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ClinicalTrials.gov public records Last synced Nov 15, 2026, 4:40 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 97–120 of 134 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: cigarette or e-cigarette Clear all

Conditions: Nicotine Dependence, Other Tobacco Product
Interventions: Nicotine, Low Dose Menthol, High Dose Menthol; Drug · Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 20 Years
Enrollment: 59 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Tobacco Cessation
Interventions: This is Quitting, Assessment only Control; Other
Lead sponsor: Truth Initiative; Other
Eligibility: 18 Years to 24 Years
Enrollment: 2,588 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Tobacco Smoking, Psychiatric Disorders
Interventions: E-cigarette; Other
Lead sponsor: Fordham University; Other
Eligibility: 21 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Lung Inflammation, HIV Seropositivity
Interventions: ECIGS, mobile contingency management (mCM), Usual brand; Other · Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 64 Years
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Electronic Cigarettes
Interventions: JUUL electronic cigarette, IQOS electronic cigarette, Own Brand cigarette; Other
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 21 Years to 55 Years
Enrollment: 22 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Nicotine Dependence
Interventions: Nicotine, Experimental Flavor, Menthol Flavor; Drug · Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 20 Years
Enrollment: 56 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Healthy Volunteers, Smoking
Interventions: Use electronic cigarette or smoke conventional cigarette; Other
Lead sponsor: British American Tobacco (Investments) Limited; Industry
Eligibility: 22 Years to 55 Years
Enrollment: 18 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017
U.S. locations: 1
States / cities: Burbank, California

Conditions: Smoking, Cigarette
Interventions: JUUL, Treatment As Usual; Device · Other
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 21 Years to 99 Years
Enrollment: 350 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: COPD
Interventions: E-cigarette (EC), Nicotine Replacement Therapy (NRT), Smoking Harm Reduction Counseling Sessions; Other · Behavioral
Lead sponsor: NYU Langone Health; Other
Eligibility: 21 Years to 75 Years
Enrollment: 146 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: New York, New York

Conditions: Tobacco Smoking, Electronic Cigarette Use, Substance Use
Interventions: CC+ECIG Condition, CC Condition, Sham Condition; Other
Lead sponsor: University of Houston; Other
Eligibility: 18 Years and older
Enrollment: 107 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Tobacco Cessation, Electronic Nicotine Delivery Systems
Interventions: Vaping - Fruit flavored ENDS, Biospecimen Collection, Vaping - tobacco flavored ENDS; Other · Procedure
Lead sponsor: Roswell Park Cancer Institute; Other
Eligibility: 21 Years and older
Enrollment: 286 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Smoking Cessation, Vaping Cessation
Interventions: Cytisinicline; Drug
Lead sponsor: Achieve Life Sciences; Industry
Eligibility: 18 Years and older
Enrollment: 479 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 29
States / cities: Mobile, Alabama • Tempe, Arizona • Little Rock, Arkansas + 26 more

Conditions: Electronic Cigarettes
Interventions: E-cigarette with sweetness type 1 and pronation level 1, E-cigarette with sweetness type 1 and pronation level 2, E-cigarette with sweetness type 2 and pronation level 1, E-cigarette with sweetness type 2 and pronation level 2; Other
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 13 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Heavy Metal Exposure From Vaping
Interventions: Non-Interventional Study; Other
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 18 Years to 29 Years
Enrollment: 58 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Schizophrenia and Related Disorders
Interventions: e-cigarette, brand name JUUL; Device
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 21 Years to 65 Years
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: New York, New York

Conditions: Tobacco Use Cessation
Interventions: web-based video game (Quit IT), Questionnaires, Salvia sample; Other · Behavioral
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2020
U.S. locations: 1
States / cities: New York, New York

