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ClinicalTrials.gov public records Last synced Oct 22, 2026, 7:03 AM EDT

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Showing 1–24 of 44 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Ventilator protocol Clear all
Withdrawn Not applicable Interventional

Mild Hypothermia for COVID-19 ARDS

NCT04570462
View directory record Official record
Conditions
COVID19 ARDS
Interventions
Hypothermia Via Cooling Machine- Arctic Sun 5000
Other
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 100 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Jun 29, 2021 · Synced Oct 22, 2026, 7:03 AM EDT
Completed Not applicable Interventional

Low-Intensity Mechanical Ventilation in the Operating Room: a Pilot Study

NCT07277244
View directory record Official record
Conditions
Robotic Surgery, Post Operative Pulmonary Complications
Interventions
Low Intensity Mechanical Ventilation
Device
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 6, 2026 · Synced Oct 22, 2026, 7:03 AM EDT
Recruiting Phase 3 Interventional

Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome

NCT06066502
View directory record Official record
Conditions
Acute Respiratory Distress Syndrome, Respiratory Failure
Interventions
Precision ventilation, Guided usual care ventilation
Other
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
1,100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2030
U.S. locations
33
States / cities
Tucson, Arizona • Little Rock, Arkansas • La Jolla, California + 25 more
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Oct 22, 2026, 7:03 AM EDT
Withdrawn Not applicable Interventional

NiPPV in the Treatment of Acute Asthma Exacerbations

NCT03219736
View directory record Official record
Conditions
Bronchial Asthma, Status Asthmaticus
Interventions
Standard of Care therapies, NiPPV Therapy, Routine Respiratory Care
Procedure · Device
Lead sponsor
Arkansas Children's Hospital Research Institute
Other
Eligibility
2 Years to 17 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Feb 22, 2023 · Synced Oct 22, 2026, 7:03 AM EDT
Terminated Not applicable Interventional Results available

Providing Optimal PEEP During Mechanical Ventilation for Obese Patients Using Esophageal Balloon

NCT03951064
View directory record Official record
Conditions
Obesity, Morbid, Ventilator-Induced Lung Injury, Respiratory Failure
Interventions
Esophageal balloon, Intervention Spontaneous Breathing Trial (SBT) and Extubation, Control Spontaneous Breathing Trial and Extubation, Intervention Weaning after Tracheostomy, Control Weaning after Tracheostomy
Device · Procedure
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
2
States / cities
Chapel Hill, North Carolina • Greenville, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 5, 2024 · Synced Oct 22, 2026, 7:03 AM EDT
Not listed Phase 2 Interventional

Airway Pressure Release Ventilation (APRV) Versus AC/VC Conventional Ventilation

NCT01339533
View directory record Official record
Conditions
Respiratory Failure, Acute Lung Injury (ALI), Acute Respiratory Distress Syndrome (ARDS)
Interventions
Mechanical Ventilation
Device
Lead sponsor
Intermountain Health Care, Inc.
Other
Eligibility
18 Years and older
Enrollment
246 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
2
States / cities
Murray, Utah • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Aug 26, 2015 · Synced Oct 22, 2026, 7:03 AM EDT
Completed Not applicable Interventional Results available

Impact of CPAP Level on V/Q Mismatch in Premature Infants

NCT02983825
View directory record Official record
Conditions
Infant, Premature, Diseases, Respiratory Insufficiency Syndrome of Newborn
Interventions
Continuous positive airway pressure (CPAP); level changes
Device
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
24 Hours to 35 Weeks
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
3
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 25, 2021 · Synced Oct 22, 2026, 7:03 AM EDT
Withdrawn Phase 4 Interventional

Automated Ventilator Controlled Weaning vs Daily Spontaneous Breathing Trial in Difficult to Wean ICU Patients

NCT00813839
View directory record Official record
Conditions
Mechanical Ventilation, Weaning
Interventions
daily weaning trails
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 8, 2015 · Synced Oct 22, 2026, 7:03 AM EDT
Recruiting Not applicable Interventional

Effects of Lung Volume on Upper Airway Patency During Drug Induced Sleep Endoscopy

NCT05350332
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Negative Pressure Ventilator, Pulmonary Function Testing (PFT), Transcutaneous Phrenic Nerve Stimulation, Percutaneous Phrenic Nerve Stimulation
Device
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
151 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Oct 22, 2026, 7:03 AM EDT
Not yet recruiting Phase 3 Interventional

Xenon for Neuroprotection During Post-Cardiac Arrest Syndrome in Comatose Survivors of an Out of Hospital Cardiac Arrest

NCT03176186
View directory record Official record
Conditions
Post-Cardiac Arrest Syndrome
Interventions
Xenon
Combination Product
Lead sponsor
Invero Pharma, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
1,436 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
8
States / cities
Hartford, Connecticut • Gainesville, Florida • Gulfport, Mississippi + 5 more
Source: ClinicalTrials.gov public record
Updated Apr 3, 2025 · Synced Oct 22, 2026, 7:03 AM EDT
Completed Not applicable Interventional Results available

Enhanced Room Cleaning in Intensive Care Units to Reduce Gown and Glove Contamination With Multi-drug-resistant Bacteria

NCT01481935
View directory record Official record
Conditions
Infection Control
Interventions
Enhanced cleaning of surfaces in ICU rooms, Sham enhanced cleaning of surfaces in ICU rooms
Other
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years and older
Enrollment
190 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 16, 2022 · Synced Oct 22, 2026, 7:03 AM EDT
Completed Not applicable Interventional Results available

