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ClinicalTrials.gov public records Last synced Nov 14, 2026, 10:11 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 132 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Transcutaneous Auricular Vagus Nerve Stimulation Clear all

Conditions: Multiple Sclerosis
Interventions: Remotely Supervised Transcranial Direct Current Stimulation (RS - tDCS), Remotely Supervised Transcutaneous Auricular Vagus Nerve Stimulation (RS - taVNS), Remotely Supervised Transcutaneous Cervical Vagus Nerve Stimulation (RS - tcVNS); Device
Lead sponsor: NYU Langone Health; Other
Eligibility: 25 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Nephrotic Syndrome in Children, Minimal Change Disease, Focal Segmental Glomerulosclerosis
Interventions: Transcutaneous auricular vagus nerve stimulation, Sham device; Device
Lead sponsor: Northwell Health; Other
Eligibility: 3 Years to 17 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 2
States / cities: New Hyde Park, New York • Philadelphia, Pennsylvania

Conditions: Stroke, Stroke Sequelae, Motor Activity
Interventions: Transcranial Magnetic Stimulation, transcutaneous auricular vagus nerve stimulation (taVNS); Device
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 65 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Acute Stress Reaction, Cognitive Performance
Interventions: Sparrow Hawk (Active), Sparrow Hawk (Sham); Device
Lead sponsor: Spark Biomedical, Inc.; Industry
Eligibility: 18 Years to 41 Years
Enrollment: 43 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Psoriasis Vulgaris
Interventions: Active taVNS, Sham taVNS; Device
Lead sponsor: Burrell College of Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Las Cruces, New Mexico

Conditions: Rosacea, Rosacea, Erythematotelangiectatic, Flushing
Interventions: Transaricular vagus nerve stimulation (taVNS); Device
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Survivor of Childhood Cancer, Insomnia, Acute Lymphoblastic Leukemia (ALL)
Interventions: Soterix tVNS device, Soterix tVNS device (sham programmed), Sleep Quality, Neurocognitive and mental health outcomes; Device · Behavioral
Lead sponsor: St. Jude Children's Research Hospital; Other
Eligibility: 20 Years to 50 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Memphis, Tennessee

Conditions: Long COVID, Chronic Fatigue Syndrome
Interventions: Transcutaneous Non-Invasive Vagus Nerve Stimulation; Device
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: Up to 70 Years
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022
U.S. locations: 1
States / cities: New York, New York

Conditions: Fibromyalgia
Interventions: Auricular transcutaneous electrical nerve stimulation device; Device
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Charlestown, Massachusetts

Conditions: Parkinson Disease
Interventions: Active taVNS, Sham Stimulation; Device
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 40 Years to 79 Years
Enrollment: 33 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Stroke, Pain
Interventions: Transcutaneous Auricular Vagus Nerve Stimulation (taVNS), Sham Auricular Stimulation; Device
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 80 Years
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Knee Osteoarthritis, Central Pain Syndrome
Interventions: Transcutaneous vagus nerve stimulation; Device
Lead sponsor: University of Texas, El Paso; Other
Eligibility: 45 Years to 90 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: El Paso, Texas

Conditions: Dyspepsia
Interventions: Alimetry, tVNS, Gastroduodenal Manometry; Device
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 80 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Chronic Kidney Disease
Interventions: Transcutaneous electrical nerve stimulation unit (TENS); Device
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 80 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: New York, New York

Conditions: Breast Cancer
Interventions: Transcutaneous vagus nerve and acupuncture point stimulation; Device
Lead sponsor: The Healing Consciousness Foundation; Other
Eligibility: 18 Years to 75 Years
Enrollment: 46 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Meadowbrook, Pennsylvania

Conditions: Healthy
Interventions: transcutaneous auricular vagus nerve stimulation 30/30, transcutaneous auricular vagus nerve stimulation 10/10; Device
Lead sponsor: University of Miami; Other
Eligibility: 18 Years to 80 Years
Enrollment: 31 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Opioid-use Disorder, Opioid Withdrawal
Interventions: Sparrow Ascent Therapy System, Lofexidine, Extended-release injectable naltrexone; Device · Drug
Lead sponsor: Spark Biomedical, Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 108 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 4
States / cities: Rancho Mirage, California • Crownsville, Maryland • Center City, Minnesota + 1 more

