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ClinicalTrials.gov public records Last synced Oct 4, 2026, 1:02 AM EDT

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Showing 73–96 of 299 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Vagal nerve stimulation Clear all
Completed Not applicable Interventional

Non-invasive Trigeminal and Vagus Nerve Stimulation for Stroke Subjects With Chronic Upper Extremity Deficits

NCT06288217
View directory record Official record
Conditions
Upper Extremity Paresis, Stroke, Chronic
Interventions
NeuraStasis Stimulator System (Non-Invasive Trigeminal and Vagus Nerve Stimulation), Upper Limb Rehabilitation, Sham Stimulation
Device · Other
Lead sponsor
NeuraStasis, Inc
Industry
Eligibility
30 Years to 85 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Oct 4, 2026, 1:02 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Vagus Nerve Stimulation to Enhance Memory in Aging

NCT07214194
View directory record Official record
Conditions
Alzheimer Disease, Aging
Interventions
Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 80 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2027 – 2028
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Oct 9, 2025 · Synced Oct 4, 2026, 1:02 AM EDT
Active, not recruiting Phase 1 Interventional

Vagal Stimulation in POTS

NCT03124355
View directory record Official record
Conditions
Postural Tachycardia Syndrome
Interventions
placebo sugar pill, Pyridostigmine Pill, Galantamine Pill, Vagal stimulation, Sham vagal stimulation
Drug · Device
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2027
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Oct 4, 2026, 1:02 AM EDT
Completed Not applicable Interventional Results available

taVNS in Mild to Moderate Parkinson's Disease

NCT04157621
View directory record Official record
Conditions
Parkinson Disease
Interventions
Active taVNS, Sham Stimulation
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
40 Years to 79 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 25, 2023 · Synced Oct 4, 2026, 1:02 AM EDT
Withdrawn Not applicable Interventional

Investigating Accelerated Learning in Tinnitus Participants Implanted With Vagus Nerve Stimulation

NCT03143842
View directory record Official record
Conditions
VNS Implanted Tinnitus Patients
Interventions
Vagus Nerve Stimulation
Device
Lead sponsor
The University of Texas at Dallas
Other
Eligibility
18 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Richardson, Texas
Source: ClinicalTrials.gov public record
Updated Jan 28, 2022 · Synced Oct 4, 2026, 1:02 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Non-invasive Nerve Stimulation and Sleep

NCT04021537
View directory record Official record
Conditions
PTSD
Interventions
non-invasive nerve stimulation
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 55 Years
Enrollment
87 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Oct 4, 2026, 1:02 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Effects of Auricular Vagus Nerve Stimulation on the Pro-inflammatory Cytokine Response in Healthy Adults

NCT01569789
View directory record Official record
Conditions
Cytokine Response to Vagus Nerve Stimulation
Interventions
Vagus Nerve Stimulator
Device
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 60 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Apr 15, 2015 · Synced Oct 4, 2026, 1:02 AM EDT
Recruiting Phase 1 Interventional

A Study of Ear Nerve Stimulation to Treat Eye Inflammation

NCT07831876
View directory record Official record
Conditions
Ocular Inflammation, Crystalline Lens; Chalcosis, Intraocular Lens Complication
Interventions
Cymbathera One System
Device
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
7
States / cities
Basking Ridge, New Jersey • Middletown, New Jersey • Montvale, New Jersey + 4 more
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Oct 4, 2026, 1:02 AM EDT
Recruiting Not applicable Interventional

Sparrow Link Neuromodulation Device for Opioid Withdrawal Management in Hospitalized Adults With Opioid Use Disorder

NCT07079826
View directory record Official record
Conditions
Opioid Withdrawal, Opioid Use Disorder (OUD)
Interventions
Sparrow Link (Active tAN), Sparrow Link (Sham tAN)
Device
Lead sponsor
Payel Roy
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Oct 4, 2026, 1:02 AM EDT
Not yet recruiting Not applicable Interventional

Modulating Inflammation in Neuro-Trauma

NCT07510074
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Nurosym taVNS, Nurosym (sham)
Device
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 75 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jul 17, 2026 · Synced Oct 4, 2026, 1:02 AM EDT
Completed No phase listed Interventional Accepts healthy volunteers Results available

Examining Transcutaneous Vagal Nerve Stimulation as a Facilitator of Social Bonding

NCT05899413
View directory record Official record
Conditions
Vagus Nerve Stimulation
Interventions
Transcutaneous vagal nerve stimulation
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 39 Years
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 4, 2025 · Synced Oct 4, 2026, 1:02 AM EDT
Completed Not applicable Interventional Results available

Non-Invasive Neurostimulation for the Prevention of Chronic Migraine

NCT01667250
View directory record Official record
Conditions
Chronic Migraine
Interventions
GammaCore Active Device, GammaCore Sham Device
Device
Lead sponsor
ElectroCore INC
Industry
Eligibility
18 Years to 65 Years
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
6
States / cities
San Francisco, California • Ann Arbor, Michigan • Springfield, Missouri + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 20, 2018 · Synced Oct 4, 2026, 1:02 AM EDT
Recruiting Phase 1 Interventional

Using taVNS to Modulate Cardiovascular Function in Individuals With Neurologic Disease