Conditions: Adverse Effect of Other Agents Primarily Affecting the Cardiovascular System, Initial Encounter
Interventions: Cigarette, NIDA test type with 16.6 mg nicotine, Cigarette, NIDA test type with <0.45 mg nicotine, Electronic cigarette with 18 mg/ml nicotine, Electronic Cigarette with no nicotine, Moist snuff, Sham Smoking, Secondhand cigarette smoke (SHS), Conditioned, filtered air, Sham Moist Snuff; Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 50 Years
Enrollment: 81 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2021
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Nicotine Vaping
Interventions: Nicotine vaping visit 1 (free-base nicotine), Nicotine vaping visit 1 (protonated nicotine), Nicotine vaping visit 2 (free-base nicotine), Nicotine vaping visit 2 (protonated nicotine); Other
Lead sponsor: Yale University; Other
Eligibility: 21 Years and older
Enrollment: 36 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Tobacco Use Disorder
Interventions: electronic cigarette, nicotine inhaler; Other · Drug
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 18 Years to 60 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: New York, New York

Conditions: Tobacco Use Disorder
Interventions: Menthol ban on cigarettes, Menthol ban on cigarettes and e-cigarettes, No menthol ban; Other
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 64 Years
Enrollment: 47 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Tobacco Use Cessation, Addiction
Interventions: Healthy Futures: Alternative-to-Suspension Curriculum; Behavioral
Lead sponsor: Stanford University; Other
Eligibility: 14 Years to 18 Years
Enrollment: 2,540 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Nicotine Vaping
Interventions: YES-CAN! program; Behavioral
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 9 Years and older
Enrollment: 1,166 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Smoking, Nicotine Addiction, Surgery
Interventions: ENDD (NJOY), NRT (NicoDerm CQ), telephone counseling, brief advice, brochure; Behavioral · Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Cigarette Smoking Behavior, E-Cigarette Use
Interventions: E-cigarette, Nicotine replacement therapy (patch, gum), both arms, CO-contingent financial incentives, both arms, Cessation counseling; Other · Drug · Behavioral
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 21 Years and older
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Search by objective public record fields.

Flavors and E-cigarette Effects in Adolescent Smokers- STUDY 1

Text Message Quit Vaping Intervention for Young Adults

The Effect of Electronic Cigarette Use on Smoking Behaviors Among Smokers Receiving Outpatient Psychiatric Treatment

Effects of E-cigarettes (ECIGs) on Pulmonary Inflammation and Behavior in HIV Infected Smokers

Assessment of Two New Electronic Cigarettes in Cigarette Smokers

Flavors and E-cigarette Effects in Adolescent Smokers- STUDY 2

E-cigarette Nicotine Pharmacokinetic Study

Switching to a Vaping Device: Evaluating Risk Reduction Among Quitline Treatment Failures

Electronic Cigarettes as a Harm Reduction Strategy Among Patients With COPD

Dual Use Approach Bias Training for Nicotine Addiction

Flavored Electronic Nicotine Delivery Systems to Lower Smoking and Exposure to Tobacco Toxicants Among Cigarette Smokers Interested in Quitting, REFLECT Trial

Safety Study of Cytisinicline in Adult Combustible and/or E-cigarette Smokers

Determination of Liquid Flavor and Nicotine Form Outcomes

Examining Heavy Metal Exposure and Respiratory Health in Young Adult Electronic Cigarette Users

Role of an E-cigarette on Smoking Displacement in Smokers With Schizophrenia

Quit IT: Preliminary Testing of a Web-based, 3D Coping Skills Game to Increase Quitting Self-Efficacy for Maintaining Smoking Abstinence Following Hospitalization

Cardiovascular Assessment of the Effects of Tobacco and Nicotine Delivery Products

Nicotine Flux, a Potentially Powerful Tool for Regulating Nicotine Delivery From Electronic Cigarettes

Electronic Cigarettes or Nicotine Inhaler for Smoking Cessation

Effect of Banning Menthol Flavorant on Cigarette and E-Cigarette Use

An Evaluation of the Tobacco Prevention Toolkit Healthy Futures: Alternative-to-Suspension Vaping Intervention

Pilot Study of the YES-CAN! Program to Prevent Youth Nicotine Vaping

The END Perioperative Smoking Pilot Study

Project E-Shift: A Harm Reduction Intervention for Chronically Unhoused Smokers.