Conditions: Healthy Controls Group - Age and Sex-matched
Interventions: Vagustim Individual Device; Device
Lead sponsor: Northwell Health; Other
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: New Hyde Park, New York

Conditions: Stress Response
Interventions: Transcutaneous Vagus Nerve Stimulation (tVNS), Evaluative Stress Task; Device · Behavioral
Lead sponsor: University of Florida; Other
Eligibility: 18 Years to 65 Years
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Anxiety, PTSD, ADHD, Depression Disorders, Post-traumatic Stress, Substance Use, Executive Function, Sleep Disturbance
Interventions: AIP-Informed Integrative Psychotherapy, Transcutaneous Auricular Vagus Nerve Stimulation, Regulated Breathing and Autonomic Regulation, Audiovisual Entrainment, Vibroacoustic Stimulation, Breathwork-Based Auditory Driving Entropy Module (BADEM), Transcranial Electrical Stimulation; Behavioral · Device
Lead sponsor: Tactical Mind Research Coalition, Inc.; Other
Eligibility: 18 Years to 70 Years
Enrollment: 240 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Tampa, Florida

Conditions: Healthy
Interventions: Transcutaneous vagal nerve stimulation, Breathing task; Device · Behavioral
Lead sponsor: Boston University Charles River Campus; Other
Eligibility: 18 Years to 70 Years
Enrollment: 81 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 2
States / cities: Boston, Massachusetts

Conditions: Premature Birth, Breastfeeding, Exclusive, Feeding; Difficult, Newborn
Interventions: taVNS soterix device; Device
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 35 Weeks and older
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Autism Spectrum Disorder, Anxiety
Interventions: Transcutaneous auricular vagus nerve stimulation; Device
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 12 Years to 17 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: PTSD - Post Traumatic Stress Disorder
Interventions: transcutaneous auricular vagus nerve stimulation, sham transcutaneous auricular vagus nerve stimulation; Device
Lead sponsor: Wayne State University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2031
U.S. locations: 1
States / cities: Detroit, Michigan

Search by objective public record fields.

Noninvasive Vagal Nerve Stimulation

taVNS for FRNS in Children

Noninvasive VNS to Facilitate Excitability in Motor Cortex

Effect of Transcutaneous Auricular Neurostimulation on Cognitive Performance in a Laboratory Model of Acute Stress Reaction

Augmenting Standard-of-care Treatment of Plaque Psoriasis by Neuromodulation

Transcutaneous Auricular Vagus Nerve Stimulation Treatment for Rosacea

Transcutaneous Auricular Vagus Nerve Stimulation for Insomnia in Survivors of Childhood Acute Lymphoblastic Leukemia

Vagus Nerve Stimulation as Treatment for Long Covid

taVNS Treatment for Fibromyalgia

taVNS in Mild to Moderate Parkinson's Disease

Post-stroke Pain taVNS

Effects of Vagus Nerve Stimulation on Central Pain Sensitivity & Parasympathetic Function in Knee Osteoarthritis

High Resolution Gastric Mapping and Gastroduodenal Manometry

Transcutaneous Auricular Vagus Nerve Stimulation Device in CKD Population

MindVybe tVNS/APS for Wellbeing in Breast Cancer Survivors

Transcutaneous Vagus Nerve Stimulation (taVNS) Dosage Study 1

Delivering Transcutaneous Auricular Neurostimulation to Improve Relapse Prevention in Opioid Use Disorder

Vagustim™ Transcutaneous Auricular Vagus Nerve Stimulation Devices

Transcutaneous Vagus Nerve Stimulation (tVNS) and Stress Regulation During Performance Tasks

Rapid Entrainment and Signal-guided Neuromodulation for Behavioral Health

Imaging Brain Fluids During Breathing

taVNS-Paired Breastfeeding to Improve Breastfeeding at Discharge

taVNS for Anxiety in ASD

Understanding Non-invasive Vagus Nerve Stimulation Effects in PTSD