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ClinicalTrials.gov public records Last synced Oct 3, 2026, 10:54 AM EDT

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Showing 25–48 of 77 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Vagus Nerve Stimulation (VNS) Device Clear all
Completed Not applicable Interventional Results available

Neurostimulation for the Relief of Acute Bronchoconstriction

NCT00762931
View directory record Official record
Conditions
Asthma
Interventions
Resolve Stimulator and Proximity Lead
Device
Lead sponsor
ElectroCore INC
Industry
Eligibility
18 Years to 65 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
6
States / cities
Chicago, Illinois • Detroit, Michigan • Royal Oak, Michigan + 3 more
Source: ClinicalTrials.gov public record
Updated May 15, 2018 · Synced Oct 3, 2026, 10:54 AM EDT
Recruiting Not applicable Interventional

Auricular VNS Following Intracerebral Hemorrhage

NCT06799390
View directory record Official record
Conditions
Intracerebral Hemorrhage
Interventions
Auricular Vagus Nerve Stimulation, Sham Auricular Vagus nerve Stimulation
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2032
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Oct 3, 2026, 10:54 AM EDT
Recruiting Not applicable Interventional

VNS Prospective Neuromodulation of Immune and Gastrointestinal Systems

NCT03953768
View directory record Official record
Conditions
Autoimmune Diseases, Epilepsy, Autonomic Dysfunction, Inflammatory Bowel Diseases
Interventions
Vagal nerve stimulation (VNS)
Device
Lead sponsor
University of Louisville
Other
Eligibility
0 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
4
States / cities
Louisville, Kentucky • Houston, Texas • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Nov 25, 2024 · Synced Oct 3, 2026, 10:54 AM EDT
Recruiting Not applicable Interventional

Vagus Nerve Stimulation(VNS) As Treatment For Fibromyalgia Patients

NCT06009159
View directory record Official record
Conditions
Fibromyalgia
Interventions
Transcutaneous Vagus Nerve Stimulation
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Oct 3, 2026, 10:54 AM EDT
Completed Not applicable Interventional Results available

VNS During Rehabilitation for Improved Upper Limb Motor Function After Stroke

NCT02243020
View directory record Official record
Conditions
Stroke, Upper Limb Deficits
Interventions
Vagus Nerve Stimulation (VNS)
Device
Lead sponsor
MicroTransponder Inc.
Industry
Eligibility
30 Years to 80 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2022
U.S. locations
3
States / cities
Minneapolis, Minnesota • Dallas, Texas • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 15, 2022 · Synced Oct 3, 2026, 10:54 AM EDT
Not yet recruiting Not applicable Interventional

Closed-Loop Vagus Nerve Stimulation (CLV) for Recovery of Gait After Spinal Cord Injury (SCI)

NCT07689227
View directory record Official record
Conditions
Spinal Cord Injury (SCI), Gait, Reduced Physical Activity, Lower Limb Functions, Walking Impairment, Mobility Impairment, Functional Mobility
Interventions
CLV, Sham
Device
Lead sponsor
The University of Texas at Dallas
Other
Eligibility
18 Years to 64 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
4
States / cities
Boston, Massachusetts • Dallas, Texas • Richardson, Texas
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Oct 3, 2026, 10:54 AM EDT
Completed Not applicable Interventional Results available

Vagus Nerve Stimulation: Treatment for Gulf Veterans With Gulf War Illness

NCT02791893
View directory record Official record
Conditions
Pain, Migraine
Interventions
VNS device, Inactive device
Device
Lead sponsor
Benjamin Natelson
Other
Eligibility
42 Years to 80 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
4
States / cities
East Orange, New Jersey • New York, New York
Source: ClinicalTrials.gov public record
Updated May 3, 2021 · Synced Oct 3, 2026, 10:54 AM EDT
Not yet recruiting Not applicable Interventional

