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ClinicalTrials.gov public records Last synced Oct 27, 2026, 8:52 AM EDT

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Showing 49–72 of 127 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Tidal volume Clear all
Terminated No phase listed Observational Results available

Study of Airway Pressure Release Ventilation and Intracranial Pressure in Patients With Severe Traumatic Brain Injury

NCT02507973
View directory record Official record
Conditions
Injury, Brain, Traumatic, Traumatic Brain Injury
Interventions
Airway Pressure Release Ventilation, Low Tidal Volume Ventilation
Other
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
14 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 28, 2022 · Synced Oct 27, 2026, 8:52 AM EDT
Withdrawn Not applicable Interventional

Effect of Applying Cuff Air Leak Pressure as Intraoperative Cuff Pressure on Postoperative Complications

NCT04302142
View directory record Official record
Conditions
Intubation Complication
Interventions
ventilation with critical intracuff pressure (Pcr)
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 1, 2022 · Synced Oct 27, 2026, 8:52 AM EDT
Recruiting Not applicable Interventional

ADHERE-LPV Advancing Delivery of High-Quality Evidence-Based Respiratory Efforts in Lung-Protective Ventilation

NCT06895148
View directory record Official record
Conditions
Ventilation
Interventions
New ventilator, control ventilator
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
1,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 22, 2026 · Synced Oct 27, 2026, 8:52 AM EDT
Recruiting Not applicable Interventional

Effects of Lung Volume on Upper Airway Patency During Drug Induced Sleep Endoscopy

NCT05350332
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Negative Pressure Ventilator, Pulmonary Function Testing (PFT), Transcutaneous Phrenic Nerve Stimulation, Percutaneous Phrenic Nerve Stimulation
Device
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
151 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Oct 27, 2026, 8:52 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Effect of Mode of Transport Ventilation on Respiratory Parameters After Cardiac Surgery

NCT02740075
View directory record Official record
Conditions
Complication of Ventilation Therapy
Interventions
Not listed
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jul 24, 2019 · Synced Oct 27, 2026, 8:52 AM EDT
Completed Not applicable Interventional

Effects of Different Tidal Volume Ventilation Strategies on Fontan Flow and Hemodynamics

NCT04633343
View directory record Official record
Conditions
Fontan Physiology
Interventions
Small volume breath and fast breathing rate for 5 minutes, Large volume breath and slow breathing rate for 5 minutes
Other
Lead sponsor
Stanford University
Other
Eligibility
2 Years to 50 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated May 14, 2025 · Synced Oct 27, 2026, 8:52 AM EDT
Completed Not applicable Interventional Results available

Efficacy and Safety of a Lung Recruitment Protocol in Children With Acute Lung Injury

NCT00830284
View directory record Official record
Conditions
Acute Respiratory Distress Syndrome, Acute Lung Injury
Interventions
Recruitment maneuver
Procedure
Lead sponsor
Boston Children's Hospital
Other
Eligibility
1 Month to 18 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 29, 2019 · Synced Oct 27, 2026, 8:52 AM EDT
Completed Phase 1 Interventional

T Cell Effector and Regulatory Mechanisms in Asthma

NCT01612936
View directory record Official record
Conditions
Asthma, Allergies
Interventions
Bronchoscopy, Segmental Allergen Challenge and Broncheoalveolar Lavage, PET-CT imaging(13NN perfusion/ventilation, 18FDG inflammation, and CT imaging)
Biological · Procedure
Lead sponsor
Andrew D. Luster, M.D.,Ph.D.
Other
Eligibility
18 Years to 50 Years
Enrollment
168 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 15, 2017 · Synced Oct 27, 2026, 8:52 AM EDT
Recruiting Not applicable Interventional

Pilot Feasibility Trial of the SafeLM Supraglottic Airway (SGA)

NCT05989880
View directory record Official record
Conditions
Anesthesia
Interventions
SafeLM as a supraglottic airway device with video capability, SafeLM as a supraglottic airway device without video capability, SafeLM as a conduit for intubation using an endotracheal tube with video capability, SafeLM as a conduit for intubation using a bougie with video capability
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 10, 2024 · Synced Oct 27, 2026, 8:52 AM EDT
Completed No phase listed Observational

