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ClinicalTrials.gov public records Last synced Oct 19, 2026, 7:17 AM EDT

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Showing 1009–1032 of 3,101 matching trials from the live ClinicalTrials.gov search.
Completed Phase 2 Interventional Accepts healthy volunteers

Effects of Strength Training on Knee Osteoarthritis

NCT00000406
Conditions
Osteoarthritis, Knee
Interventions
Progressive resistance exercise
Procedure
Lead sponsor
Indiana University
Other
Eligibility
60 Years and older
Enrollment
280 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1977 – 2006
U.S. locations
1
States / cities
Indianapolis, Indiana
Conditions
Major Depressive Disorder
Interventions
PDC-1421 Capsule
Drug
Lead sponsor
BioLite, Inc.
Industry
Eligibility
21 Years to 85 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2028
U.S. locations
1
States / cities
Los Angeles, California
Conditions
Major Depressive Disorder
Interventions
memantine, Placebo
Drug
Lead sponsor
Jerrry L Lewis
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2009
U.S. locations
1
States / cities
Iowa City, Iowa
Conditions
Major Depressive Disorder
Interventions
ABX-002, Placebo
Drug · Other
Lead sponsor
Autobahn Therapeutics, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
230 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
50
States / cities
Birmingham, Alabama • Chandler, Arizona • Phoenix, Arizona + 44 more
Conditions
Major Depressive Disorder, Healthy Controls
Interventions
Ketamine Hydrochloride, Midazolam injection
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
104 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Dallas, Texas
Active, not recruiting Phase 1Phase 2 Interventional Results available

The Effects of Ginseng on Cancer-Related Fatigue

NCT01375114
Conditions
Advanced Cancers, Solid Tumors
Interventions
Panax Ginseng, Placebo, Questionnaires
Drug · Dietary Supplement · Behavioral
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
165 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2028
U.S. locations
1
States / cities
Houston, Texas
Conditions
Major Depressive Disorder
Interventions
SAGE-217
Drug
Lead sponsor
Biogen
Industry
Eligibility
18 Years to 75 Years
Enrollment
1,515 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
52
States / cities
Dothan, Alabama • Phoenix, Arizona • Anaheim, California + 43 more
Completed Phase 3 Interventional Results available

Cognitive Therapy for Recurrent Depression

NCT00118404
Conditions
Depression
Interventions
Continuation phase cognitive therapy, Continuation phase fluoxetine, Continuation phase pill placebo, Acute phase cognitive therapy
Behavioral · Drug · Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 70 Years
Enrollment
523 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2008
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania • Dallas, Texas
Conditions
Depression
Interventions
Racemic ketamine, Spravato (Esketamine)
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
8
States / cities
Milford, Connecticut • New Haven, Connecticut • Atlanta, Georgia + 5 more
Conditions
Depression
Interventions
CATCH-IT, TEAMS
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
13 Years to 19 Years
Enrollment
636 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Completed Not applicable Interventional Accepts healthy volunteers Results available

PREPP: Preventing Postpartum Depression

NCT03283254
Conditions
Postpartum Depression (PPD)
Interventions
Practical Resources for Effective Postpartum Parenting (PREPP), Enhanced Treatment As Usual (ETAU)
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
216 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2024
U.S. locations
1
States / cities
New York, New York
Conditions
Major Depressive Disorder
Interventions
saredutant (SR48968), escitalopram, placebo
Drug
Lead sponsor
Sanofi
Industry
Eligibility
18 Years to 65 Years
Enrollment
643 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Bridgewater, New Jersey
Conditions
Borderline Personality Disorder, Borderline Personality, BPD - Borderline Personality Disorder
Interventions
Transcranial Magnetic Stimulation (TMS)
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
Los Angeles, California
Completed Phase 4 Interventional Results available

ADAPT: Addressing Depression and Pain Together

NCT01124188
Conditions
Depression, Back Pain
Interventions
Higher-dose venlafaxine, Supportive management, Problem Solving Therapy for Depression and Pain
Drug · Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
60 Years and older
Enrollment
263 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Conditions
Depression, Oppositional Defiant Disorder, Conduct Disorder
Interventions
Integrated Treatment
Behavioral
Lead sponsor
Rhode Island Hospital
Other
Eligibility
8 Years to 14 Years
Enrollment
30 participants
Timeline
2010 – 2013
U.S. locations
1
States / cities
Providence, Rhode Island
Conditions
Depression, Cognition
Interventions
Duloxetine, Placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
65 Years and older
Enrollment
311 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2004
U.S. locations
1
States / cities
Middleton, Wisconsin
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Neural Correlates of Suicidal Behavior in Youth

NCT07568054
Conditions
Suicidal Ideation, Suicide Attempt, Suicidal Behavior, Depression / Major Depressive Disorder, Hopelessness, Neurobiological
Interventions
CAMS
Behavioral
Lead sponsor
The Cleveland Clinic
Other
Eligibility
14 Years to 24 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2031
U.S. locations
1
States / cities
Cleveland, Ohio
Conditions
Major Depressive Disorder, Menopause, Perimenopause
Interventions
Pregnenolone, Placebo
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
40 Years to 67 Years · Female only
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Dallas, Texas
Conditions
Depression, Anxiety
Interventions
Meru Health Program
Behavioral
Lead sponsor
Meru Health, Inc.
Industry
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Denver, Colorado
Conditions
Depression
Interventions
motivational interviewing, brief advice in primary care
Behavioral
Lead sponsor
University of Chicago
Other
Eligibility
14 Years to 75 Years
Enrollment
93 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2011
U.S. locations
1
States / cities
Chicago, Illinois
Conditions
Depression, Anxiety
Interventions
Sanvello (app)
Device
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years and older
Enrollment
4,607 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Las Vegas, Nevada
Conditions
Pregnancy, Depression, Postpartum Depression
Interventions
MBCT-PD
Behavioral
Lead sponsor
University of Colorado, Boulder
Other
Eligibility
18 Years and older · Female only
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
4
States / cities
Boulder, Colorado • Denver, Colorado • Atlanta, Georgia
Completed Phase 1 Interventional Accepts healthy volunteers

Effect of Nicotine on Brain Reward Pathways

NCT02346539
Conditions
Depressive Disorder
Interventions
Nicotine polacrilex
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 45 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Belmont, Massachusetts
Conditions
Depression
Interventions
Sertraline, Metformin
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
20 Years to 60 Years
Enrollment
206 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
1
States / cities
St Louis, Missouri