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ClinicalTrials.gov public records Last synced Oct 14, 2026, 5:20 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 649–672 of 942 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Total knee Clear all
Completed Not applicable Interventional

Stem Cell and Growth Factor Injury and Arthritis Clinical Research Study

NCT03408145
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Hyaluronic Acid, Amniotic Tissue Allograft, Saline
Device · Drug
Lead sponsor
The Stone Research Foundation for Sports Medicine and Arthritis
Other
Eligibility
18 Years and older
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 25, 2021 · Synced Oct 14, 2026, 5:20 AM EDT
Completed Not applicable Interventional

Hypnosis for Symptom Management in Elective Orthopedic Surgery

NCT03308071
View directory record Official record
Conditions
Hypnosis, Perioperative Care, Knee Arthroplasty, Total, Postoperative Pain, Postoperative Complications
Interventions
Hypnosis
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Aug 25, 2021 · Synced Oct 14, 2026, 5:20 AM EDT
Completed Phase 4 Interventional Results available

Management of Postoperative Pain After Total Knee Replacement.

NCT01163214
View directory record Official record
Conditions
Postoperative Pain, Knee Replacement Arthroplasty
Interventions
Nerve Block, Periarticular Injection
Drug
Lead sponsor
Mark J. Spangehl, M.D.
Other
Eligibility
18 Years to 79 Years
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Nov 5, 2014 · Synced Oct 14, 2026, 5:20 AM EDT
Active, not recruiting No phase listed Observational

Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty)

NCT05787821
View directory record Official record
Conditions
Knee Pain Chronic, Osteoarthritis, Knee, Rheumatoid Arthritis, Traumatic Arthritis, Polyarthritis, Varus Deformity, Valgus Deformity, Flexion Deformity of Knee, Avascular Necrosis
Interventions
Total Knee Arthroplasty
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
760 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2035
U.S. locations
16
States / cities
Parker, Colorado • Tampa, Florida • Atlanta, Georgia + 13 more
Source: ClinicalTrials.gov public record
Updated Jul 10, 2026 · Synced Oct 14, 2026, 5:20 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Study Comparing Peri-articular Injection of Bupivacaine With and Without Epinephrine

NCT00737139
View directory record Official record
Conditions
Osteoarthritis
Interventions
Peri-articular injection of marcaine/epinephrine, Peri-articular injection of marcaine alone
Procedure
Lead sponsor
Rush University Medical Center
Other
Eligibility
19 Years to 80 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2012
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 31, 2012 · Synced Oct 14, 2026, 5:20 AM EDT
Not listed No phase listed Observational

Retrospective Chart Analysis in the Effective Use of FloSeal in Post-Operative Joint Replacements

NCT00958945
View directory record Official record
Conditions
Total Knee Arthroplasty, Arthroplasty, Replacement, Hip
Interventions
Not listed
Lead sponsor
Desert Orthopedic Center Medical Research Foundation
Other
Eligibility
18 Years to 95 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2009
U.S. locations
1
States / cities
Rancho Mirage, California
Source: ClinicalTrials.gov public record
Updated Aug 14, 2009 · Synced Oct 14, 2026, 5:20 AM EDT
Terminated Phase 4 Interventional Results available

Minimally Invasive Total Knee Replacement - Navigated Versus Non-navigated Study

NCT00733330
View directory record Official record
Conditions
Osteoarthritis
Interventions
Either P.F.C. Sigma or L.C.S. Complete knee replacement using the conventional surgical approach and manual surgical technique, Either P.F.C. Sigma or L.C.S. Complete knee replacement using minimally invasive surgical approach and computer navigation
Device
Lead sponsor
DePuy International
Industry
Eligibility
18 Years to 80 Years
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
3
States / cities
Newport Beach, California • Winston-Salem, North Carolina • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 15, 2014 · Synced Oct 14, 2026, 5:20 AM EDT
Not listed Phase 3 Interventional

A RCT Comparing Dronabinol to a Placebo for Post-operative Pain in Total Joint Arthroplasty

