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ClinicalTrials.gov public records Last synced Oct 19, 2026, 8:29 AM EDT

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Showing 1–21 of 21 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: VSL #3 Clear all
Terminated Not applicable Interventional Accepts healthy volunteers

Probiotics and the Gut Microbiome in Obese Hispanic Youth

NCT03115385
View directory record Official record
Conditions
Obesity, Abdominal, Adiposity
Interventions
VSL#3, Placebo
Dietary Supplement
Lead sponsor
University of Southern California
Other
Eligibility
12 Years to 18 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 14, 2017 · Synced Oct 19, 2026, 8:29 AM EDT
Terminated Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Safety of VSL#3 in Adult Asthmatics

NCT00852124
View directory record Official record
Conditions
Asthma
Interventions
VSL#3, VSL#3 or placebo
Biological
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 64 Years
Enrollment
3 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2013
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 20, 2023 · Synced Oct 19, 2026, 8:29 AM EDT
Terminated Phase 1Phase 2 Interventional

Effects of Probiotic on Inflammation and Microbiota in Patients With NASH

NCT03511365
View directory record Official record
Conditions
Non-Alcoholic Fatty Liver Disease, Probiotics MeSH Descriptor Data 2018, Interleukin-17 MeSH Descriptor Data 2018
Interventions
Probiotic Formulation VSL#3
Biological
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Jan 7, 2020 · Synced Oct 19, 2026, 8:29 AM EDT
Terminated Not applicable Interventional

Dose Ranging Study With the Probiotic Combination (VSL#3) in Diarrhea IBS

NCT00179582
View directory record Official record
Conditions
IBS
Interventions
VSL#3
Drug
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 27, 2019 · Synced Oct 19, 2026, 8:29 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Alcoholic Liver Disease and the Gut Microbiome

NCT05007470
View directory record Official record
Conditions
Alcohol Use Disorder, Alcoholic Liver Disease, Microbiome
Interventions
VSL #3 112.5 Capsule, Placebo
Drug · Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 6, 2025 · Synced Oct 19, 2026, 8:29 AM EDT
Terminated Phase 2Phase 3 Interventional Results available

Probiotic (VSL #3) for Gulf War Illness

NCT02011542
View directory record Official record
Conditions
Gulf War Illness
Interventions
VSL#3, Placebo
Drug
Lead sponsor
University of Utah
Other
Eligibility
35 Years to 75 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Oct 26, 2018 · Synced Oct 19, 2026, 8:29 AM EDT
Terminated Phase 1 Interventional

The Effect of a Probiotic on Hepatic Steatosis

NCT00099723
View directory record Official record
Conditions
Fatty Liver
Interventions
VSL#3
Drug
Lead sponsor
VSL Pharmaceuticals
Industry
Eligibility
45 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 11, 2010 · Synced Oct 19, 2026, 8:29 AM EDT
Completed Phase 2 Interventional Results available

Probiotic Prophylaxis of Hirschprung's Disease Associated Enterocolitis (HAEC)

NCT00630838
View directory record Official record
Conditions
Hirschsprung Disease
Interventions
VSL#3, Placebo
Drug
Lead sponsor
University of Michigan
Other
Eligibility
1 Month to 12 Months
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
2
States / cities
Ann Arbor, Michigan • Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jul 19, 2016 · Synced Oct 19, 2026, 8:29 AM EDT
Completed Phase 3 Interventional

Effect of VSL#3 on Intestinal Permeability in Pediatric Crohn's Disease

NCT00944736
View directory record Official record
Conditions
Crohn's Disease
Interventions
VSL#3, Placebo
Dietary Supplement
Lead sponsor
Children's Mercy Hospital Kansas City
Other
Eligibility
11 Years to 17 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 10, 2014 · Synced Oct 19, 2026, 8:29 AM EDT
Suspended Not applicable Interventional

Probiotics for the Prevention of Immunotherapy Induced Colitis in Patients Receiving Immunotherapy

NCT06508034
View directory record Official record
Conditions
Malignant Solid Neoplasm
Interventions
Biospecimen Collection, Live Freeze-Dried Lactic Acid Bacteria Probiotic, Questionnaire Administration
Procedure · Dietary Supplement · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 21, 2026 · Synced Oct 19, 2026, 8:29 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Gastric Acid Suppression and Probiotic Colonization

