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Showing 1–24 of 29 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Ultra-processed diet Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Ultra-Processed Foods and Executive Function

NCT06518863
View directory record Official record
Conditions
Diet Habit
Interventions
Education
Behavioral
Lead sponsor
Oklahoma State University
Other
Eligibility
18 Years to 55 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Stillwater, Oklahoma
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Sep 5, 2026, 4:41 AM EDT
Recruiting No phase listed Observational

Dietary Tracking in Heart Failure

NCT07649148
View directory record Official record
Conditions
Heart Failure, NYHA Class II Heart Failure, NYHA Class III Heart Failure
Interventions
Limiting Ultraprocessed Food (UPF) in Diet
Behavioral
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2040
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Sep 5, 2026, 4:41 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Metabolomics-Driven Insights Into Ultra-Processed Foods

NCT07717970
View directory record Official record
Conditions
Diet, Food and Nutrition
Interventions
UPF Test Diet A: Starchy, refined grains, UPF Test Diet B: Meat, fish, and bread products, UPF Diet C: Dairy products, including cheese and cream
Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
20 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2027 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 20, 2026 · Synced Sep 5, 2026, 4:41 AM EDT
Recruiting Not applicable Interventional

Ultra Crave: An Investigation of Ultra-Processed Food

NCT06044285
View directory record Official record
Conditions
Food Addiction
Interventions
Low UP (meals provided), Low UP (self-guided), Active Control
Other
Lead sponsor
University of Michigan
Other
Eligibility
22 Years to 60 Years
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Sep 5, 2026, 4:41 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Ultra-processed Food Consumption and Health Pilot Study

NCT07318064
View directory record Official record
Conditions
Obesity & Overweight
Interventions
Purple Diet, Ultra-processed diet
Behavioral
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
18 Years to 50 Years
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Jun 28, 2026 · Synced Sep 5, 2026, 4:41 AM EDT
Not yet recruiting Not applicable Interventional

Tailored Anti-Inflammatory American Diet for Patients With Crohn's Disease

NCT07671872
View directory record Official record
Conditions
Crohn's Disease, Active, Crohn's Disease (CD), Diet Interventions
Interventions
Catered Anti-Inflammatory Diet, Diet Guidance for Usual Diet
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
16 Years to 75 Years
Enrollment
122 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Sep 5, 2026, 4:41 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Early Introduction and Sustained Ingestion (EISI) Using Two Educational Opportunities in Infants

NCT07321522
View directory record Official record
Conditions
Food Allergy
Interventions
Education and Opportunities on Early Introduction, Clinician Supervised Feeding of Known Allergenic Food
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
4 Months to 11 Months
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Sep 5, 2026, 4:41 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Effect of Isocaloric Ultra Processed Versus Unprocessed Diets on Insulin Sensitivity

NCT03189121
View directory record Official record
Conditions
Obesity
Interventions
Not listed
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years to 50 Years · Male only
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 9, 2019 · Synced Sep 5, 2026, 4:41 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Dietary Guidelines for Americans-Ultra Processed Study

NCT07252037
View directory record Official record
Conditions
Overweight , Obesity, Class I Obesity
Interventions
Low-processed DGA Diet, Ultra-processed DGA Diet
Other
Lead sponsor
USDA Grand Forks Human Nutrition Research Center
Federal
Eligibility
18 Years to 65 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Grand Forks, North Dakota
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Sep 5, 2026, 4:41 AM EDT
Completed Not applicable Interventional

Diet and Depression

NCT06252701
View directory record Official record
Conditions
Depression, Major Depressive Disorder, Weight Gain, Obesity, Metabolic Syndrome
Interventions
Reduction of Ultra-processed foods
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 20, 2025 · Synced Sep 5, 2026, 4:41 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Ultra-processed Food Consumption, Gut Microbiota, and Glucose Homeostasis

NCT05358171
View directory record Official record
Conditions
Insulin Sensitivity, 24-hour Glucose Control
Interventions
HIgh UPF controlled diet, No UPF controlled diet
Other
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
40 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Blacksburg, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 13, 2026 · Synced Sep 5, 2026, 4:41 AM EDT
Active, not recruiting Not applicable Interventional

Nutritional Intervention for Endometriosis

NCT05175248
View directory record Official record
Conditions
Endometriosis
Interventions
Plant-based Intervention Group
Behavioral
Lead sponsor
Physicians Committee for Responsible Medicine
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2029
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jul 22, 2026 · Synced Sep 5, 2026, 4:41 AM EDT
Recruiting Not applicable Interventional