Modes of Ventilation During Laparoscopic Bariatric Surgery

NCT01890564
View directory record Official record
Conditions
Bariatric Surgery
Interventions
Pressure controlled ventilation, Volume controlled ventilation, PRVC ventilation
Other
Lead sponsor
Joseph D. Tobias
Other
Eligibility
14 Years to 20 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 1, 2014 · Synced Oct 27, 2026, 8:52 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Non-invasive Tidal Volume Monitoring Using the Linshom Respiratory Monitoring Device

NCT03279458
View directory record Official record
Conditions
Pulmonary Ventilation, Capnography
Interventions
Linshom Respiratory Monitoring Device
Device
Lead sponsor
University of Mississippi Medical Center
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Jackson, Mississippi
Source: ClinicalTrials.gov public record
Updated Jul 5, 2018 · Synced Oct 27, 2026, 8:52 AM EDT
Recruiting Not applicable Interventional

Platform of Randomized Adaptive Clinical Trials in Critical Illness

NCT05440851
View directory record Official record
Conditions
Respiratory Insufficiency, Extracorporeal Membrane Oxygenation Complication, Mechanical Ventilation Pressure High
Interventions
Ultra-Protective Ventilation Facilitated by Extracorporeal Support, Lung-Protective Ventilation (LPV), Driving Pressure-Limited Ventilation (DPL), Lung- and Diaphragm-Protective Ventilation and Sedation (LDPVS), Early Cohort corticosteroid dose, Extended Cohort corticosteroid dose, Usual care without routine corticosteroids, Usual care without extending corticosteroids, Usual care with fludrocortisone, Usual care without fludrocortisone, Drug 4 mL:, Drug 40 mg:, PEEP-20, PEEP-AOP, PEEP-10, VV ECMO-facilitated strategy of earlier awakening, extubation and rehabilitation, Electrical impedance tomography (EIT), no treatment / intervention arm is involved., Usual care, Early Routine IMT
Other · Drug
Lead sponsor
University Health Network, Toronto
Other
Eligibility
18 Years and older
Enrollment
6,250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
27
States / cities
Tucson, Arizona • Los Angeles, California • San Diego, California + 20 more
Source: ClinicalTrials.gov public record
Updated Oct 22, 2026 · Synced Oct 27, 2026, 8:52 AM EDT
Completed Phase 3 Interventional

Acute Respiratory Distress Syndrome Clinical Network (ARDSNet)

NCT00000579
View directory record Official record
Conditions
Respiratory Distress Syndrome, Adult, Lung Diseases
Interventions
Low Tidal Volume Ventilation, Positive End-Expiratory Pressure, Lysofylline, Methylprednisolone, Ketoconazole, Fluid Management, Pulmonary Artery Catheter
Procedure · Drug
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
13 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
1994 – 2004
U.S. locations
20
States / cities
San Francisco, California • Denver, Colorado • Chicago, Illinois + 17 more
Source: ClinicalTrials.gov public record
Updated Mar 23, 2016 · Synced Oct 27, 2026, 8:52 AM EDT
Active, not recruiting Not applicable Interventional

Low Tidal Volume Ventilation With Hyperoxia Avoidance During Cardiopulmonary Bypass (The FOCUS Trial)

NCT04978636
View directory record Official record
Conditions
Cardiac Surgery
Interventions
Continuous low-tidal volume ventilation with using FiO2 of 0.21, Continuous low tidal volume ventilation with using FiO2 of 1.0, Apnea During CPB
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
5,502 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 26, 2026 · Synced Oct 27, 2026, 8:52 AM EDT
Completed No phase listed Observational

Slope of the Pressure-Time Waveform Predicts Resistance and Compliance in Mechanically Ventilated Subjects

