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ClinicalTrials.gov public records Last synced Oct 27, 2026, 11:08 AM EDT

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Showing 1585–1608 of 3,104 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Treatment of depression Clear all
Recruiting Not applicable Interventional

Annual Wellness Visits vs GRACE-augmented Annual Wellness Visits For Older Adults With High Needs - Phase 2

NCT07166861
View directory record Official record
Conditions
Aging, Preventive Care, Multimorbidity, Palliative Care
Interventions
Annual Wellness Visit, Annual Wellness Visits + Geriatric Resources and Assessment for the Care of Elders (AWV + GRACE)
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
7,140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
4
States / cities
Derby, Connecticut • Boston, Massachusetts • Winston-Salem, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 6, 2026 · Synced Oct 27, 2026, 11:08 AM EDT
Not listed Phase 3 Interventional

Telemedicine or Standard Care in Treating Patients With Depression and/or Pain Caused By Cancer

NCT00313573
View directory record Official record
Conditions
Depression, Pain, Unspecified Adult Solid Tumor, Protocol Specific
Interventions
management of therapy complications, pain therapy, psychosocial assessment and care, quality-of-life assessment
Procedure
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
480 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2006
U.S. locations
17
States / cities
Anderson, Indiana • Bedford, Indiana • Columbus, Indiana + 8 more
Source: ClinicalTrials.gov public record
Updated Sep 20, 2013 · Synced Oct 27, 2026, 11:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Psychotherapy on Stress Biochemistry: An RCT of Psychotherapy and Emotional Freedom Techniques (EFT)

NCT00641394
View directory record Official record
Conditions
Stress, Depression, Anxiety
Interventions
Psychotherapy: Emotional Freedom Techniques (EFT), Cognitive Behavioral Therapy (CBT)
Behavioral
Lead sponsor
Soul Medicine Institute
Other
Eligibility
18 Years to 75 Years
Enrollment
83 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Santa Rosa, California
Source: ClinicalTrials.gov public record
Updated Apr 25, 2018 · Synced Oct 27, 2026, 11:08 AM EDT
Terminated Not applicable Interventional

Feasibility of a Technology-Based Treatment Support System

NCT03121937
View directory record Official record
Conditions
Depression, Depressive Disorder, Major
Interventions
Mobile App
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Arlington Heights, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 10, 2018 · Synced Oct 27, 2026, 11:08 AM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Neurofunctional and Neurochemical Markers of Treatment Response in Bipolar Disorder

NCT00608075
View directory record Official record
Conditions
Bipolar I Disorder
Interventions
Lithium
Drug
Lead sponsor
University of Cincinnati
Other
Eligibility
15 Years to 55 Years
Enrollment
260 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2017
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 6, 2016 · Synced Oct 27, 2026, 11:08 AM EDT
Completed Not applicable Interventional Results available

Bright Start Study

NCT05356130
View directory record Official record
Conditions
Depression
Interventions
Written Educational Material on BLT, Enhanced BLT Encouragement and Adherence Promotion
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years to 69 Years
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jun 6, 2025 · Synced Oct 27, 2026, 11:08 AM EDT
Completed No phase listed Observational

Genetic Susceptibility to Radiation-Induced Skin Reactions in Racial/Ethnic Groups of Patients With Breast Cancer

NCT01407770
View directory record Official record
Conditions
Breast Cancer, Cognitive Ability, General, Fatigue, Pain, Psychosocial Deprivation, Radiation Toxicity, Skin Abnormalities
Interventions
DNA analysis, gene expression analysis, enzyme-linked immunosorbent assay, flow cytometry, laboratory biomarker analysis, questionnaire administration, adjuvant therapy, assessment of therapy complications, quality-of-life assessment, 3-dimensional conformal radiation therapy, breast irradiation, external beam radiation therapy, hypofractionated radiation therapy, intensity-modulated radiation therapy, whole breast irradiation
Genetic · Other · Procedure + 1 more
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older · Female only
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 28, 2023 · Synced Oct 27, 2026, 11:08 AM EDT
Completed Phase 3 Interventional Results available

