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ClinicalTrials.gov public records Last synced Nov 15, 2026, 1:30 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 25–48 of 134 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: cigarette or e-cigarette Clear all

Conditions: Tobacco-Related Carcinoma
Interventions: Biospecimen Collection, Carbon Monoxide Measurement, Vaping session, Survey Administration; Procedure · Other
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 21 Years to 65 Years
Enrollment: 375 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Electronic Nicotine Delivery Systems
Interventions: Influencer marketing; Behavioral
Lead sponsor: University of Southern California; Other
Eligibility: 16 Years to 17 Years
Enrollment: 1,462 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Hypertension, Tobacco Cigarette Smoking, Electronic Cigarettes, Cardiovascular
Interventions: Nicotine E-cigarette, Tobacco Cigarette; Other
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 50 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Vaping
Interventions: Social Media Intervention; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 13 Years to 21 Years
Enrollment: 500 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Tobacco Use
Interventions: Product A, Product B, Product C, Product D, Product E, Product F; Other
Lead sponsor: Altria Client Services LLC; Industry
Eligibility: 22 Years to 65 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 3
States / cities: Lexington, Kentucky • Springfield, Missouri • Knoxville, Tennessee

Conditions: Electronic Cigarette Use
Interventions: 5% nicotine (Partial Nicotine Reduction), 3% or 2.4% nicotine (Partial Nicotine Reduction), 5% nicotine (Total Nicotine Reduction), 0% nicotine (Total Nicotine Reduction); Other
Lead sponsor: Florida International University; Other
Eligibility: 21 Years to 35 Years
Enrollment: 116 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Tobacco Use
Interventions: Cigarette Brand Switching, E-cigarette Flavor; Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Marijuana Dependence
Interventions: Nicotine, Cannabis, PAX Loose Leaf Vaporizer; Drug · Device
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years to 70 Years
Enrollment: 8 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Tobacco Use
Interventions: Ploom HTP Menthol HTS; MX3 (681), Ploom HTP Tobacco HTS; R8 (120), Smoking Abstinence (menthol), Smoking Abstinence (non-menthol); Other
Lead sponsor: Altria Client Services LLC; Industry
Eligibility: 22 Years to 65 Years
Enrollment: 921 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 8
States / cities: Bentonville, Arkansas • Rogers, Arkansas • Overland Park, Kansas + 5 more

Conditions: Cigarette Smoking
Interventions: NIDA Standard Research E-cigarette (SREC); Device
Lead sponsor: University of Southern California; Other
Eligibility: 22 Years to 55 Years
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2028
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Cervical Dysplasia
Interventions: Nicotine Replacement Therapy, Electronic Cigarettes; Other · Device
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years to 65 Years · Female only
Enrollment: 31 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Hiv, Lung Injury
Interventions: Not listed
Lead sponsor: Pennington Biomedical Research Center; Other
Eligibility: 18 Years and older
Enrollment: 23 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 2
States / cities: Baton Rouge, Louisiana • New Orleans, Louisiana

Conditions: Message Exposure
Interventions: educational message exposure; Behavioral
Lead sponsor: University of Georgia; Other
Eligibility: 18 Years to 29 Years
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Athens, Georgia

Conditions: Smoking, Tobacco Use
Interventions: Electronic Cigarette; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 21 Years and older
Enrollment: 638 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Electronic Cigarette Use
Interventions: Standardized research e-cigarette (SREC); Device
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 41 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Smoking
Interventions: NNC Spectrum Cigarette, VLNC Spectrum Cigarette, Moderate nicotine level e-liquid, Low nicotine level e-liquid, Tobacco Flavors, Tobacco and non-tobacco e-liquid flavors; Other
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 156 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2020
U.S. locations: 2
States / cities: Winston-Salem, North Carolina • Philadelphia, Pennsylvania

Conditions: Electronic Nicotine Delivery Systems, Tobacco Products, Cigarette Smoking
Interventions: EQUIP, Standard Care; Behavioral
Lead sponsor: University of Chicago; Other
Eligibility: 18 Years to 26 Years
Enrollment: 46 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Smoking, Cigarette, Electronic Cigarette Use
Interventions: Cue Reactivity Task, Computerized Visual Dot Probe, Choice Task; Behavioral
Lead sponsor: Brown University; Other
Eligibility: 21 Years to 34 Years
Enrollment: 82 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Cardiovascular Risk Factor, Nicotine Dependence
Interventions: Electronic Cigarette; Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years and older
Enrollment: 16 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 2
States / cities: San Francisco, California

Conditions: Vaping
Interventions: Financial reward graphic message, Health reward graphic message, Self-efficacy graphic message, Social norms graphic message; Behavioral
Lead sponsor: University of Rochester; Other
Eligibility: 12 Years to 17 Years
Enrollment: 362 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Smoking, Smoking Cessation
Interventions: Not listed
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 18 Years and older
Enrollment: 96 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2017
U.S. locations: 2
States / cities: New York, New York

Conditions: Smoking, Cigarette, Electronic Cigarettes
Interventions: Spectrum Research Cigarettes; Behavioral
Lead sponsor: Brown University; Other
Eligibility: 15 Years to 20 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Smoking, Cigarette, Smoking E-cigarette, Healthy Volunteer
Interventions: [18F]NOS; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 45 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2028
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Tobacco Use
Interventions: Behavioral and pharmacological support to reduce combustible tobacco use.; Behavioral
Lead sponsor: Rose Research Center, LLC; Industry
Eligibility: 21 Years and older
Enrollment: 100 participants
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: San Francisco, California

Search by objective public record fields.

Manipulating E-Cigarette Nicotine to Promote Public Health

Influencer E-Cigarette and Cannabis Marketing: a Survey-Based Experiment Among Adolescents

Cardiovascular Impacts of E-cigarettes Among Older Adults

Social Media Intervention to Stop Nicotine and Cannabis Vaping Among Adolescents

Pharmacokinetic and Subjective Effects of Heated Tobacco Products

Assessing the Effect of Nicotine Reduction on ENDS User's Addiction and Exposures

Impact of Cigarette and E-cigarette Flavors on Adult Smoking Behavior

Vaping THC From Electronic Cigarettes

Changes in Biomarker of Exposure in Adults Who Smoke Cigarettes Switching From Cigarettes to Heated Tobacco Products

Are Smokers Switching to Vaping at Lower Risk for Cancer? (Electronic Cigarettes and Cancer Risk)

Smoking Cessation in Women With Gynecological Conditions

Effects of Using E-Cigarettes on Lungs in People With HIV (HBS Ancillary)

A Neuroimaging Approach to Advance Mechanistic Understanding of Tobacco Use Escalation Risk Among Young Adult African American Vapers

Clinical Outcomes of a Nationwide, Naturalistic E-Cig Trial (CONNECT)

Switching Individuals in Treatment for Opioid Use Disorder Who Smoke Cigarettes to the SREC

Project 2 Cigarette and E-cigarette Nicotine Content and E-liquid Flavors

Development of a Mobile Health Intervention for Electronic Cigarette Use Among Young Adults

Dual Use of ENDS and Combustible Cigarettes

Short-Term Cardiovascular Effects of E-Cigarettes: Influence of Device Power

Graphic Messages to Prevent E-Cigarette Use Among Black and Latino Adolescents

Alternate Nicotine Delivery Systems and Airway Epithelial Biology

Evaluating New Nicotine Standards for Cigarettes - Project 3

Imaging Sex Differences in Smoking-Induced Pulmonary Inflammation

Comparative Tobacco Interventions for Individuals With Severe and Persisting Behavioral Health Disorders