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Showing 1–24 of 37 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Very Low Nicotine Content Cigarette Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Low Nicotine Cigarettes, Smoking, and Chronic Pain

NCT05032755
View directory record Official record
Conditions
Chronic Pain, Smoking, Cigarette
Interventions
SPECTRUM NRC 102/103 investigational cigarettes, SPECTRUM NRC 600/601 investigational cigarettes
Other
Lead sponsor
Duke University
Other
Eligibility
21 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 28, 2025 · Synced Sep 23, 2026, 9:15 AM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Cardiovascular Effects of Very Low Nicotine Content Cigarettes

NCT05707871
View directory record Official record
Conditions
Tobacco Use
Interventions
SPECTRUM cigarettes, usual brand of Cigarettes
Drug · Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
21 Years and older
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Sep 23, 2026, 9:15 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Effects of Nicotine Reduction on Smoking Behavior in ADHD Smokers

NCT02599571
View directory record Official record
Conditions
Nicotine Dependence, ADHD
Interventions
Very low nicotine content cigarettes, Conventional nicotine content cigarettes
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 40 Years
Enrollment
71 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
2
States / cities
Durham, North Carolina • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 26, 2020 · Synced Sep 23, 2026, 9:15 AM EDT
Completed Phase 2 Interventional Results available

Randomized Trial to Evaluate the Effectiveness of X-22 as a Smoking Cessation Aid

NCT01400815
View directory record Official record
Conditions
Smoking Cessation
Interventions
X-22 Smoking Cessation Product, Active Control Cigarettes
Drug
Lead sponsor
22nd Century Limited, LLC
Industry
Eligibility
18 Years to 65 Years
Enrollment
234 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
3
States / cities
Sacramento, California • Metairie, Louisiana • Austin, Texas
Source: ClinicalTrials.gov public record
Updated Nov 18, 2021 · Synced Sep 23, 2026, 9:15 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Innovative Interventions for Smoking Cessation

NCT01050569
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Nicotine Patch, VLNC Cigarette, VLNC Cigarette Plus Nicotine Patch
Drug · Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
235 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2012
U.S. locations
2
States / cities
Duluth, Minnesota • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 17, 2019 · Synced Sep 23, 2026, 9:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Project 2 Cigarette and E-cigarette Nicotine Content and E-liquid Flavors

NCT03185546
View directory record Official record
Conditions
Smoking
Interventions
NNC Spectrum Cigarette, VLNC Spectrum Cigarette, Moderate nicotine level e-liquid, Low nicotine level e-liquid, Tobacco Flavors, Tobacco and non-tobacco e-liquid flavors
Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
156 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
2
States / cities
Winston-Salem, North Carolina • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 13, 2021 · Synced Sep 23, 2026, 9:15 AM EDT
Completed Not applicable Interventional

Project 2: Strategies for Reducing Nicotine Content in Cigarettes

NCT02139930
View directory record Official record
Conditions
Nicotine Dependence, Tobacco Smoking
Interventions
Normal Nicotine Control Group, Immediate Nicotine Reduction Group, Gradual Nicotine Reduction Group
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
1,250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
10
States / cities
Phoenix, Arizona • San Francisco, California • Tampa, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Aug 14, 2018 · Synced Sep 23, 2026, 9:15 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Project 3, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in People With Current Affective Disorders

NCT02232737
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Very low nicotine content cigarettes
Other
Lead sponsor
Brown University
Other
Eligibility
18 Years to 70 Years
Enrollment
775 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
2
States / cities
Providence, Rhode Island • Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Dec 6, 2022 · Synced Sep 23, 2026, 9:15 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Switching to Very Low Nicotine Content Cigarettes vs Reducing Cigarettes Per Day

NCT03060083
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Very low nicotine content (VLNC) cigarettes and nicotine replacement therapy (NRT), Reduce cigarettes per day (CPD) with nicotine replacement therapy (NRT)
Other
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older
Enrollment
74 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Oct 3, 2022 · Synced Sep 23, 2026, 9:15 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Young Adults and Low Nicotine Cigarettes

NCT03699865
View directory record Official record
Conditions
Smoking
Interventions
Nicotine content
Other
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
21 Years to 29 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 14, 2024 · Synced Sep 23, 2026, 9:15 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Impact of Nicotine Reduction on Adolescent Cigarette Use, Alternative Tobacco Use, and Harm From Tobacco

NCT03860077
View directory record Official record
Conditions
Nicotine Dependence, Cigarettes, Uncomplicated
Interventions
Very Low Nicotine Content Cigarettes, Normal Nicotine Content Cigarettes
Drug
Lead sponsor
Brown University
Other
Eligibility
15 Years to 20 Years
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Dec 18, 2023 · Synced Sep 23, 2026, 9:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Impact of Exclusive Use of Low Nicotine Cigarettes on Compensatory Smoking

NCT03311646
View directory record Official record
Conditions
Smoking
Interventions
Normal nicotine content cigarettes (NNC, Baseline), Very low nicotine content (VLNC)
Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 27, 2020 · Synced Sep 23, 2026, 9:15 AM EDT
Completed Not applicable Interventional Results available

