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ClinicalTrials.gov public records Last synced Oct 6, 2026, 7:45 PM EDT

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Showing 49–72 of 3,107 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Treatment as usual therapy Clear all
Terminated Phase 4 Interventional

Combinatorial Pharmacogenomics Testing in Treatment-Naïve Major Depressive Disorder

NCT03537547
View directory record Official record
Conditions
Major Depressive Disorder, Depression, Depressive Disorder, Depressive Episode, Depression, Unipolar
Interventions
GeneSight Psychotropic test, FDA-approved antidepressant or antipsychotic treatment
Other · Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 65 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 5, 2020 · Synced Oct 6, 2026, 7:45 PM EDT
Active, not recruiting Not applicable Interventional

Moderators and Mediators (M & M Trial) of Psychosocial Treatments of Chronic Pain

NCT06044649
View directory record Official record
Conditions
Chronic Pain, Neck Pain, Back Pain
Interventions
Cognitive Behavioral Therapy, Acceptance and Commitment Therapy, Emotional Awareness and Expression Therapy, Treatment as Usual
Behavioral · Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
408 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
2
States / cities
Chicago, Illinois • Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Oct 6, 2026, 7:45 PM EDT
Completed Not applicable Interventional

Treatment for Borderline Personality Disorder

NCT00055315
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Systems Training for Emotional Predictability and Problem Solving (STEPPS), Treatment As Usual (TAU)
Behavioral
Lead sponsor
University of Iowa
Other
Eligibility
18 Years and older
Enrollment
383 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2011
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 16, 2017 · Synced Oct 6, 2026, 7:45 PM EDT
Completed Not applicable Interventional Results available

Perioperative Mental Health in Orthopedic Surgery

NCT05697835
View directory record Official record
Conditions
Orthopedic Surgery, Older Adults, Depression, Anxiety
Interventions
Behavioral activation, Medication optimzation, Care as usual
Behavioral · Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
60 Years and older
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 9, 2026 · Synced Oct 6, 2026, 7:45 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Comparing Intravenous Hydromorphone to Usual Care

NCT01429298
View directory record Official record
Conditions
Pain
Interventions
Hydromorphone, Usual care
Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
21 Years to 65 Years
Enrollment
350 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated May 18, 2018 · Synced Oct 6, 2026, 7:45 PM EDT
Completed Not applicable Interventional Results available

A Bridge to Treatment: The Therapeutic Workplace and Methadone Treatment

NCT01416584
View directory record Official record
Conditions
Opiate Dependence
Interventions
methadone contingency, Methadone & Abstinence Contingency
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 65 Years
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 5, 2017 · Synced Oct 6, 2026, 7:45 PM EDT
Recruiting Not applicable Interventional

Youth Empowerment and Safety Intervention

NCT07214233
View directory record Official record
Conditions
Suicide, Self-Injurious Behavior
Interventions
Treatment as Usual, Peer Support Services (PSS)
Behavioral
Lead sponsor
Case Western Reserve University
Other
Eligibility
12 Years to 17 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 8, 2026 · Synced Oct 6, 2026, 7:45 PM EDT
Not listed Not applicable Interventional

Treatment of Insomnia and Depression in Elders (TIDE)

NCT01648049
View directory record Official record
Conditions
Depression, Insomnia
Interventions
Integrated Cognitive Behavioral Therapy (CBT), Treatment as usual
Behavioral
Lead sponsor
University of Alabama, Tuscaloosa
Other
Eligibility
50 Years to 100 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2012
U.S. locations
1
States / cities
Tuscaloosa, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 2, 2015 · Synced Oct 6, 2026, 7:45 PM EDT
Not listed Not applicable Interventional

Comparing a Patient Self-Assessment Software to Treatment as Usual in Opioid Prescriber and Patient Opioid Outcomes

NCT04945525
View directory record Official record
Conditions
Opioid-use Disorder, Opioid Misuse, Opioid Use, Chronic Pain
Interventions
Care Continuity Program
Other
Lead sponsor
Sure Med Compliance
Industry
Eligibility
18 Years and older
Enrollment
1,840 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Mobile, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 30, 2021 · Synced Oct 6, 2026, 7:45 PM EDT
Completed Not applicable Interventional

Using a Preparation and Education Intervention to Reduce Postpartum Depression Among New Mothers (The MADE IT 2 Study)

NCT00951717
View directory record Official record
Conditions
Depression, Postpartum, Depression
Interventions
Behavioral education intervention
Behavioral
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older · Female only
Enrollment
590 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 22, 2011 · Synced Oct 6, 2026, 7:45 PM EDT
Completed Phase 2 Interventional

Enhanced Medical Rehabilitation for Disablement

NCT00951691
View directory record Official record
Conditions
Hip Fracture, Depression
Interventions
Enhanced acute medical rehabilitation, Treatment as usual
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
60 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 19, 2014 · Synced Oct 6, 2026, 7:45 PM EDT
Not listed Not applicable Interventional

Neural Biomarkers of Electroconvulsive Therapy Response

NCT04763655
View directory record Official record
Conditions
Electroconvulsive Therapy Treated Patients
Interventions
clinical and neuropsychological testing
Diagnostic Test
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 80 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Glen Oaks, New York
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced Oct 6, 2026, 7:45 PM EDT
Completed Phase 3 Interventional Results available

