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ClinicalTrials.gov public records Last synced Nov 7, 2026, 10:05 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 2497–2520 of 3,107 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Treatment of depression Clear all

Conditions: Depression, Palliative Care, Cancer, Mental Disorder
Interventions: Methylphenidate, Placebo, Selective Serotonin Uptake Inhibitor (SSRI); Drug
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 18 Years and older
Enrollment: 47 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2010
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Posttraumatic Stress Disorder, Depression, Insomnia Disorder
Interventions: Cognitive Behavioral Social Rhythm Group Therapy, Present Centered Group Therapy; Behavioral
Lead sponsor: University of Arizona; Other
Eligibility: 18 Years to 65 Years · Male only
Enrollment: 115 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 2
States / cities: Tucson, Arizona

Conditions: Depressive Symptoms, Mild Traumatic Brain Injury
Interventions: CNRM DTx, Psychoeducation Comparison; Device · Other
Lead sponsor: Henry M. Jackson Foundation for the Advancement of Military Medicine; Other
Eligibility: 18 Years to 65 Years
Enrollment: 113 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Depressive Symptoms
Interventions: Group-based therapy; Behavioral
Lead sponsor: Oregon Research Institute; Other
Eligibility: 18 Years to 28 Years
Enrollment: 91 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Eugene, Oregon

Conditions: Depression, Anxiety
Interventions: App-based Cognitive Behavioral Therapy (CBT), Psychotherapy; Behavioral
Lead sponsor: NYU Langone Health; Other
Eligibility: 13 Years to 22 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 3
States / cities: New Brunswick, New Jersey • Brooklyn, New York • Glen Oaks, New York

Conditions: HIV, Depression, Anxiety
Interventions: PositiveLinks with Counseling, Standard of Care (SOC); Behavioral
Lead sponsor: University of Florida; Other
Eligibility: 18 Years to 90 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Alcohol Use Disorder, Cannabis Use Disorder
Interventions: InTEGRA, MET/CBT; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 14 Years to 21 Years
Enrollment: 294 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 2
States / cities: Farmington, Connecticut • Boston, Massachusetts

Conditions: Depression
Interventions: Lithium, Ketamine, Placebo; Drug
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 21 Years to 65 Years
Enrollment: 34 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: New York, New York

Conditions: Alcohol Abuse, Cannabis Abuse, Major Depressive Disorder, Substance-Related Disorders
Interventions: Integrated Cognitive Behavioral Therapy, Twelve Step Facilitation Therapy; Behavioral
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 18 Years to 70 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2004
U.S. locations: 1
States / cities: San Diego, California

Conditions: Anhedonia, Depression
Interventions: Carbidopa Levodopa, Placebo; Drug
Lead sponsor: Emory University; Other
Eligibility: 25 Years to 55 Years
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Suicide, Attempted, Suicide and Depression, Suicide Threat
Interventions: Ketamine Hydrochloride, Midazolam Hydrochloride; Drug
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 13 Years to 18 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Depression, Hypertension
Interventions: Mindfulness-Based Stress Reduction (MBSR; CALM-Chicago Study); Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Major Depressive Disorder
Interventions: Repetitive transcranial magnetic stimulation (rTMS); Device
Lead sponsor: Paul E. Croarkin; Other
Eligibility: 12 Years to 21 Years
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 2
States / cities: Rochester, Minnesota • Charleston, South Carolina

Conditions: Major Depressive Disorder
Interventions: rTMS; Device
Lead sponsor: University of New Mexico; Other
Eligibility: 60 Years to 79 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Albuquerque, New Mexico

Conditions: Heart Failure, Congestive
Interventions: Intervention; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 384 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 4
States / cities: Palo Alto, California • Denver, Colorado • Richmond, Virginia + 1 more

Conditions: Body Image Disturbance, Disordered Eating Behaviors, Eating Disorder Prevention
Interventions: Wysa Digital Chatbot Program; Behavioral
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 13 Years to 19 Years
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Depression
Interventions: Imipramine hydrochloride; Drug
Lead sponsor: GEIGY Pharmaceuticals; Industry
Eligibility: 18 Years to 65 Years
U.S. locations: 1
States / cities: New York, New York

Conditions: Depression
Interventions: Theta Burst Stimulation; Device
Lead sponsor: Erika Forbes; Other
Eligibility: 18 Years to 26 Years
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Generalized Anxiety Disorder, Social Anxiety Disorder, Panic Disorder, Agoraphobia, Posttraumatic Stress Disorder, Major Depressive Disorder
Interventions: Float pool, Float chair; Behavioral
Lead sponsor: Laureate Institute for Brain Research, Inc.; Other
Eligibility: 18 Years to 60 Years
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: Tulsa, Oklahoma

Conditions: Depression, Postpartum
Interventions: Zuranolone; Drug
Lead sponsor: Biogen; Industry
Eligibility: 18 Years and older · Female only
Enrollment: 305 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Woonsocket, Rhode Island

Conditions: Major Depressive Disorder
Interventions: ALKS 5461; Drug
Lead sponsor: Alkermes, Inc.; Industry
Eligibility: 18 Years to 70 Years
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014
U.S. locations: 8
States / cities: Jacksonville, Florida • Orlando, Florida • Atlanta, Georgia + 5 more

Conditions: Traumatic Brain Injury, Depression
Interventions: In-person Cognitive Behavioral Therapy, Telephone Cognitive Behavioral Therapy; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2013
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Cancer
Interventions: management of therapy complications, massage therapy, pain therapy, psychosocial assessment and care, quality-of-life assessment; Procedure
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 18 Years to 120 Years
Enrollment: 39 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2013
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Bipolar Depression
Interventions: Lamotrigine, 1H-MR; Drug · Procedure
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 65 Years
Enrollment: 72 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2014
U.S. locations: 1
States / cities: Rochester, Minnesota

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Methylphenidate for Depressed Cancer Patients Receiving Palliative Care

A Trial of Group Psychotherapy for Veterans and Military Personnel With Post Traumatic Stress Disorder (PTSD)

Digital Therapeutic for Depression After Head Injury in Current and Former US Military Personnel

Pilot Study Comparing Two Versions of Group Cognitive-behavioral Indicated Prevention Programs

SilverCloud as a School-Based Intervention for Vulnerable Youth

A Behavioral mHealth Intervention for People With HIV With Anxiety and Depression

Integrated Treatment for Enhancing Growth in Recovery During Adolescence

Ketamine Plus Lithium in Treatment-Resistant Depression

Study Comparing Two Types of Psychotherapy for Treating Depression and Substance Abuse

Dopaminergic Therapy for Anhedonia - 2

Ketamine Versus Midazolam for Recurrence of Suicidality in Adolescents

Community-based Approach to Lowering Stress Through Mindfulness

rTMS for Depressed Teens: A Sham-Controlled Trial, Part 2

Individualized Targeting and Neuromodulation of Late-Life Depression

Patient-Centered Heart Failure Trial

Adolescent Chatbot

Antidepressant Treatment of AIDS Related Depression.

Treatment, Emotion, and Neuromodulation of Depression (TREND) Study

Floatation-REST (Reduced Environmental Stimulation Therapy) for Anxiety and Depression

A Study to Learn More About How Zuranolone Affects Postpartum Depression Symptoms in Participants Who Took it Within 1 Year After The End of Their Pregnancy

A Study of Different Titration Schedules of ALKS 5461 in Adults With Major Depressive Disorder (MDD)

Life Improvement Following Traumatic Brain Injury

Massage Therapy in Treating the Symptoms of Patients With Locally Advanced or Metastatic Cancer

Bipolar Depression Before and After Lamotrigine Treatment