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ClinicalTrials.gov public records Last synced Nov 15, 2026, 3:13 AM EST

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Showing 25–48 of 127 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: gum chewing Clear all

Conditions: Quitting Smoking, Smoking Cessation, Smoking, Cigarette
Interventions: Text message smoking treatment, Nicotine replacement therapy sampling, Wisconsin Tobacco QuitLine Referral, Referral to Primary Care Provider, BREATHE 2 Cessation Study, Additional modalities to learn about and request treatment; Behavioral · Drug · Combination Product
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older
Enrollment: 12,376 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Interaction Drug Food
Interventions: Cinnamon (2 g), Nicotine gum (2.5 mg), Letrozole (2.5 mg); Dietary Supplement · Drug
Lead sponsor: Washington State University; Other
Eligibility: 18 Years to 64 Years
Enrollment: 16 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Spokane, Washington

Conditions: Smoking Cessation
Interventions: Internet-All Nations Breath of Life (I-ANBL), Honoring the Gift of Heart Health, Nicotine gum, Patch, or Lozenge or Zyban® or Chantix®; Other · Drug
Lead sponsor: Won Choi, PhD, MPH; Other
Eligibility: 18 Years and older
Enrollment: 251 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2019
U.S. locations: 2
States / cities: Kansas City, Kansas • Pablo, Montana

Conditions: Chronic Kidney Disease
Interventions: K2CG chewing gum (20mg chitosan), K2CG chewing gum (60mg chitosan); Other
Lead sponsor: Denver Nephrologists, P.C.; Other
Eligibility: 18 Years and older
Enrollment: 167 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 4
States / cities: Tempe, Arizona • Denver, Colorado • Meridian, Idaho + 1 more

Conditions: Tobacco Use
Interventions: Product A, Product B, Product C, Product D, Product E, Product F; Other
Lead sponsor: Altria Client Services LLC; Industry
Eligibility: 22 Years to 65 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 3
States / cities: Lexington, Kentucky • Springfield, Missouri • Knoxville, Tennessee

Conditions: Xerostomia
Interventions: sugar-free chewing gum, chewing gum, mouth rinse, mouth spray; Other · Drug
Lead sponsor: University of Oklahoma; Other
Eligibility: 13 Years and older
Enrollment: 28 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2010
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Ileus
Interventions: chewing gum; Other
Lead sponsor: State University of New York - Upstate Medical University; Other
Eligibility: 18 Years to 89 Years
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2011
U.S. locations: 1
States / cities: Syracuse, New York

Conditions: Smoking, Alcoholism
Interventions: Cognitive Behavior Therapy for alcohol and smoking cessation, Nicoderm CQ nicotine patch, Placebo gum, Nicotine gum - Nicorette®; Behavioral · Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 96 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2006
U.S. locations: 1
States / cities: Newington, Connecticut

Conditions: Tobacco Use Disorder
Interventions: Oral tobacco, Nicotine Gum; Other · Drug
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 70 Years
Enrollment: 391 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2014
U.S. locations: 2
States / cities: Minneapolis, Minnesota • Eugene, Oregon

Conditions: Smoking, Homeless Persons
Interventions: Bupropion, Nicotine replacement therapy, Contingency Management; Drug · Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Smoking Cessation, Tobacco Use Cessation, Tobacco Smoking
Interventions: Nicorette, Tobacco Quit-line, Brief Behavioral Counseling, Intensive Behavioral Counseling; Drug · Behavioral
Lead sponsor: University of Miami; Other
Eligibility: 18 Years and older
Enrollment: 608 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Gingivitis
Interventions: Functional Chitosan Chewing Gum, Control Chewing Gum, Oral hygiene measures; Device · Behavioral
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years and older
Enrollment: 34 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Nicotine Addiction, Smoking Cessation
Interventions: Nicotine polacrilex, STAM 1100mAh CE4 eGo Clearomizer; Drug · Other
Lead sponsor: Creighton University; Other
Eligibility: 19 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013
U.S. locations: 1
States / cities: Omaha, Nebraska

Conditions: Tobacco Use
Interventions: VLN menthol cigarettes (A), Usual Brand Menthol Cigarettes (B), Nicotine gum (C); Other · Drug
Lead sponsor: 22nd Century Group, Inc.; Industry
Eligibility: 22 Years to 65 Years
Enrollment: 55 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018
U.S. locations: 1
States / cities: Overland Park, Kansas

