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ClinicalTrials.gov public records Last synced Nov 6, 2026, 5:17 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 2425–2448 of 3,107 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Treatment of depression Clear all

Conditions: Major Depression
Interventions: CURB; Behavioral
Lead sponsor: Benjamin Van Voorhees, MD, MPH; Other
Eligibility: 13 Years to 17 Years
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Depressive Disorder, Depression, Depressive Disorder, Major, Mood Disorders, Mental Disorders
Interventions: OPC-34712 + ADT, Placebo + ADT; Drug
Lead sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 1,539 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 52
States / cities: Birmingham, Alabama • Costa Mesa, California • Glendale, California + 49 more

Conditions: Adult-Onset Growth Hormone Deficiency
Interventions: Not listed
Lead sponsor: Garcia, Jose M., MD, PhD; Individual
Eligibility: 18 Years to 65 Years
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2022
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Anxiety
Interventions: Psilocybin (drug), Niacin, MRI; Drug · Other · Diagnostic Test
Lead sponsor: Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center; Other
Eligibility: 18 Years to 70 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2008
U.S. locations: 1
States / cities: Torrance, California

Conditions: Posttraumatic Stress Disorder, Depression
Interventions: Behavioral Activation treatment, Treatment as Usual; Behavioral · Other
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 81 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2013
U.S. locations: 2
States / cities: Portland, Oregon • Seattle, Washington

Conditions: Diabetes Mellitus, Type 2
Interventions: Empowerment and CBT Classes; Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 50 Years and older
Enrollment: 121 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Depression in Adolescence, Adverse Childhood Experiences
Interventions: Behavioral Activation (BA) Therapy, Problem Solving Therapy (PST); Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 12 Years to 15 Years
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Major Depressive Disorder
Interventions: agomelatine, placebo; Drug
Lead sponsor: Novartis; Industry
Eligibility: 18 Years to 70 Years
Enrollment: 508 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2006
U.S. locations: 42
States / cities: Scottsdale, Arizona • Little Rock, Arkansas • Cerritos, California + 38 more

Conditions: Lung Cancer
Interventions: LuCA Behavioral Intervention; Behavioral
Lead sponsor: Duke University; Other
Eligibility: 60 Years and older
Enrollment: 16 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Major Depressive Disorder
Interventions: Fisher Wallace Cranial Electrotherapy Stimulator Device; Device
Lead sponsor: ProofPilot; Industry
Eligibility: 21 Years and older
Enrollment: 175 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: New York, New York

Conditions: Traumatic Brain Injury
Interventions: Behavioral Activation, Treatment as Usual; Behavioral · Other
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 21 Years and older
Enrollment: 46 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Treatment Resistant Depression
Interventions: MK-1942, Placebo; Drug
Lead sponsor: Merck Sharp & Dohme LLC; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 99 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 45
States / cities: Birmingham, Alabama • Little Rock, Arkansas • Bellflower, California + 40 more

Conditions: Sleep, Postpartum Depression, Pregnancy Related, Insomnia, Sleep Deprivation, Sleep Hygiene, Sleep Disturbance
Interventions: Education about behavioral strategies to improve sleep; Behavioral
Lead sponsor: Rhode Island Hospital; Other
Eligibility: 18 Years to 99 Years
Enrollment: 55 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Bipolar Disorder, Major Depressive Disorder, Psychosis
Interventions: Lurasidone, FDA Approved antidepressant treatment; Drug
Lead sponsor: George West Mental Health Foundation d/b/a Skyland Trail; Other
Eligibility: 18 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Well-Being, Psychological, Anxiety Depression
Interventions: PERSIST; Behavioral
Lead sponsor: Duke University; Other
Eligibility: 25 Years and older
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Major Depressive Diorder, Early Life Trauma
Interventions: Lumateperone 42 mg, Placebo; Drug · Other
Lead sponsor: University of Texas at Austin; Other
Eligibility: 21 Years to 70 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Pediatric Cancer, Neuroblastoma, Sarcoma, Wilms Tumor and Other Childhood Kidney Tumors, Childhood Soft Tissue Sarcoma, Childhood Bone Sarcoma, Childhood Malignant Intestinal Neoplasm, Childhood Malignant Liver Neoplasm, Childhood Malignant Lung Neoplasm, Childhood Malignant Ovarian Neoplasm, Childhood Malignant Pleural Neoplasm, Childhood Neuroblastic Tumor, Childhood Sarcoma
Interventions: Wearing Smartwatch, Patient Report Outcomes, Blood Draw, Clinical Data Review; Other
Lead sponsor: Mayo Clinic; Other
Eligibility: 3 Years to 25 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2030
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Depression
Interventions: Transcranial Electrical Stimulation (tES); Device
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Depression
Interventions: Music therapy; Other
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 7 Years to 15 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: New York, New York

