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ClinicalTrials.gov public records Last synced Nov 15, 2026, 5:03 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 36 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Trazodone Hydrochloride Clear all

Conditions: Sleep Apnea, Spinal Cord Injury
Interventions: Acute episodic hypoxia, Supplemental oxygen, Trazodone, Placebo, Sham; Procedure · Drug
Lead sponsor: John D. Dingell VA Medical Center; Federal
Eligibility: 18 Years to 89 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2027
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Delirium, Agitation
Interventions: Risperidone, Trazodone, Placebo; Drug
Lead sponsor: Rochester General Hospital; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2016
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Sleep Apnea, Obstructive
Interventions: Placebo pill, Trazodone; Drug
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years to 70 Years
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Hypoactive Sexual Desire Disorder (DSM-IV-TR Defined), Sexual Interest/Arousal Disorder (DSM-5 Defined)
Interventions: bupropion, Lorexys low-dose, Lorexys moderate-dose; Drug
Lead sponsor: S1 Biopharma, Inc.; Industry
Eligibility: 25 Years to 50 Years · Female only
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 2
States / cities: Beachwood, Ohio • Cincinnati, Ohio

Conditions: Insomnia, Insomnia Chronic, Insomnia, Primary, Blood Pressure, Blood Pressure, High
Interventions: Cognitive Behavioral Treatment for Insomnia (CBT-I), Trazodone, Placebo; Behavioral · Drug · Other
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 600 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 3
States / cities: Denver, Colorado • Hershey, Pennsylvania • Pittsburgh, Pennsylvania

Conditions: Obstructive Sleep Apnea
Interventions: Placebo oral tablet, Trazodone Hydrochloride; Drug
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 21 Years to 70 Years
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Post Traumatic Stress Disorder
Interventions: Quetiapine Fumarate, Standard of care meducations; Drug · Other
Lead sponsor: The University of Texas Health Science Center at San Antonio; Other
Eligibility: 18 Years and older
Enrollment: 28 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: San Antonio, Texas

Conditions: Insomnia, Mental Health Disorder, Substance Use Disorder
Interventions: Quetiapine, Trazodone; Drug
Lead sponsor: VA Connecticut Healthcare System; Federal
Eligibility: 18 Years and older
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: West Haven, Connecticut

Conditions: Depression
Interventions: Clemastine Fumarate, Placebo; Drug
Lead sponsor: University of Illinois Chicago; Other
Eligibility: 60 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Post-Traumatic Stress Disorder
Interventions: Cognitive Behavioral Therapy, Motivational Interviewing, FDA-Approved Anti-Anxiety Medications, Standard Care Control; Behavioral · Drug
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 207 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2013
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Insomnia, End Stage Renal Disease
Interventions: Cognitive Behavioral Therapy for Insomnia, Trazodone, Placebo; Behavioral · Drug
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 126 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Obstructive Sleep Apnea
Interventions: Placebo, Acetazolamide, Trazodone, Atomoxetine and eszopiclone; Drug
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 21 Years to 70 Years
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Lumbar Spinal Stenosis
Interventions: NSAIDs; adjunctive analgesics; adjunctive anti-depressants, Lumbar epidural injection, Joint Mobilizations (spine, sacroiliac, hip), Individualized exercises: clinical setting, Group Exercise: community setting; Drug · Procedure · Other
Lead sponsor: Michael Schneider, DC, PhD; Other
Eligibility: 60 Years and older
Enrollment: 259 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Poor Quality Sleep, Opiate Addiction
Interventions: Trazodone, Placebo; Drug
Lead sponsor: Butler Hospital; Other
Eligibility: 18 Years to 75 Years
Enrollment: 137 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2010
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Delirium, Morality, Quality of Life, Psych, Treatment Side Effects
Interventions: Trazodone, Quetiapine, Placebo; Drug
Lead sponsor: University of Southern California; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2028 – 2030
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Chronic Insomnia
Interventions: Zolpidem, Internet Cognitive Behavioral Therapy for Insomnia (CBT-I), Trazodone; Drug · Behavioral
Lead sponsor: California Pacific Medical Center Research Institute; Other
Eligibility: 18 Years to 80 Years
Enrollment: 155 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 7
States / cities: Birmingham, Alabama • Tucson, Arizona • Columbia, Missouri + 4 more