NCT04298528
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Dronabinol, Placebo
Drug · Other
Lead sponsor
Colorado Joint Replacement
Other
Eligibility
21 Years to 75 Years
Enrollment
460 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 10, 2023 · Synced Oct 14, 2026, 5:20 AM EDT
Completed Not applicable Interventional Results available

Closed Incision Negative Pressure Therapy Versus Standard of Care Surgical Dressing in Revision Total Knee Arthroplasty

NCT03274466
View directory record Official record
Conditions
Surgical Wound, Revision Total Knee Arthroplasty, Wounds and Injuries, Joint Disease, Musculoskeletal Disease, Prosthesis-Related Infections, Infection, Postoperative Complications, Pathologic Processes
Interventions
Closed Incision Negative Pressure Therapy (ciNPT), Standard of Care Dressing
Device
Lead sponsor
KCI USA, Inc
Industry
Eligibility
22 Years and older
Enrollment
294 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
17
States / cities
Weston, Florida • Tucker, Georgia • New Orleans, Louisiana + 10 more
Source: ClinicalTrials.gov public record
Updated Oct 16, 2024 · Synced Oct 14, 2026, 5:20 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Group Physical Therapy for Knee Osteoarthritis

NCT00642772
View directory record Official record
Conditions
Osteoarthritis
Interventions
Group Physical Therapy
Other
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 28, 2015 · Synced Oct 14, 2026, 5:20 AM EDT
Completed No phase listed Observational

Safety and Efficacy of the Journey II BCS Total Knee System

NCT01705067
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
TKA with Journey II BCS Total Knee System
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
Not listed
Enrollment
209 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2023
U.S. locations
12
States / cities
Los Angeles, California • Fort Wayne, Indiana • Indianapolis, Indiana + 8 more
Source: ClinicalTrials.gov public record
Updated Jun 13, 2024 · Synced Oct 14, 2026, 5:20 AM EDT
Completed Not applicable Interventional Results available

ATTUNE Single-Use Instrumentation vs. ATTUNE Reusable Instrumentation in Primary Total Knee Arthroplasty

NCT02574312
View directory record Official record
Conditions
Osteoarthritis, Post-traumatic Arthritis
Interventions
ATTUNE TKA with ATTUNE RUI, ATTUNE TKA with ATTUNE SUI
Device
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
22 Years to 80 Years
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
2
States / cities
La Jolla, California • Wilkes-Barre, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 9, 2020 · Synced Oct 14, 2026, 5:20 AM EDT
Not yet recruiting Not applicable Interventional

Knee Positioning After Total Knee Replacement

NCT07747116
View directory record Official record
Conditions
Knee Arthroplasty
Interventions
Knee Flexion, Standard Care
Other · Procedure
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 7, 2026 · Synced Oct 14, 2026, 5:20 AM EDT
Completed Phase 4 Interventional

Postoperative Pain and Analgesic Requirements After Preoperative Methadone for Primary TKA

NCT06691633
View directory record Official record
Conditions
Osteoarthritis (OA) of the Knee
Interventions
Preoperative Methadone, Preoperative Oxycodone
Drug
Lead sponsor
University of Louisville
Other
Eligibility
21 Years to 89 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Nov 15, 2024 · Synced Oct 14, 2026, 5:20 AM EDT
Terminated Not applicable Interventional

Embolic Events Detected During Total Knee Arthroplasty With the Use of RIA (Reamer-Irrigator-Aspirator)

NCT00815958
View directory record Official record
Conditions
Total Knee Replacement
Interventions
Reaming with Synthes RIA (Reamer-Irrigator-Aspirator), Reaming with conventional reamer
Procedure
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 24, 2017 · Synced Oct 14, 2026, 5:20 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Pain Control With Total Knee Replacement

NCT01680549
View directory record Official record
Conditions
Postoperative Pain
Interventions
Gabapentin
Drug
Lead sponsor
Texas Tech University Health Sciences Center
Other
Eligibility
25 Years to 89 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
1
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated Jan 31, 2024 · Synced Oct 14, 2026, 5:20 AM EDT
Recruiting No phase listed Observational

