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ClinicalTrials.gov public records Last synced Sep 6, 2026, 6:27 AM EDT

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Showing 1–24 of 26 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: VNS Control Clear all
Active, not recruiting Not applicable Interventional

Targeted Plasticity Therapy for Upper Limb Rehabilitation in Spinal Cord Injuries

NCT04288245
View directory record Official record
Conditions
Spinal Cord Injuries, Upper Extremity Paresis
Interventions
Active Vagus Nerve Stimulation, Placebo Vagus Nerve Stimulation
Device
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years to 64 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 3, 2026 · Synced Sep 6, 2026, 6:27 AM EDT
Recruiting Not applicable Interventional

A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression

NCT03887715
View directory record Official record
Conditions
Treatment Resistant Depression
Interventions
Vagus Nerve Stimulation (VNS)
Device
Lead sponsor
LivaNova
Industry
Eligibility
18 Years and older
Enrollment
6,800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2030
U.S. locations
101
States / cities
Birmingham, Alabama • Huntsville, Alabama • Burlingame, California + 85 more
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Sep 6, 2026, 6:27 AM EDT
Recruiting Not applicable Interventional

Paired Non-invasive VNS in Adolescent Cerebral Palsy Rehabilitation

NCT07394608
View directory record Official record
Conditions
Cerebral Palsy
Interventions
Non-invasive taVNS
Device
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
12 Years to 17 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 12, 2026 · Synced Sep 6, 2026, 6:27 AM EDT
Enrolling by invitation Not applicable Interventional

Vagus Nerve Stimulation (VNS) in Spinal Cord Injury (SCI) Adaptive Follow-On Study

NCT06351111
View directory record Official record
Conditions
SCI - Spinal Cord Injury
Interventions
Active VNS
Device
Lead sponsor
The University of Texas at Dallas
Other
Eligibility
18 Years to 64 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
2
States / cities
Dallas, Texas • Richardson, Texas
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Sep 6, 2026, 6:27 AM EDT
Recruiting No phase listed Observational

Vagal Nerve Stimulation in Enhanced Stroke Recovery: The VALOR Registry

NCT05694663
View directory record Official record
Conditions
Chronic Ischemic Stroke
Interventions
Vivistim
Device
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Sep 6, 2026, 6:27 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

A Study on the Immune Response and Safety of Various Potencies of an Investigational Chickenpox Vaccine Compared With a Marketed Chickenpox Vaccine, Given to Healthy Children 12 to 15 Months of Age

NCT05084508
View directory record Official record
Conditions
Chickenpox
Interventions
Investigational varicella vaccine low potency, Investigational varicella vaccine medium potency, Investigational varicella vaccine high potency, Licensed varicella vaccine Lot 1, Licensed varicella vaccine Lot 2, Measles, mumps, and rubella vaccine, Hepatitis A vaccine, 13-valent pneumococcal conjugate vaccine
Biological
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
12 Months to 15 Months
Enrollment
800 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
41
States / cities
Bryant, Arkansas • Jonesboro, Arkansas • Little Rock, Arkansas + 37 more
Source: ClinicalTrials.gov public record
Updated Feb 27, 2025 · Synced Sep 6, 2026, 6:27 AM EDT
Completed Not applicable Interventional Results available

Pivotal Study of VNS During Rehab After Stroke (VNS-REHAB)

NCT03131960
View directory record Official record
Conditions
Cerebrovascular Stroke, Upper Extremity Paresis
Interventions
Paired Vagus Nerve Stimulation, Rehabilitation
Device · Other
Lead sponsor
MicroTransponder Inc.
Industry
Eligibility
22 Years to 80 Years
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
15
States / cities
Scottsdale, Arizona • Downey, California • Santa Monica, California + 12 more
Source: ClinicalTrials.gov public record
Updated Jul 19, 2022 · Synced Sep 6, 2026, 6:27 AM EDT
Completed Not applicable Interventional

Safety and Feasibility of Paired Vagus Nerve Stimulation With Rehabilitation for Improving Upper Extremity Function in People With Cervical Spinal Cord Injury

