Study of the Safety and Efficacy of Fixed Dose OPC-34712 as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder (the Pyxis Trial)
Public ClinicalTrials.gov record NCT01360645. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Trial of the Safety and Efficacy of Fixed Dose OPC-34712 as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder, the Pyxis Trial
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
To compare the effect of OPC-34712 (brexpiprazole) to the effect of placebo (an inactive substance) as add on treatment to an assigned FDA approved antidepressant treatment (ADT) in patients with Major Depressive Disorder who demonstrate an incomplete response to a prospective trial of the same assigned FDA approved ADT
Study identification
- NCT ID
- NCT01360645
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 826 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 2011 (Type not available)
- Primary completion
- May 2013 (Actual)
- Completion
- Jun 2013 (Actual)
- Last update posted
- Nov 26, 2015
2011 – 2013
United States locations
- U.S. sites
- 37
- U.S. states
- 18
- U.S. cities
- 37
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Arcadia | California | — | — |
| Research Site | Beverly Hills | California | — | — |
| Research Site | Fresno | California | — | — |
| Research Site | Oceanside | California | — | — |
| Research Site | San Diego | California | — | — |
| Research Site | San Francisco | California | — | — |
| Research Site | Sherman Oaks | California | — | — |
| Research Site | Denver | Colorado | — | — |
| Research Site | Norwalk | Connecticut | — | — |
| Research Site | Coral Springs | Florida | — | — |
| Research Site | Fort Myers | Florida | — | — |
| Research Site | Hialeah | Florida | — | — |
| Research Site | Jacksonville | Florida | — | — |
| Research Site | Melbourne | Florida | — | — |
| Research Site | Orlando | Florida | — | — |
| Research Site | Indianapolis | Indiana | — | — |
| Research Site | Prairie Village | Kansas | — | — |
| Research Site | Wichita | Kansas | — | — |
| Research Site | New Orleans | Louisiana | — | — |
| Research Site | Shreveport | Louisiana | — | — |
| Research Site | Belmont | Massachusetts | — | — |
| Research Site | Boston | Massachusetts | — | — |
| Research Site | Lincoln | Nebraska | — | — |
| Research Site | New York | New York | — | — |
| Research Site | Rochester | New York | — | — |
| Research Site | Dayton | Ohio | — | — |
| Research Site | Toledo | Ohio | — | — |
| Research Site | Salem | Oregon | — | — |
| Research Site | Allentown | Pennsylvania | — | — |
| Research Site | Bala-Cynwyd | Pennsylvania | — | — |
| Research Site | Bridgeville | Pennsylvania | — | — |
| Research Site | Philadelphia | Pennsylvania | — | — |
| Research Site | San Antonio | Texas | — | — |
| Research Site | Murray | Utah | — | — |
| Research Site | Woodstock | Vermont | — | — |
| Research Site | Richmond | Virginia | — | — |
| Research Site | Seattle | Washington | — | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 20 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01360645, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 26, 2015 · Synced Oct 30, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01360645 live on ClinicalTrials.gov.