgery, Hip Surgery
Interventions
Fast-Dissolve Melatonin Pill, Fast-Dissolve Placebo Pill
Dietary Supplement · Other
Lead sponsor
Stanford University
Other
Eligibility
12 Years to 18 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced Oct 4, 2026, 10:22 AM EDT
Not yet recruiting Not applicable Interventional

Sleep Harmonization Via Bundled Team-Based Interventions in the ICU

NCT07840560
View directory record Official record
Conditions
Sleep Deprivation, Critical Illness, Sleep-Wake Disorders, Bundle Care, Implementation Science, Delirium
Interventions
Nighttime noise & light reduction, Clustering patient-care interactions, Non-pharmacologic sleep aids, Daytime light exposure, Encourage out-of-bed activity, Medication management to support nighttime sleep
Behavioral · Other
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
62,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
7
States / cities
La Jolla, California • San Francisco, California • Orlando, Florida + 4 more
Source: ClinicalTrials.gov public record
Updated Sep 25, 2026 · Synced Oct 4, 2026, 10:22 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

A Study of Melatonin Concentration During Lactation

NCT06393296
View directory record Official record
Conditions
Breastfeeding
Interventions
Not listed
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Eau Claire, Wisconsin
Source: ClinicalTrials.gov public record
Updated Aug 12, 2026 · Synced Oct 4, 2026, 10:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Potential Effects of Inofolic Plus on Abnormal Ovarian Reserve Parameters in Subfertile Women

NCT01290432
View directory record Official record
Conditions
Infertility, Female
Interventions
Inofolic Plus
Dietary Supplement
Lead sponsor
Palm Beach Center for Reproductive Medicine
Other
Eligibility
18 Years to 42 Years · Female only
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Wellington, Florida
Source: ClinicalTrials.gov public record
Updated May 25, 2012 · Synced Oct 4, 2026, 10:22 AM EDT
Completed No phase listed Observational

Circadian Phase in Bipolar Depression: Is it Delayed and Does it Normalize With Remission?

NCT01784341
View directory record Official record
Conditions
Bipolar Disorder
Interventions
Not listed
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 55 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 28, 2017 · Synced Oct 4, 2026, 10:22 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Melatonin Agonist Effects of Tasimelteon Versus Placebo in Patients With Major Depressive Disorder

NCT01428661
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
tasimelteon, placebo
Drug
Lead sponsor
Vanda Pharmaceuticals
Industry
Eligibility
18 Years to 65 Years
Enrollment
507 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
40
States / cities
Garden Grove, California • Irvine, California • Los Alamitos, California + 36 more
Source: ClinicalTrials.gov public record
Updated Jun 19, 2015 · Synced Oct 4, 2026, 10:22 AM EDT
Completed Early Phase 1 Interventional

Biological Clock Dysfunction in Optic Nerve Hypoplasia

NCT00825591
View directory record Official record
Conditions
Biological Clock Dysfunction, Optic Nerve Hypoplasia
Interventions
Melatonin, Placebo Comparator
Dietary Supplement
Lead sponsor
Yale University
Other
Eligibility
2 Years to 10 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 25, 2020 · Synced Oct 4, 2026, 10:22 AM EDT
Terminated Phase 2 Interventional Results available

Melatonin for Adolescent Migraine Prevention Study

NCT03150797
View directory record Official record
Conditions
Migraine
Interventions
Melatonin, Placebo oral capsule
Drug
Lead sponsor
Amy Gelfand
Other
Eligibility
10 Years to 17 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
2
States / cities
Los Angeles, California • San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 13, 2023 · Synced Oct 4, 2026, 10:22 AM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Melatonin Use in the Intensive Care Elderly Population

NCT03013790
View directory record Official record
Conditions
Delirium, Melatonin
Interventions
Melatonin
Drug
Lead sponsor
MICE Trial Group
Other
Eligibility
65 Years and older
Enrollment
600 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Pueblo, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 13, 2017 · Synced Oct 4, 2026, 10:22 AM EDT
Completed Not applicable Interventional Results available

A SMART Design to Improve Sleep Disturbance in Adolescents With Neurodevelopmental Disorders

NCT03730194
View directory record Official record
Conditions
Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder, Sleep Disturbance
Interventions
Melatonin, Bedtime Bank
Dietary Supplement · Behavioral
Lead sponsor
University of Nebraska
Other
Eligibility
10 Years to 18 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Dec 22, 2023 · Synced Oct 4, 2026, 10:22 AM EDT
Completed Phase 2 Interventional

RECOVER-SLEEP: Platform Protocol

NCT06404086
View directory record Official record
Conditions
Long COVID, Long COVID-19, Hypersomnia, Sleep Disturbance
Interventions
Modafinil, Modafinil Placebo, Solriamfetol, Solriamfetol Placebo, Melatonin, Melantonin Placebo, Tailored lighting (TL) Active, Tailored lighting (TL) Placebo
Drug · Device
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
830 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
47
States / cities
Phoenix, Arizona • Tucson, Arizona • Palo Alto, California + 31 more
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Oct 4, 2026, 10:22 AM EDT
Completed Phase 3 Interventional Results available

Efficacy and Safety of Circadin® in the Treatment of Sleep Disturbances in Children With Neurodevelopment Disabilities

NCT01906866
View directory record Official record
Conditions
Sleep Disorders
Interventions
Circadin 2/5/10 mg, Placebo
Drug
Lead sponsor
Neurim Pharmaceuticals Ltd.
Industry
Eligibility
2 Years to 17 Years
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
18
States / cities
Phoenix, Arizona • Miami Lakes, Florida • Orange City, Florida + 14 more
Source: ClinicalTrials.gov public record
Updated Apr 23, 2024 · Synced Oct 4, 2026, 10:22 AM EDT
Completed Not applicable Interventional

Out-patient Wake Therapy, Light Therapy and Sleep Phase Advance for Depression

NCT02750631
View directory record Official record
Conditions
Unipolar Depression
Interventions
Triple Therapy
Other
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 29, 2017 · Synced Oct 4, 2026, 10:22 AM EDT