NCT03327051
View directory record Official record
Conditions
Probiotics
Interventions
Omeprazole, VSL #3, Placebo
Drug · Dietary Supplement
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 75 Years
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Mar 11, 2020 · Synced Oct 19, 2026, 8:29 AM EDT
Completed Phase 2 Interventional

A Pilot Trial to Determine the Efficacy of VSL#3 for Reducing Colonization by VRE

NCT00933556
View directory record Official record
Conditions
Anti-biotic Resistance
Interventions
VSL#3, sugar pill (placebo)
Dietary Supplement
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 8, 2015 · Synced Oct 19, 2026, 8:29 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Effects of Triphala and VSL#3 Probiotic Supplementation on Stool Microbiome Profiles and Inflammation

NCT03907501
View directory record Official record
Conditions
Human Microbiome
Interventions
Synbiotic, Probiotic, Placebo
Dietary Supplement
Lead sponsor
University of California, San Diego
Other
Eligibility
65 Years and older
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jul 6, 2023 · Synced Oct 19, 2026, 8:29 AM EDT
Terminated Phase 2 Interventional Results available

Effect of VSL#3 on Bone Mineral Density in Postmenopausal Women

NCT03165747
View directory record Official record
Conditions
Menopausal Osteoporosis
Interventions
VSL#3, Placebo
Drug · Other
Lead sponsor
Emory University
Other
Eligibility
50 Years to 65 Years · Female only
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 4, 2020 · Synced Oct 19, 2026, 8:29 AM EDT
Completed Phase 2 Interventional Results available

Study Of Dacomitinib (PF-00299804) In Advanced NSCLC Patients (Post Chemo Or Select First Line) To Evaluate Prophylactic Intervention On Derm And GI AEs And PRO

NCT01465802
View directory record Official record
Conditions
Non Small Cell Lung Cancer (NSCLC)
Interventions
Dacomitinib, Doxycycline, Probiotic, Alclometasone cream
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years and older
Enrollment
236 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
79
States / cities
Duarte, California • Fullerton, California • Irvine, California + 49 more
Source: ClinicalTrials.gov public record
Updated Jan 9, 2019 · Synced Oct 19, 2026, 8:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Modulation of Type 1 Diabetes Susceptibility Through the Use of Probiotics

NCT03423589
View directory record Official record
Conditions
Type1diabetes, Type1 Diabetes Mellitus
Interventions
VSL#3
Dietary Supplement
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
5 Years to 17 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 22, 2024 · Synced Oct 19, 2026, 8:29 AM EDT
Not listed Phase 2Phase 3 Interventional

Probiotic (Visbiome) for Gulf War Illness

NCT03078530
View directory record Official record
Conditions
Gulf War Illness
Interventions
Placebo, Visbiome, VSL#3
Drug
Lead sponsor
Ashok Tuteja
Federal
Eligibility
35 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Dec 13, 2017 · Synced Oct 19, 2026, 8:29 AM EDT
Completed Early Phase 1 Interventional

Impact of Probiotics on Oral Microbiota in Older Adults With Dysphagia

NCT03682094
View directory record Official record
Conditions
Dysphagia
Interventions
VSL#3
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
65 Years to 99 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 16, 2024 · Synced Oct 19, 2026, 8:29 AM EDT
Terminated Phase 3 Interventional

Probiotics and Recovery From Surgery

NCT01970683
View directory record Official record
Conditions
Major Abdominal Operation
Interventions
VSL #3 BID
Dietary Supplement
Lead sponsor
Catholic Health Initiatives
Other
Eligibility
18 Years to 99 Years
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Des Moines, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 25, 2017 · Synced Oct 19, 2026, 8:29 AM EDT
Terminated Phase 1 Interventional

The Use of VSL#3 in Irritable Bowel Syndrome in Children

NCT00932841
View directory record Official record
Conditions
Irritable Bowel Syndrome
Interventions
Placebo, VSL#3 900 billion bacteria, VSL#3 90 billion bacteria
Other · Drug
Lead sponsor
Dayton Children's Hospital
Other
Eligibility
13 Years to 18 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Dayton, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 20, 2012 · Synced Oct 19, 2026, 8:29 AM EDT
Completed Phase 1 Interventional

Safety Study of Probiotics in Adults With Irritable Bowel Syndrome

NCT00971711
View directory record Official record
Conditions
Irritable Bowel Syndrome
Interventions
Probiotic
Biological
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 60 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
2
States / cities
Houston, Texas • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Mar 8, 2016 · Synced Oct 19, 2026, 8:29 AM EDT