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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: hypothermia Clear all
Completed Not applicable Interventional Results available

Delayed Rewarming for Neuroprotection in Infants Following Cardiopulmonary Bypass Surgery

NCT03036072
View directory record Official record
Conditions
Post-Op Complication
Interventions
Strict normothermia, Delayed Rewarming
Other · Device
Lead sponsor
Alexa Craig
Other
Eligibility
Up to 6 Months
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Portland, Maine
Source: ClinicalTrials.gov public record
Updated Jul 12, 2020 · Synced Sep 23, 2026, 12:41 PM EDT
Terminated Phase 2 Interventional

Evaluation of Ultrafast Hypothermia Before Reperfusion in STEMI Patients

NCT01655433
View directory record Official record
Conditions
ST-elevation MI, Hypothermia
Interventions
Velomedix APLS device, No Hypothermia Treatment
Device · Other
Lead sponsor
Velomedix, Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
5
States / cities
Huntsville, Alabama • Los Angeles, California • Gainesville, Georgia + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 24, 2014 · Synced Sep 23, 2026, 12:41 PM EDT
Terminated Not applicable Interventional Results available

To Study the Effect of Early Cooling in Acute Subdural Hematoma Patients

NCT02064959
View directory record Official record
Conditions
Subdural Hematoma, Traumatic
Interventions
Temperature management Zoll Intravascular Temperature Management device
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
22 Years to 65 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
5
States / cities
Miami, Florida • Atlanta, Georgia • Cincinnati, Ohio + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 18, 2020 · Synced Sep 23, 2026, 12:41 PM EDT
Recruiting Not applicable Interventional

Investigation of a Device to Deliver Intra-Operative Therapeutic Hypothermia for Hearing Preservation in Cochlear Implantation

NCT06375278
View directory record Official record
Conditions
Cochlear Implants, Cochlear Implantation, Hearing Loss
Interventions
Intra-Ear Canal Cooling Catheter
Device
Lead sponsor
Restorear Devices LLC
Industry
Eligibility
18 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jul 22, 2026 · Synced Sep 23, 2026, 12:41 PM EDT
Not listed Phase 1Phase 2 Interventional

Safety and Feasibility Study of Targeted Temperature Management After ICH

NCT01607151
View directory record Official record
Conditions
Intracerebral Hemorrhage
Interventions
Normothermia, Hypothermia
Other
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 4, 2015 · Synced Sep 23, 2026, 12:41 PM EDT
Recruiting Phase 2 Interventional

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of RLS-0071 in Newborns With Moderate or Severe Hypoxic-Ischemic Encephalopathy Undergoing Therapeutic Hypothermia

NCT05778188
View directory record Official record
Conditions
Hypoxic-Ischemic Encephalopathy
Interventions
RLS-0071, Placebo
Drug
Lead sponsor
ReAlta Life Sciences, Inc.
Industry
Eligibility
Up to 10 Hours
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
15
States / cities
Little Rock, Arkansas • Orange, California • San Diego, California + 11 more
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Sep 23, 2026, 12:41 PM EDT
Active, not recruiting Not applicable Interventional

Continued Access Study to Evaluate Performance of the Organ Recovery Systems _LifePort® Liver Transporter System, a Machine Perfusion System, for Liver Transplant (PILOT™_CA)

NCT05574361
View directory record Official record
Conditions
Liver Transplantation
Interventions
Hypothermic Machine Perfusion
Device
Lead sponsor
Organ Recovery Systems, Inc.
Industry
Eligibility
18 Years and older
Enrollment
385 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
5
States / cities
Chicago, Illinois • Newark, New Jersey • Cincinnati, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 2, 2026 · Synced Sep 23, 2026, 12:41 PM EDT
Completed Not applicable Interventional

The Effect of Therapeutic Hypothermia on Deceased Donor Renal Graft Outcomes - a Randomized Controlled Trial From the Region 5 Donor Management Goals Workgroup

NCT01680744
View directory record Official record
Conditions
Deceased Organ Donor, Mild Hypothermia, Renal Function
Interventions
Hypothermia
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
370 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Dec 3, 2014 · Synced Sep 23, 2026, 12:41 PM EDT
Completed No phase listed Observational

Near-Infrared Spectroscopy Comparison Study

NCT01352260
View directory record Official record
Conditions
Total Aortic Arch Replacement
Interventions
Not listed
Lead sponsor
Nonin Medical, Inc
Industry
Eligibility
18 Years to 65 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 20, 2012 · Synced Sep 23, 2026, 12:41 PM EDT
Recruiting No phase listed Observational

Cool Prime Comparative Effectiveness Study for Mild HIE

NCT04621279
View directory record Official record
Conditions
Mild Hypoxic Ischemic Encephalopathy of Newborn
Interventions
Normothermia, Whole body therapeutic hypothermia
Procedure
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
36 Weeks and older
Enrollment
460 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Sep 23, 2026, 12:41 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Quantitative Assessment of Sucking for Early Diagnosis of Brain Injury in Infants at High Risk

NCT03246243
View directory record Official record
Conditions
Hypoxic-Ischemic Encephalopathy, Hypoglycemia, Neonatal Abstinence Syndrome
Interventions
nfant feeding solution
Device
Lead sponsor
Boston Children's Hospital
Other
Eligibility
Up to 6 Months
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 20, 2021 · Synced Sep 23, 2026, 12:41 PM EDT
Not listed Not applicable Interventional

Optimising the Duration of Cooling in Mild Encephalopathy

NCT03409770
View directory record Official record
Conditions
Neonatal Encephalopathy, Hypothermia Neonatal, Magnetic Resonance Spectroscopy
Interventions
Therapeutic hypothermia
Other
Lead sponsor
Thayyil, Sudhin
Individual
Eligibility
Up to 6 Hours
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Michigan Center, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 3, 2023 · Synced Sep 23, 2026, 12:41 PM EDT
Terminated Phase 2 Interventional Results available

