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ClinicalTrials.gov public records Last synced Nov 6, 2026, 10:32 PM EST

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Showing 1–24 of 426 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: electronic cigarette Clear all

Conditions: Vaping
Interventions: Expert, one-sided, Expert, two-sided, Peer, one-sided, Peer, two-sided; Other
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 18 Years to 24 Years
Enrollment: 112 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: Worcester, Massachusetts

Conditions: Smoking, Smoking Behaviors, Nicotine Dependence
Interventions: E-cigarette with 2.4% Nicotine with Menthol and Tobacco Flavors, E-cigarette with 2.4% Nicotine with Tobacco Flavor Only, E-cigarette with 5% Nicotine with Menthol and Tobacco Flavors, E-cigarette with 5% Nicotine with Tobacco Flavor Only, Tobacco Pouches with 3mg Nicotine with Menthol and Tobacco Flavors, Tobacco Pouches with 3mg Nicotine with Tobacco Flavor Only, Tobacco Pouches with 6mg Nicotine with Menthol and Tobacco Flavors, Tobacco Pouches with 6mg Nicotine with Tobacco Flavor Only; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 21 Years and older
Enrollment: 256 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Adolescent Substance Use
Interventions: Guiding Good Choices; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 11 Years to 12 Years
Enrollment: 3,636 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2025
U.S. locations: 3
States / cities: Oakland, California • Aurora, Colorado • Detroit, Michigan

Conditions: Vaping
Interventions: Youth Perceptions of Influencer Age and Fitness Contexts in E-Cigarette Marketing; Other
Lead sponsor: University of Southern California; Other
Eligibility: 14 Years to 17 Years
Enrollment: 700 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Tobacco-Related Carcinoma
Interventions: Health Education, Interview, Smoking Cessation Intervention, Survey Administration, Text Message-Based Navigation Intervention; Behavioral · Other
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 18 Years to 35 Years
Enrollment: 292 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Smoking, Nicotine Dependence
Interventions: Nicotine e-cigarette, Non-nicotine e-cigarette; Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Alcohol Abuse, Nicotine Dependence Tobacco Product
Interventions: E-cig use; Behavioral
Lead sponsor: Indiana University; Other
Eligibility: 21 Years and older
Enrollment: 35 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Cardiovascular Risk Factor, Nicotine Dependence
Interventions: Low Nicotine E-Liquid, Medium or High Nicotine E-Liquid; Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years to 70 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023
U.S. locations: 2
States / cities: San Francisco, California

Conditions: Lung Inflammation, HIV Seropositivity
Interventions: ECIGS, mobile contingency management (mCM), Usual brand; Other · Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 64 Years
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Vaping
Interventions: Not listed
Lead sponsor: Yale University; Other
Eligibility: 12 Years to 15 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 2
States / cities: New Haven, Connecticut • Boston, Massachusetts

Conditions: E-Cig Use
Interventions: Remote Contingency Management (CM) for nicotine abstinence, Control; Behavioral · Other
Lead sponsor: Yale University; Other
Eligibility: 13 Years to 20 Years
Enrollment: 108 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Tobacco Dependence
Interventions: Normal Nicotine Content research cigarettes, High Nicotine e-cigarette, Very Low Nicotine Content research cigarettes, Zero Nicotine e-cigarette; Other
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 21 Years to 70 Years
Enrollment: 88 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Hershey, Pennsylvania

Conditions: Smoking, Tobacco Use
Interventions: Low Power, High Power, Low Concentration, High Concentration; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 21 Years and older
Enrollment: 93 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Smoking
Interventions: E-cigarette; Other
Lead sponsor: Prisma Health-Upstate; Other
Eligibility: 21 Years and older
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Greenville, South Carolina

Conditions: E-cigarette Use
Interventions: Stanford Vaping Prevention curriculum; Behavioral
Lead sponsor: Stanford University; Other
Eligibility: 10 Years to 20 Years
Enrollment: 2,779 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Health Behavior, Wellness, Psychological, Substance Use
Interventions: Cue reactivity paradigm; Other
Lead sponsor: Brown University; Other
Eligibility: 13 Years to 16 Years
Enrollment: 224 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Electronic Cigarette Use
Interventions: RELX ENDS Tobacco Flavor, RELX ENDS Menthol Flavor, RELX ENDS Tobacco and Menthol Flavors; Other
Lead sponsor: Cheerain HK Limited; Industry
Eligibility: 22 Years to 65 Years
Enrollment: 194 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2021
U.S. locations: 5
States / cities: Bentonville, Arkansas • Lexington, Kentucky • Springfield, Missouri + 2 more

