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ClinicalTrials.gov public records Last synced Oct 22, 2026, 1:01 AM EDT

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Showing 1–24 of 36 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: isoflurane Clear all
Completed No phase listed Observational

To Observe Whether Isoflurane Can Treat COVID-19 Patients

NCT04492943
View directory record Official record
Conditions
COVID-19
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 2, 2020 · Synced Oct 22, 2026, 1:01 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Effects of Subanesthetic Concentrations of Isoflurane/Nitrous Oxide - 3

NCT00000251
View directory record Official record
Conditions
Opioid-Related Disorders, Substance-Related Disorders
Interventions
30% N2O, 0.2% isoflurane, 0.4% isoflurane, 100% oxygen
Drug · Other
Lead sponsor
University of Chicago
Other
Eligibility
21 Years to 32 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1994 – 1996
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 2, 2015 · Synced Oct 22, 2026, 1:01 AM EDT
Terminated Phase 4 Interventional Results available

Post Anesthesia Emergence and Behavioral Changes in Children Undergoing MRI

NCT02111447
View directory record Official record
Conditions
Delirium on Emergence
Interventions
Propofol, Sevoflurane, Isoflurane
Drug
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
2 Years to 12 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jul 23, 2019 · Synced Oct 22, 2026, 1:01 AM EDT
Terminated Not applicable Interventional Results available

Intravenous Versus Inhalational Anesthesia in Parkinson's Disease

NCT00615472
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Isoflurane, Remifentanil, Propofol
Drug
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2011
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 13, 2015 · Synced Oct 22, 2026, 1:01 AM EDT
Recruiting Phase 3 Interventional

Sevoflurane/Dexmedetomidine vs. Isoflurane for Pediatric Emergence Delirium

NCT06624592
View directory record Official record
Conditions
Delirium on Emergence
Interventions
Sevoflurane, Isoflurane
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
2 Years to 7 Years
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 16, 2025 · Synced Oct 22, 2026, 1:01 AM EDT
Not listed Early Phase 1 Interventional

Inhalational Anesthesia vs TIVA in Endoscopic Tympanoplasty

NCT05993039
View directory record Official record
Conditions
Perforated Eardrum
Interventions
Isoflurane Inhalant Product, Sevoflurane inhalant product, Propofol injection, Remifentanil Injection
Drug
Lead sponsor
Our Lady of the Lake Hospital
Other
Eligibility
0 Years to 100 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Nov 1, 2023 · Synced Oct 22, 2026, 1:01 AM EDT
Completed Not applicable Interventional Results available

Pain After Laparoscopic Cholecystectomy

NCT00983918
View directory record Official record
Conditions
Postoperative Pain
Interventions
Desflurane, Sevoflurane, Isoflurane, Propofol
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 64 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 1, 2019 · Synced Oct 22, 2026, 1:01 AM EDT
Enrolling by invitation Phase 3 Interventional Accepts healthy volunteers

GA + ESP vs. SA + ESP in Lumbar Decompression Surgeries

NCT05444751
View directory record Official record
Conditions
Lumbar Disc Herniation, Lumbar Disc Disease, Lumbar Radiculopathy
Interventions
General anesthetic, SA + ESP
Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
142 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Oct 22, 2026, 1:01 AM EDT
Completed Phase 3 Interventional Results available

Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU2)

NCT05327296
View directory record Official record
Conditions
Sedation
Interventions
Isoflurane, Propofol
Drug
Lead sponsor
Sedana Medical
Industry
Eligibility
18 Years and older
Enrollment
282 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
16
States / cities
Long Beach, California • Los Angeles, California • Redwood City, California + 12 more
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Oct 22, 2026, 1:01 AM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

Differential Effects of Various Anesthetic Agents on Cognitive Function in Patients With Alzheimer's Disease

NCT01870453
View directory record Official record
Conditions
Alzheimer Disease
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
Not listed
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 16, 2018 · Synced Oct 22, 2026, 1:01 AM EDT
Completed Not applicable Interventional

Dexmedetomidine on Intraoperative Somatosensory and Motor Evoked Potential Monitoring During Neurosurgery in Pediatric Patients

NCT01512147
View directory record Official record
Conditions
Tethered Spinal Cord, Brain Tumor, Cranio Cervical Compression
Interventions
Isoflurane, Propofol, Dexmedetomidine
Other
Lead sponsor
Oregon Health and Science University
Other
Eligibility
2 Years to 12 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Apr 5, 2018 · Synced Oct 22, 2026, 1:01 AM EDT
Completed Not applicable Interventional Results available

Decision Support for Intraoperative Low Blood Pressure

NCT02726620
View directory record Official record
Conditions
Hypotension
Interventions
Attending real-time decision support, In-room real-time decision support, Attending feedback emails, In-room provider feedback emails, Anesthesia Information Management System (AIMS), Perioperative Data Warehouse (PDW), General anesthesia, Pager system, Central neuraxial anesthesia, Non-cardiac surgery, Propofol, Sevoflurane, Desflurane, Isoflurane, Ephedrine, Phenylephrine, Norepinephrine, Epinephrine, Dobutamine, Dopamine, Isoproterenol, Milrinone, Atropine, Glycopyrrolate, Vasopressin, Terlipressin, Sodium Chloride 0.9%, Ringer's lactate, Hydroxyethyl starch solutions, Fresh Frozen Plasma, Packed Red Blood Cells, Albumin solutions, Plasma-Lyte, Lidocaine, Bupivacaine, Levobupivacaine, Ropivacaine, Mepivacaine, Tetracaine, Prilocaine, Procaine, Chloroprocaine, Benzocaine, Articaine
Procedure · Device · Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
60 Years to 100 Years
Enrollment
22,435 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 16, 2019 · Synced Oct 22, 2026, 1:01 AM EDT
Completed Phase 4 Interventional Results available