Conditions: Depression, Melancholia
Interventions: Sertraline, Nortriptyline; Drug
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 60 Years to 95 Years
Enrollment: 110 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1997 – 2002
U.S. locations: 1
States / cities: New York, New York

Conditions: Depressive Symptoms
Interventions: Resiliency Class, Case Management; Behavioral · Other
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years and older
Enrollment: 168 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2014
U.S. locations: 3
States / cities: Los Angeles, California • Torrance, California

Conditions: Traumatic Brain Injury, Chronic Pain, Post Traumatic Stress Disorder, Depression, Anxiety
Interventions: ACT on Life, Education, Resources, and Support; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 176 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Major Depressive Disorder
Interventions: DEX-CRF stimulation test, Psychosocial stress induction, Brain imaging of sad mood , self-reference, reward, Acoustic startle; Drug · Behavioral · Procedure
Lead sponsor: Emory University; Other
Eligibility: 18 Years to 45 Years
Enrollment: 113 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2011
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Depression in Old Age
Interventions: Engage-A, Training and utilizing Engage-A therapy; Behavioral · Other
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 55 Years and older
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: White Plains, New York

Search by objective public record fields.

Chicago Urban Resiliency Building (CURB)

Study of the Safety and Efficacy of Two Fixed Doses of OPC-34712 as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder (the Polaris Trial)

Metabolic and QOL Effects of GH Treatment in Patients With TBI and AGHD

Effects of Psilocybin in Advanced-Stage Cancer Patients With Anxiety

Behavioral Activation for PTSD/Depression Treatment in OIF/OEF Veterans

Mood and Diabetes Empowerment & Improvement Training

Shaping Actions and Responses to Emotions

Efficacy, Safety and Tolerability of Agomelatine in the Treatment of Major Depressive Disorder

Lung Cancer and Aging: Improving Well-being for Older Adults With Lung Cancer

Fisher Wallace Neurostimulation & Depression Study

ACTIVE: Activity Therapy to Increase Veteran Engagement

Efficacy and Safety of MK-1942 When Added to Stable Antidepressant Therapy in Participants With Treatment-Resistant Depression (TRD) (MK-1942-006)

The Dream Team: Testing Implementation of a Sleep Intervention for Perinatal Women Delivered by Direct Care Workers

Sleep Quality, Cognitive Performance, and Computerized Cognitive Training

Personal Resilience Skills to Improve Surgery Training

Neurocircuitry Mechanisms and Efficacy of Lumateperone as Adjunctive Therapy for Major Depressive Disorder and History of Early Life Abuse

Biomarkers of Resiliency In Childhood Cancer Surgery

fMRI Study of tES in Major Depression

Assessment of Music Experiences in Navigating Depression Part 2

Antidepressant Treatment of Melancholia in Late Life

Building Resiliency and Increasing Community Hope

One-day Life Skills Workshop for Veterans With TBI, Pain, and Psychopathology: Evaluating Efficacy and Mechanism of Change

Characterizing Psychological Consequences of Childhood Trauma

Reaching and Engaging Depressed Senior Center Clients