Diuretic Comparison Project

NCT02185417
View directory record Official record
Conditions
Hypertension
Interventions
Hydrochlorothiazide (HCTZ), Chlorthalidone (CTD)
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
65 Years and older
Enrollment
20,723 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
69
States / cities
Birmingham, Alabama • Anchorage, Alaska • Fayetteville, Arkansas + 64 more
Source: ClinicalTrials.gov public record
Updated May 22, 2024 · Synced Oct 6, 2026, 7:45 PM EDT
Completed Not applicable Interventional

START NOW in the Treatment of Opioid Addicted Individuals

NCT05552040
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
START NOW Group
Behavioral
Lead sponsor
Carilion Clinic
Other
Eligibility
18 Years to 70 Years
Enrollment
141 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 23, 2022 · Synced Oct 6, 2026, 7:45 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events

NCT06112418
View directory record Official record
Conditions
Diabetes Mellitus, Type 2, PreDiabetes, Metabolic Syndrome
Interventions
The Cleerly CAD Staging System
Device
Lead sponsor
Cleerly, Inc.
Industry
Eligibility
55 Years and older
Enrollment
7,500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2029
U.S. locations
125
States / cities
Chandler, Arizona • Scottsdale, Arizona • Sun City, Arizona + 100 more
Source: ClinicalTrials.gov public record
Updated Sep 28, 2026 · Synced Oct 6, 2026, 7:45 PM EDT
Completed Not applicable Interventional

Web-based CBT4CBT for Alcohol

NCT01615497
View directory record Official record
Conditions
Alcohol Abuse or Dependence
Interventions
Standard Treatment as Usual (TAU), Web-based CBT4CBT for alcohol plus TAU, Web-based CBT with minimal clinical contact
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 70 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
2
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 9, 2020 · Synced Oct 6, 2026, 7:45 PM EDT
Completed Not applicable Interventional Results available

Group-based Integrative Pain Management (IPMP+ Pilot)

NCT05906784
View directory record Official record
Conditions
Chronic Pain
Interventions
group acupuncture, Integrative Group Medical Visits
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 30, 2025 · Synced Oct 6, 2026, 7:45 PM EDT
Recruiting Not applicable Interventional

A Pilot Randomized Controlled Trial of the Hopeful and Healthy Living Program

NCT06940843
View directory record Official record
Conditions
Serious Mental Illness, Older Adults
Interventions
Hopeful and Healthy Living (HHL)
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
50 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 20, 2026 · Synced Oct 6, 2026, 7:45 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Neuroimaging Reward, Behavioral Treatment, and Smoking Cessation

NCT02927847
View directory record Official record
Conditions
Smoking
Interventions
Nicotine Patch, SPECTRUM Nicotine Research Cigarettes (.03 mg), Behavioral Activation, Supportive Counseling
Drug · Behavioral
Lead sponsor
Maggie M Sweitzer, PhD
Other
Eligibility
18 Years to 55 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 28, 2022 · Synced Oct 6, 2026, 7:45 PM EDT
Completed Phase 2 Interventional Results available

Interventions Against Insulin Resistance in Pulmonary Arterial Hypertension

NCT03617458
View directory record Official record
Conditions
Pulmonary Artery Hypertension
Interventions
Metformin, Placebo, mHealth Intervention, Usual Care
Drug · Device
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
1
States / cities
Nashvile, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Oct 6, 2026, 7:45 PM EDT
Completed Not applicable Interventional

Recovery From Psychosis in Schizophrenia - The Impact of Cognitive-Behavioral Therapy

NCT00791440
View directory record Official record
Conditions
Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder
Interventions
Cognitive-Behavior Therapy, Standard Psychiatric Treatment
Behavioral · Other
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 50 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 13, 2012 · Synced Oct 6, 2026, 7:45 PM EDT
Completed Not applicable Interventional Results available

Management Strategies for Patients With Low Back Pain and Sciatica

NCT02391350
View directory record Official record
Conditions
Low Back Pain, Sciatica, Physical Therapy
Interventions
Education and re-assurance, Physical Therapy
Behavioral · Procedure
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 60 Years
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jan 22, 2021 · Synced Oct 6, 2026, 7:45 PM EDT
Completed Not applicable Interventional

Improving Activity and Quality of Life Following Orthopaedic Trauma: The Trauma Collaborative Care Study (TCCS)

NCT01907893
View directory record Official record
Conditions
Severe Orthopedic Trauma
Interventions
Trauma Collaborative Care Plus Treatment as Usual
Behavioral
Lead sponsor
Major Extremity Trauma Research Consortium
Other
Eligibility
18 Years to 60 Years
Enrollment
900 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
13
States / cities
Denver, Colorado • Tampa, Florida • Indianapolis, Indiana + 9 more
Source: ClinicalTrials.gov public record
Updated Apr 18, 2017 · Synced Oct 6, 2026, 7:45 PM EDT
Recruiting Phase 1 Interventional

CD33KO-HSPC Infusion Followed by CART-33 Infusion(s) for Refractory/Relapsed AML

NCT05945849
View directory record Official record
Conditions
Leukemia, Myeloid, Acute
Interventions
CD33KO-HSPC; CART33
Biological
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2044
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Oct 6, 2026, 7:45 PM EDT