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Showing 1–24 of 831 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Effect of Oral Pregabalin on Spinal Neurotransmitters in Patients Undergoing Knee Replacement

NCT00729690
Conditions
PAIN
Interventions
Pregabalin, Placebo
Drug
Lead sponsor
Asokumar Buvanendran
Other
Eligibility
55 Years to 75 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Chicago, Illinois
Conditions
Pain
Interventions
Exparel, Ropivacaine cocktail (PIC), Bupivacaine
Drug
Lead sponsor
University of Utah
Other
Eligibility
40 Years to 90 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Salt Lake City, Utah
Conditions
Flexion Contracture
Interventions
KneeMD
Device
Lead sponsor
Anne Arundel Health System Research Institute
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Annapolis, Maryland
Conditions
Arthroplasty, Replacement, Knee, Nerve Block
Interventions
Adductor Canal Nerve Block Catheter, Adductor Canal Nerve Block Sham Catheter, Bupivacaine
Device · Drug
Lead sponsor
University of Chicago
Other
Eligibility
Up to 85 Years
Enrollment
165 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Withdrawn Not applicable Interventional Accepts healthy volunteers

A Randomized Controlled Trial for Partial Knee Arthroplasty

NCT05037734
Conditions
Degenerative Joint Disease of Knee, Osteoarthritis, Traumatic Arthritis, Varus Deformity, Knee Pain Chronic
Interventions
Persona Partial Knee System
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
Not listed
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2030
U.S. locations
1
States / cities
Jackson, Mississippi
Completed Phase 4 Interventional Accepts healthy volunteers

Trial of Liposomal Bupivacaine for TKA

NCT05635916
Conditions
Knee Replacement, Total Knee Arthroplasty, Post-Operative Pain
Interventions
Liposomal bupivacaine, Bupivacaine
Drug
Lead sponsor
Northern Light Mercy Hospital
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Portland, Maine
Withdrawn No phase listed Observational Accepts healthy volunteers

Sleep Patterns After Total Joint Replacement Surgery

NCT04896892
Conditions
Arthroplasty, Replacement, Knee, Arthroplasty, Replacement, Hip
Interventions
Not listed
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Detroit, Michigan
Conditions
Knee Osteoarthritis
Interventions
Neuromuscular electrical stimulation (NMES), Standard Rehabilitation Protocol
Procedure · Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
50 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
2
States / cities
Aurora, Colorado
Conditions
Postoperative Urinary Retention
Interventions
Tamsulosin, Placebo
Drug
Lead sponsor
University of Michigan
Other
Eligibility
35 Years and older · Male only
Enrollment
176 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Ann Arbor, Michigan
Conditions
Arthroplasty
Interventions
Continuous Adductor Canal Block, General, Epidural, Spinal
Procedure
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
157 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Chicago, Illinois
Conditions
Arthroplasty, Replacement, Knee
Interventions
Not listed
Lead sponsor
Colorado Joint Replacement
Other
Eligibility
Not listed
Enrollment
340 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2019
U.S. locations
1
States / cities
Denver, Colorado
Conditions
Acute Pain
Interventions
Morphine, Placebo
Drug
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years to 80 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
1
States / cities
Stony Brook, New York
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Arista Hemostatic Powder for Total Knee Post Operative Outcomes Study

NCT05522153
Conditions
Blood Loss, Surgical
Interventions
Arista
Drug
Lead sponsor
Virtua Health, Inc.
Other
Eligibility
18 Years and older
Enrollment
61 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Marlton, New Jersey
Conditions
Osteoarthritis, Post-traumatic; Arthrosis
Interventions
methylprednisolone acetate, active comparator
Drug
Lead sponsor
New Lexington Clinic
Other
Eligibility
18 Years to 95 Years
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Lexington, Kentucky
Conditions
Venous Thromboembolism (VTE), Deep Vein Thrombosis (DVT), Pulmonary Embolism (PE), Spine Metastasis
Interventions
Apixaban
Drug
Lead sponsor
James Bayley
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
3
States / cities
Pittburgh, Pennsylvania • Pittsburgh, Pennsylvania
Conditions
Pain Management, Function, Minimally Invasive Total Knee Arthroplasty, Celecoxib
Interventions
Celecoxib
Drug
Lead sponsor
St. Louis Joint Replacement Institute
Other
Eligibility
Not listed
Enrollment
107 participants
Timeline
2007 – 2009
U.S. locations
1
States / cities
St Louis, Missouri
Terminated Not applicable Interventional

Health Partner Evaluation at Princeton

NCT03386786
Conditions
Total Knee Arthroplasty; Total Hip Arthroplasty
Interventions
Health Partner, Standard Care
Behavioral
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
18 Years and older
Enrollment
127 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Plainsboro, New Jersey
Conditions
Knee Arthroplasty
Interventions
Total Knee Arthroplasty, MAKO® Robot Assisted Medial Knee Arthroplasty, RESTORIS Multicompartmental Knee System, Depuy Knee Replacement System, Stryker® Knee Replacement System
Procedure · Device
Lead sponsor
Northwest Surgical Specialists, Vancouver
Other
Eligibility
21 Years to 80 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2023
U.S. locations
1
States / cities
Vancouver, Washington
Conditions
Arthropathy of Knee, Arthritis Knee, Arthritis, Degenerative
Interventions
Fitbit
Other
Lead sponsor
Benaroya Research Institute
Other
Eligibility
18 Years to 100 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Seattle, Washington
Conditions
Acute Blood Loss Anemia, Osteoarthritis, Knee
Interventions
Tranexamic Acid, Placebo
Drug
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Detroit, Michigan
Conditions
Knee Arthroplasty
Interventions
video or education session in addition to standard consent
Other
Lead sponsor
jasvinder singh
Federal
Eligibility
18 Years to 110 Years
Enrollment
176 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Minneapolis, Minnesota
Conditions
Arthroplasty, Replacement, Knee
Interventions
CORI™ KNEE TENSIONER
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
4
States / cities
New York, New York • New Albany, Ohio • Pittsburgh, Pennsylvania + 1 more
Conditions
Total Knee Arthroplasty, Total Knee Arthroplasty Recovery
Interventions
Intra-articular Posteromedial Surgeon Administered (IPSA) Block with LIA, Local Infiltration Analgesia (LIA), Bupivacaine liposome injectable suspension (IPSA block), Bupivacaine liposome injectable suspension (LIA)
Procedure · Drug
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Los Angeles, California
Conditions
Postoperative Complications, Memory Disorders
Interventions
pulsatile saline lavage, carbon dioxide lavage
Device
Lead sponsor
Kinamed Incorporated
Industry
Eligibility
50 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Durham, North Carolina