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ClinicalTrials.gov public records Last synced Oct 20, 2026, 1:04 PM EDT

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Showing 1033–1056 of 3,101 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Treatment of depression Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Investigation of Brain Network Dynamics in Depression

NCT01931995
View directory record Official record
Conditions
Major Depressive Disorder, Recurrent
Interventions
TMS positively correlated DLPFC, TMS to negatively correlated DLPFC
Device · Procedure
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 50 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2018
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 7, 2021 · Synced Oct 20, 2026, 1:04 PM EDT
Completed Phase 3 Interventional

A Clinical Trial of IPT-A to Prevent Suicide in Depressed Adolescents With Suicidal Behavior

NCT01447602
View directory record Official record
Conditions
Unipolar Depression, Dysthymia
Interventions
IPT-A
Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
12 Years to 19 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 4, 2014 · Synced Oct 20, 2026, 1:04 PM EDT
Recruiting Phase 4 Interventional

The Effects of Lumateperone on Obesity and Physiologic Aging and Their Association With Antidepressant Response in Bipolar Depression

NCT07699445
View directory record Official record
Conditions
Bipolar Depression Depressed Phase, Obesity & Overweight
Interventions
Lumateperone 42 mg
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 11, 2026 · Synced Oct 20, 2026, 1:04 PM EDT
Withdrawn Not applicable Interventional

A Behavioral Intervention for Depression and Chronic Pain in Primary Care (Relief-Hybrid)

NCT04290845
View directory record Official record
Conditions
Chronic Pain, Depression
Interventions
Relief-Hybrid
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
50 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
4
States / cities
New York, New York • White Plains, New York
Source: ClinicalTrials.gov public record
Updated Mar 24, 2023 · Synced Oct 20, 2026, 1:04 PM EDT
Completed Not applicable Interventional Results available

African American Knowledge Optimized for Mindfully Healthy Adolescents

NCT00578318
View directory record Official record
Conditions
Depression
Interventions
Motivational Interviewing Active
Behavioral
Lead sponsor
Georgetown University
Other
Eligibility
11 Years to 17 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 17, 2013 · Synced Oct 20, 2026, 1:04 PM EDT
Terminated Not applicable Interventional

Nu-V3 Non-Invasive Nerve Stimulation Device Trial for Chronic Pain, Anxiety, Depression, Sleeplessness

NCT05335980
View directory record Official record
Conditions
Chronic Pain, Anxiety, Depression, Sleeplessness
Interventions
Nu-V3
Device
Lead sponsor
Nu-Life Solutions
Industry
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Apr 20, 2022 · Synced Oct 20, 2026, 1:04 PM EDT
Completed Phase 4 Interventional

Effectiveness of Ketamine for Depression and Suicidal Ideation in the Emergency Department

NCT04266288
View directory record Official record
Conditions
Depression, Depression Severe, Depression Acute, Depression and Suicide, Suicidal Ideation
Interventions
Ketamine, Sodium Chloride 0.9%
Drug
Lead sponsor
MercyOne Des Moines Medical Center
Other
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Des Moines, Iowa
Source: ClinicalTrials.gov public record
Updated Sep 1, 2020 · Synced Oct 20, 2026, 1:04 PM EDT
Completed Not applicable Interventional Results available

Stress in Inflammatory Bowel Disease

NCT05202418
View directory record Official record
Conditions
Inflammatory Bowel Diseases, Psychological
Interventions
Biofeedback Enhanced Treatment
Behavioral
Lead sponsor
Emory University
Other
Eligibility
13 Years to 18 Years
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
3
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 22, 2025 · Synced Oct 20, 2026, 1:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Games to Overcome Late Life Depression

NCT02229188
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Problem Solving Therapy, Evolution, Words
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
60 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2018
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 19, 2018 · Synced Oct 20, 2026, 1:04 PM EDT
Completed Not applicable Interventional

Youth Partners in Care: Depression and Quality Improvement

NCT02030782
View directory record Official record
Conditions
Depression
Interventions
Quality Improvement (QI) for depression, Usual Care
Other
Lead sponsor
Agency for Healthcare Research and Quality (AHRQ)
Federal
Eligibility
13 Years to 21 Years
Enrollment
418 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2003
U.S. locations
5
States / cities
Los Angeles, California • Venice, California • Ventura, California + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 9, 2014 · Synced Oct 20, 2026, 1:04 PM EDT
Terminated Phase 4 Interventional Results available

Study on Allopregnanolone and Depression in Perimenopausal Women

NCT05329779
View directory record Official record
Conditions
Depression
Interventions
brexanolone, placebo
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
40 Years to 60 Years · Female only
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Oct 20, 2026, 1:04 PM EDT
Completed Phase 4 Interventional Results available

A Study of Infliximab for Treatment Resistant Major Depression

NCT00463580
View directory record Official record
Conditions
Depression
Interventions
Infliximab, Placebo
Drug
Lead sponsor
Emory University
Other
Eligibility
25 Years to 60 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 8, 2025 · Synced Oct 20, 2026, 1:04 PM EDT
Completed Not applicable Interventional

Treatment for Depression Among HIV-Infected Youth

NCT01049789
View directory record Official record
Conditions
HIV, Depression, HIV Infections
Interventions
COMB - Combination Cognitive Behavioral Therapy and Medication Management, TAU - Treatment as Usual
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
16 Years to 24 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
4
States / cities
Tampa, Florida • The Bronx, New York • Philadelphia, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 28, 2017 · Synced Oct 20, 2026, 1:04 PM EDT
Active, not recruiting Phase 4 Interventional Accepts healthy volunteers

