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ClinicalTrials.gov public records Last synced Nov 14, 2026, 9:07 PM EST

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Showing 1–24 of 41 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Trier social stress test Clear all

Conditions: Trauma, Posttraumatic Stress Disorder
Interventions: Trier Social Stress Test (TSST), No stress condition; Behavioral · Other
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 21 Years to 30 Years
Enrollment: 197 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2016
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Depression in Adolescence
Interventions: Trier Social Stress Test (TSST); Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 14 Years to 21 Years
Enrollment: 160 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Mitochondrial Diseases
Interventions: Trier social stress test; Behavioral
Lead sponsor: Columbia University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 110 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2024
U.S. locations: 1
States / cities: New York, New York

Conditions: Borderline Personality Disorder (BPD), Healthy Controls Group - Age and Sex-matched
Interventions: Stress Induction; Behavioral
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years to 45 Years
Enrollment: 76 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Stress Response
Interventions: Transcutaneous Vagus Nerve Stimulation (tVNS), Evaluative Stress Task; Device · Behavioral
Lead sponsor: University of Florida; Other
Eligibility: 18 Years to 65 Years
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Pregnancy Related, Stress, Psychological, Glucose Intolerance During Pregnancy, Emotional Stress, Postprandial Hyperglycemia, Insulin Sensitivity/Resistance
Interventions: Psychosocial stress, Control non-stress; Behavioral
Lead sponsor: University of California, Irvine; Other
Eligibility: 18 Years to 40 Years · Female only
Enrollment: 113 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2024
U.S. locations: 2
States / cities: Irvine, California • Orange, California

Conditions: Social Stress
Interventions: Trier Social Stress Test (TSST); Behavioral
Lead sponsor: Massachusetts Institute of Technology; Other
Eligibility: 18 Years to 55 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Cambridge, Massachusetts

Conditions: Adverse Childhood Experience, Endothelial Function (FMD), Endothelial Injury, Mitochondrial Function, Oxidative Stress, Psychosocial Influence on Cardiovascular Disease
Interventions: Mitoquinone mesylate (MitoQ), Placebo; Dietary Supplement
Lead sponsor: University of Iowa; Other
Eligibility: 18 Years to 29 Years
Enrollment: 300 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Anxiety, Depression
Interventions: Laboratory Biomarker Analysis, Physiologic Testing, Questionnaire Administration; Other
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 163 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2016
U.S. locations: 2
States / cities: Winston-Salem, North Carolina

Conditions: Psychological Stress, Social Interaction
Interventions: Stress, Social Context; Other
Lead sponsor: University of Washington; Other
Eligibility: 21 Years to 50 Years
Enrollment: 160 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Pregnancy Related, Stress, Psychological, Glucose Intolerance During Pregnancy
Interventions: Trier Social Stress Test, Placebo Non-stress task; Behavioral
Lead sponsor: University of California, Irvine; Other
Eligibility: 18 Years to 40 Years · Female only
Enrollment: 38 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: Orange, California

Conditions: Cannabis Use Disorders
Interventions: Stress + cue exposure, No stress + cue exposure; Other
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 65 Years
Enrollment: 87 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Anxiety
Interventions: Trier Social Stress Test; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 11 Years to 34 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Migraine Headache
Interventions: Stress, Fasting; Behavioral · Other
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Anxiety, Adolescent Development, Substance Use
Interventions: Trier Social Stress Test; Behavioral
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 12 Years to 14 Years
Enrollment: 180 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2030
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Adolescent Development, Stress, Emotional Disturbances
Interventions: Trier Social Stress Test, Emotional go/no-go task; Behavioral
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 11 Years to 14 Years · Female only
Enrollment: 53 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Smoking, Smoking Behaviors, Smoking Cessation, Stress Reaction
Interventions: Not listed
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 18 Years to 75 Years · Male only
Enrollment: 92 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 2
States / cities: Los Angeles, California • Charleston, South Carolina

Conditions: Anhedonia, Stress Response, Adolescent Development
Interventions: Montreal Imaging Stress Task, Trier Social Stress Test for Children; Behavioral
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 13 Years to 15 Years
Enrollment: 192 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2030
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Chronic Kidney Disease
Interventions: Racialized Stressful Event Recall, Non-Racialized Stressful Event Recall; Behavioral
Lead sponsor: Emory University; Other
Eligibility: 25 Years to 65 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Cannabis Use
Interventions: Trier Social Stress Task (TSST); Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 50 Years to 80 Years
Enrollment: 47 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: OCD, Obsessive-Compulsive Disorder
Interventions: Provocation OC task (Provoc), Trier Social Stress Test (TSST), Exposure provocation task; Behavioral
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 21 Years to 70 Years
Enrollment: 27 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2027
U.S. locations: 3
States / cities: Pittsburgh, Pennsylvania • Providence, Rhode Island • Houston, Texas

Conditions: Stress, Eating Behavior
Interventions: Acute Laboratory Stressor, Low affect video; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 14 Years to 19 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Stress, Mental Stress
Interventions: Melatonin 3 MG Oral Tablet, Placebo Oral Tablet; Dietary Supplement
Lead sponsor: Baylor University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 16 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Waco, Texas

Conditions: Blood Pressure, Inflammation, Catecholamines
Interventions: Trier social stress test, Diesel exhaust; Behavioral · Other
Lead sponsor: University of Washington; Other
Eligibility: 22 Years to 49 Years
Enrollment: 22 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Seattle, Washington

Search by objective public record fields.

Stress-induced Drinking in Emerging Adults: the Role of Trauma History

Inflammatory and Glutamatergic Mechanisms of Sustained Threat in Adolescents With Depression

Mitochondrial Stress, Brain Imaging, and Epigenetics

Affect-based Impulsivity in Borderline Personality Disorder

Transcutaneous Vagus Nerve Stimulation (tVNS) and Stress Regulation During Performance Tasks

Emotion-Diet Interactions in Pregnancy

Investigating the Effects of Social Stress on Brain Imaging

Probing the Role of Mitochondrial Oxidative Stress in Impaired Vascular Function Among Young Adults With Early Life Adversity

Stress and Coping in Caregivers of Younger Patients With Cancer

Exploring the Decision to Drink (More) Alcohol Following Manipulations of Stress and Social Context

Maternal Emotions and Diet in Pregnancy

Stress and Marijuana Cue-elicited Craving and Reactivity

Examining Cortisol and Alpha Amylase in a Healthy Sample of Youth and Adults

Acute Stress Response in Migraine Sufferers

Adverse Adolescent Pathways to Substance Use

Neurophysiology, Estrogen, and Stress Exposure in the Emergence of Depression in Adolescent Girls

Translational Research Center in Lung Cancer Disparities (TRACER) Project 2

Stress Trajectories and Anhedonia in Adolescence Research Study

Stress and CKD Among African Americans

Stress-Reactivity and Cannabis Use in Cannabis-Using Older Adults

Measuring Automated Behavioral Observations & Vocal Expressions (ABOVE)

Stress Reactivity Study in Adolescents

Influence of Melatonin on Cardiovascular and Thermoregulatory Responses to Stress

Mental Stress & Diesel Exhaust on Cardiovascular Health