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ClinicalTrials.gov public records Last synced Nov 15, 2026, 1:20 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 134 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: cigarette or e-cigarette Clear all

Conditions: Electronic Cigarette Use
Interventions: Health Assessments; Other
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 21 Years and older
Enrollment: 600 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Smoking, Tobacco Use, Tobacco Smoking
Interventions: Product A, Product B, Product C, Product D, Product N, Product E; Other
Lead sponsor: RAI Services Company; Industry
Eligibility: 21 Years to 60 Years
Enrollment: 42 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022
U.S. locations: 2
States / cities: Lexington, Kentucky • Knoxville, Tennessee

Conditions: Secondhand Smoke
Interventions: Nicotine polacrilex, Electronic Cigarette, Dissolvable Tobacco Lozenge; Drug
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years to 65 Years
Enrollment: 89 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Cigarette Smoking-Related Carcinoma
Interventions: Cigarette Smoking, Computed Tomography, Positron Emission Tomography, Questionnaire Administration; Behavioral · Procedure · Other
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 21 Years to 50 Years
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Nicotine Use Disorder
Interventions: Retrieval Extinction Training (RET), Control Retrieval Extinction Training (RET); Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 25 Years to 65 Years
Enrollment: 191 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Alcohol Use, E-cigarette Use, Cigarette Use
Interventions: Experimental Tobacco Marketplace, Hypothetical Novel Nicotine Product Purchase Tasks; Behavioral
Lead sponsor: Mark J Rzeszutek, PhD; Other
Eligibility: 21 Years and older
Enrollment: 737 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Cannabis, Nicotine
Interventions: Cannabis, Nicotine; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 26 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Cigarette Smoking
Interventions: E-cigarette Switching, Financial Incentives; Behavioral
Lead sponsor: University of Oklahoma; Other
Eligibility: 21 Years to 100 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Smoking, Smoking Behaviors, Nicotine Dependence
Interventions: E-cigarette with 2.4% Nicotine with Menthol and Tobacco Flavors, E-cigarette with 2.4% Nicotine with Tobacco Flavor Only, E-cigarette with 5% Nicotine with Menthol and Tobacco Flavors, E-cigarette with 5% Nicotine with Tobacco Flavor Only, Tobacco Pouches with 3mg Nicotine with Menthol and Tobacco Flavors, Tobacco Pouches with 3mg Nicotine with Tobacco Flavor Only, Tobacco Pouches with 6mg Nicotine with Menthol and Tobacco Flavors, Tobacco Pouches with 6mg Nicotine with Tobacco Flavor Only; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 21 Years and older
Enrollment: 256 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Nicotine Dependence, Cigarettes
Interventions: AI-enhanced smartphone app, AI-enhanced smartphone app, but with delayed access; Behavioral
Lead sponsor: State University of New York at Buffalo; Other
Eligibility: 14 Years to 20 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Electronic Cigarette Use, Cigarette Use, Electronic, Tobacco Use, Tobacco Smoking
Interventions: Switch from UB of Combustible Cigarette to JUUL 5% Virginia Tobacco ENDS, Switch from UB of Combustible Cigarette to JUUL 3% Virginia Tobacco ENDS, Switch from UB of Combustible Cigarette to JUUL 5% Mint ENDS, Switch from UB of Combustible Cigarette to JUUL 3% Mint ENDS, Switch from UB of Combustible Cigarette to JUUL 5% Menthol ENDS, Switch from UB of Combustible Cigarette to JUUL 3% Menthol ENDS, Switch from UB of Combustible Cigarette to JUUL 5% Mango ENDS, Switch from UB of Combustible Cigarette to JUUL 3% Mango ENDS, Switch to Dual-use of JUUL 5% and UB of Combustible Cigarette, Tobacco/Nicotine Abstention, Usual Brand of cigarettes; Other
Lead sponsor: Juul Labs, Inc.; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 279 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 5
States / cities: Little Rock, Arkansas • Rogers, Arkansas • St Louis, Missouri + 2 more