Effects of Ultra Processed Food on Intestinal Energy Harvest

NCT06853288
View directory record Official record
Conditions
Obesity and Overweight
Interventions
Diet containing 80% ultra processed foods, Diet containing 20% ultra processed foods
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
25 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 2, 2025 · Synced Sep 5, 2026, 4:41 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Testing Ultra-processed Warning Labels in United States

NCT07533877
View directory record Official record
Conditions
Diet, Consumer Behavior, Nutrition Labeling
Interventions
Label exposure in mock-up UPF products
Behavioral
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
18 Years and older
Enrollment
7,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Sep 5, 2026, 4:41 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Highly Processed Foods and Vascular Health

NCT05628350
View directory record Official record
Conditions
Cardiovascular Diseases
Interventions
No UPF controlled diet, High UPF controlled diet
Other
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
40 Years to 65 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Blacksburg, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 21, 2026 · Synced Sep 5, 2026, 4:41 AM EDT
Recruiting Not applicable Interventional

Role of Race in Nutritional Approach in Men on ADT

NCT06682390
View directory record Official record
Conditions
Prostate Cancer Metastatic Disease
Interventions
Hypocaloric anti-inflammatory diet
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older · Male only
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
2
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Dec 14, 2025 · Synced Sep 5, 2026, 4:41 AM EDT
Recruiting Not applicable Interventional

GF-NOURISH (Gluten Free Nutrition Optimization Through Ultra-processed Food Reduction and Improved Strategies for Health)

NCT06356220
View directory record Official record
Conditions
Celiac Disease in Children, Nutrition Disorder, Child
Interventions
Gluten-Free Diet Education
Other
Lead sponsor
Boston Children's Hospital
Other
Eligibility
2 Years to 18 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Sep 5, 2026, 4:41 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Western Diet Patterns on Plasma Inflammatory and Cardio Metabolic Health Signatures in Middle-aged Adults

NCT04275843
View directory record Official record
Conditions
Healthy Diet
Interventions
Traditional Diet, Modern Diet
Dietary Supplement
Lead sponsor
Duke University
Other
Eligibility
35 Years to 60 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 12, 2022 · Synced Sep 5, 2026, 4:41 AM EDT
Completed Not applicable Interventional

You Are What You Eat: Food as a Risk Factor and a Treatment for Depression

NCT06242665
View directory record Official record
Conditions
Depression
Interventions
Low UPF Meals (Study Provided), Low UPF Nutritional Guidance, Low UPF Snacks (Study Provided)
Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 19, 2026 · Synced Sep 5, 2026, 4:41 AM EDT
Recruiting Not applicable Interventional

THREAT: Testing Harms Related to Exposure to Allergenic and Epithelial Toxins

NCT07271381
View directory record Official record
Conditions
Allergic, Inflammatory
Interventions
Environmental Exposures, Control Exposures
Other
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years to 80 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 9, 2026 · Synced Sep 5, 2026, 4:41 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Analysis of MicroBial Metabolites After Eating Refined Food

NCT04308473
View directory record Official record
Conditions
Dietary Habits
Interventions
Ultra-processed Food Meal, Whole Food Meal
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Sep 5, 2026, 4:41 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of Ultra Processed Versus Unprocessed Diets on Energy Intake

NCT03407053
View directory record Official record
Conditions
Healthy Diet
Interventions
Ultra-processed diet, Unprocessed diet
Dietary Supplement
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years to 50 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 28, 2021 · Synced Sep 5, 2026, 4:41 AM EDT
Completed Not applicable Interventional Results available

Effect of Ultra-processed Versus Unprocessed Diets on Energy Metabolism

NCT05290064
View directory record Official record
Conditions
Healthy Diet, Obesity
Interventions
Ultra-processed food, high energy density (UPF HL), Ultra-processed food, both low (UPF LL), Ultra-processed food, both high (UPF HH), Unprocessed food diet (UNF LL)
Other
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
18 Years to 60 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Sep 5, 2026, 4:41 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The UnProcessed Pantry Project (UP3)

NCT04241133
View directory record Official record
Conditions
Diet, Healthy, Diet Habit, Disease, Chronic, Health Behavior, Rural Health
Interventions
The UnProcessed Pantry Project (UP3)
Behavioral
Lead sponsor
Montana State University
Other
Eligibility
18 Years and older
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Bozeman, Montana
Source: ClinicalTrials.gov public record
Updated May 1, 2022 · Synced Sep 5, 2026, 4:41 AM EDT