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ClinicalTrials.gov public records Last synced Oct 2, 2026, 3:20 PM EDT

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Showing 25–48 of 54 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: digital breast tomosynthesis (DBT) Clear all
Completed No phase listed Observational

Digital Breast Tomosynthesis Preference Study

NCT00776126
View directory record Official record
Conditions
Breast Cancer
Interventions
Digital Breast Tomosynthesis Exam
Device
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Other
Eligibility
18 Years and older · Female only
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 6, 2017 · Synced Oct 2, 2026, 3:20 PM EDT
Completed No phase listed Observational

Simulated Screening Study for Breast Imaging

NCT01807754
View directory record Official record
Conditions
Breast Cysts, Breast Tumors
Interventions
X-ray and ultrasound imaging scanning, Photoacoustic imaging scans for breast cancer screening
Procedure
Lead sponsor
University of Michigan
Other
Eligibility
30 Years to 80 Years · Female only
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2020
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 21, 2020 · Synced Oct 2, 2026, 3:20 PM EDT
Terminated Early Phase 1 Interventional

Comparison of CE-DBT and MRI in Patients With Known Breast Lesions

NCT05754749
View directory record Official record
Conditions
Breast Cancer
Interventions
Iohexol 350 Mg/mL Injectable Solution
Drug
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Other
Eligibility
18 Years and older · Female only
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Oct 2, 2026, 3:20 PM EDT
Terminated Not applicable Interventional Results available

Assessment of Diagnostic Accuracy and Performance of Digital Breast Tomosynthesis Compared to Mammography (ADAPT)

NCT02324205
View directory record Official record
Conditions
Breast Cancer, Tumors, Breast
Interventions
DBT and FFDM
Device
Lead sponsor
GE Healthcare
Industry
Eligibility
30 Years and older · Female only
Enrollment
196 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
2
States / cities
Boca Raton, Florida • Voorhees Township, New Jersey
Source: ClinicalTrials.gov public record
Updated Feb 26, 2019 · Synced Oct 2, 2026, 3:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparison of Full-Field Digital Mammography With Digital Breast Tomography for Screening Call-Back Rates

NCT01236781
View directory record Official record
Conditions
Breast Neoplasms
Interventions
Screening Tomosynthesis, Diagnostic Tomosynthesis
Device
Lead sponsor
American College of Radiology
Other
Eligibility
25 Years and older · Female only
Enrollment
558 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
2
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 5, 2025 · Synced Oct 2, 2026, 3:20 PM EDT
Completed Not applicable Interventional Results available

Multicenter Hologic Tomosynthesis Study

NCT00971087
View directory record Official record
Conditions
Breast Cancer
Interventions
Hologic Selenia Dimensions Digital Breast Tomosynthesis System
Device
Lead sponsor
Hologic, Inc.
Industry
Eligibility
18 Years to 110 Years · Female only
Enrollment
3,521 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
22
States / cities
Scottsdale, Arizona • Newport Beach, California • Sacramento, California + 19 more
Source: ClinicalTrials.gov public record
Updated Feb 26, 2025 · Synced Oct 2, 2026, 3:20 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Comparison of Breast Cancer Screening With CESM to DBT in Women With Dense Breasts

NCT05625659
View directory record Official record
Conditions
Breast Cancer
Interventions
Dual-Energy Contrast-Enhanced Spectral Mammography (CESM)
Diagnostic Test
Lead sponsor
American College of Radiology
Other
Eligibility
45 Years to 74 Years · Female only
Enrollment
2,032 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
12
States / cities
Birmingham, Alabama • Boca Raton, Florida • The Villages, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Jul 31, 2026 · Synced Oct 2, 2026, 3:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Molecular Breast Imaging and Digital Breast Tomosynthesis in Screening Patients With Dense Breast Tissue

NCT03220893
View directory record Official record
Conditions
Breast Carcinoma
Interventions
Digital Breast Tomosynthesis (DBT), Scintimammography
Procedure · Radiation
Lead sponsor
Mayo Clinic
Other
Eligibility
40 Years to 75 Years · Female only
Enrollment
3,023 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2025
U.S. locations
5
States / cities
Detroit, Michigan • Rochester, Minnesota • Toledo, Ohio + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 24, 2026 · Synced Oct 2, 2026, 3:20 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Multi-Reader, Multi-Case, Cross-Over, Retrospective Study to Evaluate Effectiveness of Lunit INSIGHT DBT