Study of the Safety and Efficacy of Fixed Dose OPC-34712 as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder (the Pyxis Trial)

NCT01360645
View directory record Official record
Conditions
Depressive Disorder, Depression, Depressive Disorder, Major, Mood Disorders, Mental Disorders
Interventions
OPC-34712 + ADT, Placebo + ADT
Drug
Lead sponsor
Otsuka Pharmaceutical Development & Commercialization, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
826 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
37
States / cities
Arcadia, California • Beverly Hills, California • Fresno, California + 34 more
Source: ClinicalTrials.gov public record
Updated Nov 26, 2015 · Synced Oct 27, 2026, 11:08 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Evaluation of Geriatric Assessment and Management for Older Adults With Non-small Cell Lung Cancer Receiving Chemotherapy Radiation Therapy

NCT06139627
View directory record Official record
Conditions
Lung Non-Small Cell Carcinoma, Stage III Lung Cancer AJCC v8
Interventions
Best Practice, Biospecimen Collection, Communication Intervention, Comprehensive Geriatric Assessment, Electronic Health Record Review, Survey Administration
Other · Procedure
Lead sponsor
City of Hope Medical Center
Other
Eligibility
60 Years and older
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2031
U.S. locations
3
States / cities
Duarte, California • Rochester, New York • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Oct 27, 2026, 11:08 AM EDT
Completed Not applicable Interventional

Effectiveness of Telepsychiatry-based Culturally Sensitive Collaborative Treatment of Depressed Chinese Americans

NCT00854542
View directory record Official record
Conditions
Depression
Interventions
Telepsychiatry-based Culturally Sensitive Collaborative Treatment
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
241 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 1, 2016 · Synced Oct 27, 2026, 11:08 AM EDT
Completed Phase 3 Interventional Results available

Efficacy and Safety Study of Seroquel SR in the Treatment of Major Depressive Disorder

NCT00388973
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Quetiapine
Drug
Lead sponsor
AstraZeneca
Industry
Eligibility
66 Years and older
Enrollment
338 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
13
States / cities
Birmingham, Alabama • San Diego, California • Fort Myers, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated Apr 1, 2010 · Synced Oct 27, 2026, 11:08 AM EDT
Completed Not applicable Interventional

Moderate Physical Activity in Helping Patients Recover Physically and Emotionally From Stage II Or Stage III Colorectal Cancer

NCT00373022
View directory record Official record
Conditions
Anxiety Disorder, Colorectal Cancer, Depression, Psychosocial Effects of Cancer and Its Treatment
Interventions
exercise intervention, flow cytometry, laboratory biomarker analysis, management of therapy complications, psychosocial assessment and care, quality-of-life assessment
Behavioral · Other · Procedure
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated May 27, 2010 · Synced Oct 27, 2026, 11:08 AM EDT
Completed Phase 2 Interventional Results available

Telephone Administered Psychotherapy for the Treatment of Depression for Veterans in Rural Areas

NCT00223652
View directory record Official record
Conditions
Depressive Disorder, Depression
Interventions
Telephone cognitive behavioral therapy
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
3
States / cities
San Francisco, California • Hines, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 24, 2015 · Synced Oct 27, 2026, 11:08 AM EDT
Completed Not applicable Interventional Results available

Reducing the Burden of Depression Related Disability

NCT02111811
View directory record Official record
Conditions
Depression
Interventions
Veterans Work and Health Initiative
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
253 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
2
States / cities
Coatesville, Pennsylvania • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 28, 2020 · Synced Oct 27, 2026, 11:08 AM EDT
Completed Phase 3 Interventional Results available

A Study to Evaluate the Efficacy, Safety, and Tolerability of Fixed Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant Depression

NCT02417064
View directory record Official record
Conditions
Treatment-resistant Depression
Interventions
Esketamine, Placebo, Duloxetine (Oral Antidepressant), Escitalopram (Oral antidepressant), Sertraline (Oral Antidepressant), Venlafaxine Extended Release (XR) (Oral Antidepressant)
Drug
Lead sponsor
Janssen Research & Development, LLC
Industry
Eligibility
18 Years to 64 Years
Enrollment
346 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
37
States / cities
Birmingham, Alabama • Little Rock, Arkansas • Garden Grove, California + 34 more
Source: ClinicalTrials.gov public record
Updated Apr 29, 2025 · Synced Oct 27, 2026, 11:08 AM EDT
Completed Phase 4 Interventional Results available