NCT00750074
View directory record Official record
Conditions
Respiration Disorders
Interventions
Not listed
Lead sponsor
Gregory A. Schmidt
Other
Eligibility
18 Years to 99 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Feb 28, 2017 · Synced Oct 27, 2026, 8:52 AM EDT
Terminated Early Phase 1 Interventional

PVB vs Ketamine/Lidocaine in Rib Fracture Patients

NCT04413799
View directory record Official record
Conditions
Rib Fractures, Rib Trauma, Rib Fracture Multiple, Pain, Acute
Interventions
lidocaine, ketamine intravenous infusion, paravertebral block with ropivicaine
Combination Product · Drug
Lead sponsor
George Washington University
Other
Eligibility
18 Years to 80 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jun 22, 2025 · Synced Oct 27, 2026, 8:52 AM EDT
Recruiting Not applicable Interventional

Feasibility and Efficacy Study of the CardioPulmonary Management (CPM) System in Patients With Chronic Heart Failure

NCT05650541
View directory record Official record
Conditions
Heart Failure
Interventions
CardioPumlonary Management System
Device
Lead sponsor
Analog Device, Inc.
Other
Eligibility
18 Years and older
Enrollment
1,200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
7
States / cities
Palm Springs, California • Miami, Florida • Orlando, Florida + 4 more
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Oct 27, 2026, 8:52 AM EDT
Terminated Not applicable Interventional

The Effects of Different Ventilator Strategies on Inflammation and Injury in Normal Lungs

NCT01003730
View directory record Official record
Conditions
Acute Respiratory Distress Syndrome
Interventions
Ventilator settings
Other
Lead sponsor
University of Medicine and Dentistry of New Jersey
Other
Eligibility
18 Years to 65 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated May 5, 2015 · Synced Oct 27, 2026, 8:52 AM EDT
Completed Not applicable Interventional Results available

Implementation of Nudges to Promote Utilization of Low Tidal Volume Ventilation (INPUT) Study

NCT04663802
View directory record Official record
Conditions
ARDS, Critical Illness, Acute Respiratory Distress Syndrome, Acute Respiratory Failure
Interventions
Default order set, Physician-targeted accountable justification, Respiratory therapist (RT)-targeted accountable justification
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 99 Years
Enrollment
7,342 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
5
States / cities
Plainsboro, New Jersey • Philadelphia, Pennsylvania • West Chester, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 8, 2024 · Synced Oct 27, 2026, 8:52 AM EDT
Completed Not applicable Interventional

ETT Cuff Leak: TV Ratios

NCT02768831
View directory record Official record
Conditions
Surgical Procedures, Operative
Interventions
CPAP, Tidal volume
Other
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
Not listed
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 21, 2024 · Synced Oct 27, 2026, 8:52 AM EDT
Completed Not applicable Interventional

Low-Intensity Mechanical Ventilation in the Operating Room: a Pilot Study

NCT07277244
View directory record Official record
Conditions
Robotic Surgery, Post Operative Pulmonary Complications
Interventions
Low Intensity Mechanical Ventilation
Device
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 6, 2026 · Synced Oct 27, 2026, 8:52 AM EDT
Completed Not applicable Interventional Results available

Comparison of Low and High Tidal Volumes in Acute Spinal Cord Injury

NCT04912583
View directory record Official record
Conditions
Spinal Cord Injuries
Interventions
High tidal volume, Low tidal volume
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
2
States / cities
Englewood, Colorado • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 15, 2025 · Synced Oct 27, 2026, 8:52 AM EDT
Terminated Not applicable Interventional

Acute Lung Injury Ventilator Evaluation (ALIVE)

NCT01901354
View directory record Official record
Conditions
Acute Lung Injury, Adult Respiratory Distress Syndrome
Interventions
Low-tidal-volume ventilation, Airway Pressure Release Ventilation (APRV)
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 28, 2017 · Synced Oct 27, 2026, 8:52 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pre-op Use of Incentive Spirometry in Obese Patients

NCT01004146
View directory record Official record
Conditions
Lung Function, Bariatric Surgery
Interventions
Incentive Spirometry
Procedure
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 3, 2014 · Synced Oct 27, 2026, 8:52 AM EDT