Conditions: Aging
Interventions: Nicotine gum, Placebo gum; Drug · Other
Lead sponsor: University of California, Berkeley; Other
Eligibility: 18 Years to 85 Years
Enrollment: 44 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Berkeley, California

Conditions: Xerostomia Due to Radiotherapy (Disorder)
Interventions: Stromal Vascular Fraction, Usual Care; Biological · Other
Lead sponsor: Midwestern Regional Medical Center; Other
Eligibility: 21 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Zion, Illinois

Conditions: Anesthesia, Surgery
Interventions: Gum, Control; Other
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 75 Years
Enrollment: 86 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Post-operative Ileus
Interventions: Nicotine gum, Regular chewing gum; Drug · Other
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 18 Years to 85 Years
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: Weston, Florida

Conditions: Smoking Cessation
Interventions: WEB, Social Network, Nicotine Replacement Therapy (NRT); Behavioral
Lead sponsor: Truth Initiative; Other
Eligibility: 18 Years and older
Enrollment: 5,292 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2017
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Smoking Cessation
Interventions: Varenicline, Oral Nicotine Replacement Therapy (NRT), Medication Reminders, Tobacco Cessation Counseling; Drug · Behavioral
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years to 65 Years
Enrollment: 34 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Xerostomia, Head and Neck Cancer
Interventions: Bone Marrow Aspiration, Ultrasound Imaging of Salivary Glands, Salivary Assay, Quality of Life Instruments; Procedure · Diagnostic Test · Other
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years to 89 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Dental Plaque Accumulation
Interventions: MIIP-E2 containing gum, placebo gum without MIIP-E2; Device
Lead sponsor: Lactea Therapeutics, LLC; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 32 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Tobacco Use Disorder
Interventions: active repetitive transcranial magnetic stimulation, sham repetitive transcranial magnetic stimulation, cognitive behavioral therapy for smoking cessation, nicotine replacement therapy; Device · Behavioral · Drug
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 75 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Smoking Cessation, Tobacco Use Disorder
Interventions: Nicotine Replacement Therapies, Nicotine patch, Folic Acid; Drug · Dietary Supplement
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 13 Years to 18 Years
Enrollment: 128 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2002 – 2004
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Search by objective public record fields.

BREATHE 2 Clinic Stop-Smoking Treatment Outreach Study

Evaluating the Pharmacokinetics and Drug Interaction Potential of the Botanical Dietary Supplement Cinnamon

Web-based Smoking Cessation Program for Tribal College Students

A Study to Evaluate Chitosan Chewing Gum in Patients With Chronic Kidney Disease

Pharmacokinetic and Subjective Effects of Heated Tobacco Products

Comparing Over-the-counter Dry Mouth Remedies After Radiation

Does Chewing Gum After Elective Laparoscopic Colectomy Surgery Decrease Ileus?

Combination Nicotine Replacement for Alcoholic Smokers

Efficacy of Oral Tobacco Products Compared to a Medicinal Nicotine

Contingency Management for Smoking Cessation in Homeless Smokers

Smoking Cessation Program in the Construction Sector

Functional Chewing Gum in Reduction of Gingival Inflammation

e-Cigarettes Versus NRT Gum for Smoking Cessation

Evaluation of Abuse Liability of Very Low Nicotine (VLN) Mentholated Cigarettes

Effects of Nicotine and Attention on Frequency Tuning in Auditory Cortex

Stromal Vascular Fraction for Treatment of Xerostomia

Post-operative Sore Throat and Gum Chewing

Nicotine Gum Recovery After Colorectal Surgery

Improving Adherence to Web-Based Cessation Programs: A Social Network Approach

Effectiveness of Combination Varenicline and Oral Nicotine Replacement Therapy (COMBO)

Salivary Gland Autotransplantation for Treatment of XRT Induced Xerostomia

4-day Plaque Accumulation Model Evaluating Compound Containing Gum

Neuroimaging Correlates and Feasibility of Transcranial Magnetic Stimulation (TMS) to Improve Smoking Cessation Outcomes in Veterans With Comorbid PTSD

Effectiveness of Various Smoking Cessation Therapies in Reducing Smoking in Adolescents - 1