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ClinicalTrials.gov public records Last synced Oct 8, 2026, 8:37 PM EDT

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Showing 97–120 of 173 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: e-cig with nicotine Clear all
Completed Phase 4 Interventional Results available

The END Perioperative Smoking Pilot Study

NCT02482233
View directory record Official record
Conditions
Smoking, Nicotine Addiction, Surgery
Interventions
ENDD (NJOY), NRT (NicoDerm CQ), telephone counseling, brief advice, brochure
Behavioral · Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 9, 2022 · Synced Oct 8, 2026, 8:37 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Low Nicotine Content Cigarettes in Vulnerable Populations: Affective Disorders

NCT04090879
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Either normal nicotine content cigarettes (15.8mg/g) or reduced nicotine content cigarettes (0.4mg/g), E-Cigarettes
Other
Lead sponsor
Brown University
Other
Eligibility
18 Years to 70 Years
Enrollment
326 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
2
States / cities
Providence, Rhode Island • Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Apr 1, 2025 · Synced Oct 8, 2026, 8:37 PM EDT
Completed Phase 1 Interventional Results available

Effects of E-Cigarette Flavors on Adults TCORS 2.0

NCT03635333
View directory record Official record
Conditions
Nicotine Use Disorder
Interventions
Nicotine, Flavor
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 50 Years
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 19, 2025 · Synced Oct 8, 2026, 8:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Study to Investigate the Nicotine Pharmacokinetic Profiles and Pharmacodynamic Effects of P4M3 Variants

NCT03379740
View directory record Official record
Conditions
Vaping, Nicotine Absorption
Interventions
E-cigarette, P4M3-1.7%, P4M3-1.7%LA, P4M3-3%LA, P4M3-4%LA
Other
Lead sponsor
Philip Morris Products S.A.
Industry
Eligibility
21 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
High Point, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 22, 2019 · Synced Oct 8, 2026, 8:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Effect of Electronic Cigarette Liquid Characteristics in Smokers.

NCT03861078
View directory record Official record
Conditions
Electronic Cigarettes
Interventions
Own Brand Cigarette, ECIG 15 mg nicotine, sweetened, ECIG 15 mg nicotine, unsweet, ECIG 0 mg nicotine, sweetened, ECIG 0 mg nicotine, unsweet
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
21 Years to 55 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 23, 2022 · Synced Oct 8, 2026, 8:37 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

The Interaction of Flavor With Nicotine Form in Adult Smokers

NCT04262817
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Nicotine form, E-cigarette experimental flavor
Drug · Other
Lead sponsor
Yale University
Other
Eligibility
21 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 26, 2023 · Synced Oct 8, 2026, 8:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Goal2QuitVaping for Nicotine Vaping Cessation Among Adolescents

NCT04951193
View directory record Official record
Conditions
Depressive Symptoms, Depression, Adolescent Behavior
Interventions
Behavioral Activation Therapy app, Treatment as Usual
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
16 Years to 20 Years
Enrollment
106 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 21, 2024 · Synced Oct 8, 2026, 8:37 PM EDT
Withdrawn Phase 1 Interventional Accepts healthy volunteers

The Acute Cardiovascular Effects of Nicotine in E-cigarettes (ACE) Study

NCT03010995
View directory record Official record
Conditions
Cigarette Smoking Toxicity, Nicotine, Acute Cardiovascular Disease
Interventions
Prazosin
Drug
Lead sponsor
University of Louisville
Other
Eligibility
18 Years to 40 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 26, 2018 · Synced Oct 8, 2026, 8:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

E-cigarettes and Blood Vessel Function

NCT02740595
View directory record Official record
Conditions
Nicotine Dependence
Interventions
one time exposure to e-cig with nicotine, one time exposure to e-cig without nicotine, one time exposure to empty e-cig
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
21 Years to 45 Years
Enrollment
148 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 5, 2023 · Synced Oct 8, 2026, 8:37 PM EDT
Completed Not applicable Interventional

Feasibility and Acceptability of Switching to E-cigarettes Among Cigarette Smokers Engaged in SUD Treatment

NCT05918887
View directory record Official record
Conditions
Tobacco Dependence Caused by Cigarettes
Interventions
NJOY ACE commercial e-cigarette
Device
Lead sponsor
University of Nevada, Reno
Other
Eligibility
21 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Reno, Nevada
Source: ClinicalTrials.gov public record
Updated May 13, 2025 · Synced Oct 8, 2026, 8:37 PM EDT
Completed Early Phase 1 Interventional

Compensatory Behavior of E-cig Users in Response to Reduced Nicotine E-liquids

NCT06602492
View directory record Official record
Conditions
Healthy, Nicotine Addiction, Electronic Cigarette Use
Interventions
Lower nicotine e-liquid, Higher nicotine eliquid
Drug
Lead sponsor
Rochester Institute of Technology
Other
Eligibility
21 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Sep 27, 2024 · Synced Oct 8, 2026, 8:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Oral Nicotine Product Messaging to Communicate Risk of Use for Young Adults

NCT07702435
View directory record Official record
Conditions
Tobacco-Related Carcinoma
Interventions
Behavioral Intervention, Survey Administration
Behavioral · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
18 Years to 30 Years
Enrollment
607 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Oct 8, 2026, 8:37 PM EDT
Active, not recruiting Early Phase 1 Interventional

Electronic Cigarette-derived Oxidants and Cardiopulmonary Effects

NCT05239793
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease
Interventions
NJOY e-cigarette
Drug
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
21 Years to 74 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 27, 2025 · Synced Oct 8, 2026, 8:37 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Remote Trial - Tobacco Product Standard (VLNC)

