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Showing 1–24 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Thermal Stimuli Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Study to Investigate Efficacy of Two Experimental Oral Rinses in Providing Long Term Relief From Pain Derived From Exposed Dentine in Response to Chemical, Thermal, Tactile, or Osmotic Stimuli.

NCT02651467
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Experimental Oral Rinse 1 (1.5% w/w KOX, 0ppm F, pH 7.0), Experimental Oral Rinse 2 (2.0% w/w KOX, 45ppm F, pH 4.5), Placebo Oral Rinse (0% w/w KOX 0ppm F, pH 4.5 )
Other
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
221 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 26, 2018 · Synced Sep 4, 2026, 11:15 AM EDT
Recruiting Early Phase 1 Interventional

Functional Neuroimaging to Detect the Neural Signatures of the Unpleasantness of Pain and Effort

NCT06472622
View directory record Official record
Conditions
Fatigue Syndrome, Chronic
Interventions
Thermal Pain Stimulation, Physical Effort Stimulation
Device
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years to 50 Years
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2034
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Sep 4, 2026, 11:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pain Sensitivity During Puberty

NCT05145595
View directory record Official record
Conditions
Pain
Interventions
Thermal Sensory Analyzer, Pressure Stimuli, Mechanical Stimuli, Pain Ratings, Thermal pain thresholds, Pressure pain thresholds (PPT), Mechanical temporal summation, Conditioned pain modulation (CPM) efficiency, Offset analgesia efficiency, Cold pain tolerance
Device · Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
9 Years to 16 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 8, 2026 · Synced Sep 4, 2026, 11:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Transcranial Magnetic Stimulation (TMS) and Stimulus Controllability on Pain Perception

NCT01030133
View directory record Official record
Conditions
Chronic Pain
Interventions
Operator Role Real TMS, Receiver Role Real TMS, Operator Role Sham TMS, Receiver Role Sham TMS, All Participants Operator Role
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 75 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Sep 27, 2018 · Synced Sep 4, 2026, 11:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Diode Laser as a Biomarker for Neuropathic Pain of Peripheral Origin.

NCT06030297
View directory record Official record
Conditions
Peripheral Neuropathy
Interventions
Diode Laser fiber type Selective Stimulator, ZTlido 1.8 % Topical System, PeriCam PSI NR, Medoc Quantitative Sensory Testing, Inactive Topical System
Procedure · Drug · Diagnostic Test + 1 more
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
2
States / cities
Palo Alto, California • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Sep 4, 2026, 11:15 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Central Mechanisms of Chronic Pain and Fatigue Subtitle: Functional Imaging of Brain and Spinal Cord

NCT03075254
View directory record Official record
Conditions
Chronic Fatigue Syndrome, Fibromyalgia
Interventions
A Peltier for Sensory testing, functional magnetic resonance imaging for Brain Neuroimaging, fMRI for Spinal Cord Neuroimaging
Device
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 70 Years
Enrollment
197 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2024
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 26, 2025 · Synced Sep 4, 2026, 11:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

N-of-few Study of Pain Perception

NCT04664400
View directory record Official record
Conditions
Healthy
Interventions
Symbolic conditioning, Conditioning, Instructions, Counterfactual
Behavioral
Lead sponsor
Trustees of Dartmouth College
Other
Eligibility
18 Years to 55 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Hanover, New Hampshire
Source: ClinicalTrials.gov public record
Updated Apr 17, 2023 · Synced Sep 4, 2026, 11:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Measuring Attention During Immersive Virtual Reality Distraction

NCT06615245
View directory record Official record
Conditions
Distraction
Interventions
No VR vs. immersive high tech VR, Plausible control vs immersive High Tech VR
Behavioral
Lead sponsor
Hunter Hoffman
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Dec 5, 2024 · Synced Sep 4, 2026, 11:15 AM EDT
Completed Not applicable Interventional

Cordotomy for Refractory Cancer Pain

NCT02345629
View directory record Official record
Conditions
Advanced Cancers, Pain
Interventions
Cordotomy, Pain/Symptom Questionnaire, Sharpness Sensory Testing, Heat Pain Sensory Testing
Procedure · Behavioral
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 6, 2023 · Synced Sep 4, 2026, 11:15 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Endometriosis and Migraine

NCT06785129
View directory record Official record
Conditions
Migraine, Endometriosis
Interventions
Thermal stimuli, Pressure stimuli, Pain ratings, Conditioned pain modulation (CPM) response, Hormonal assessment
Device · Behavioral · Biological
Lead sponsor
Washington University School of Medicine
Other
Eligibility
12 Years to 45 Years · Female only
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2030
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Sep 4, 2026, 11:15 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Puberty, Sex Hormones and Pain Sensitivity in Adolescents With Migraine

NCT05738213
View directory record Official record
Conditions
Migraine
Interventions
Thermal stimuli, Pressure stimuli, Pain ratings, Pressure pain thresholds (PPT), Conditioned pain modulation (CPM) response, PedMIDAS (Pediatric Migraine Disability Assessment), Hormonal assessment, Pubertal status
Device · Behavioral · Diagnostic Test + 1 more
Lead sponsor
Washington University School of Medicine
Other
Eligibility
11 Years to 15 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Sep 4, 2026, 11:15 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Characterization of Nociception Phenotype in Individuals With Intellectual Disability

