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Conditions: Optic, Atrophy, Hereditary, Leber
Interventions: GS010, Sham Intravitreal Injection; Biological · Device
Lead sponsor: GenSight Biologics; Industry
Eligibility: 15 Years and older
Enrollment: 39 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 3
States / cities: Los Angeles, California • Atlanta, Georgia • Philadelphia, Pennsylvania

Conditions: Abscess, Pain
Interventions: Intranasal Fentanyl, Intravenous Morphine; Drug
Lead sponsor: Columbia University; Other
Eligibility: 4 Years to 18 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: New York, New York

Conditions: Acute Lymphoblastic Leukemia, Pediatric
Interventions: Use of Virtual Reality Headset; Other
Lead sponsor: Children's National Research Institute; Other
Eligibility: 7 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Sinusitis
Interventions: Gold Laser, Microdebridement; Device · Procedure
Lead sponsor: Texas Tech University Health Sciences Center; Other
Eligibility: 18 Years and older
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Lubbock, Texas

Conditions: Needle Phobia
Interventions: Lidocaine patch 4%; Drug
Lead sponsor: Ohio State University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 135 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Periodontitis, Infant, Premature
Interventions: Periodontal scaling and root planing, Scaling and root planing; Procedure
Lead sponsor: University of Minnesota; Other
Eligibility: 16 Years and older · Female only
Enrollment: 823 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2006
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Drug Reaction to Analgesic Nos
Interventions: RX0041 4%, Placebo, RX0041 8%; Drug
Lead sponsor: Pharmaceutical Project Solutions, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 648 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 2
States / cities: Mount Arlington, New Jersey • Columbia, South Carolina

Conditions: Knee Osteoarthritis
Interventions: Duloxetine, Intra-Articular Injection, Nerve Procedure with long acting blocks, Nerve Procedure with nerve ablation, Pain Coping Skills Training, Best Practices; Drug · Combination Product · Procedure + 2 more
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 1,937 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 24
States / cities: Sacramento, California • San Diego, California • Aurora, Colorado + 19 more

Conditions: Dental Fear, Anesthesia, Local, Pediatric Dentistry
Interventions: Synapse TENS device, Topical anesthetic gel; Device · Drug
Lead sponsor: Boston University; Other
Eligibility: 6 Years to 14 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Lentigo
Interventions: lidocaine 2.5%/prilocaine 2.5% topical anesthetic, lidocaine 7%/tetracaine 7% topical anesthetic, placebo vehicle, Q-switched 532nm Laser; Drug · Device
Lead sponsor: Northwestern University; Other
Eligibility: 25 Years to 65 Years · Female only
Enrollment: 48 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2024
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: IUD
Interventions: Menstrual disc with EMLA cream, Cervical cap with EMLA cream; Combination Product
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Obesity, Morbid, Surgery, Bariatric Surgery Candidate
Interventions: Neurontin, Dilaudid Injectable Product, Marcaine Injectable Product, Oxycodone Hydrochloride, Hycet 7.5Mg-325Mg/15Ml Solution, Zofran Injection, Scopolamine patch, Ativan, Flexeril Oral Product, Tylenol Suspension; Drug
Lead sponsor: University of California, Davis; Other
Eligibility: 35 Years to 65 Years · Female only
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Sacramento, California

Conditions: Keloid
Interventions: The Lutronic electronic carbon dioxide (eCO2) Plus laser system, Intralesional Triamcinolone Acetonide; Device · Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Any Ear Nose or Throat Conditions, With Identified Need for a Diagnostic Procedure or Surgery on or Through the Mucous Membranes of the Nasal Cavities
Interventions: Cocaine HCl 4% Topical Solution, Cocaine HCl 10% Topical Solution, Placebo Topical Solution; Drug
Lead sponsor: Lannett Company, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 646 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Cavities of Teeth
Interventions: Pulp vitality testing, Photos, local and/or topical anesthetic, rubber dam, tooth surface cleaned, enamel margins, Adhesive Systems, cavity preparation, Shade selection using Easy Shade 5, Light Curing, Contoured and polished, Consent, Health Questionnaire, xray, Release of medical information signed, Oral Exam, Teeth Assessment, Clinical Assessment, Tokuyama Universal Bond, ScotchBond; Diagnostic Test · Other · Drug + 3 more
Lead sponsor: Erica Teixeira; Other
Eligibility: 18 Years and older
Enrollment: 36 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2025
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Malocclusion
Interventions: Micro-osteoperforation, Anesthestic, Chlorhexidine; Device · Drug · Other
Lead sponsor: University of Florida; Other
Eligibility: 18 Years to 55 Years
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Post-Operative Pain
Interventions: LMX4, LMX4 Placebo; Drug
Lead sponsor: Ferndale Laboratories, Inc.; Industry
Eligibility: 3 Months to 3 Years · Male only
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Dental Anaesthesia, Dental Pain, Dental Analgesia
Interventions: Photobiomodulation, Topical Benzocaine, Local Anesthesia; Device · Drug
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 6 Years to 12 Years
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Shoulder Pain
Interventions: lidocaine, ethyl chloride, Kenalog; Drug
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 18 Years to 70 Years
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Hershey, Pennsylvania