Conditions: Sleep Disordered Breathing, Able Bodied
Interventions: Trazodone + positive airway pressure (PAP) therapy, Oxygen + positive airway pressure (PAP) therapy; Drug
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Insomnia
Interventions: Trazodone, Eszopiclone, Placebo; Drug · Other
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 75 Years
Enrollment: 673 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 35
States / cities: Birmingham, Alabama • Tuscaloosa, Alabama • Phoenix, Arizona + 31 more

Conditions: Sleep Disorder
Interventions: Trazodone, Sentra PM, Sentra PM and Trazodone (CoPack Kit Trazamine), Placebo trazodone and placebo Sentra PM; Drug · Other
Lead sponsor: Targeted Medical Pharma; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 111 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Sleep Apnea, Obstructive; Post-Traumatic Stress Disorders
Interventions: Trazodone, Placebo, Epiglottic catheter; Drug · Device
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years to 70 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: San Diego, California

Conditions: AMCI - Amnestic Mild Cognitive Impairment, Sleep Disturbance
Interventions: Trazodone, Placebo; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 55 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Posttraumatic Stress Disorder
Interventions: Cognitive Behavioral Therapy, Motivational Interviewing, FDA-Approved Anti-Anxiety Medications, Standard Care Control; Behavioral · Drug
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Insomnia Comorbid to Psychiatric Disorder, Primary Insomnia
Interventions: Behavioral Insomnia Therapy, Zolpidem, Trazodone, Cognitive Therapy; Behavioral · Drug
Lead sponsor: Jack Edinger, PhD; Other
Eligibility: 21 Years and older
Enrollment: 211 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2017
U.S. locations: 1
States / cities: Denver, Colorado

Conditions: Delirium, Delirium of Mixed Origin, Delirium, Sepsis Associated, Delirium in Old Age, Delirium Confusional State, Psych, Morality, Treatment Side Effects
Interventions: Trazodone, Quetiapine; Drug
Lead sponsor: University of Southern California; Other
Eligibility: 18 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 1
States / cities: Los Angeles, California

Search by objective public record fields.

Treatment of Sleep Apnea in Patients With Cervical Spinal Cord Injury

Efficacy and Safety of Risperidone and Trazodone Monotherapy and Combination Therapy in Critically Ill Patients With Delirium

The Effects of Trazodone on Sleep Apnea Severity

Phase 1b/2a Unblinded Study of Responses in Premenopausal Women With HSDD to Lorexys Evaluating Efficacy and Safety

Cognitive Behavioral Therapy and Trazodone Effects on Sleep and Blood Pressure in Insomnia

Trazodone on OSA Endotypes

Quetiapine Augmentation of PE Therapy for the Treatment of Co-occurring PTSD and Mild Traumatic Brain Injury

Comparison of Quetiapine and Trazodone Treatment for Insomnia in Dually Diagnosed Veterans

Clemastine for Improving White Matter and Boosting Antidepressant Response in Late-life Depression

Patient-Centered Collaborative Care for Preventing Post-Traumatic Stress Disorder After Traumatic Injury

Short and Long-Term Effectiveness of Existing Insomnia Therapies for Patients Undergoing Hemodialysis

Rescue Pharmacotherapy for OSA

Study Comparing 3 Different Treatments for Arthritis of the Lower Back (Lumbar Spinal Stenosis)

Insomnia and Drug Relapse Risk

RCT: Trazodone vs Quetiapine vs Placebo for Treating ICU Delirium (TraQ)

CBT-I or Zolpidem/Trazodone for Insomnia

Central Apnea in Heart Failure: Physiological Mechanisms to Inform Treatment

National Adaptive Trial for PTSD Related Insomnia

A Double-blind Placebo Controlled Trial of Sentra PM, a Medical Food

Obstructive Sleep Apnea and Arousal Threshold in Patients With Post-traumatic Stress Disorder

Targeting Cognition in Early Alzheimer's Disease by Improving Sleep With Trazodone

Piloting Acute Care to Primary Care Linkage of Safety Net Patients

Sequenced Therapies for Comorbid and Primary Insomnias

Trazodone vs. Quetiapine for the Treatment of ICU Delirium