Efficacy Study of a Novel Device to Clean the Endotracheal Tube

NCT01765530
View directory record Official record
Conditions
Endotracheal Extubation, Airway Obstruction, Airway Control, Pneumonia, Ventilator-Associated, Breathing Mechanics
Interventions
ETT cleaning maneuver
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 99 Years
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 18, 2017 · Synced Oct 22, 2026, 7:03 AM EDT
Completed Not applicable Interventional

CDC Prevention Epicenters Wake Up and Breathe Collaborative

NCT01583413
View directory record Official record
Conditions
Ventilator-associated Pneumonia
Interventions
Daily SAT & SBT
Procedure
Lead sponsor
Harvard Pilgrim Health Care
Other
Eligibility
Not listed
Enrollment
3,342 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
5
States / cities
Chicago, Illinois • Salem, Massachusetts • St Louis, Missouri + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 11, 2013 · Synced Oct 22, 2026, 7:03 AM EDT
Completed Phase 4 Interventional

Common Canister Protocol for Inhaler Administration in Mechanically Ventilated Patients

NCT01935388
View directory record Official record
Conditions
Ventilator Associated Pneumonia
Interventions
Common canister
Other
Lead sponsor
Barnes-Jewish Hospital
Other
Eligibility
18 Years and older
Enrollment
354 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 7, 2016 · Synced Oct 22, 2026, 7:03 AM EDT
Recruiting Not applicable Interventional

Careful Ventilation in Acute Respiratory Distress Syndrome (COVID-19 and Non-COVID-19)

NCT03963622
View directory record Official record
Conditions
ARDS
Interventions
Respiratory Mechanics, Standard Ventilation Strategy
Other
Lead sponsor
Unity Health Toronto
Other
Eligibility
18 Years and older
Enrollment
740 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 16, 2026 · Synced Oct 22, 2026, 7:03 AM EDT
Completed Not applicable Interventional

Mechanical Power-Guided Lung Protective Ventilation (VentCoach) in Acute Hypoxemic and/or Hypercapnic Respiratory Failure

NCT07294768
View directory record Official record
Conditions
Mechanical Ventilation
Interventions
VentCoach, Standard of Care
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 19, 2025 · Synced Oct 22, 2026, 7:03 AM EDT
Completed Not applicable Interventional Results available

Chlorhexidine Gluconate Oral Care for Adults Experiencing Trauma

NCT01382446
View directory record Official record
Conditions
Ventilator Associated Pneumonia
Interventions
Chlorhexidine gluconate, Toothpaste
Drug · Other
Lead sponsor
St. Joseph's Hospital and Medical Center, Phoenix
Other
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Feb 6, 2017 · Synced Oct 22, 2026, 7:03 AM EDT
Completed Not applicable Interventional Results available

Effort of Breathing Guided Ventilator Protocol

NCT02989246
View directory record Official record
Conditions
Ventilators, Mechanical, Work of Breathing
Interventions
Ventilator protocol, Esophageal Catheter
Other · Device
Lead sponsor
Children's Hospital Los Angeles
Other
Eligibility
37 Weeks to 18 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 30, 2024 · Synced Oct 22, 2026, 7:03 AM EDT
Active, not recruiting Not applicable Interventional

CT for Personalized Mechanical Ventilation

NCT05977153
View directory record Official record
Conditions
Ventilator-Induced Lung Injury, Sepsis Syndrome, Mechanical Ventilation Complication
Interventions
PEEP (positive end-expiratory pressure) - maximum, PEEP (positive end-expiratory pressure) - standard
Procedure
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 26, 2025 · Synced Oct 22, 2026, 7:03 AM EDT
Terminated Not applicable Interventional

Symptom Based Performance of Airway Clearance After Starting Highly Effective Modulators for Cystic Fibrosis (SPACE-CF)

NCT05392855
View directory record Official record
Conditions
Cystic Fibrosis, Mucociliary Clearance Defect
Interventions
Symptom driven performance of airway clearance, Continuous daily performance of airway clearance
Other
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 20, 2024 · Synced Oct 22, 2026, 7:03 AM EDT
Not listed Not applicable Interventional

The Frequency of Screening and SBT Technique Trial: The FAST Trial

NCT02969226
View directory record Official record
Conditions
Critically Ill
Interventions
Once daily screening, Twice daily screening, PS SBTs, T-piece SBTs
Procedure
Lead sponsor
Unity Health Toronto
Other
Eligibility
16 Years and older
Enrollment
760 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
5
States / cities
Long Beach, California • Los Angeles, California • Boston, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Dec 5, 2018 · Synced Oct 22, 2026, 7:03 AM EDT
Completed Not applicable Interventional Results available

Pilot Study on Pairing Sedation Strategies and Weaning

NCT02219659
View directory record Official record
Conditions
Acute Respiratory Failure
Interventions
Sedation Protocol with Daily Interruption, Sedation Protocol Without Daily Interruption, Fentanyl Push First
Drug
Lead sponsor
MemorialCare Health System
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Long Beach, California
Source: ClinicalTrials.gov public record
Updated Oct 7, 2025 · Synced Oct 22, 2026, 7:03 AM EDT
Completed Not applicable Interventional

Mechanical Ventilator Weaning in Chronically Ventilated Patients

NCT06976554
View directory record Official record
Conditions
Mechanical Ventilation Complication
Interventions
weaning
Procedure
Lead sponsor
University of California, Los Angeles
Other
Eligibility
Not listed
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 3, 2025 · Synced Oct 22, 2026, 7:03 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Variation In Facial Morphology As A Determinant Of Face Covering Performance: FACEFIT

NCT05388201
View directory record Official record
Conditions
Healthy
Interventions
N95, KN95, KF94, Surgical
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 55 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 29, 2024 · Synced Oct 22, 2026, 7:03 AM EDT