NCT05601661
View directory record Official record
Conditions
Cervical Spinal Cord Injury
Interventions
Active VNS, Sham VNS, Arm rehabilitation
Device · Other
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 27, 2025 · Synced Sep 6, 2026, 6:27 AM EDT
Not yet recruiting Not applicable Interventional

Trans Auricular Vagal Nerve Stimulation in Patients With IBS-C

NCT07662083
View directory record Official record
Conditions
Irritable Bowel Syndrome (IBS-C)
Interventions
Transcutaneous Auricular Vagus Nerve Stimulation (ta-VNS), Sham Transcutaneous Auricular Vagus Nerve Stimulation
Device
Lead sponsor
West Virginia University
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Sep 6, 2026, 6:27 AM EDT
Recruiting Not applicable Interventional

VNS Algorithm for Advanced Dosing

NCT07725601
View directory record Official record
Conditions
Epilepsies
Interventions
Rapid Titration VNS programming, Standard VNS programming
Device
Lead sponsor
Fernando Vale
Other
Eligibility
18 Years to 75 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Sep 6, 2026, 6:27 AM EDT
Completed Not applicable Interventional Results available

Vagus Nerve Stimulation (VNS) Paired With Tones for Tinnitus

NCT01962558
View directory record Official record
Conditions
Tinnitus
Interventions
VNS Treatment, VNS Control
Device
Lead sponsor
MicroTransponder Inc.
Industry
Eligibility
22 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
3
States / cities
Iowa City, Iowa • Buffalo, New York • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Apr 5, 2018 · Synced Sep 6, 2026, 6:27 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

A Study on the Immune Response and Safety of a Combined Measles, Mumps, Rubella, Chickenpox Vaccine Compared to a Marketed Combined Vaccine, Given to Healthy Children 4 to 6 Years of Age

NCT05630846
View directory record Official record
Conditions
Measles; Mumps; Rubella; Chickenpox, Measles
Interventions
Investigational MMRV(H)NS vaccine, Investigational MM(H)RVNS vaccine, Investigational M(L)M(L)R(L)V(L)NS vaccine, Marketed MMRV_Lot 1 and Lot 2 vaccine
Biological
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
4 Years to 6 Years
Enrollment
801 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
35
States / cities
Birmingham, Alabama • Jonesboro, Arkansas • Bellflower, California + 30 more
Source: ClinicalTrials.gov public record
Updated Jun 21, 2025 · Synced Sep 6, 2026, 6:27 AM EDT
Terminated Not applicable Interventional

Paired Vagus Nerve Stimulation Mechanisms

NCT06716112
View directory record Official record
Conditions
Chronic Stroke
Interventions
Vagus Nerve Stimulation (VNS) Device, Sham VNS Device, Upper Extremity Rehabilitation
Device · Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
22 Years to 79 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
New York, New York • Richardson, Texas
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Sep 6, 2026, 6:27 AM EDT
Recruiting Phase 3 Interventional Accepts healthy volunteers

A Study on the Immune Response and Safety of an Investigational Chickenpox Vaccine and a Marketed Measles, Mumps and Rubella Vaccine When Administered as Intramuscular Injection to Healthy Children 12 to 15 Months of Age

NCT06855160
View directory record Official record
Conditions
Chickenpox
Interventions
Candidate varicella vaccine, Marketed varicella vaccine, MMR vaccine, Hepatitis A vaccine, PCV (pneumococcal conjugate vaccine) 13, PCV 20, Vaxneuvance
Biological
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
12 Months to 15 Months
Enrollment
911 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
13
States / cities
Tucson, Arizona • Huntington Park, California • Sherman Oaks, California + 10 more
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Sep 6, 2026, 6:27 AM EDT
Enrolling by invitation Not applicable Interventional

Wireless Nerve Stimulation Device To Enhance Recovery After Stroke

NCT04534556
View directory record Official record
Conditions
Stroke, Chronic Stroke, Upper Extremity Paresis, Ischemic Stroke, Hemorrhagic Stroke
Interventions
Active Vagus Nerve Stimulation, Placebo Vagus Nerve Stimulation
Device
Lead sponsor
Baylor Research Institute
Other
Eligibility
22 Years to 79 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Sep 6, 2026, 6:27 AM EDT
Recruiting Not applicable Interventional

