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ClinicalTrials.gov public records Last synced Oct 16, 2026, 9:19 AM EDT

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Showing 625–648 of 951 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: bupivacaine hydrochloride Clear all
Withdrawn Phase 4 Interventional

EXPAREL Facia Iliaca Compartment Block for Intertrochanteric Hip Fracture

NCT03955458
View directory record Official record
Conditions
Hip Fractures, Intertrochanteric Fractures
Interventions
EXPAREL, Ropivacaine, Bupivacaine Hydrochloride
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
65 Years to 85 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 27, 2020 · Synced Oct 16, 2026, 9:19 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Modified TAP (Transverse Abdominis Plane) Block in Colorectal Surgery

NCT04781075
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Pain Scale, Exparel Injectable Product, Bupivacaine Injection
Other · Drug
Lead sponsor
Ochsner Health System
Other
Eligibility
18 Years to 75 Years
Enrollment
76 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Sep 10, 2021 · Synced Oct 16, 2026, 9:19 AM EDT
Active, not recruiting Phase 3 Interventional

Bupivacaine vs Placebo for Unilateral Mastectomy Surgical Site Post-operative Pain Control

NCT03351348
View directory record Official record
Conditions
Breast Cancer
Interventions
Bupivacaine, patient-reported pain scores, saline
Drug · Behavioral · Other
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older · Female only
Enrollment
165 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2027
U.S. locations
7
States / cities
Basking Ridge, New Jersey • Middletown, New Jersey • Montvale, New Jersey + 4 more
Source: ClinicalTrials.gov public record
Updated Aug 4, 2026 · Synced Oct 16, 2026, 9:19 AM EDT
Withdrawn Phase 4 Interventional

A Comparison of Exparel Local Anesthetic in Total Knee Arthroplasty (TKA) Patients

NCT02765815
View directory record Official record
Conditions
Osteoarthritis, Knee, Arthroplasty, Replacement, Knee
Interventions
Liposomal bupivacaine, 266mg, Bupivacaine 0.5 % with Epinephrine, Ketorolac 30mg, Morphine 10mg, Bupivacaine 0.25% with Epinephrine
Drug
Lead sponsor
Holy Cross Hospital, Florida
Other
Eligibility
18 Years to 88 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Fort Lauderdale, Florida
Source: ClinicalTrials.gov public record
Updated Aug 9, 2017 · Synced Oct 16, 2026, 9:19 AM EDT
Completed Phase 2 Interventional Results available

IINB vs. QLB for Elective Open Inguinal Herniorrhaphy

NCT03007966
View directory record Official record
Conditions
Nerve Block, Herniorrhaphy, Regional Anesthesia
Interventions
Ilioinguinal / Iliohypogastric Block, Quadratus Lumborum Block, Bupivacaine 0.25%, Epinephrine 1:200k, Clonidine 1.66mcg/cc
Procedure · Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 90 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 18, 2019 · Synced Oct 16, 2026, 9:19 AM EDT
Terminated Not applicable Interventional Results available

Comparison Study of Transversus Abdominal Plane, Paravertebral and Epidural Blocks in Laparoscopic Colectomy

NCT02164929
View directory record Official record
Conditions
Laparoscopic Colorectal Resection
Interventions
TAP block, Epidural, Paravertebral block, Acetaminophen 1g IV, Dexamethasone 4mg, Midazolam up to 2mg, Propofol 1-2.5 mg/kg, Sevoflurane to keep a bispectral index of between 40-60, Local infiltration with 10 mL of plain ropivacaine 0.25%, Lidocaine, Epinephrine, Hydromorphone
Procedure · Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 25, 2017 · Synced Oct 16, 2026, 9:19 AM EDT
Completed Phase 2 Interventional Results available

Intercostal Liposomal Bupivacaine for the Management of Blunt Chest Wall Trauma

NCT02749968
View directory record Official record
Conditions
Blunt Chest Wall Trauma, Rib Fracture, Sternal Fracture
Interventions
Liposomal bupivacaine, 0.9% sodium chloride
Drug
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 4, 2022 · Synced Oct 16, 2026, 9:19 AM EDT
Completed Phase 3 Interventional Results available

