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Showing 1–24 of 25 matching trials from the live ClinicalTrials.gov search.
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Completed Phase 2 Interventional

HKT-500-US12 In Adult Patients With OA Knee Pain

NCT00647231
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
HKT-500 Topical Patch, Placebo Patch
Drug · Other
Lead sponsor
Hisamitsu Pharmaceutical Co., Inc.
Industry
Eligibility
45 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
29
States / cities
Birmingham, Alabama • Phoenix, Arizona • Little Rock, Arkansas + 25 more
Source: ClinicalTrials.gov public record
Updated Jun 3, 2015 · Synced Sep 9, 2026, 9:32 AM EDT
Completed Phase 3 Interventional

Ketoprofen Topical Patch, 20% in the Treatment of Pain Associated With Osteoarthritis Flare of the Knee

NCT00365586
View directory record Official record
Conditions
Osteoarthritis
Interventions
Ketoprofen Topical Patch , 20%
Drug
Lead sponsor
APR Applied Pharma Research s.a.
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Feb 18, 2020 · Synced Sep 9, 2026, 9:32 AM EDT
Completed Phase 1Phase 2 Interventional

Study to Determine the Efficacy and Safety of ELS-M11 in Acute Migraine

NCT02057315
View directory record Official record
Conditions
Migraine Headaches
Interventions
ELS-M11, Placebo
Drug
Lead sponsor
Achelios Therapeutics
Industry
Eligibility
18 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
2
States / cities
Ann Arbor, Michigan • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 10, 2017 · Synced Sep 9, 2026, 9:32 AM EDT
Terminated Phase 2 Interventional Results available

PET Imaging of Cyclooxygenase in Multiple Sclerosis

NCT05062083
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
11C-MC1, 11C-PS13, Ketoprofen, Celecoxib
Drug
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 99 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 26, 2024 · Synced Sep 9, 2026, 9:32 AM EDT
Completed Phase 3 Interventional

Ketoprofen Topical Patch 20% in the Treatment of Pain Associated With Shoulder, Elbow or Knee Tendonitis or Bursitis

NCT00352625
View directory record Official record
Conditions
Tendonitis, Bursitis
Interventions
Ketoprofen Topical Patch 20%
Drug
Lead sponsor
APR Applied Pharma Research s.a.
Other
Eligibility
18 Years and older
Enrollment
330 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Feb 18, 2020 · Synced Sep 9, 2026, 9:32 AM EDT
Completed Phase 3 Interventional

HKT-500 in Adult Patients With Osteoarthritis (OA) Knee Pain

NCT00792727
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
ketoprofen Patch, Placebo Patch
Drug · Other
Lead sponsor
Hisamitsu Pharmaceutical Co., Inc.
Industry
Eligibility
45 Years and older
Enrollment
380 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
36
States / cities
Birmingham, Alabama • Chandler, Arizona • Peoria, Arizona + 31 more
Source: ClinicalTrials.gov public record
Updated Jun 3, 2015 · Synced Sep 9, 2026, 9:32 AM EDT
Completed Phase 3 Interventional

HKT-500 in the Treatment of Adult Patients With Ankle Sprain

NCT00927641
View directory record Official record
Conditions
Ankle Sprain
Interventions
Ketoprofen Patch, Placebo Patch
Drug · Other
Lead sponsor
Hisamitsu Pharmaceutical Co., Inc.
Industry
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
25
States / cities
Birmingham, Alabama • Phoenix, Arizona • Tucson, Arizona + 21 more
Source: ClinicalTrials.gov public record
Updated Jun 3, 2015 · Synced Sep 9, 2026, 9:32 AM EDT
Terminated No phase listed Observational

Characterization of Treatment Responses in Lymphedema

NCT03783715
View directory record Official record
Conditions
Lymphedema
Interventions
Ketoprofen
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 75 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Oct 9, 2023 · Synced Sep 9, 2026, 9:32 AM EDT
Terminated Phase 3 Interventional

A Phase 3 Study to Evaluate the Long-Term Safety of ThermoProfen™ in Patients With Mild to Moderate Pain Associated With Osteoarthritis of the Knee.