Vagus Nerve Stimulation(VNS) As Treatment For Fibromyalgia Patients

NCT06009159
View directory record Official record
Conditions
Fibromyalgia
Interventions
Transcutaneous Vagus Nerve Stimulation
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 5, 2025 · Synced Sep 6, 2026, 6:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

VNS-supplemented Motor Retraining After Stroke

NCT04088578
View directory record Official record
Conditions
Stroke, Acute
Interventions
Training, Vagus Nerve Stimulation, Sham Stimulation
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 75 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 31, 2022 · Synced Sep 6, 2026, 6:27 AM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Microelectrode Recordings From the Vagus Nerve in Awake Humans

NCT06016686
View directory record Official record
Conditions
Epilepsy
Interventions
VNS stimulation and intraneural recordings, Record multi-unit activity from intraneural sites
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 40 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 19, 2026 · Synced Sep 6, 2026, 6:27 AM EDT
Recruiting Phase 3 Interventional Accepts healthy volunteers

A Study on the Immune Response and Safety of an Investigational Chickenpox Vaccine When Given to Healthy Children 12 to 15 Months of Age

NCT06740630
View directory record Official record
Conditions
Chickenpox
Interventions
Investigational varicella vaccine_Lot 1, Investigational varicella vaccine_Lot 2, Investigational varicella vaccine_Lot 3, Marketed varicella vaccine_Lot 1, Marketed varicella vaccine_Lot 2, MMR vaccine, Hepatitis A vaccine, PCV (pneumococcal conjugate vaccine) 13, PCV 20, Vaxneuvance
Biological
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
12 Months to 15 Months
Enrollment
1,840 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
59
States / cities
Mobile, Alabama • Hot Springs, Arkansas • Sherwood, Arkansas + 50 more
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Sep 6, 2026, 6:27 AM EDT
Recruiting Phase 3 Interventional Accepts healthy volunteers

A Study on the Safety of an Investigational Chickenpox Vaccine, When Given to Healthy Children, 12 to 15 Months of Age

NCT06693895
View directory record Official record
Conditions
Chickenpox
Interventions
Investigational varicella vaccine, Marketed varicella vaccine, Measles, mumps, and rubella vaccine, Hepatitis A vaccine, PCV (pneumococcal conjugate vaccine) 13, PCV 20, Vaxneuvance
Biological
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
12 Months to 15 Months
Enrollment
750 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
22
States / cities
Phoenix, Arizona • Tucson, Arizona • Huntington Park, California + 18 more
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Sep 6, 2026, 6:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

VNS-induced Corticospinal Plasticity

NCT04088565
View directory record Official record
Conditions
Stroke
Interventions
Paired-Associative Stimulation (PAS), Vagus Nerve Stimulation (VNS), Sham Stimulation
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 75 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 31, 2022 · Synced Sep 6, 2026, 6:27 AM EDT
Recruiting Not applicable Interventional

Transcutaneous Auricular Neurostimulation After Lumbar Surgery

NCT06100172
View directory record Official record
Conditions
Pain, Postoperative, Opioid Use, Lumbar Spine Injury
Interventions
Sparrow Ascent Transcutaneous Auricular Neurostimulation (tAN), Sham Control Device
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 14, 2025 · Synced Sep 6, 2026, 6:27 AM EDT
Not yet recruiting Not applicable Interventional

Modulating Inflammation in Neuro-Trauma

NCT07510074
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Nurosym taVNS, Nurosym (sham)
Device
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 75 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Sep 6, 2026, 6:27 AM EDT
Completed Phase 2 Interventional Results available

Transcutaneous Vagus Nerve Stimulation (tVNS) and Robotic Training to Improve Arm Function After Stroke

NCT03592745
View directory record Official record
Conditions
Stroke, Cerebrovascular Accident (CVA), Hemiparesis
Interventions
Transcutaneous Vagus Nerve Stimulation (tVNS), Sham Transcutaneous Vagus Nerve Stimulation (tVNS)
Device
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 85 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Jun 28, 2021 · Synced Sep 6, 2026, 6:27 AM EDT