Mild Hypothermia and Supplemental Magnesium Sulfate Infusion in Severe Traumatic Brain Injury (TBI) Subjects

NCT01333488
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Arctic Sun, Magnesium Sulfate
Device · Drug
Lead sponsor
United States Department of Defense
Federal
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Hollywood, Florida
Source: ClinicalTrials.gov public record
Updated Oct 27, 2015 · Synced Sep 23, 2026, 12:41 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Neonatal Erythropoietin And Therapeutic Hypothermia Outcomes in Newborn Brain Injury (NEATO)

NCT01913340
View directory record Official record
Conditions
Hypoxic-ischemic Encephalopathy, Neonatal Encephalopathy, Birth Asphyxia
Interventions
Erythropoietin, Normal saline
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
30 Minutes to 24 Hours
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
7
States / cities
Little Rock, Arkansas • Palo Alto, California • San Francisco, California + 4 more
Source: ClinicalTrials.gov public record
Updated Jul 12, 2020 · Synced Sep 23, 2026, 12:41 PM EDT
Recruiting Not applicable Interventional

Retrograde Versus Antegrade Perfusion in Low-Moderate Hypothermia for Aortic Arch Surgery

NCT06986967
View directory record Official record
Conditions
Brain Function, Hemiarch Cardiac Procedure
Interventions
Antegrade Perfusion, Retrograde Perfusion
Procedure
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Sep 23, 2026, 12:41 PM EDT
Completed No phase listed Observational

Hypothermia's Impact on Pharmacology

NCT01560338
View directory record Official record
Conditions
Cardiac Arrest, Hypothermia
Interventions
Not listed
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
Up to 18 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
9
States / cities
Birmingham, Alabama • Washington D.C., District of Columbia • Louisville, Kentucky + 6 more
Source: ClinicalTrials.gov public record
Updated Mar 1, 2021 · Synced Sep 23, 2026, 12:41 PM EDT
Withdrawn Phase 2 Interventional

Therapeutic Hypothermia for Severe Acute Pancreatitis

NCT01794858
View directory record Official record
Conditions
Pancreatitis
Interventions
Therapeutic Hypothermia
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 10, 2016 · Synced Sep 23, 2026, 12:41 PM EDT
Withdrawn Phase 1 Interventional

Safety and Efficacy of IV Diazoxide as an Additive to Hyperkalemic Cardioplegia in Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass

NCT04830982
View directory record Official record
Conditions
Myocardial Stunning
Interventions
IV Diazoxide, Placebo
Drug · Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 18, 2022 · Synced Sep 23, 2026, 12:41 PM EDT
Not yet recruiting Phase 3 Interventional

Xenon for Neuroprotection During Post-Cardiac Arrest Syndrome in Comatose Survivors of an Out of Hospital Cardiac Arrest

NCT03176186
View directory record Official record
Conditions
Post-Cardiac Arrest Syndrome
Interventions
Xenon
Combination Product
Lead sponsor
Invero Pharma, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
1,436 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
8
States / cities
Hartford, Connecticut • Gainesville, Florida • Gulfport, Mississippi + 5 more
Source: ClinicalTrials.gov public record
Updated Apr 2, 2025 · Synced Sep 23, 2026, 12:41 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Dexmed/Buspirone Synergism on Shivering

NCT00334360
View directory record Official record
Conditions
Hypothermia
Interventions
dexmedetomidine, buspirone, Bus and Dex, Control
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 40 Years · Male only
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2007
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 28, 2016 · Synced Sep 23, 2026, 12:41 PM EDT
Active, not recruiting Phase 2 Interventional

Trial of Therapeutic Hypothermia in Patients With ARDS

NCT04545424
View directory record Official record
Conditions
Respiratory Distress Syndrome, Adult
Interventions
Hypothermia, Neuromuscular Blocking Agents, Standard of care
Device · Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 85 Years
Enrollment
340 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
19
States / cities
Los Angeles, California • New Haven, Connecticut • Atlanta, Georgia + 12 more
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Sep 23, 2026, 12:41 PM EDT
Withdrawn Not applicable Interventional

Hypothermia During ECMO to Decrease Brain Injury

NCT01675388
View directory record Official record
Conditions
Neonatal Respiratory Failure
Interventions
Hypothermia
Other
Lead sponsor
Sood, Beena G., MD, MS
Individual
Eligibility
1 Day to 28 Days
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 17, 2014 · Synced Sep 23, 2026, 12:41 PM EDT
Recruiting No phase listed Observational

Clinical Microbial Species & Antibiotic Resistance ID in ED Patients Presenting With Infection - is Rapid ID Possible & Accurate?

NCT01904188
View directory record Official record
Conditions
Sepsis, Systemic Inflammatory Response Syndrome, Infection Mixed, Infection, Bacterial, Infection, Fungal, Infection, Coronavirus, Antibiotic Resistance Genes, Human Genome Analysis
Interventions
Gene Z or other rapid diagnostic techniques developed in our lab (as of 2018 not using Gene Z - now using In-Dx along with other developed techniquesregularly)
Device
Lead sponsor
Michigan State University
Other
Eligibility
18 Years and older
Enrollment
2,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2032
U.S. locations
2
States / cities
Lansing, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Sep 23, 2026, 12:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Hypothermia and the Effect of Ambient Temperature

NCT02436382
View directory record Official record
Conditions
Hypothermia
Interventions
change in temperature
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
Female only
Enrollment
846 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated May 10, 2016 · Synced Sep 23, 2026, 12:41 PM EDT