NCT05473429
View directory record Official record
Conditions
Intellectual Disability
Interventions
TSA2 Thermosensory Stimulator
Device
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
8 Years to 30 Years
Enrollment
215 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 30, 2026 · Synced Sep 4, 2026, 11:15 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Quantitative Studies of Urinary Bladder Sensation

NCT00903435
View directory record Official record
Conditions
Interstitial Cystitis
Interventions
Quantitative Sensory Testing and Stimulus
Other
Lead sponsor
Timothy Ness, MD
Other
Eligibility
19 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Nov 30, 2011 · Synced Sep 4, 2026, 11:15 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Sociocultural & Biobehavioral Influences on Pain Expression and Assessment

NCT03258580
View directory record Official record
Conditions
Normal Physiology, Healthy Volunteers, Pain
Interventions
Medoc thermal stimulator, Electric shock stimulator, Cold water bath, Pain assessment performance feedback
Device · Behavioral
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
18 Years to 60 Years
Enrollment
700 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2027
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Sep 4, 2026, 11:15 AM EDT
Recruiting No phase listed Observational

Endometriosis Pain

NCT06101303
View directory record Official record
Conditions
Pelvic Pain, Endometriosis
Interventions
Psychophysical assessment, Psychophysical assessments of experimental pain, Blood, urine and saliva samples, Biopsy and surgery-related data.
Other · Behavioral · Diagnostic Test + 1 more
Lead sponsor
Washington University School of Medicine
Other
Eligibility
12 Years to 45 Years · Female only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Sep 4, 2026, 11:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Real-Time fMRI Feedback Effects on Pain Perception

NCT01588197
View directory record Official record
Conditions
Cognitive Pain Control
Interventions
Attention/Distraction Strategy, Stimulus Quality/Severity Strategy, Control Strategy
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2016
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 13, 2019 · Synced Sep 4, 2026, 11:15 AM EDT
Terminated Phase 4 Interventional Results available

Tianeptine for Treatment Resistant Depression

NCT04249596
View directory record Official record
Conditions
Treatment Resistant Depression
Interventions
Tianeptine Sodium
Drug
Lead sponsor
Jonathan A. Javitch, MD, PhD
Other
Eligibility
21 Years to 60 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
3
States / cities
Stanford, California • New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Sep 4, 2026, 11:15 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Migraine in Adolescents

NCT05654012
View directory record Official record
Conditions
Migraine
Interventions
MRI, Thermal Stimuli, Pressure stimuli, Pain ratings, Pressure pain thresholds (PPT), Conditioned pain modulation (CPM) efficiency, Hormonal assessment, Migraine-related measures, Neural assessments, Pubertal status
Device · Behavioral · Diagnostic Test
Lead sponsor
Washington University School of Medicine
Other
Eligibility
10 Years to 13 Years
Enrollment
250 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2030
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Sep 4, 2026, 11:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Virtual Reality Analgesia for Brief Thermal Pain

NCT05130307
View directory record Official record
Conditions
Pain, Acute
Interventions
virtual reality game
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 23, 2022 · Synced Sep 4, 2026, 11:15 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Brain and Genetic Predictors of Individual Differences in Pain and Analgesia

NCT03781570
View directory record Official record
Conditions
Pain, Acute
Interventions
Placebo Cream, Control Cream
Behavioral
Lead sponsor
Trustees of Dartmouth College
Other
Eligibility
18 Years to 55 Years
Enrollment
541 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 3, 2025 · Synced Sep 4, 2026, 11:15 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Virtual Contexts for Affective Modulation

NCT06986122
View directory record Official record
Conditions
Pain Control, Anxiety, Memory
Interventions
Pain Threat Manipulation, Pain Controllability Manipulation
Behavioral
Lead sponsor
Trustees of Dartmouth College
Other
Eligibility
18 Years to 55 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Hanover, New Hampshire
Source: ClinicalTrials.gov public record
Updated Oct 30, 2025 · Synced Sep 4, 2026, 11:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Magic Bowl Virtual Reality Analgesia

NCT07192822
View directory record Official record
Conditions
Pain Acute
Interventions
Virtual Reality distraction, No Virtual Reality, One brief pain stimulus, Two simultaneous brief thermal stimuli
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 6, 2026 · Synced Sep 4, 2026, 11:15 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Neural and Psychological Mechanisms of Pain Perception

NCT02446262
View directory record Official record
Conditions
Pain, Normal Physiology, Healthy Volunteers
Interventions
Instructions, Attention, Thermal Pain, Placebo instructions
Behavioral
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
18 Years to 50 Years
Enrollment
550 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2027
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Sep 4, 2026, 11:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Water-friendly Virtual Reality and Brief Thermal Pain

NCT04245475
View directory record Official record
Conditions
Pain, Acute
Interventions
Virtual Reality psychological pain reduction
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 25, 2021 · Synced Sep 4, 2026, 11:15 AM EDT