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ClinicalTrials.gov public records Last synced Oct 28, 2026, 10:45 AM EDT

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Showing 1–24 of 32 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Unified Protocol (UP) Clear all
Completed Not applicable Interventional Results available

Study of a Transdiagnostic, Emotion-focused Group Intervention for Young Adults With Substance Use Disorders

NCT03315208
View directory record Official record
Conditions
Substance Use Disorders, Depression, Anxiety, Emotional Disorder, Suicidal Ideation, Suicidal and Self-injurious Behavior
Interventions
Unified Protocol (UP), Treatment as Usual (TAU)
Behavioral · Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 26 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 1, 2021 · Synced Oct 28, 2026, 10:45 AM EDT
Completed Not applicable Interventional

Exploring Two Treatments for Misophonia

NCT04198597
View directory record Official record
Conditions
Misophonia
Interventions
Unified Protocol for Transdiagnostic Treatment of Emotional Disorders, Process-based Cognitive Behavioral Therapy
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 25, 2022 · Synced Oct 28, 2026, 10:45 AM EDT
Completed Not applicable Interventional Results available

Pilot Study of Cognitive Behavioral Therapy for Anxiety and Bipolar I Disorder

NCT01892306
View directory record Official record
Conditions
Bipolar Disorder, Anxiety Disorders
Interventions
UP CBT, Treatment as usual
Behavioral · Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 12, 2017 · Synced Oct 28, 2026, 10:45 AM EDT
Completed Not applicable Interventional

Unified Protocol for Adolescents (UP-A) Change Processes

NCT03102008
View directory record Official record
Conditions
Anxiety Disorders, Depression, Obsessive-Compulsive Disorder, Adolescent - Emotional Problem, Emotional Disorder
Interventions
Unified Protocol for Emotional Disorders in Adolescents (UP-A)
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
13 Years to 17 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated Nov 27, 2018 · Synced Oct 28, 2026, 10:45 AM EDT
Completed Not applicable Interventional

Assisting Obsessive Compulsive Disorder (OCD) Patients With Discontinuing Long-term Serotonin Reuptake Inhibitors (SRIs)

NCT02103621
View directory record Official record
Conditions
Obsessive Compulsive Disorder
Interventions
Unified Protocol (UP), Taper and Monitoring (TAP-M)
Behavioral
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 75 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jun 14, 2018 · Synced Oct 28, 2026, 10:45 AM EDT
Completed Not applicable Interventional

Addressing Psychological Risk Factors Underlying Smoking Persistence in COPD Patients: The Fresh Start-II Study

NCT04646174
View directory record Official record
Conditions
Copd, Smoking Cessation, Nicotine Dependence, Tobacco Use, Cigarette Smoking
Interventions
Unified Protocol adapted for smoking cessation, American Lung Association self-management strategies for smoking cessation
Behavioral
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 29, 2023 · Synced Oct 28, 2026, 10:45 AM EDT
Recruiting Not applicable Interventional

Telemedicine-Delivered Unified Protocol for Cognitive Behavioral Therapy for Anxiety and Depression

NCT05734313
View directory record Official record
Conditions
Diabetes, Type 1 Diabetes
Interventions
Unified protocol for cognitive behavioral therapy (UP-CBT), Continuous Glucose Monitoring (CGM)
Behavioral · Device
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
18 Years to 64 Years
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
2
States / cities
Boston, Massachusetts • The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Oct 30, 2025 · Synced Oct 28, 2026, 10:45 AM EDT
Not listed Not applicable Interventional

Treatment for Youth (Ages 8 to 16 Years Old) With Misophonia (U-HEAR)

NCT04365543
View directory record Official record
Conditions
Misophonia
Interventions
Unified Protocols for Transdiagnostic Treatment of Emotional Disorders in Children and Adolescents (UP-C/A) for youth with misophonia, Psychoeducation and Relaxation Therapy (PRT)
Behavioral
Lead sponsor
University of South Florida
Other
Eligibility
8 Years to 16 Years
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
2
States / cities
Coral Gables, Florida • St. Petersburg, Florida
Source: ClinicalTrials.gov public record
Updated Apr 28, 2020 · Synced Oct 28, 2026, 10:45 AM EDT
Completed Not applicable Interventional

Integrated CBT to Improve Functioning in Veterans With Anxiety and Substance Use

NCT04871100
View directory record Official record
Conditions
Anxiety Disorder, Posttraumatic Stress Disorder, Hazardous Drinking
Interventions
Unified Protocol- Alcohol, Usual care
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 2, 2026 · Synced Oct 28, 2026, 10:45 AM EDT
Completed Not applicable Interventional Results available

Addressing Psychological Risk Factors Underlying Smoking Persistence in COPD Patients: The Fresh Start Study

NCT04043728
View directory record Official record
Conditions
Copd, Smoking Cessation, Nicotine Dependence, Tobacco Use, Cigarette Smoking
Interventions
Unified Protocol adapted for smoking cessation
Behavioral
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 17, 2021 · Synced Oct 28, 2026, 10:45 AM EDT
Completed No phase listed Observational

Youth PHP Pilot Transdiagnostic Treatment Implementation and Effectiveness Study

NCT04792151
View directory record Official record
Conditions
Emotional Disorder
Interventions
Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Children and Adolescents
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
6 Years to 85 Years
Enrollment
304 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 19, 2022 · Synced Oct 28, 2026, 10:45 AM EDT
Completed Not applicable Interventional Results available