NCT05716958
View directory record Official record
Conditions
Breast Cancer
Interventions
Digital Breast Tomosynthesis
Radiation
Lead sponsor
Lunit Inc.
Industry
Eligibility
22 Years and older · Female only
Enrollment
262 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Annapolis, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 2, 2026, 3:20 PM EDT
Completed No phase listed Observational

Dual-energy Contrast-enhanced (2D and 3D Mammography Versus Contrast-enhanced MRI)- A Pilot Study

NCT01433640
View directory record Official record
Conditions
Breast Cancer
Interventions
Not listed
Lead sponsor
Hologic, Inc.
Industry
Eligibility
25 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 18, 2015 · Synced Oct 2, 2026, 3:20 PM EDT
Recruiting Phase 2 Interventional

Acolbifene Versus Low Dose Tamoxifen for the Prevention of Breast Cancer in Premenopausal Women at High Risk for Development of Breast Cancer

NCT05941520
View directory record Official record
Conditions
Breast Atypical Hyperplasia, Breast Carcinoma, Breast Ductal Carcinoma In Situ, Breast Lobular Carcinoma In Situ
Interventions
Acolbifene Hydrochloride, Biospecimen Collection, Mammography, Questionnaire Administration, Random Periareolar Fine-Needle Aspiration, Tamoxifen
Drug · Procedure · Other
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
35 Years and older · Female only
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
4
States / cities
Duarte, California • Chicago, Illinois • Kansas City, Kansas + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Oct 2, 2026, 3:20 PM EDT
Recruiting Early Phase 1 Interventional

Neoadjuvant Therapy and Contrast-enhanced Mammography for Early Stage Breast Cancer

NCT06220214
View directory record Official record
Conditions
Breast Cancer, Locally Advanced Breast Cancer, Neoadjuvant Chemotherapy, HER2-positive Breast Cancer, Triple Negative Breast Cancer, TNBC, Triple Negative Breast Cancer
Interventions
CEDM, CEDBT, Omnipaque 350mgI/mL Solution for Injection
Diagnostic Test · Drug
Lead sponsor
Alison Stopeck
Other
Eligibility
18 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Oct 2, 2026, 3:20 PM EDT
Completed Not applicable Interventional

Contrast Enhanced Spectral Mammography With Digital Breast Tomosynthesis For Patients With Newly Diagnosed Breast Cancer

NCT03176979
View directory record Official record
Conditions
Breast Carcinoma
Interventions
Contrast Agent, Digital Tomosynthesis Mammography, Dual-Energy Contrast-Enhanced Digital Spectral Mammography
Other · Procedure
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older · Female only
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Nov 18, 2021 · Synced Oct 2, 2026, 3:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Early Detection of Breast Cancer Using Tomosynthesis Imaging

NCT00637598
View directory record Official record
Conditions
Breast Neoplasms
Interventions
Mammography and tomosynthesis imaging
Radiation
Lead sponsor
Duke University
Other
Eligibility
Female only
Enrollment
385 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2013
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 13, 2017 · Synced Oct 2, 2026, 3:20 PM EDT
Completed Not applicable Interventional Results available

Contrast-Enhanced Mammography for Breast Cancer Staging in Patients Referred for a Second Opinion

NCT05036083
View directory record Official record
Conditions
Breast Carcinoma, Invasive Breast Carcinoma
Interventions
Contrast-Enhanced Mammography, Digital Tomosynthesis Mammography, Electronic Health Record Review, Iodinated Contrast Agent
Procedure · Other · Drug
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older · Female only
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 17, 2025 · Synced Oct 2, 2026, 3:20 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Automated Breast Ultrasound and Digital Breast Tomosynthesis Screening Compared to Full Field Digital Mammography in Women With Dense Breasts