NCT00532038
View directory record Official record
Conditions
Osteoarthritis
Interventions
ThermoProfen™ (Matrix Transdermal Ketoprofen/CHADD™ System)
Drug
Lead sponsor
ZARS Pharma Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
179 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
20
States / cities
Anaheim, California • San Diego, California • Westlake Village, California + 17 more
Source: ClinicalTrials.gov public record
Updated Mar 15, 2012 · Synced Sep 9, 2026, 9:32 AM EDT
Completed Phase 2 Interventional

A Pilot Study on the Onset of Action of KTP, 20% in the Treatment of Acute Pain Associated With Tendonitis or Bursitis of the Shoulder, Elbow or Knee

NCT00903994
View directory record Official record
Conditions
Tendonitis of the Shoulder, Elbow, or Knee
Interventions
Ketoprofen Topical Patch 20%
Drug
Lead sponsor
APR Applied Pharma Research s.a.
Other
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007
U.S. locations
2
States / cities
Phoenix, Arizona • Stockbridge, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 17, 2020 · Synced Sep 9, 2026, 9:32 AM EDT
Completed Phase 3 Interventional

Study of Safety and Efficacy of Diractin® for the Treatment of Osteoarthritis (OA) of the Knee

NCT00722852
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
ketoprofen in Diractin®, Placebo
Drug
Lead sponsor
IDEA AG
Industry
Eligibility
46 Years and older
Enrollment
555 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
37
States / cities
Phoenix, Arizona • Tempe, Arizona • Tucson, Arizona + 32 more
Source: ClinicalTrials.gov public record
Updated Oct 4, 2009 · Synced Sep 9, 2026, 9:32 AM EDT
Completed Phase 3 Interventional

Ketoprofen 10% Cream for Treatment of Pain Associated With Mild to Moderate Acute Soft Tissue Injury

NCT00765700
View directory record Official record
Conditions
Sprain, Strain, Acute Soft Tissue Injury
Interventions
Topical Ketoprofen 10% Cream, Topical Placebo Cream
Drug
Lead sponsor
Imprimis Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
364 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 26, 2013 · Synced Sep 9, 2026, 9:32 AM EDT
Completed Phase 3 Interventional

Efficacy of ThermoProfen in Patients With Mild to Moderate Pain Associated With Osteoarthritis of the Knee

NCT00488267
View directory record Official record
Conditions
Osteoarthritis
Interventions
ThermoProfen™ (Matrix Transdermal Ketoprofen/CHADD™ System), Placebo Matrix/CHADD Patch, Ketoprofen matrix/placebo CHADD Patch
Drug
Lead sponsor
ZARS Pharma Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
679 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
36
States / cities
Peoria, Arizona • Anaheim, California • Buena Park, California + 33 more
Source: ClinicalTrials.gov public record
Updated May 29, 2012 · Synced Sep 9, 2026, 9:32 AM EDT
Recruiting Phase 2 Interventional

Reversing External-beam Radiotherapy-associated Fibrosis Syndrome: an Interventional Bayesian Adaptive Randomized-controlled Orphan Drug Platform Trial for Orodental Sequelae (Reverse-fibrose)

NCT06912763
View directory record Official record
Conditions
Fibrosis Syndrome, Lymphedema, Head &Amp; Neck Cancer, Fibrosis
Interventions
Pravastatin (drug), Pentoxifylline, ketoprofen, Pirfenidoneone, Standard of Care (SOC), tocopherol
Drug · Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
Female only
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2031
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Sep 9, 2026, 9:32 AM EDT
Completed Phase 3 Interventional

HKT-500 in Adult Patients With Ankle Sprain

NCT00680784
View directory record Official record
Conditions
Ankle Sprain
Interventions
HKT-500 Ketoprofen Topical Patch, Placebo Patch
Drug · Other
Lead sponsor
Hisamitsu Pharmaceutical Co., Inc.
Industry
Eligibility
18 Years and older
Enrollment
260 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
30
States / cities
Birmingham, Alabama • Montgomery, Alabama • Anaheim, California + 26 more
Source: ClinicalTrials.gov public record
Updated Jun 3, 2015 · Synced Sep 9, 2026, 9:32 AM EDT
Not listed Phase 3 Interventional Accepts healthy volunteers

The Efficacy and Safety of Intra-oral Topical Ketoprofen for the Treatment of Acute Migraine