Conditions: Neoplasms, Malignant, Breast Neoplasm, Carcinoma, Basal Cell, Carcinoma, Squamous Cell, Melanoma, Skin Neoplasm, Head and Neck Neoplasms
Interventions: Carlo Erba Ink Injection, EPR Oximetry Measurement; Device · Other
Lead sponsor: Philip Schaner; Other
Eligibility: 18 Years and older
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Lebanon, New Hampshire

Conditions: Stress Urinary Incontinence, Intrinsic Sphincter Deficiency
Interventions: Topical lidocaine, EMLA cream, Periurethral block; Procedure
Lead sponsor: Medstar Health Research Institute; Other
Eligibility: 18 Years and older · Female only
Enrollment: 23 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 3
States / cities: Washington D.C., District of Columbia

Conditions: Skin Inflammation, Allergic Contact Dermatitis
Interventions: Squaric Acid Dibutyl Ester, Known patch test allergens, Dupilumab, Adalimumab, Ustekinumab, Guselkumab, Canakinumab, Sarilumab, Triamcinolone Acetonide, Betamethasone Valerate, Fluticasone Propionate, Microneedle, Suction blistering, Skin punch biopsy; Drug · Other · Device + 1 more
Lead sponsor: Wei-Che Ko; Other
Eligibility: 18 Years and older
Enrollment: 45 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Worcester, Massachusetts

Conditions: Healthy
Interventions: Nitroglycerin 15mg, Nitroglycerin 30mg, Lidocaine 20mg, Lidocaine 40mg, Placebo; Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 35 Years
Enrollment: 19 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Diagnostic, Procedures and Surgeries on or Through Accessible Mucous Membranes, of the Nasal Cavities
Interventions: Cocaine HCl 4% Topical Solution, Cocaine HCl 10% Topical Solution, Placebo Topical Solution; Drug
Lead sponsor: Lannett Company, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 159 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2015
U.S. locations: 2
States / cities: Bridgeport, Connecticut • Plano, Texas

Search by objective public record fields.

Efficacy Study of GS010 for the Treatment of Vision Loss up to 6 Months From Onset in LHON Due to the ND4 Mutation

Efficacy of Intranasal Fentanyl at Reducing Pain During Abscess Incision and Drainage (I&D) in Children

Virtual Reality During Lumbar Punctures in Acute Lymphoblastic Leukemia

Gold Laser Vs. Micro-Debriders for Functional Endoscopic Sinus Surgery

Lidocaine Patch vs Intradermal Lidocaine for Epidural Needle Insertion Pain

Obstetrics and Periodontal Therapy (OPT) Study

Topical Anesthetic for Procedures Through the Nose

A Sequenced Strategy for Improving Outcomes in People With Knee Osteoarthritis Pain

Effectiveness of Synapse Transcutaneous Electronic Nerve Stimulation (TENS) During Dental Procedures Among Children

The Effect of Topical Anesthetics on Patients' Pain and Operative Experience During Treatment With QSwitched Laser

Use of Cervical Cap and Menstrual Disc for Application of Topical Anesthetic Prior to IUD Insertion

Multimodal Analgesia Effect on Post Surgical Patient

Fractional Laser Assisted Steroid Therapy vs Intralesional Steroids in the Treatment of Keloids

Topical Application of Cocaine HCl 4%, or 10%, or Placebo Solution in Local (Topical) Anesthesia

Esthetics of Dental Composite and Adhesive System

Alveolar Microperforation for Inflammation-Enhanced Tooth Movement During Orthodontic Treatment

LMX-4 for Postoperative Pain Management in Infants and Children Undergoing Penoplasty Surgery

Photobiomodulation and Tooth Analgesia

The Efficacy of Local Anesthetics to Reduce Shoulder Pain Post-Steroid Injections

EPR Tumor Oximetry With CE India Ink

Local Anesthesia Before Bulkamid Injection

Using a Contact Dermatitis Model With Biologic Medications to Study Skin Inflammation

Radial Artery Dilation Study: The Effect of Topical Administration of Nitroglycerin and Lidocaine Versus Lidocaine Alone of the Radial Artery Diameter

Topical Application of Cocaine HCl 4% and 10% on Safety and Efficacy in Local (Topical) Anesthesia