Identifying and Treating Depression in Hemodialysis Patients

NCT03390933
View directory record Official record
Conditions
Depression, Hemodialysis-Induced Symptom
Interventions
Fluoxetine
Drug
Lead sponsor
MetroHealth Medical Center
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 17, 2024 · Synced Oct 27, 2026, 11:08 AM EDT
Not yet recruiting No phase listed Observational

REWIRE: Real-world Engagement With Interventional and Rejoyn Effectiveness

NCT07792252
View directory record Official record
Conditions
Major Depressive Disorder (MDD)
Interventions
Rejoyn, Cognitive Behavioral Therapy (CBT) exercises
Device · Behavioral
Lead sponsor
Yale University
Other
Eligibility
22 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
Greenwich, Connecticut • New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Oct 27, 2026, 11:08 AM EDT
Recruiting Phase 4 Interventional

Identifying and Treating Depression in the Orthopaedic Trauma Population

NCT05976347
View directory record Official record
Conditions
Depression
Interventions
Fluoxetine 20 MG, Duloxetine 30 MG, Observation
Drug · Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Oct 27, 2026, 11:08 AM EDT
Active, not recruiting No phase listed Observational

Investigating the Impact of Proactive Palliative Care

NCT03667378
View directory record Official record
Conditions
Metastatic Solid Tumor Cancers, Locally Advanced Solid Tumor Cancers
Interventions
Expectations Survey (CanCORS), Values Survey (Serious Illness Care Program), Functional Assessment of Cancer Therapy-General (FACT-G), NCCN Distress Thermometer, Hospital Anxiety and Depression Scale (HADS), Quality of Communication (QOC), visits with a supportive care clinician
Behavioral
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 5, 2026 · Synced Oct 27, 2026, 11:08 AM EDT
Completed Phase 2 Interventional Results available

Pilot Study of Open-label Placebo to Treat Major Depressive Disorder

NCT01103271
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Open-label Placebo
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 60 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 14, 2013 · Synced Oct 27, 2026, 11:08 AM EDT
Terminated Phase 2 Interventional Results available

Salicylic Augmentation in Depression

NCT03152409
View directory record Official record
Conditions
Depression, Depressive Disorder, Major Depressive Disorder, Treatment Resistant Depression
Interventions
Aspirin 325mg, Placebo Oral Tablet
Drug
Lead sponsor
Jessica Harder
Other
Eligibility
18 Years to 65 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 31, 2024 · Synced Oct 27, 2026, 11:08 AM EDT
Terminated Not applicable Interventional Results available

Bright Light Therapy for Depression Symptoms in Adults With Cystic Fibrosis (CF) and COPD

NCT04921332
View directory record Official record
Conditions
Cystic Fibrosis, Depressive Symptoms, Chronic Obstructive Pulmonary Disease
Interventions
Bright Light Therapy (BLT) Lamp
Device
Lead sponsor
Erica Osborn
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 28, 2023 · Synced Oct 27, 2026, 11:08 AM EDT
Terminated Phase 3 Interventional Accepts healthy volunteers

Efficacy Study of Lisdexamfetamine to Treat Bipolar Depression

NCT01093963
View directory record Official record
Conditions
Bipolar Depression
Interventions
Lisdexamfetamine, Placebo
Drug
Lead sponsor
Lindner Center of HOPE
Other
Eligibility
18 Years to 55 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
Mason, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 2, 2015 · Synced Oct 27, 2026, 11:08 AM EDT
Completed Phase 2 Interventional Results available

Treatment of Depression in Parkinson's Disease Trial

NCT00062738
View directory record Official record
Conditions
Parkinson Disease, Depression
Interventions
paroxetine, Nortriptyline, placebo
Drug · Other
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
35 Years to 80 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2009
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Nov 24, 2015 · Synced Oct 27, 2026, 11:08 AM EDT