Conditions: Nicotine Dependence, Tobacco Toxicity, Nicotine Dependence, Cigarettes, Cardiovascular Risk Factor, Nicotine Withdrawal
Interventions: SREC; Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years to 70 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Smoking Behaviors
Interventions: Aim 1: Online survey, Eye Tracking Activity, Eye tracking survey, Online Experimental Marketplace (ETM), Aim 3 survey, Cognitive Interviews, Supplemental Aim 1 Interviews; Other · Behavioral
Lead sponsor: Case Comprehensive Cancer Center; Other
Eligibility: 16 Years to 28 Years
Enrollment: 658 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Electronic Cigarettes
Interventions: E-cigarette Lab Session 15 watts, 10 mg nicotine, E-cigarette Lab Session 15 watts, 30 mg nicotine, E-cigarette Lab Session 30 watts, 10 mg nicotine, E-cigarette Lab Session 30 watts, 30 mg nicotine, Own Brand Session - E-cigarette, Own Brand Session - E-cigarette/Cigarette; Other
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 21 Years to 55 Years
Enrollment: 48 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Smoking Cessation
Interventions: Smoking cessation; Behavioral
Lead sponsor: Virtua Health, Inc.; Other
Eligibility: 18 Years and older
Enrollment: 76 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Voorhees Township, New Jersey

Conditions: Health Behavior
Interventions: Nicotine with Tobacco Flavor and Tobacco & Menthol Flavor; Drug
Lead sponsor: UConn Health; Other
Eligibility: 18 Years to 55 Years
Enrollment: 27 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: Farmington, Connecticut

Conditions: Tobacco Use
Interventions: e-cigarette, Nicotine patch, Nicotine lozenge; Behavioral · Other
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 21 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: E Cigarette Use, Cessation, Tobacco, Cessation, Nicotine
Interventions: Nicotine Replacement Therapies, Brief Behavioral Counseling; Drug · Behavioral
Lead sponsor: West Virginia University; Other
Eligibility: 21 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 2
States / cities: Greenville, North Carolina • Morgantown, West Virginia

Conditions: Cigarette Smoking-Related Carcinoma
Interventions: Nicotine Replacement, Questionnaire Administration, Electronic Cigarette; Drug · Other · Device
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 21 Years and older
Enrollment: 169 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Nicotine Dependence
Interventions: E-cigarettes; Combination Product
Lead sponsor: Duke University; Other
Eligibility: 21 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Electronic Cigarettes
Interventions: e-Cigarette; Other
Lead sponsor: University of Southern California; Other
Eligibility: 21 Years and older
Enrollment: 45 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Nicotine Dependence
Interventions: NJOY King 26 mg nicotine Electronic Nicotine Delivery System; Other
Lead sponsor: LA Clinical Trials; Other
Eligibility: 18 Years to 65 Years
Enrollment: 33 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013
U.S. locations: 1
States / cities: Burbank, California

Conditions: Tobacco-Related Carcinoma
Interventions: Discrete Choice Study, Survey Administration; Other
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 15 Years and older
Enrollment: 3,400 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Healthy Adult Participants
Interventions: 0 mg oral nicotine pouches, 3 mg oral nicotine pouches, 6 mg oral nicotine pouches, cigarette or e-cigarette; Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years to 65 Years
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: San Francisco, California

Search by objective public record fields.

Effects of E-cigarette Use on Health

CSD201301: Study to Assess Elements of Abuse Liability for Four P13 Nicotine Pouches

Preliminary Investigation of Novel Methods to Reduce Children's Secondhand Smoke Exposure

Free-Base Nicotine or Nicotine Salt e-Liquids in Current E-Cigarette Smokers, PeloPET Study

Behavioral Memory Modulation in Nicotine Addiction

Tobacco Product Susceptibility and Substitutability by Rurality and Alcohol Use

Behavioral Pharmacology of Cannabis and Nicotine

E-Cigarettes and Financial Incentives to Promote Tobacco Harm Reduction Among Adults Accessing Shelter Services

Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction

AI-Enhanced App-based Intervention for Adolescent E-cigarette Cessation

Changes in Biomarkers of Cigarette Smoke Exposure After Switching Either Exclusively or Partly to JUUL ENDS

Cigarette Harm Reduction With Electronic Cigarette Use

C-FLASH (Cigarillo Flavor and Abuse Liability, Attention, and Substitution in youtH)

Effects of E-Cigarette Power and Nicotine Content in Dual Users and Vapers

Effectiveness of Smoking Cessation Program in a Community Health System

Effects of Electronic Cigarettes on Nicotine Concentrations

Quit or Switch: E-cigarette Study

Evaluation of Dependence and Nicotine Replacement Therapy-Supported Cessation Efforts Among Regular Electronic Cigarette Use

Gender Differences in Switching From Smoking Regular Cigarettes to E-Cigarettes

The Role of Nicotine and Non-Nicotine Alkaloids in E-Cigarette Use and Dependence

Effects of e-Cigarettes on Perceptions and Behavior

Evaluation of Short-term Safety and Use Patterns of an Electronic Nicotine Delivery System

Studying the Impacts of Higher Taxes and Bans on Electronic Cigarettes to Improve Public Health

Understanding Oral Nicotine Pouch Use in Healthy Volunteers