Very-Low Nicotine Cigarettes and Non-Daily Smokers

NCT02228824
View directory record Official record
Conditions
Smoking
Interventions
Very low nicotine content cigarettes, Normal nicotine content cigarettes
Drug
Lead sponsor
Saul Shiffman
Other
Eligibility
18 Years and older
Enrollment
312 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 30, 2018 · Synced Sep 23, 2026, 9:15 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Impact of Very Low Nicotine Content Cigarettes in a Complex Marketplace

NCT03272685
View directory record Official record
Conditions
Tobacco Smoking, Nicotine Dependence
Interventions
Very Low Nicotine Content Cigarettes, Normal Nicotine Content Cigarettes
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
21 Years and older
Enrollment
799 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
6
States / cities
San Francisco, California • Minneapolis, Minnesota • Durham, North Carolina + 3 more
Source: ClinicalTrials.gov public record
Updated Aug 19, 2024 · Synced Sep 23, 2026, 9:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Strengthening Instrumental Extinction to Prevent Smoking Relapse (VLNCCue)

NCT02538042
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Nicotine Patch, SPECTRUM Nicotine Research Cigarettes (0.07 mg), MCE-
Drug · Behavioral
Lead sponsor
Francis McClernon, Ph.D.
Other
Eligibility
18 Years to 65 Years
Enrollment
87 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 13, 2018 · Synced Sep 23, 2026, 9:15 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Project 2, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Opioid Abusers

NCT02250664
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Very low nicotine content cigarettes
Other
Lead sponsor
University of Vermont
Other
Eligibility
18 Years to 70 Years
Enrollment
775 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
2
States / cities
Baltimore, Maryland • Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Nov 30, 2022 · Synced Sep 23, 2026, 9:15 AM EDT
Completed Not applicable Interventional

Project 1, Study 1: Investigating the Impact of Nicotine Using Spectrum Cigarettes

NCT01681875
View directory record Official record
Conditions
Tobacco Dependence
Interventions
very low nicotine content cigarettes
Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
839 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
9
States / cities
San Francisco, California • Tampa, Florida • Baltimore, Maryland + 6 more
Source: ClinicalTrials.gov public record
Updated Aug 14, 2018 · Synced Sep 23, 2026, 9:15 AM EDT
Recruiting Not applicable Interventional

Opioids, Low Nicotine Cigarettes, and Chronic Pain

NCT06747871
View directory record Official record
Conditions
Chronic Pain, Tobacco Use, Opioid Substitution Treatment
Interventions
Very Low Nicotine Cigarettes (VLNC), Normal Nicotine Cigarettes (NNC)
Behavioral
Lead sponsor
Duke University
Other
Eligibility
21 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 8, 2026 · Synced Sep 23, 2026, 9:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Low Nicotine Content Cigarettes in Vulnerable Populations: Women of Reproductive Age

NCT04092387
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Varying the nicotine content of cigarettes, E-Cigarettes
Other
Lead sponsor
University of Vermont
Other
Eligibility
21 Years to 44 Years · Female only
Enrollment
326 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
2
States / cities
Baltimore, Maryland • Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Mar 17, 2025 · Synced Sep 23, 2026, 9:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Low Nicotine Cigarettes Plus Electronic Cigarettes

NCT04058717
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Normal Nicotine Content research cigarettes, High Nicotine e-cigarette, Very Low Nicotine Content research cigarettes, Zero Nicotine e-cigarette
Other
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
21 Years to 70 Years
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 10, 2025 · Synced Sep 23, 2026, 9:15 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Project 1, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Childbearing Age Women

NCT02250534
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Very low nicotine content cigarettes
Other
Lead sponsor
University of Vermont
Other
Eligibility
18 Years to 44 Years · Female only
Enrollment
775 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
2
States / cities
Baltimore, Maryland • Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Nov 30, 2022 · Synced Sep 23, 2026, 9:15 AM EDT
Completed Phase 2 Interventional

Very Low Nicotine Cigarettes in Smokers With Schizophrenia

NCT02019459
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Very low nicotine content cigarettes, standard nicotine content cigarettes
Other
Lead sponsor
Brown University
Other
Eligibility
18 Years to 70 Years
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Apr 8, 2018 · Synced Sep 23, 2026, 9:15 AM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Nicotine Regulation for Dual Users of E-cigarettes and Cigarettes

NCT06614504
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Varying the nicotine content of cigarettes, Varying the nicotine content of e-cigarettes
Other
Lead sponsor
University of Vermont
Other
Eligibility
21 Years and older
Enrollment
308 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
2
States / cities
Providence, Rhode Island • Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Jun 26, 2025 · Synced Sep 23, 2026, 9:15 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Facilitating Smoking Cessation With Reduced Nicotine Cigarettes

NCT02796391
View directory record Official record
Conditions
Smoking Cessation
Interventions
Very Low Nicotine Content (VLNC) Cigarettes, One on One Counseling
Drug · Behavioral
Lead sponsor
H. Lee Moffitt Cancer Center and Research Institute
Other
Eligibility
18 Years and older
Enrollment
163 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Nov 13, 2022 · Synced Sep 23, 2026, 9:15 AM EDT