Community Study of Outcome Monitoring for Emotional Disorders in Teens

NCT02567266
View directory record Official record
Conditions
Depression, Anxiety
Interventions
Unified Protocol for Adolescents (UP-A), Youth Outcomes Questionnaire, Treatment as Usual
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
12 Years to 18 Years
Enrollment
196 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
2
States / cities
West Hartford, Connecticut • Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated Aug 18, 2021 · Synced Oct 28, 2026, 10:45 AM EDT
Completed Not applicable Interventional

CO-PARENT: COVID-19 - Parent Action in Response to Emotions and Needs for Treatment

NCT04431856
View directory record Official record
Conditions
Anxiety, Depression, Traumatic Stress Disorder
Interventions
Unified Protocol for COVID-19 Parenting Stress (UP-COVID), SHG
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Dec 1, 2020 · Synced Oct 28, 2026, 10:45 AM EDT
Recruiting Not applicable Interventional

Unified Protocol: Community Connections

NCT06038721
View directory record Official record
Conditions
Mental Health Issue, Anxiety Disorder, Depressive Disorder, Parenting
Interventions
The Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders in Children, The Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders in Adolescents
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
7 Years to 17 Years
Enrollment
1,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Oct 28, 2026, 10:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Increasing Treatment Efficacy Using SMART Methods for Personalizing Care

NCT04642898
View directory record Official record
Conditions
Anxiety Disorders, Post Traumatic Stress Disorder, Obsessive-Compulsive Disorder
Interventions
Standard UP Treatment, Capitalization UP Treatment, Compensation UP Treatment
Behavioral
Lead sponsor
Shannon E. Sauer-Zavala
Other
Eligibility
18 Years and older
Enrollment
61 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 30, 2025 · Synced Oct 28, 2026, 10:45 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Using Machine Learning to Optimize User Engagement and Clinical Response to Digital Mental Health Interventions

NCT05567640
View directory record Official record
Conditions
Anxiety Disorders and Symptoms, Depressive Symptoms
Interventions
The Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP), Space for depression, Space for resilience
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years and older
Enrollment
1,800 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 31, 2026 · Synced Oct 28, 2026, 10:45 AM EDT
Completed Not applicable Interventional

Efficacy Evaluation of a Unified Transdiagnostic Treatment for Anxiety Disorders

NCT01243606
View directory record Official record
Conditions
Anxiety Disorders, Mood Disorders
Interventions
Single Diagnosis Treatment Protocol, Unified Protocol (UP)
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 9, 2017 · Synced Oct 28, 2026, 10:45 AM EDT
Completed Not applicable Interventional

Flourishing and Virtue in Cognitive-Behavioral Therapy for Anxiety and Depressive Disorders

NCT05120232
View directory record Official record
Conditions
Anxiety Disorders, Depressive Disorder
Interventions
Unified Protocol, Modified Unified Protocol (UP+)
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years and older
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 7, 2025 · Synced Oct 28, 2026, 10:45 AM EDT
Completed Not applicable Interventional

Project COPE (Coping Options for Parent Empowerment)

NCT04715906
View directory record Official record
Conditions
Anxiety Disorders, Depression
Interventions
UP-Caregiver
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Apr 27, 2022 · Synced Oct 28, 2026, 10:45 AM EDT
Suspended Not applicable Interventional

Stress, Anxiety, and Mood Group Therapy

NCT03855683
View directory record Official record
Conditions
Depressive Disorders, Anxiety Disorders
Interventions
Unified Protocol for The Treatment of Emotional Disorders
Behavioral
Lead sponsor
Palo Alto University
Other
Eligibility
18 Years to 50 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Los Altos, California
Source: ClinicalTrials.gov public record
Updated Sep 18, 2020 · Synced Oct 28, 2026, 10:45 AM EDT
Completed Not applicable Interventional Results available

Isolating Mechanisms in the Treatment of Borderline Personality Disorder

NCT03408860
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Countering Emotional Behaviors Module from Unified Protocol
Other
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 16, 2022 · Synced Oct 28, 2026, 10:45 AM EDT
Active, not recruiting Not applicable Interventional

Comparing Cognitive-Behavioral Therapy Versus Mindfulness-Based Therapy for Autistic Adults

NCT06060860
View directory record Official record
Conditions
Autism Spectrum Disorder, Depression, Anxiety
Interventions
Cognitive-Behavioral Therapy (CBT), Mindfulness-Based Cognitive Therapy (MBCT)
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
2
States / cities
Chapel Hill, North Carolina • Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 9, 2026 · Synced Oct 28, 2026, 10:45 AM EDT
Completed Not applicable Interventional

Exploring the Acceptability and Efficacy of a Transdiagnostic Treatment for Misophonia

NCT04612374
View directory record Official record
Conditions
Misophonia
Interventions
Unified Protocol for Transdiagnostic Treatment of Emotional Disorders, Revised Unified Protocol for Transdiagnostic Treatment of Emotional Disorders
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 16, 2022 · Synced Oct 28, 2026, 10:45 AM EDT
Completed Not applicable Interventional

A Waitlist-Controlled Trial of the Unified Protocol for the Treatment of Emotional Disorders in Adolescents

NCT00628888
View directory record Official record
Conditions
Anxiety Disorders, Depression
Interventions
Unified Protocol for Adolescents (UP-A)
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
12 Years to 18 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Dec 19, 2014 · Synced Oct 28, 2026, 10:45 AM EDT