NCT06442384
View directory record Official record
Conditions
Tobacco Use
Interventions
Tobacco and non-tobacco e-cigarettes, Tobacco only e-cigarettes
Other
Lead sponsor
Masonic Cancer Center, University of Minnesota
Other
Eligibility
21 Years and older
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 10, 2025 · Synced Oct 8, 2026, 8:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Moment Study: Mixed Method E-cigarette Study

NCT02261363
View directory record Official record
Conditions
Smoking
Interventions
Ecig group 1
Other
Lead sponsor
Truth Initiative
Other
Eligibility
18 Years and older
Enrollment
117 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated May 8, 2025 · Synced Oct 8, 2026, 8:37 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Manipulating E-Cigarette Nicotine to Promote Public Health

NCT06448351
View directory record Official record
Conditions
Tobacco-Related Carcinoma
Interventions
Biospecimen Collection, Carbon Monoxide Measurement, Vaping session, Survey Administration
Procedure · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years to 65 Years
Enrollment
375 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 14, 2026 · Synced Oct 8, 2026, 8:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Establishing the Effect of Flavor on the Addictive Potential of Electronic Cigarettes

NCT03905928
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Nicotine Containing ECIG with tobacco flavor, Nicotine Containing ECIG with Strawberry Vanilla Flavor, Placebo ECIG with Tobacco Flavor, Placebo ECIG with Strawberry Vanilla Flavor
Other
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
21 Years to 60 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 22, 2025 · Synced Oct 8, 2026, 8:37 PM EDT
Suspended No phase listed Observational Accepts healthy volunteers

Patients' Attitudes Toward and Experiences With Buprenorphine Treatment

NCT05121428
View directory record Official record
Conditions
Opioid-use Disorder, Acceptability of Health Care, Opioid-Related Disorders
Interventions
Not listed
Lead sponsor
Cambridge Health Alliance
Other
Eligibility
18 Years and older
Enrollment
817 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 11, 2025 · Synced Oct 8, 2026, 8:37 PM EDT
Completed Phase 3 Interventional

COMET2 Project 1 Filter Ventilation Study

NCT03637972
View directory record Official record
Conditions
Smoking, Tobacco Use
Interventions
Ventilated cigarettes only, Unventilated cigarettes only, Access to Experimental Marketplace: Ventilated cigarettes + alternative nicotine delivery systems, Access to Experimental Marketplace: Unventilated cigarettes + ANDS
Other
Lead sponsor
Masonic Cancer Center, University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
118 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
2
States / cities
Minneapolis, Minnesota • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 29, 2022 · Synced Oct 8, 2026, 8:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Study to Evaluate the Pharmacokinetic Profiles of Cigarettes and E-Cigarettes With Nicotine Salt Formulations

NCT03822546
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Conventional cigarette, myblu 25 mg freebase, myblu 16 mg nicotine salt, myblu 25 mg nicotine salt, myblu 40 mg nicotine salt, blu PRO 48 mg nicotine salt
Other
Lead sponsor
Fontem Ventures BV
Industry
Eligibility
25 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Jan 30, 2019 · Synced Oct 8, 2026, 8:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Nicotine Uptake, Measures of Abuse Liability, and Puffing Topography With Use of RELX ENDS Products by ENDS Consumers

NCT04620616
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
RELX ENDS Tobacco Flavor, RELX ENDS Menthol Flavor, Subject Usual Brand ENDS
Other
Lead sponsor
Cheerain HK Limited
Industry
Eligibility
22 Years to 59 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
2
States / cities
Cypress, California • Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Jan 19, 2021 · Synced Oct 8, 2026, 8:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Low Nicotine Content Cigarettes in Vulnerable Populations: Women of Reproductive Age

NCT04092387
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Varying the nicotine content of cigarettes, E-Cigarettes
Other
Lead sponsor
University of Vermont
Other
Eligibility
21 Years to 44 Years · Female only
Enrollment
326 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
2
States / cities
Baltimore, Maryland • Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Mar 18, 2025 · Synced Oct 8, 2026, 8:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Appeal and Impact of E-cigarettes in Smokers With SMI

NCT03050853
View directory record Official record
Conditions
Tobacco Dependence, Schizophrenia, Bipolar Disorder, Schizoaffective Disorder
Interventions
E-cigarette
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
2
States / cities
Louisville, Kentucky • Lawrence, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 29, 2021 · Synced Oct 8, 2026, 8:37 PM EDT
Recruiting Not applicable Interventional

Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction

NCT06077240
View directory record Official record
Conditions
Smoking, Smoking Behaviors, Nicotine Dependence
Interventions
E-cigarette with 2.4% Nicotine with Menthol and Tobacco Flavors, E-cigarette with 2.4% Nicotine with Tobacco Flavor Only, E-cigarette with 5% Nicotine with Menthol and Tobacco Flavors, E-cigarette with 5% Nicotine with Tobacco Flavor Only, Tobacco Pouches with 3mg Nicotine with Menthol and Tobacco Flavors, Tobacco Pouches with 3mg Nicotine with Tobacco Flavor Only, Tobacco Pouches with 6mg Nicotine with Menthol and Tobacco Flavors, Tobacco Pouches with 6mg Nicotine with Tobacco Flavor Only
Behavioral
Lead sponsor
Yale University
Other
Eligibility
21 Years and older
Enrollment
256 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 19, 2026 · Synced Oct 8, 2026, 8:37 PM EDT