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ClinicalTrials.gov public records Last synced Oct 22, 2026, 3:55 AM EDT

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Showing 1–24 of 66 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Tissue expander Clear all
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Trial of Drain Antisepsis After Tissue Expander Breast Reconstruction

NCT01286168
View directory record Official record
Conditions
Nonmalignant Breast Conditions, Breast Cancer
Interventions
Sodium hypochlorite (Dakin's Solution), Chlorhexidine gluconate disk, Control, Occlusive Adhesive Dressing
Device · Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 90 Years
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
2
States / cities
San Francisco, California • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 19, 2014 · Synced Oct 22, 2026, 3:55 AM EDT
Completed Phase 3 Interventional

Tissue Expander/Implant Reconstruction: A Single-Blinded, Randomized, Controlled Trial

NCT00639106
View directory record Official record
Conditions
Breast Cancer
Interventions
Alloderm, Questionnaires, Without ALLODERM, Questionnaires
Procedure
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
21 Years to 75 Years · Female only
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2018
U.S. locations
3
States / cities
Ann Arbor, Michigan • New York, New York • Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 3, 2018 · Synced Oct 22, 2026, 3:55 AM EDT
Withdrawn Phase 3 Interventional

Comparing Two Different Surgical Techniques for Breast Reconstruction

NCT04716959
View directory record Official record
Conditions
Breast Reconstruction
Interventions
Prepectoral Prosthetic Breast Reconstruction, Subpectoral Prosthetic Breast Reconstruction
Procedure
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
21 Years to 60 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
7
States / cities
Basking Ridge, New Jersey • Middletown, New Jersey • Montvale, New Jersey + 4 more
Source: ClinicalTrials.gov public record
Updated Jan 3, 2022 · Synced Oct 22, 2026, 3:55 AM EDT
Completed No phase listed Observational

Tissue Expansion in Breast Reconstruction Without Drains

NCT03784859
View directory record Official record
Conditions
Breast Cancer, Hereditary Breast and Ovarian Cancer Syndrome, Breast Implant; Complications
Interventions
Insertion of Tissue Expander with Fluid Reservoir
Device
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
21 Years and older · Female only
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 6, 2020 · Synced Oct 22, 2026, 3:55 AM EDT
Terminated Not applicable Interventional Results available

Liposomal Bupivacaine in Implant Based Breast Reconstruction

NCT02659501
View directory record Official record
Conditions
Breast Cancer, Postoperative Pain
Interventions
Liposomal bupivacaine, Bupivacaine with epinephrine, Morphine sulfate, Hydrocodone/acetaminophen, Diazepam
Drug
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 99 Years · Female only
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jan 12, 2021 · Synced Oct 22, 2026, 3:55 AM EDT
Completed Not applicable Interventional

Delayed-Delayed Breast Reconstruction

NCT01256528
View directory record Official record
Conditions
Breast Cancer
Interventions
Delayed Breast Reconstruction
Procedure
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older · Female only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 15, 2016 · Synced Oct 22, 2026, 3:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparison of One-port and Two-port Tissue Expanders for Breast Reconstruction

NCT02725801
View directory record Official record
Conditions
Breast Cancer
Interventions
Allergen one-port tissue expander placement, AlloX2 two-port tissue expander placement
Device
Lead sponsor
Lesley Wong
Other
Eligibility
18 Years and older · Female only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Sep 4, 2020 · Synced Oct 22, 2026, 3:55 AM EDT
Completed Not applicable Interventional Results available

Feasibility Study of Meso BioMatrix Device for Breast Reconstruction

NCT01823107
View directory record Official record
Conditions
Breast Cancer
Interventions
Meso BioMatrix Device
Device
Lead sponsor
Kensey Nash Corporation
Industry
Eligibility
21 Years and older · Female only
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
6
States / cities
Detroit, Michigan • Garden City, New York • Bala-Cynwyd, Pennsylvania + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 10, 2019 · Synced Oct 22, 2026, 3:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Patient Controlled Tissue Expansion for Breast Reconstruction

NCT01425268
View directory record Official record
Conditions
Breast Cancer
Interventions
AeroForm Tissue Expansion, Saline Tissue Expansion
Device · Procedure
Lead sponsor
AirXpanders, Inc.
Industry
Eligibility
18 Years to 70 Years · Female only
Enrollment
158 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
17
States / cities
Greenbrae, California • Los Angeles, California • Orange, California + 12 more
Source: ClinicalTrials.gov public record
Updated Jun 27, 2017 · Synced Oct 22, 2026, 3:55 AM EDT
Not listed Phase 1Phase 2 Interventional

Safety and Feasibility of Hypertonic Saline Solution After Aneurysmal Subarachnoid Hemorrhage:

NCT02432157
View directory record Official record
Conditions
Subarachnoid Hemorrhage, Cerebral Vasospasm, Hyponatremia
Interventions
HTS 3%, Standard fluid management
Drug
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years to 70 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 11, 2016 · Synced Oct 22, 2026, 3:55 AM EDT
Completed Not applicable Interventional

Prospective Trial of Subcutaneous Versus Subpectoral 2-Staged Implant-Based Breast Reconstruction

NCT02775409
View directory record Official record
Conditions
Breast Reconstruction Following Mastectomy
Interventions
Subcutaneous placement, Submuscular placement
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 30, 2021 · Synced Oct 22, 2026, 3:55 AM EDT
Completed No phase listed Observational

Quantification of Breast Sensation Following Postmastectomy Breast Reconstruction