Trans Auricular Vagal Nerve Stimulation in Patients With IBS-C

NCT07662083
View directory record Official record
Conditions
Irritable Bowel Syndrome (IBS-C)
Interventions
Transcutaneous Auricular Vagus Nerve Stimulation (ta-VNS), Sham Transcutaneous Auricular Vagus Nerve Stimulation
Device
Lead sponsor
West Virginia University
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Oct 3, 2026, 10:54 AM EDT
Active, not recruiting Not applicable Interventional

Noninvasive Vagal Nerve Stimulation

NCT06816004
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
Remotely Supervised Transcranial Direct Current Stimulation (RS - tDCS), Remotely Supervised Transcutaneous Auricular Vagus Nerve Stimulation (RS - taVNS), Remotely Supervised Transcutaneous Cervical Vagus Nerve Stimulation (RS - tcVNS)
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
25 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 29, 2026 · Synced Oct 3, 2026, 10:54 AM EDT
Recruiting Not applicable Interventional

Transcutaneous Vagus Nerve Stimulation for Attention and Memory

NCT06723743
View directory record Official record
Conditions
Traumatic Brain Injury (TBI) Patients
Interventions
Transcutaneous vagus nerve stimulation for attention in veterans with TBI, Soterix Medical Vagus Nerve Stimulation mini-CT
Other · Device
Lead sponsor
Baylor College of Medicine
Other
Eligibility
25 Years to 64 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Oct 3, 2026, 10:54 AM EDT
Completed Not applicable Interventional Results available

Vagus Nerve Stimulation (VNS) Paired With Tones for Tinnitus

NCT01962558
View directory record Official record
Conditions
Tinnitus
Interventions
VNS Treatment, VNS Control
Device
Lead sponsor
MicroTransponder Inc.
Industry
Eligibility
22 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
3
States / cities
Iowa City, Iowa • Buffalo, New York • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Apr 6, 2018 · Synced Oct 3, 2026, 10:54 AM EDT
Recruiting Not applicable Interventional

A Pilot Trial of taVNS for SRNS in Children (kidNEY-VNS)

NCT05583942
View directory record Official record
Conditions
Nephrotic Syndrome in Children, Minimal Change Disease, Focal Segmental Glomerulosclerosis
Interventions
trascutaneous auricular vagus nerve stimulation, Sham device
Device
Lead sponsor
Northwell Health
Other
Eligibility
3 Years to 17 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
2
States / cities
New Hyde Park, New York • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 17, 2026 · Synced Oct 3, 2026, 10:54 AM EDT
Recruiting Not applicable Interventional

VNS Algorithm for Advanced Dosing

NCT07725601
View directory record Official record
Conditions
Epilepsies
Interventions
Rapid Titration VNS programming, Standard VNS programming
Device
Lead sponsor
Fernando Vale
Other
Eligibility
18 Years to 75 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 24, 2026 · Synced Oct 3, 2026, 10:54 AM EDT
Completed Phase 3 Interventional Results available

Closed Loop Vagal Nerve Stimulation for Patients With Posttraumatic Stress Disorder

NCT02992899
View directory record Official record
Conditions
PostTraumatic Stress Disorder
Interventions
GammaCore/electroCore non-invasive VNS device, Sham gammaCore/electroCore, O-15 water
Device · Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years to 70 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jun 14, 2021 · Synced Oct 3, 2026, 10:54 AM EDT
Terminated Not applicable Interventional Results available

Non-invasive Vagus Nerve Stimulation in the Treatment of Crohn's Disease - A Pilot Study

NCT05165108
View directory record Official record
Conditions
Crohn Disease
Interventions
Vagal Nerve Stimulator
Device
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 75 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 6, 2025 · Synced Oct 3, 2026, 10:54 AM EDT
Active, not recruiting Not applicable Interventional

Non-invasive Vagus Nerve Stimulation in Patients Undergoing Electrophysiological Study

NCT05350150
View directory record Official record
Conditions
Neuromodulation
Interventions
Auricular Vagal Nerve Stimulation
Device
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 15, 2026 · Synced Oct 3, 2026, 10:54 AM EDT
Recruiting Not applicable Interventional