NCT01228552
View directory record Official record
Conditions
Migraine Disorders, Migraine Headache, Migraine, Acute Migraine
Interventions
Topical, intra-oral ketoprofen gel, Placebo gel
Drug · Other
Lead sponsor
Behar, Caren, M.D.
Individual
Eligibility
18 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Valhalla, New York
Source: ClinicalTrials.gov public record
Updated Jun 7, 2011 · Synced Sep 9, 2026, 9:32 AM EDT
Completed Phase 3 Interventional

Efficacy and Safety of Ketoprofen Topical Patch 20% in the Treatment of Pain Associated With Ankle Sprain or Strain

NCT00351104
View directory record Official record
Conditions
Sprain, Strain
Interventions
Ketoprofen Topical Patch 20%
Drug
Lead sponsor
APR Applied Pharma Research s.a.
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Feb 18, 2020 · Synced Sep 9, 2026, 9:32 AM EDT
Completed Phase 3 Interventional

HKT-500 in Adult Patients With Shoulder Pain

NCT00680472
View directory record Official record
Conditions
Pain
Interventions
HKT-500 Ketoprofen Topical Patch, Placebo Patch
Drug · Other
Lead sponsor
Hisamitsu Pharmaceutical Co., Inc.
Industry
Eligibility
18 Years and older
Enrollment
368 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
35
States / cities
Birmingham, Alabama • Tempe, Arizona • Fullerton, California + 30 more
Source: ClinicalTrials.gov public record
Updated Jun 3, 2015 · Synced Sep 9, 2026, 9:32 AM EDT
Completed Phase 2 Interventional

A Long-Term Safety Study of IDEA-033 in Comparison to Oral Naproxen for the Treatment of Osteoarthritis of the Knee

NCT00265304
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Ketoprofen
Drug
Lead sponsor
IDEA AG
Industry
Eligibility
18 Years and older
Enrollment
550 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2005
U.S. locations
93
States / cities
Birmingham, Alabama • Montgomery, Alabama • Northport, Alabama + 77 more
Source: ClinicalTrials.gov public record
Updated Mar 19, 2009 · Synced Sep 9, 2026, 9:32 AM EDT
Completed Phase 2 Interventional

Transdermal Ketoprofen to Treat Mild to Moderate Osteoarthritis (OA) Pain of the Knee

NCT00108810
View directory record Official record
Conditions
Pain, Osteoarthritis, Knee
Interventions
Transdermal Ketoprofen Patch with CHADD, Placebo transdermal patch
Drug
Lead sponsor
ZARS Pharma Inc.
Industry
Eligibility
40 Years to 75 Years
Enrollment
118 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005
U.S. locations
5
States / cities
Buena Park, California • Washington D.C., District of Columbia • Daytona Beach, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 4, 2012 · Synced Sep 9, 2026, 9:32 AM EDT
Terminated Phase 3 Interventional

Efficacy and Safety of Ketoprofen Topical Patch 20% in the Treatment of Pain Associated With Shoulder, Elbow or Knee Tendonitis or Bursitis

NCT00426985
View directory record Official record
Conditions
Tendonitis, Bursitis
Interventions
Ketoprofen Topical Patch 20%, Placebo
Drug · Other
Lead sponsor
APR Applied Pharma Research s.a.
Other
Eligibility
18 Years and older
Enrollment
381 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Sep 9, 2026, 9:32 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Novel Topical Therapies for the Treatment of Genital Pain

NCT02099006
View directory record Official record
Conditions
Female Genital Diseases
Interventions
Amitriptyline, Baclofen, Ketoprofen, Ketamine, Loperamide, Gabapentin, placebo
Drug
Lead sponsor
University of Rochester
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jul 14, 2016 · Synced Sep 9, 2026, 9:32 AM EDT
Completed Phase 4 Interventional Results available

Lymphedema Study for Arm or Leg Lymphedema

NCT02257970
View directory record Official record
Conditions
Lymphedema
Interventions
Ketoprofen, Placebo
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 90 Years
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2017
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Oct 26, 2022 · Synced Sep 9, 2026, 9:32 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Topical Intra-Oral Ketoprofen for Migraine Prevention

NCT01211795
View directory record Official record
Conditions
Migraine
Interventions
topical intraoral ketoprofen gel, Placebo Gel
Drug · Other
Lead sponsor
Behar, Caren, M.D.
Individual
Eligibility
18 Years to 75 Years
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Valhalla, New York
Source: ClinicalTrials.gov public record
Updated Jun 7, 2011 · Synced Sep 9, 2026, 9:32 AM EDT