Comparing Hemodynamic Changes for Intubation With Shikani Intubating Stylet and Macintosh Laryngoscope

NCT01271543
View directory record Official record
Conditions
Anesthesia
Interventions
Endotracheal Intubation
Device
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 15, 2016 · Synced Oct 22, 2026, 1:01 AM EDT
Completed Phase 4 Interventional

General Anesthetics in CAncer REsection Surgery (GA-CARES) Trial

NCT03034096
View directory record Official record
Conditions
Anesthesia, General, Surgical Oncology
Interventions
Propofol, Volatile Agent
Drug
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years and older
Enrollment
1,826 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
5
States / cities
Buffalo, New York • New Hyde Park, New York • New York, New York + 2 more
Source: ClinicalTrials.gov public record
Updated May 4, 2025 · Synced Oct 22, 2026, 1:01 AM EDT
Terminated Not applicable Interventional Results available

Isoflurane Preconditioning for Liver Resections

NCT01031550
View directory record Official record
Conditions
Liver Disease
Interventions
isoflurane, propofol
Drug
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 20, 2017 · Synced Oct 22, 2026, 1:01 AM EDT
Completed Not applicable Interventional Results available

Cognitive Effects of Inhalational Versus Intravenous General Anesthesia in the Elderly

NCT00788008
View directory record Official record
Conditions
Lumbar Spondylosis, Cervical Spondylosis, Hip Osteoarthritis, Knee Osteoarthritis
Interventions
inhalation anesthesia with isoflurane vs. TIVA with propofol
Drug
Lead sponsor
Duke University
Other
Eligibility
65 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
2
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 26, 2015 · Synced Oct 22, 2026, 1:01 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

TIVA vs TXA in Sinus Surgery to Evaluate Operative Blood Loss and Surgical Field Quality

NCT05639686
View directory record Official record
Conditions
Rhinosinusitis Chronic, Sinus Cancer, Sinus Polyp, Encephalocele
Interventions
Tranexamic acid injection, Total Intravenous Anesthesia, Inhalational isoflurane
Drug
Lead sponsor
Our Lady of the Lake Hospital
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Mar 23, 2023 · Synced Oct 22, 2026, 1:01 AM EDT
Completed Phase 1 Interventional Results available

General Anesthesia Emergence Induced by Methylphenidate

NCT02327195
View directory record Official record
Conditions
Delayed Emergence From Anesthesia
Interventions
Methylphenidate HCl, Placebo
Drug
Lead sponsor
Nicoleta Stoicea
Other
Eligibility
18 Years to 65 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 12, 2022 · Synced Oct 22, 2026, 1:01 AM EDT
Completed Phase 3 Interventional

Opioid-free Anesthesia for Open Cardiac Surgery: A Prospective Randomized Controlled Trial

NCT04197570
View directory record Official record
Conditions
Opioid Use, Heart; Surgery, Heart, Functional Disturbance as Result, Anesthesia
Interventions
Opioid Anesthetics, Non Opioid Analgesics
Drug
Lead sponsor
Benaroya Research Institute
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jul 28, 2020 · Synced Oct 22, 2026, 1:01 AM EDT
Completed Phase 4 Interventional Results available

Markers of Alzheimers Disease and Cognitive Outcomes After Perioperative Care

NCT01993836
View directory record Official record
Conditions
Alzheimers Disease, Postoperative Delirium, Post Operative Cognitive Dysfunction
Interventions
Total intravenous anesthesia with propofol, General anesthesia with isoflurane
Drug
Lead sponsor
Duke University
Other
Eligibility
60 Years and older
Enrollment
191 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 22, 2023 · Synced Oct 22, 2026, 1:01 AM EDT
Withdrawn Not applicable Interventional

Desflurane Versus Isoflurane for Speeding Postanesthetic Recovery and Hospital Discharge

NCT06252207
View directory record Official record
Conditions
Surgery
Interventions
Desflurane, Isoflurane
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 5, 2026 · Synced Oct 22, 2026, 1:01 AM EDT
Active, not recruiting Phase 3 Interventional

A Pooled Analysis of Long-Term Outcomes After Inhaled Isoflurane Via the Sedaconda ACD-S Compared to Intravenous Propofol

NCT06809218
View directory record Official record
Conditions
Post-Intensive Care Syndrome, Sedation
Interventions
Inhaled isoflurane administered by Sedaconda ACD-S, Intravenous infusion of propofol
Drug
Lead sponsor
Sedana Medical
Industry
Eligibility
18 Years and older
Enrollment
312 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Feb 5, 2025 · Synced Oct 22, 2026, 1:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Bispectral Index (BIS™) and Levels of Sedation With Common Inhalational Anesthetics in Healthy Volunteers (OLIVER)

NCT04602546
View directory record Official record
Conditions
Anesthesia
Interventions
BIS Complete Monitoring System
Device
Lead sponsor
Medtronic - MITG
Industry
Eligibility
18 Years to 60 Years
Enrollment
211 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
3
States / cities
San Francisco, California • Durham, North Carolina • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 18, 2023 · Synced Oct 22, 2026, 1:01 AM EDT
Completed Phase 3 Interventional Results available

Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU1)

NCT05312385
View directory record Official record
Conditions
Sedation
Interventions
Isoflurane, Propofol, Isoflurane (run-ins)
Drug
Lead sponsor
Sedana Medical
Industry
Eligibility
18 Years and older
Enrollment
277 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
14
States / cities
Aurora, Colorado • Atlanta, Georgia • Chicago, Illinois + 9 more
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Oct 22, 2026, 1:01 AM EDT