Non-invasive Vagus Nerve Stimulation (nVNS) for Post-Traumatic Stress Disorder (PTSD)

NCT07523685
View directory record Official record
Conditions
PTSD, Post Traumatic Stress Disorder PTSD, PTSD - Post Traumatic Stress Disorder, Post Traumatic Stress Disorder, Post Traumatic Stress Disorders, Post-traumatic Stress Disorder (PTSD), Post-Traumatic Stress Disorder, PTSD
Interventions
non-invasive vagus nerve stimulation
Device
Lead sponsor
Acacia Clinics
Industry
Eligibility
18 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Sunnyvale, California
Source: ClinicalTrials.gov public record
Updated Apr 27, 2026 · Synced Oct 3, 2026, 10:54 AM EDT
Not yet recruiting Not applicable Interventional

Treatment of Fibromyalgia and PTSD With Live and Inactive Vagus Nerve Stimulation With PEPC

NCT07718984
View directory record Official record
Conditions
Fibromyalgia (FM), Posttraumatic Stress Disorder (PTSD)
Interventions
tAN plus PEPC, sham plus PEPC
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2030
U.S. locations
1
States / cities
Decatur, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 29, 2026 · Synced Oct 3, 2026, 10:54 AM EDT
Recruiting Not applicable Interventional

Paired Non-invasive VNS in Adolescent Cerebral Palsy Rehabilitation

NCT07394608
View directory record Official record
Conditions
Cerebral Palsy
Interventions
Non-invasive taVNS
Device
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
12 Years to 17 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 13, 2026 · Synced Oct 3, 2026, 10:54 AM EDT
Completed Not applicable Interventional Results available

Vagal Nerve Stimulation for Post COVID Fatigue

NCT05445427
View directory record Official record
Conditions
Post COVID Syndrome, Fatigue, Headache
Interventions
vagal nerve stimulator
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Oct 3, 2026, 10:54 AM EDT
Terminated Not applicable Interventional

Effect of Transcutaneous Electrical Auricular Stimulation of the Vagus Nerve in Kidney Transplant Recipients

NCT04256837
View directory record Official record
Conditions
Vagus Nerve Stimulation
Interventions
Transcutaneous electrical auricular vagus nerve stimulation (VNS)
Device
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Dec 14, 2022 · Synced Oct 3, 2026, 10:54 AM EDT
Recruiting Not applicable Interventional

Targeted Plasticity Therapy for PTSD

NCT06266364
View directory record Official record
Conditions
PTSD, Post Traumatic Stress Disorder
Interventions
Active VNS stimulation, Sham VNS stimulation
Device
Lead sponsor
The University of Texas at Dallas
Other
Eligibility
22 Years to 79 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
3
States / cities
Austin, Texas • Dallas, Texas • Richardson, Texas
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Oct 3, 2026, 10:54 AM EDT
Recruiting Not applicable Interventional

Auricular Vagal Nerve Stimulation for Hypermobile Ehlers-Danlos Syndrome

NCT05212129
View directory record Official record
Conditions
Functional Gastrointestinal Disorders, Hypermobile Ehlers-Danlos Syndrome, Postural Orthostatic Tachycardia Syndrome, Autonomic Nervous System Disease, Autonomic Nervous System Imbalance
Interventions
Percutaneous vagal nerve stimulation (pVNS) device, Acoustic vagal nerve stimulation (aVNS) treatment
Device · Other
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
10 Years to 18 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 13, 2026 · Synced Oct 3, 2026, 10:54 AM EDT
Completed Phase 2 Interventional Results available

Transcutaneous Vagus Nerve Stimulation (tVNS) and Robotic Training to Improve Arm Function After Stroke

NCT03592745
View directory record Official record
Conditions
Stroke, Cerebrovascular Accident (CVA), Hemiparesis
Interventions
Transcutaneous Vagus Nerve Stimulation (tVNS), Sham Transcutaneous Vagus Nerve Stimulation (tVNS)
Device
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 85 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Jun 29, 2021 · Synced Oct 3, 2026, 10:54 AM EDT