Efficacy, Safety, and Pharmacokinetics of Femoral Nerve Block With EXPAREL in Total Knee Arthroplasty

NCT02713178
View directory record Official record
Conditions
Pain
Interventions
bupivacaine liposome injectable suspension, Placebo
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
232 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
14
States / cities
Mobile, Alabama • Englewood, Colorado • Miami, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Dec 1, 2020 · Synced Oct 16, 2026, 9:19 AM EDT
Completed Phase 3 Interventional Results available

Comparison of Sternal Wound Infiltration With Liposomal Bupivacaine v. Bupivacaine Hydrochloride

NCT03270514
View directory record Official record
Conditions
Coronary Artery Disease, Coronary Artery Stenoses, Valve Regurgitation, Mitral, Valve Regurgitation, Tricuspid
Interventions
Exparel Injectable Product, Bupivacaine Hydrochloride
Drug
Lead sponsor
Kathirvel Subramaniam
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 5, 2021 · Synced Oct 16, 2026, 9:19 AM EDT
Completed Phase 4 Interventional Results available

Effects of a Surgical Site Injection on Pain Scores and Narcotic Use After Orthopaedic Trauma Surgery

NCT03693404
View directory record Official record
Conditions
Pertrochanteric Fracture
Interventions
Marcaine, Duramorph , ketorolac, Bupivacaine (Marcaine), General Anesthetics
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
190 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 21, 2022 · Synced Oct 16, 2026, 9:19 AM EDT
Completed Phase 4 Interventional Results available

The Use of Bupivacaine and Ropivacaine for Sciatic Nerve Block

NCT01272921
View directory record Official record
Conditions
The Duration of Motor Block May Vary Between 12-36 Hrs
Interventions
Bupivacaine, Ropivacaine
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 75 Years
Enrollment
142 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2010
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 6, 2017 · Synced Oct 16, 2026, 9:19 AM EDT
Completed Phase 4 Interventional Results available

Sphenopalatine Ganglion Blocks RCT

NCT03666663
View directory record Official record
Conditions
Migraine
Interventions
Lidocaine, Bupivacaine, Ropivacaine, Placebo
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 11, 2021 · Synced Oct 16, 2026, 9:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of the Duration of Bupivacaine Spinal Block in Orthopedic Procedures With and Without Epinephrine Wash

NCT02619409
View directory record Official record
Conditions
Arthropathy of Hip, Arthropathy of Knee
Interventions
Bupivacaine Only, EPI25, EPI50 group, EPI75 group, EPI100 group
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 6, 2023 · Synced Oct 16, 2026, 9:19 AM EDT
Completed Phase 4 Interventional Results available

A Health Economic Trial in Adult Patients Undergoing Ileostomy Reversal MA402S23B501

NCT01509638
View directory record Official record
Conditions
Retraction of Colostomy
Interventions
Group 1 Standard of Care, Group 2 EXPAREL
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
2
States / cities
Weston, Florida • Beachwood, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 6, 2014 · Synced Oct 16, 2026, 9:19 AM EDT
Withdrawn Not applicable Interventional

Stem Cells vs. Steroids for Discogenic Back Pain

NCT04735185
View directory record Official record
Conditions
Chronic Low Back Pain, Degenerative Disc Disease
Interventions
Autologous stem cells, Corticosteroid, Local anesthetic
Other · Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 100 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 7, 2025 · Synced Oct 16, 2026, 9:19 AM EDT
Completed Phase 4 Interventional

A Multi-surgery Assessment of ZYNRELEF (HTX-011), AMAZE.

NCT06109415
View directory record Official record
Conditions
Postoperative Pain, Total Shoulder Arthroplasty, Multimodal Analgesia
Interventions
HTX-011, Bupivacaine Hydrochloride, Ibuprofen, Acetaminophen, Luer lock applicator
Drug · Device
Lead sponsor
Heron Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
5
States / cities
Little Rock, Arkansas • Jenks, Oklahoma • Bellaire, Texas + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 31, 2023 · Synced Oct 16, 2026, 9:19 AM EDT
Completed Phase 4 Interventional Results available