A Comparison of Prolonged Exposure Therapy, Pharmacotherapy, and Their Combination for PTSD

NCT04961190
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Prolonged Exposure Therapy, Pharmacotherapy with paroxetine or venlafaxine XR
Behavioral · Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 75 Years
Enrollment
304 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
7
States / cities
Birmingham, Alabama • Menlo Park, California • San Diego, California + 4 more
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Oct 20, 2026, 1:04 PM EDT
Completed No phase listed Observational

Neuroimaging Studies of the Treatment of Bipolar Depression With Citalopram

NCT01639482
View directory record Official record
Conditions
Bipolar Depression
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 64 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 7, 2019 · Synced Oct 20, 2026, 1:04 PM EDT
Completed Not applicable Interventional Results available

Intervention for Veterans With Depression, Substance Disorder, and Trauma

NCT00958217
View directory record Official record
Conditions
Depressive Symptoms, Substance-related Disorders, Posttraumatic Stress Disorders
Interventions
Cognitive Processing Therapy-Modified (CPT-M), Integrated Cognitive Behavioral Therapy (ICBT)
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
154 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 24, 2016 · Synced Oct 20, 2026, 1:04 PM EDT
Completed Not applicable Interventional

Use of Psychologist-administered Cognitive Behavioral Therapy (CBT) or Self-administered CBT for the Treatment of Anxiety and/or Depression in Inflammatory Bowel Disease (IBD)

NCT05377840
View directory record Official record
Conditions
Crohn Disease, Ulcerative Colitis (UC)
Interventions
Psychologist-administered Cognitive Behavioral Therapy, Self-Administered Cognitive Behavioral Therapy
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 12, 2026 · Synced Oct 20, 2026, 1:04 PM EDT
Completed No phase listed Observational

Antidepressant Safety in Kids Study

NCT00395213
View directory record Official record
Conditions
Anxiety Disorders, Depressive Disorders, Eating Disorders, Obsessive Compulsive Disorder
Interventions
Selective serotonin reuptake inhibitor (SSRI) and serotonin-norepinephrine reuptake inhibitor (SNRI) medications
Drug
Lead sponsor
Duke University
Other
Eligibility
7 Years to 17 Years
Enrollment
569 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 17, 2015 · Synced Oct 20, 2026, 1:04 PM EDT
Completed Phase 1Phase 2 Interventional

Allogeneic Human Mesenchymal Stem Cell Infusion vs Placebo in Alcohol Use Disorder and Major Depression.

NCT03265808
View directory record Official record
Conditions
Major Depressive Disorder, Alcohol Use Disorder
Interventions
allogeneic human mesenchymal stem cells (allo-hMSCs), Placebo
Drug
Lead sponsor
Ihsan M Salloum, MD, MPH
Other
Eligibility
18 Years to 75 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
1
States / cities
Harlingen, Texas
Source: ClinicalTrials.gov public record
Updated Jan 9, 2026 · Synced Oct 20, 2026, 1:04 PM EDT
Recruiting Phase 2 Interventional

Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression

NCT06511908
View directory record Official record
Conditions
Suicide, Depressive Disorder, Treatment-Resistant, Ketamine, Molecular Mechanisms of Pharmacological Action, Neurotransmitter Agents, Excitatory Amino Acid Agents, Physiological Effects of Drugs, Depressive Disorder, Major, Depressive Disorder, Depression, Mental Disorders, Mood Disorders, Behavioral Symptoms
Interventions
(2R,6R)-hydroxynorketamine (0.25 to 2.0 mg/kg), Placebo
Drug
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 70 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 5, 2026 · Synced Oct 20, 2026, 1:04 PM EDT
Completed Not applicable Interventional Results available

A Pilot Study on Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment of Bipolar Depression

NCT00699218
View directory record Official record
Conditions
Mood Disorder, Bipolar Disorder, Major Depression, Depression
Interventions
Magnetic Stimulator Rapid2 made by Magstim Company Ltd. U.K.
Device
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Jul 23, 2018 · Synced Oct 20, 2026, 1:04 PM EDT
Recruiting Not applicable Interventional

Telehealth Music Therapy for Adults With Endocrine Disorder and Depression

NCT07413874
View directory record Official record
Conditions
Type 1 Diabetes, Hashimoto Disease, Graves Disease, Addison Disease, Autoimmune Polyglandular Syndrome Type III, Depression, Endocrine System Diseases
Interventions
Telehealth Resource Oriented Music Therapy
Behavioral
Lead sponsor
Appalachian State University
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Boone, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 30, 2026 · Synced Oct 20, 2026, 1:04 PM EDT
Recruiting Not applicable Interventional

Personalized Mobile Cognitive Behavioral Therapy Application

NCT05699525
View directory record Official record
Conditions
Anxiety Disorders and Symptoms, Depression, Bipolar Disorder, Symptoms
Interventions
Personalized MAYA Mobile App, General MAYA Mobile App
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 25 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Oct 20, 2026, 1:04 PM EDT
Completed Phase 1 Interventional

Magnetic Stimulation for Parkinson Disease

NCT00029276
View directory record Official record
Conditions
Parkinson's Disease, Depression
Interventions
Prefrontal transcranial magnetic brain stimulation
Procedure
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
40 Years to 75 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2005
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 18, 2006 · Synced Oct 20, 2026, 1:04 PM EDT