NCT00588419
View directory record Official record
Conditions
Breast Cancer, Cancer
Interventions
breast exam and questionaire
Behavioral
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
21 Years and older · Female only
Enrollment
153 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 9, 2021 · Synced Oct 22, 2026, 3:55 AM EDT
Completed Phase 4 Interventional Results available

Acellular Dermal Matrix in Tissue Expander Breast Reconstruction: A Prospective, Randomized, Clinical Trial Comparing SurgiMend PRS and AlloDerm RTU

NCT01781299
View directory record Official record
Conditions
Breast Cancer, Mastectomy
Interventions
AlloDerm RTU, SurgiMend PRS
Device
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older · Female only
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 12, 2017 · Synced Oct 22, 2026, 3:55 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Botulinum Toxin A (Botox) in Tissue Expander Breast Reconstruction

NCT01591746
View directory record Official record
Conditions
Breast Cancer, Pain, Postoperative, BRCA1 Mutation, BRCA2 Mutation, Breast Diseases, Neoplasms
Interventions
Botulinum Toxin Type A, Placebo
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
131 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2017
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 10, 2019 · Synced Oct 22, 2026, 3:55 AM EDT
Recruiting No phase listed Observational

Postoperative Outcomes and Patient Satisfaction With Mayo Clinic Florida Care Hotel After Mastectomy and Tissue Expander Placement

NCT06783179
View directory record Official record
Conditions
Breast Carcinoma
Interventions
Non-Interventional Study
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Oct 22, 2026, 3:55 AM EDT
Terminated Not applicable Interventional

Pulsed Lavage in Implant-Based Breast Reconstruction

NCT05585710
View directory record Official record
Conditions
Breast Reconstruction
Interventions
Pulsed Lavage Washout, Implant-based breast reconstruction, Bilateral or unilateral mastectomy, Tissue expander, Acellular dermal matrix
Other · Procedure · Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 75 Years · Female only
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Oct 20, 2026 · Synced Oct 22, 2026, 3:55 AM EDT
Completed Not applicable Interventional

Pre-pectoral AlloDerm® to Reinforce Tissues in Tissue Expander Breast Reconstruction

NCT03195322
View directory record Official record
Conditions
Postoperative Pain, Postoperative Nausea and Vomiting, Quality of Life, Breast Cancer, Breast Prosthesis; Pain
Interventions
Pre-pectoral Tissue Expander
Procedure
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older · Female only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 16, 2021 · Synced Oct 22, 2026, 3:55 AM EDT
Recruiting Not applicable Interventional

Melodi Matrix™ in Breast Reconstruction

NCT06027996
View directory record Official record
Conditions
Breast Reconstruction
Interventions
Absorbable Antibacterial Matrix
Device
Lead sponsor
Melodi Health, Inc.
Industry
Eligibility
22 Years and older · Female only
Enrollment
702 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
10
States / cities
Palo Alto, California • Ann Arbor, Michigan • Rochester, Minnesota + 7 more
Source: ClinicalTrials.gov public record
Updated Dec 8, 2025 · Synced Oct 22, 2026, 3:55 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Novel Surgical Irrigation Solution in Post-Mastectomy Reconstruction: Evaluating Xperience™

NCT06649890
View directory record Official record
Conditions
Surgical Site Infection, Surgical Complication, Implant Infection, Implant Complication
Interventions
Xperience™ Advanced Surgical Irrigation, Dilute Povidone-Iodine
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older · Female only
Enrollment
224 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 7, 2025 · Synced Oct 22, 2026, 3:55 AM EDT
Completed Phase 4 Interventional Results available

PEMF and PEC Blocks in Mastectomy Reconstruction Patients

NCT03360214
View directory record Official record
Conditions
Breast Cancer Female
Interventions
Bupivacaine Hydrochloride, Placebo Drug, Pulsed Electromagnetic Field (PEMF) Device, Placebo Device, Ropivacaine Hydrochloride
Drug · Other · Device
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older · Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 15, 2025 · Synced Oct 22, 2026, 3:55 AM EDT
Terminated Not applicable Interventional Results available

Management of Complex Wounds Using a Constant Tension External Tissue Expander

NCT01171521
View directory record Official record
Conditions
Wounds and Injuries
Interventions
DermaClose Group
Device
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 26, 2016 · Synced Oct 22, 2026, 3:55 AM EDT
Completed Not applicable Interventional

Reusable Versus Disposable Draping System in Breast Reconstruction Surgery

NCT01176786
View directory record Official record
Conditions
Mastectomy, Infections, Breast Reconstruction
Interventions
Culture Swabs, Rodac Plate Cultures
Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older · Female only
Enrollment
107 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 7, 2017 · Synced Oct 22, 2026, 3:55 AM EDT
Completed Phase 4 Interventional

A Comparison of Dermal Autograft to AlloDerm in Breast Reconstruction

NCT01561287
View directory record Official record
Conditions
Mastectomy Related Lymphedema, Breast Reconstruction, Breast Cancer
Interventions
Dermal Autograft, AlloDerm
Procedure
Lead sponsor
University of Kentucky
Other
Eligibility
Female only
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated May 11, 2016 · Synced Oct 22, 2026, 3:55 AM EDT
Completed Not applicable Interventional Results available

Blossom Smart Expander Technology in Breast Reconstruction in Participants With Breast Cancer Undergoing Mastectomy

NCT03657069
View directory record Official record
Conditions
Breast Carcinoma, Breast Disorder
Interventions
Blossom, Breast-Q -Reconstruction module (preoperative) version 2.0 satisfaction with breasts questionnaire
Device · Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older · Female only
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jan 22, 2024 · Synced Oct 22, 2026, 3:55 AM EDT