Effectiveness of Exparel TAP Block in Breast Free Flap Reconstruction

NCT04777591
View directory record Official record
Conditions
Postoperative Pain, Breast Reconstruction
Interventions
Liposomal bupivacaine TAP block, Bupivacain
Drug
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older · Female only
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
2
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 23, 2024 · Synced Oct 16, 2026, 9:19 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Analgesic Benefit of PECS Blocks for Biceps Tenodesis Shoulder Surgery

NCT02741713
View directory record Official record
Conditions
Biceps Tendonitis
Interventions
PECS "Pectoralis" 1 and 2 Blocks, Interscalene Block, Sham Block, Solution for Injection in Interscalene Block, Solution for Injection in Sham Block, Solution for Injection PECS Blocks
Procedure · Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 27, 2018 · Synced Oct 16, 2026, 9:19 AM EDT
Completed Phase 3 Interventional Results available

Trial of Extended Release Bupivacaine for Pain Relief After Surgery

NCT02574520
View directory record Official record
Conditions
Post Operative Pain
Interventions
SABER-Bupivacaine (Part 1), SABER-Bupivacaine (Part 2), Saline Placebo, Bupivacaine HCl
Drug
Lead sponsor
Durect
Industry
Eligibility
18 Years and older
Enrollment
399 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
21
States / cities
Florence, Alabama • Sheffield, Alabama • Arcadia, California + 13 more
Source: ClinicalTrials.gov public record
Updated Jul 13, 2021 · Synced Oct 16, 2026, 9:19 AM EDT
Recruiting Phase 4 Interventional

Erector Spinae Block for Thoracic Surgery

NCT05521789
View directory record Official record
Conditions
Pulmonary Neoplasm, Pulmonary Cancer, Thoracic Diseases, Thoracic Cancer, Thoracic Neoplasms
Interventions
ESB Thoracic
Drug
Lead sponsor
George Washington University
Other
Eligibility
18 Years to 90 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Feb 25, 2026 · Synced Oct 16, 2026, 9:19 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Impact of Quadratus Lumborum Block on Recovery Profile After Ventral Hernia Repair

NCT03794882
View directory record Official record
Conditions
Pain, Postoperative, Opioid Use
Interventions
Quadratus Lumborum Block, Standard Medical Management
Combination Product · Procedure
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 80 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 21, 2022 · Synced Oct 16, 2026, 9:19 AM EDT
Terminated Phase 4 Interventional Results available

Liposomal Bupivacaine vs Peripheral Nerve Block

NCT03922620
View directory record Official record
Conditions
Pain, Acute, Surgery, Anesthesia, Opioid Use
Interventions
Liposomal bupivacaine, Peripheral Nerve Block
Drug
Lead sponsor
Geisinger Clinic
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Danville, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 23, 2023 · Synced Oct 16, 2026, 9:19 AM EDT
Completed Phase 4 Interventional Results available

Spinal Versus General Anesthesia With Popliteal and Adductor Canal Blocks for Ambulatory Foot and Ankle Surgery.

NCT02996591
View directory record Official record
Conditions
Nerve Block, General Anesthesia, Spinal Anesthesia, Pain, Postoperative Nausea and Vomiting
Interventions
25 mL of 0.25% bupivacaine plus 2 mg preservative-free (PF) dexamethasone / 30 ml for popliteal nerve block, 10 mL of 0.25% bupivacaine plus 2 mg preservative-free (PF) dexamethasone / 30 ml for adductor canal nerve block, Midazolam, 2-5 mg IV + Glycopyrrolate, 0.1 mg IV + Ketamine, 10-20 mg + propofol as needed, 45-60 mg of 1.5% mepivacaine for spinal anesthesia, LMA insertion + titrated propofol infusion + sevoflurane + ketamine 10 mg/hr for general anesthesia
Procedure · Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 75 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 12, 2019 · Synced Oct 16, 2026, 9:19 AM EDT
Terminated Phase 3 Interventional Results available

ITM + Bupivacaine QLB vs. ITM + Sham Saline QLB for Cesarean Delivery Pain

NCT03261193
View directory record Official record
Conditions
Pain, Postoperative
Interventions
ITM + Sham QLB, ITM + Bupivacaine QLB
Drug
Lead sponsor
Nicholas Schott
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 6, 2024 · Synced Oct 16, 2026, 9:19 AM EDT