NCT02042456
View directory record Official record
Conditions
Breast Cancer
Interventions
Digital Breast Tomosynthesis, Automated Whole Breast Ultrasound, Full Field Digital Mammography
Device
Lead sponsor
GE Healthcare
Industry
Eligibility
18 Years and older · Female only
Enrollment
124 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 20, 2015 · Synced Oct 2, 2026, 3:20 PM EDT
Completed No phase listed Observational

Testing Digital Breast Tomosynthesis vs. Regular Mammogram in Detecting Breast Cancer in Women Having Screening Mammogram

NCT00535678
View directory record Official record
Conditions
Breast Cancer
Interventions
Not listed
Lead sponsor
GE Healthcare
Industry
Eligibility
18 Years and older · Female only
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Princeton, New Jersey
Source: ClinicalTrials.gov public record
Updated May 14, 2010 · Synced Oct 2, 2026, 3:20 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers Results available

Abbreviated Breast MRI and Digital Tomosynthesis Mammography in Screening Women With Dense Breasts

NCT02933489
View directory record Official record
Conditions
Asymptomatic
Interventions
Contrast-enhanced Magnetic Resonance Imaging, Digital Tomosynthesis Mammography, Quality-of-Life Assessment, Questionnaire Administration
Diagnostic Test · Other
Lead sponsor
ECOG-ACRIN Cancer Research Group
Network
Eligibility
40 Years to 75 Years · Female only
Enrollment
1,516 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2026
U.S. locations
67
States / cities
Gilbert, Arizona • Pasadena, California • Denver, Colorado + 54 more
Source: ClinicalTrials.gov public record
Updated Feb 25, 2026 · Synced Oct 2, 2026, 3:20 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

B.Brilliant Revelation Comparision Study

NCT07067788
View directory record Official record
Conditions
Breast Cancer Screening
Interventions
Breast Imaging
Diagnostic Test
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older · Female only
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 24, 2026 · Synced Oct 2, 2026, 3:20 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Digital Breast Tomosynthesis Guided Tomographic Optical Breast Imaging (TOBI)

NCT02033486
View directory record Official record
Conditions
Breast Cancer
Interventions
TOBI + DBT
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
30 Years to 80 Years · Female only
Enrollment
375 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2021
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 18, 2019 · Synced Oct 2, 2026, 3:20 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Breast Cancer Screening for Underserved Women: Comparing Outcomes and Lowering Recall Rates With 3D- vs. 2D-mammography

NCT03979729
View directory record Official record
Conditions
Breast Cancer Screening
Interventions
Routine Screening Mammogram (3D + 2D), Routine Screening Mammogram (2D), No Screening Mammogram
Other
Lead sponsor
New Mexico Cancer Research Alliance
Other
Eligibility
40 Years and older · Female only
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Oct 5, 2022 · Synced Oct 2, 2026, 3:20 PM EDT
Completed No phase listed Observational

Clinical Utility of Whole Breast Screening Ultrasound in Patients Undergoing Digital Breast Tomosynthesis

NCT02174406
View directory record Official record
Conditions
Breast Screening
Interventions
breast ultrasound, DBT (Full field digital mammography + tomosynthesis)
Procedure
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
30 Years and older · Female only
Enrollment
1,494 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 23, 2023 · Synced Oct 2, 2026, 3:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of the Efficacy of Digital Breast Tomosynthesis Imaging

NCT01373671
View directory record Official record
Conditions
Breast Cancer
Interventions
SIEMENS INSPIRATION DIGITAL BREAST TOMOSYNTHESIS (DBT) SYSTEM
Device
Lead sponsor
Siemens Medical Solutions USA - CSG
Industry
Eligibility
30 Years and older · Female only
Enrollment
764 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Malvern, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 7, 2020 · Synced Oct 2, 2026, 3:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Assessment of Digital Breast Tomosynthesis (DBT) in the Screening Environment

NCT01106911
View directory record Official record
Conditions
Breast Abnormalities
Interventions
tomosynthesis and screening mammography
Device
Lead sponsor
University of Pittsburgh
Other
Eligibility
35 Years to 55 Years · Female only
Enrollment
1,080 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2010
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 25, 2016 · Synced Oct 2, 2026, 3:20 PM EDT