NCT07557706
View directory record Official record
Conditions
PARKINSON DISEASE (Disorder)
Interventions
transcutaneous auricular vagus nerve stimulation
Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 80 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 18, 2026 · Synced Oct 4, 2026, 1:02 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Effect of Stimulation on the Vagus Nerve

NCT04206540
View directory record Official record
Conditions
Healthy Subjects
Interventions
Transcutaneous Auricular Vagus Nerve Stimulation, Vagal Stimulation
Device · Procedure
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2027
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 6, 2026 · Synced Oct 4, 2026, 1:02 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Vagal Nerve Stimulation to Reduce Inflammation and Hyperadrenergia

NCT02983266
View directory record Official record
Conditions
Spinal Cord Injury
Interventions
InTENsity MicroCombo
Device
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Oct 9, 2018 · Synced Oct 4, 2026, 1:02 AM EDT
Terminated Not applicable Interventional Results available

Study Assessing Vagus Nerve Stimulation in CoViD-19 Respiratory Symptoms

NCT04382391
View directory record Official record
Conditions
COVID, Corona Virus Infection, Respiratory Failure, Respiratory Distress Syndrome, Adult, ARDS, Human, SARS (Severe Acute Respiratory Syndrome)
Interventions
gammaCore® Sapphire (non-invasive vagus nerve stimulator), Standard of care therapies
Device · Other
Lead sponsor
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 1, 2024 · Synced Oct 4, 2026, 1:02 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Transcutaneous Auricular Vagus Nerve Stimulation to Enhance Motor Learning

NCT05316519
View directory record Official record
Conditions
Neurological Injury, Motor Disorders, Paresis
Interventions
Transcutaneous Vagus Nerve Stimulation
Other
Lead sponsor
VA Pittsburgh Healthcare System
Federal
Eligibility
18 Years to 75 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 9, 2024 · Synced Oct 4, 2026, 1:02 AM EDT
Active, not recruiting Not applicable Interventional

Non-Invasive Median Nerve Stimulation to Attenuate Atrial Tachyarrhythmias After Catheter Ablation for Atrial Fibrillation

NCT06748157
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
CardiaCare RR2, Sham Device
Device
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Oct 4, 2026, 1:02 AM EDT
Completed Not applicable Interventional

Non-invasive Vagus Nerve Stimulation for the Prevention of Migraines

NCT03716505
View directory record Official record
Conditions
Migraine Disorders
Interventions
gammaCore Sapphire active, gammaCore Sapphire Sham
Device
Lead sponsor
ElectroCore INC
Industry
Eligibility
18 Years to 75 Years
Enrollment
231 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
30
States / cities
Scottsdale, Arizona • Carlsbad, California • Palo Alto, California + 27 more
Source: ClinicalTrials.gov public record
Updated Sep 11, 2020 · Synced Oct 4, 2026, 1:02 AM EDT
Not yet recruiting Phase 2 Interventional

nVNS, CBD, and SoC for Persistent Post-Traumatic Headache

NCT07624279
View directory record Official record
Conditions
Persistent Post Traumatic Headache
Interventions
Non-Invasive Vagus Nerve Stimulation, Cannabidiol, Standard of Care
Device · Drug
Lead sponsor
American Society of Pain and Neuroscience, Inc.
Other
Eligibility
18 Years to 75 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
8
States / cities
Scottsdale, Arizona • Los Angeles, California • Washington D.C., District of Columbia + 5 more
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Oct 4, 2026, 1:02 AM EDT
Completed Not applicable Interventional Results available

Impact of Transcutaneous Vagal Nerve Stimulation on Stress Response in Major Depression

NCT04448327
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
active tVNS, Sham tVNS
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
50 Years to 65 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Oct 4, 2026, 1:02 AM EDT
Recruiting Not applicable Interventional

EEG Changes and DNA Markers Related to taVNS in Stroke Patients: a Preliminary Study

NCT06226493
View directory record Official record
Conditions
Stroke
Interventions
Transcutaneous vagus nerve stimulation
Device
Lead sponsor
Casa Colina Hospital and Centers for Healthcare
Other
Eligibility
18 Years to 80 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Pomona, California
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Oct 4, 2026, 1:02 AM EDT
Withdrawn Phase 2Phase 3 Interventional

Vagus Nerve Stimulation to Augment Recovery From Minimally Conscious or Persistently Vegetative States After Traumatic Brain Injury

NCT01260090
View directory record Official record
Conditions
Minimally Conscious States Due to Traumatic Brain Injury, Persistently Vegetative States Due to Traumatic Brain Injury
Interventions
Vagus nerve stimulation;, No stimulation
Device
Lead sponsor
VA New York Harbor Healthcare System
Federal
Eligibility
18 Years to 60 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 27, 2023 · Synced Oct 4, 2026, 1:02 AM EDT
Withdrawn Not applicable Interventional

Using Transcutaneous Auricular Vagus Nerve Stimulation to Treat Acute Alcohol Withdrawal

NCT04159909
View directory record Official record
Conditions
Alcohol Withdrawal, Alcohol Use Disorder
Interventions
Transcutaneous Nerve Stimulation, Sham Stimulation
Device
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Mar 13, 2024 · Synced Oct 4, 2026, 1:02 AM EDT