A Multi-Center Study Assessing the Safety and Efficacy of the LEGION Medial Stabilized (MS) Insert in Patients Undergoing a Total Knee Arthroplasty (TKA)

NCT07199738
View directory record Official record
Conditions
Inflammatory Arthritis, Primary Total Knee Arthroplasty Due to Degenerative Joint Disease (Primary Diagnosis of Osteoarthritis), Post-traumatic Arthritis
Interventions
Cemented CoCr, Cemented Oxinium, Cementless
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
144 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2036
U.S. locations
4
States / cities
Newton, Massachusetts • New York, New York • Charleston, South Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Oct 14, 2026, 5:20 AM EDT
Completed Phase 2 Interventional Results available

Effectiveness of Two Types of Treatment in Restoring Muscle After Hip or Knee Surgery

NCT00393848
View directory record Official record
Conditions
Hip Fracture, Osteoarthritis, Femur Head Necrosis
Interventions
Essential amino acid supplement, Ketoconazole, Placebo
Drug
Lead sponsor
University of Arkansas
Other
Eligibility
30 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Jun 2, 2014 · Synced Oct 14, 2026, 5:20 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Clinical Outcomes With Omni Apex Ultracongruent Knee System

NCT01367938
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
OMNI Apex Ultracongruent Knee Device
Device
Lead sponsor
Spokane Joint Replacement Center
Other
Eligibility
21 Years to 80 Years
Enrollment
69 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2018
U.S. locations
1
States / cities
Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Dec 5, 2018 · Synced Oct 14, 2026, 5:20 AM EDT
Completed Phase 1 Interventional

Study in Patients Undergoing Debridement, Antibiotics, and Implant Retention (DAIR) for Treatment of a Periprosthetic Joint Infection (PJI) Occurring After Total Knee Arthroplasty (TKA)

NCT05137314
View directory record Official record
Conditions
Joint Infection
Interventions
PLG0206
Drug
Lead sponsor
Peptilogics
Industry
Eligibility
18 Years to 79 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
12
States / cities
Palo Alto, California • Sarasota, Florida • Baltimore, Maryland + 8 more
Source: ClinicalTrials.gov public record
Updated May 21, 2025 · Synced Oct 14, 2026, 5:20 AM EDT
Not listed No phase listed Observational

Return to Physical Activities After Total Knee Arthroplasty

NCT03039907
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee
Interventions
Total Knee Arthroplasty
Procedure
Lead sponsor
Cincinnati Sportsmedicine Research and Education Foundation
Other
Eligibility
20 Years to 65 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 8, 2020 · Synced Oct 14, 2026, 5:20 AM EDT
Completed No phase listed Observational

Prospective, Multiconfiguration Study to Assess Functional Performance of Primary Total Knee Arthroplasty System

NCT01746524
View directory record Official record
Conditions
Osteoarthritis
Interventions
ATTUNE Primary Total Knee Arthroplasty
Device
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
22 Years to 80 Years
Enrollment
1,138 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
9
States / cities
Orange, California • San Diego, California • Fort Collins, Colorado + 6 more
Source: ClinicalTrials.gov public record
Updated Apr 11, 2019 · Synced Oct 14, 2026, 5:20 AM EDT
Withdrawn Not applicable Interventional

Adductor Canal Nerve Block Following Total Knee Arthroplasty

NCT01939379
View directory record Official record
Conditions
Post-op Pain
Interventions
Morphine PCA started at the end of surgery, 1 Percocet 1/325mg every 4 hours; may receive a second Percocet if needed., For the 30ml ropivacaine the intervention would be the subject can request extra pain medication which would be Percocet and/or morphine PCA.
Drug
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 99 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Apr 20, 2021 · Synced Oct 14, 2026, 5:20 AM EDT
Completed No phase listed Observational Results available

Pain and Function After Orthopedic Surgery

NCT01390298
View directory record Official record
Conditions
Chronic Pain
Interventions
Observational
Other
Lead sponsor
Wake Forest University
Other
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 19, 2019 · Synced Oct 14, 2026, 5:20 AM EDT