Conditions: Nicotine Dependence
Interventions: Not listed
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 60 Years
Enrollment: 159 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: Started 2013
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Tobacco Use
Interventions: 3 mg/mL nicotine strength e-liquid, 6 mg/mL nicotine strength e-liquid, 12 mg/mL nicotine strength e-liquid, 24 mg/mL nicotine strength e-liquid; Drug
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 18 Years and older
Enrollment: 81 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Smoking
Interventions: Usual Brand Cigarette, Electronic Cigarette #1, Electronic Cigarette #2, Leading U.S. Nicotine Gum; Other
Lead sponsor: R.J. Reynolds Vapor Company; Industry
Eligibility: 21 Years to 60 Years
Enrollment: 153 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Smoking Cessation, Electronic Cigarette Use
Interventions: Varenicline, Nicotine patch, Dual Focused Cessation Counseling, Smoking Focused Cessation Counseling, Counseling Intensity: 1 Session, Counseling Intensity: 4 Sessions; Drug · Behavioral · Other
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 21 Years and older
Enrollment: 500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Tobacco Dependence, Tobacco Smoking
Interventions: Smoke-free home resident intervention, Lay Health Worker coaching; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 544 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Vaping, E-Cig Use
Interventions: cytisinicline, Placebo, Behavioral support; Drug · Behavioral
Lead sponsor: Achieve Life Sciences; Industry
Eligibility: 18 Years and older
Enrollment: 160 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 5
States / cities: Lexington, Kentucky • Boston, Massachusetts • Rochester, New York + 2 more

Conditions: Tobacco Use, Nicotine Dependence, Other Tobacco Product, Tobacco Smoking
Interventions: JUUL 5%, Virginia Tobacco, ENDS product; Other
Lead sponsor: Juul Labs, Inc.; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018
U.S. locations: 2
States / cities: Charlotte, North Carolina • Raleigh, North Carolina

Search by objective public record fields.

Responses to Message Source and Presentation Using Psychophysiology

Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction

Guiding Good Choices for Health

Influencer Marketing and Adolescent E-cigarette Use

Nicotine and Tobacco Message Framing to Change Smoking Behavior in Diverse Groups of Young Adult Smokers

Short Term Effects of Electronic Cigarettes in Tobacco Dependent Adults

Reactions to E-cigs and Alcohol

Vaping High vs. Low Nicotine E-Liquid

Effects of E-cigarettes (ECIGs) on Pulmonary Inflammation and Behavior in HIV Infected Smokers

A Virtual Reality Vaping Prevention Intervention for Adolescents

Quit Nicotine: E-Cig Cessation Intervention

Low Nicotine Cigarettes Plus Electronic Cigarettes

Impact of E-cigarette Characteristics on Reinforcement and Tobacco Use Patterns

E-cigarettes as a Harm Reduction Strategy

Evaluation of the Be Vape Free Curriculum of the Tobacco Prevention Toolkit

Teen Health Choices & Wellness

Characterization of Product Use in Smokers Switching From Cigarettes to a RELX Electronic Nicotine Delivery System

Multimodal Neuroimaging Genetic Biomarkers of Nicotine AddictionSeverity

Electronic Cigarette Unit Price Manipulations in the Experimental Tobacco Marketplace

Assess Biomarkers of Tobacco Exposure and Nicotine Pharmacokinetics in Smokers After a 5-Day In-Clinic Confinement Switch to an Electronic Cigarette or Nicotine Gum

The Avenues Study: Dual Use Cessation

Smoke-free Home Study in Subsidized Housing

A Study of Cytisinicline for Vaping Cessation in Adult Smokers

A Study to Characterize Puff Topography With Use of JUUL 5% Electronic Nicotine Delivery Systems (ENDS) in Adult Smokers